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Auteur Evdokia ANAGNOSTOU |
Documents disponibles écrits par cet auteur (64)
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Metabolic mapping of deep brain structures and associations with symptomatology in autism spectrum disorders / Krissy A. R. DOYLE-THOMAS in Research in Autism Spectrum Disorders, 8-1 (January 2014)
[article]
Titre : Metabolic mapping of deep brain structures and associations with symptomatology in autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Krissy A. R. DOYLE-THOMAS, Auteur ; Dallas CARD, Auteur ; Latha V. SOORYA, Auteur ; A. TING WANG, Auteur ; Jin FAN, Auteur ; Evdokia ANAGNOSTOU, Auteur Article en page(s) : p.44-51 Langues : Anglais (eng) Mots-clés : Magnetic resonance spectroscopy Autism spectrum disorders Deep gray matter Caudate nucleus Putamen Thalamus and social cognition Index. décimale : PER Périodiques Résumé : Abstract Structural neuroimaging studies in autism report atypical volume in deep brain structures which are related to symptomatology. Little is known about metabolic changes in these regions, and how they vary with age and sex, and/or relate to clinical behaviors. Using magnetic resonance spectroscopy we measured N-acetylaspartate, choline, creatine, myoinositol and glutamate in the caudate, putamen, and thalamus of 20 children with autism and 16 typically developing controls (7–18 years). Relative to controls, individuals with autism had elevated glutamate/creatine in the putamen. In addition, both groups showed age-related increases in glutamate in this region. Boys, relative to girls had increased choline/creatine in the thalamus. Lastly, there were correlations between glutamate, choline, and myoinositol in all three regions, and behavioral scores in the ASD group. These findings suggest changes in deep gray matter neurochemistry, which are sensitive to diagnosis, age and sex, and are associated with behavioral differences. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.10.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=220
in Research in Autism Spectrum Disorders > 8-1 (January 2014) . - p.44-51[article] Metabolic mapping of deep brain structures and associations with symptomatology in autism spectrum disorders [Texte imprimé et/ou numérique] / Krissy A. R. DOYLE-THOMAS, Auteur ; Dallas CARD, Auteur ; Latha V. SOORYA, Auteur ; A. TING WANG, Auteur ; Jin FAN, Auteur ; Evdokia ANAGNOSTOU, Auteur . - p.44-51.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 8-1 (January 2014) . - p.44-51
Mots-clés : Magnetic resonance spectroscopy Autism spectrum disorders Deep gray matter Caudate nucleus Putamen Thalamus and social cognition Index. décimale : PER Périodiques Résumé : Abstract Structural neuroimaging studies in autism report atypical volume in deep brain structures which are related to symptomatology. Little is known about metabolic changes in these regions, and how they vary with age and sex, and/or relate to clinical behaviors. Using magnetic resonance spectroscopy we measured N-acetylaspartate, choline, creatine, myoinositol and glutamate in the caudate, putamen, and thalamus of 20 children with autism and 16 typically developing controls (7–18 years). Relative to controls, individuals with autism had elevated glutamate/creatine in the putamen. In addition, both groups showed age-related increases in glutamate in this region. Boys, relative to girls had increased choline/creatine in the thalamus. Lastly, there were correlations between glutamate, choline, and myoinositol in all three regions, and behavioral scores in the ASD group. These findings suggest changes in deep gray matter neurochemistry, which are sensitive to diagnosis, age and sex, and are associated with behavioral differences. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.10.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=220 Novel Therapeutics in Autism Spectrum Disorders / Evdokia ANAGNOSTOU
Titre : Novel Therapeutics in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Evdokia ANAGNOSTOU, Auteur ; Caitlyn MCKEEVER, Auteur ; Azadeh KUSHKI, Auteur Année de publication : 2013 Importance : p.103-109 Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Résumé : Although ASD (autistic spectrum disorder) has seen significant gains in the area of therapeutics over the last 2 decades, it has also been characterized by the inability to successfully treat core symptom domains. In this chapter, we discuss challenges faced in this area, including limitations related to measuring outcomes, ability to capture the heterogeneity of ASD adequately, and lack of data in the rapidly growing adult population who have ASD. We then discuss novel approaches to therapeutics research in ASD, which include translating emerging findings from genomics, neuropathology and animal models into treatment, and discuss potential novel molecular targets in this area, such as glutamate/GABA related pathways, oxytocin/vasopressin, and immune modulation. The need to combine such treatments with evolving psychoeducational interventions is highlighted as it has the potential to modify the developmental trajectories of individuals with ASD. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 Novel Therapeutics in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Evdokia ANAGNOSTOU, Auteur ; Caitlyn MCKEEVER, Auteur ; Azadeh KUSHKI, Auteur . - 2013 . - p.103-109.
Langues : Anglais (eng)
Index. décimale : SCI-D SCI-D - Neurosciences Résumé : Although ASD (autistic spectrum disorder) has seen significant gains in the area of therapeutics over the last 2 decades, it has also been characterized by the inability to successfully treat core symptom domains. In this chapter, we discuss challenges faced in this area, including limitations related to measuring outcomes, ability to capture the heterogeneity of ASD adequately, and lack of data in the rapidly growing adult population who have ASD. We then discuss novel approaches to therapeutics research in ASD, which include translating emerging findings from genomics, neuropathology and animal models into treatment, and discuss potential novel molecular targets in this area, such as glutamate/GABA related pathways, oxytocin/vasopressin, and immune modulation. The need to combine such treatments with evolving psychoeducational interventions is highlighted as it has the potential to modify the developmental trajectories of individuals with ASD. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire Obsessive-compulsive disorder in children and youth: neurocognitive function in clinic and community samples / Russell SCHACHAR in Journal of Child Psychology and Psychiatry, 63-8 (August 2022)
[article]
Titre : Obsessive-compulsive disorder in children and youth: neurocognitive function in clinic and community samples Type de document : Texte imprimé et/ou numérique Auteurs : Russell SCHACHAR, Auteur ; Annie DUPUIS, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Stelios GEORGIADES, Auteur ; Noam SORENI, Auteur ; Paul D. ARNOLD, Auteur ; Christie L. BURTON, Auteur ; Jennifer CROSBIE, Auteur Article en page(s) : p.881-889 Langues : Anglais (eng) Mots-clés : Adolescent Attention Child Comorbidity Humans Obsessive-Compulsive Disorder/diagnosis Phenotype Reaction Time/physiology Ocd Stop-signal task executive function neurocognition Index. décimale : PER Périodiques Résumé : BACKGROUND: Neurocognitive impairments are common in OCD, although not well studied in children and youth with the disorder. METHOD: Using the stop-signal task (SST), we measured response inhibition (stop-signal reaction time-SSRT), sustained attention (reaction time variability-RTV), reaction time (RT), and performance monitoring (post-error slowing-PES) in OCD cases and controls from two samples of children and youth. A Clinic OCD group (n=171, aged 7-17years) was recruited from a specialty clinic after rigorous assessment. A typically developing (Clinic TD, n=157) group was enlisted through advertisement. A community OCD sample (Community OCD, n=147) and controls (Community TD n=13,832, aged 6-17 years) were recruited at a science museum. We also identified a community group with high OCD traits without an OCD diagnosis (Community High Trait; n=125). RESULTS: Clinic OCD participants had longer SSRT and greater RTV than Clinic TD. These effects were greater in younger OCD participants and, for SSRT, in those on medication for OCD. The Community OCD group did not differ from Controls but was similar to the Clinic OCD group in ADHD and ASD comorbidity and medication usage. The Community High Trait group had longer SSRT and atypical PES suggesting that symptom severity predicts neurocognitive function. No group differences were found in RT. CONCLUSIONS: In the largest study of neurocognitive performance in children with OCD to date, we found impaired response inhibition and sustained attention in OCD participants in comparison to typically developing peers. Performance was worse in younger OCD participants. In the community sample, participants with high OCD trait scores but no OCD diagnosis had impaired response inhibition and error processing, suggesting that OCD might be under-recognized. En ligne : http://dx.doi.org/10.1111/jcpp.13533 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486
in Journal of Child Psychology and Psychiatry > 63-8 (August 2022) . - p.881-889[article] Obsessive-compulsive disorder in children and youth: neurocognitive function in clinic and community samples [Texte imprimé et/ou numérique] / Russell SCHACHAR, Auteur ; Annie DUPUIS, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Stelios GEORGIADES, Auteur ; Noam SORENI, Auteur ; Paul D. ARNOLD, Auteur ; Christie L. BURTON, Auteur ; Jennifer CROSBIE, Auteur . - p.881-889.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-8 (August 2022) . - p.881-889
Mots-clés : Adolescent Attention Child Comorbidity Humans Obsessive-Compulsive Disorder/diagnosis Phenotype Reaction Time/physiology Ocd Stop-signal task executive function neurocognition Index. décimale : PER Périodiques Résumé : BACKGROUND: Neurocognitive impairments are common in OCD, although not well studied in children and youth with the disorder. METHOD: Using the stop-signal task (SST), we measured response inhibition (stop-signal reaction time-SSRT), sustained attention (reaction time variability-RTV), reaction time (RT), and performance monitoring (post-error slowing-PES) in OCD cases and controls from two samples of children and youth. A Clinic OCD group (n=171, aged 7-17years) was recruited from a specialty clinic after rigorous assessment. A typically developing (Clinic TD, n=157) group was enlisted through advertisement. A community OCD sample (Community OCD, n=147) and controls (Community TD n=13,832, aged 6-17 years) were recruited at a science museum. We also identified a community group with high OCD traits without an OCD diagnosis (Community High Trait; n=125). RESULTS: Clinic OCD participants had longer SSRT and greater RTV than Clinic TD. These effects were greater in younger OCD participants and, for SSRT, in those on medication for OCD. The Community OCD group did not differ from Controls but was similar to the Clinic OCD group in ADHD and ASD comorbidity and medication usage. The Community High Trait group had longer SSRT and atypical PES suggesting that symptom severity predicts neurocognitive function. No group differences were found in RT. CONCLUSIONS: In the largest study of neurocognitive performance in children with OCD to date, we found impaired response inhibition and sustained attention in OCD participants in comparison to typically developing peers. Performance was worse in younger OCD participants. In the community sample, participants with high OCD trait scores but no OCD diagnosis had impaired response inhibition and error processing, suggesting that OCD might be under-recognized. En ligne : http://dx.doi.org/10.1111/jcpp.13533 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 Patterns and impact of technology use in autistic children / Robyn CARDY in Research in Autism Spectrum Disorders, 108 (October 2023)
[article]
Titre : Patterns and impact of technology use in autistic children Type de document : Texte imprimé et/ou numérique Auteurs : Robyn CARDY, Auteur ; Corinna SMITH, Auteur ; Hamshi SUGANTHAN, Auteur ; Zhuoran JIANG, Auteur ; Baiyu WANG, Auteur ; Mahan MALIHI, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Azadeh KUSHKI, Auteur Article en page(s) : p.102253 Mots-clés : Autism Children Technology Screen time Index. décimale : PER Périodiques Résumé : Background Autistic children and youth spend a significant amount of their time interacting with technology, however, the characterization of use remains sparse. The objectives of this study were to 1) characterise the patterns and purpose of technology use among autistic children compared to non-autistic children, 2) explore the impact of how technology use affects child and family well-being, and 3) examine parents' attitudes towards childrens' technology use. Methods A 44-question anonymous parent-report survey developed in consultation with families of autistic children and clinicians was available online for 22 months, from April 2018 through February 2020. Parents and caregivers of children 19-years-old and younger were eligible to complete the survey. Results 611 survey responses were collected (autism group = 407; community group = 204). The autism group exhibited greater technology use across all time points of interest, with tablets being the most frequently used device type. The autism group was also more likely to use technology for therapeutic and recreational activities. The autism group experienced more positive impacts on quality of life and benefited more in areas of social, motor, language, and emotion regulation skills from technology use than the community group. Parents of older children, males, and those in the autism group were more likely to report displaced socialising with technology use. Positive attitudes were more likely to be reported by parents of autistic children and younger children, whereas negative feelings were more likely to be reported by parents of older and male children. Limitations The study findings must be interpreted within the context of several limitations, including the size and representativeness of the sample, potential for bias from parent-report, and limitations in the survey design (closed-ended questions). Conclusions Autistic children exhibited more technology use than non-autistic children. Parental perceptions of impact were highly mixed, and included potential benefits for recreation and supports. Implications for technology developers and clinical practitioners are discussed. En ligne : https://doi.org/10.1016/j.rasd.2023.102253 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=514
in Research in Autism Spectrum Disorders > 108 (October 2023) . - p.102253[article] Patterns and impact of technology use in autistic children [Texte imprimé et/ou numérique] / Robyn CARDY, Auteur ; Corinna SMITH, Auteur ; Hamshi SUGANTHAN, Auteur ; Zhuoran JIANG, Auteur ; Baiyu WANG, Auteur ; Mahan MALIHI, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Azadeh KUSHKI, Auteur . - p.102253.
in Research in Autism Spectrum Disorders > 108 (October 2023) . - p.102253
Mots-clés : Autism Children Technology Screen time Index. décimale : PER Périodiques Résumé : Background Autistic children and youth spend a significant amount of their time interacting with technology, however, the characterization of use remains sparse. The objectives of this study were to 1) characterise the patterns and purpose of technology use among autistic children compared to non-autistic children, 2) explore the impact of how technology use affects child and family well-being, and 3) examine parents' attitudes towards childrens' technology use. Methods A 44-question anonymous parent-report survey developed in consultation with families of autistic children and clinicians was available online for 22 months, from April 2018 through February 2020. Parents and caregivers of children 19-years-old and younger were eligible to complete the survey. Results 611 survey responses were collected (autism group = 407; community group = 204). The autism group exhibited greater technology use across all time points of interest, with tablets being the most frequently used device type. The autism group was also more likely to use technology for therapeutic and recreational activities. The autism group experienced more positive impacts on quality of life and benefited more in areas of social, motor, language, and emotion regulation skills from technology use than the community group. Parents of older children, males, and those in the autism group were more likely to report displaced socialising with technology use. Positive attitudes were more likely to be reported by parents of autistic children and younger children, whereas negative feelings were more likely to be reported by parents of older and male children. Limitations The study findings must be interpreted within the context of several limitations, including the size and representativeness of the sample, potential for bias from parent-report, and limitations in the survey design (closed-ended questions). Conclusions Autistic children exhibited more technology use than non-autistic children. Parental perceptions of impact were highly mixed, and included potential benefits for recreation and supports. Implications for technology developers and clinical practitioners are discussed. En ligne : https://doi.org/10.1016/j.rasd.2023.102253 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=514 Pharmacotherapy in autism spectrum disorder / Sharon SMILE
Titre : Pharmacotherapy in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Sharon SMILE, Auteur ; Evdokia ANAGNOSTOU, Auteur Année de publication : 2015 Importance : p.43-62 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=271 Pharmacotherapy in autism spectrum disorder [Texte imprimé et/ou numérique] / Sharon SMILE, Auteur ; Evdokia ANAGNOSTOU, Auteur . - 2015 . - p.43-62.
Langues : Anglais (eng)
Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=271 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire Physical activity participation among adolescents with autism spectrum disorder / Patrick JACHYRA in Autism, 25-3 (April 2021)
PermalinkA pilot dose finding study of pioglitazone in autistic children / L. CAPANO in Molecular Autism, 9 (2018)
PermalinkPractice patterns and determinants of wait time for autism spectrum disorder diagnosis in Canada / M. PENNER in Molecular Autism, 9 (2018)
PermalinkPractitioner Review: Pharmacological treatment of attention-deficit/hyperactivity disorder symptoms in children and youth with autism spectrum disorder: a systematic review and meta-analysis / R. RODRIGUES in Journal of Child Psychology and Psychiatry, 62-6 (June 2021)
PermalinkA randomized, placebo controlled trial of omega-3 fatty acids in the treatment of young children with autism / Deepali MANKAD in Molecular Autism, (March 2015)
PermalinkReview of neuroimaging in Autism Spectrum Disorders: what have we learned and where we go from here / Evdokia ANAGNOSTOU in Molecular Autism, (April 2011)
PermalinkRigor in science and science reporting: updated guidelines for submissions to Molecular Autism / Joseph D. BUXBAUM in Molecular Autism, 10 (2019)
PermalinkSpecificity of autonomic arousal to anxiety in children with autism spectrum disorder / Tabitha A. CHIU in Autism Research, 9-4 (April 2016)
PermalinkSystematic review of clinical guidance documents for autism spectrum disorder diagnostic assessment in select regions / M. PENNER in Autism, 22-5 (July 2018)
PermalinkTransdiagnostic Patterns of Sensory Processing in Autism and ADHD / Anahid POURTOUSI ; Connie YANG ; Zining DING ; Bobby STOJANOSKI ; Evdokia ANAGNOSTOU ; Robert NICOLSON ; Elizabeth KELLEY ; Stelios GEORGIADES ; Jennifer CROSBIE ; Russell SCHACHAR ; Muhammad AYUB ; Ryan A. STEVENSON in Journal of Autism and Developmental Disorders, 54-1 (January 2024)
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