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Auteur Wei XI |
Documents disponibles écrits par cet auteur (3)
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Association of urinary polycyclic aromatic hydrocarbon metabolites with symptoms among autistic children: A case-control study in Tianjin, China / Peiying LI in Autism Research, 15-10 (October 2022)
[article]
Titre : Association of urinary polycyclic aromatic hydrocarbon metabolites with symptoms among autistic children: A case-control study in Tianjin, China Type de document : Texte imprimé et/ou numérique Auteurs : Peiying LI, Auteur ; Qiaoyun YANG, Auteur ; Yao LI, Auteur ; Yu HAN, Auteur ; Zhiyi QU, Auteur ; Lei GAO, Auteur ; Tingkai CUI, Auteur ; Wenjuan XIONG, Auteur ; Wei XI, Auteur ; Xin ZHANG, Auteur Article en page(s) : p.1941-1960 Langues : Anglais (eng) Mots-clés : autism spectrum disorder behavioral characteristics case-control study children internal exposure polycyclic aromatic hydrocarbon Index. décimale : PER Périodiques Résumé : Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants that are associated with altered neurodevelopment and various neurodevelopmental disorders. However, studies evaluating internal biomarkers of PAH exposure in reference to the severity of autism spectrum disorder (ASD) symptomology and autistic behaviors are scarce. Hence, we conducted a case-control study evaluating 12 urinary hydroxylated PAH metabolites (i.e., hydroxy-PAHs) in 101 children with autism and 101 neurotypical children, matching according to sex and age in a 1:1 ratio. In children with ASD, the severity of symptomology and autistic behaviors were assessed using the child autism rating scale (CARS) and the autism behavior checklist (ABC). We found that urinary levels of nine of the hydroxy-PAHs were statistically significantly higher in the ASD group, with the exception of 2-hydroxynaphthalene (2-OHNap) and 4-hydroxyphenanthrene (4-OHPhe). Moreover, urinary hydroxy-PAH levels were associated with ASD risk, with odds ratios ranging from 1.86 to 17.19. Exposures to 1-hydroxynaphthalene (1-OHNap,Î2 = 3.32), hydroxyphenanthrenes (1/2/3 + 9-OHPhes,Î2 = 3.41-5.12), 1-hydroxypyrene (1-OH-Pyr;Î2 = 3.91), 2-hydroxybenzofuran (2-OHDBF;Î2 = 3.93), and â‘OH-PAHs (Î2 = 4.67) were positively associated with CARS scores after adjusting for covariates (all p< 0.05). When applying the ABC scale, 1-OHPyr levels were positively associated with ABC total scores (Î2 = 18.54), with the strongest associations evidenced in regard to the social relatedness (Î2 = 6.51) and language domains (Î2 = 6.51) (all p< 0.05). Bayesian kernel machine regression (BKMR) showed consistent positive exposure responses for 1-OHNap, 1-OHPhe, and 3 + 9-OHPhe levels in regard to CARS scores, and for 1-OHPyr levels in regard to ABC total scores. Our findings suggest that children with ASD may have higher urinary levels of hydroxy-PAHs, and that these biomarker levels are associated with an increased odds of ASD, an increased severity of autism symptomology, and increased autistic behaviors in children with autism. LAY SUMMARY: We conducted an epidemiologic study evaluating the associations of urinary hydroxy-PAH levels with autism spectrum disorder (ASD), autism symptomology, and autistic behaviors. We found that urinary hydroxy-PAHs were statistically significantly associated with ASD. We note strong statistically significant associations between 1-OHNap, 1-OHPhe, and 3 + 9-OHPhe levels and increased severity of autism symptomology, as well as a strong statistically significant association between 1-OHPyr levels and behavioral characteristics within the social and linguistic domains. This work, if confirmed, will contribute to the future development of diagnostics for children with mild autism, as well as to environmental measures to promote the health and wellbeing of children with autism spectrum disorders. En ligne : http://dx.doi.org/10.1002/aur.2788 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488
in Autism Research > 15-10 (October 2022) . - p.1941-1960[article] Association of urinary polycyclic aromatic hydrocarbon metabolites with symptoms among autistic children: A case-control study in Tianjin, China [Texte imprimé et/ou numérique] / Peiying LI, Auteur ; Qiaoyun YANG, Auteur ; Yao LI, Auteur ; Yu HAN, Auteur ; Zhiyi QU, Auteur ; Lei GAO, Auteur ; Tingkai CUI, Auteur ; Wenjuan XIONG, Auteur ; Wei XI, Auteur ; Xin ZHANG, Auteur . - p.1941-1960.
Langues : Anglais (eng)
in Autism Research > 15-10 (October 2022) . - p.1941-1960
Mots-clés : autism spectrum disorder behavioral characteristics case-control study children internal exposure polycyclic aromatic hydrocarbon Index. décimale : PER Périodiques Résumé : Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants that are associated with altered neurodevelopment and various neurodevelopmental disorders. However, studies evaluating internal biomarkers of PAH exposure in reference to the severity of autism spectrum disorder (ASD) symptomology and autistic behaviors are scarce. Hence, we conducted a case-control study evaluating 12 urinary hydroxylated PAH metabolites (i.e., hydroxy-PAHs) in 101 children with autism and 101 neurotypical children, matching according to sex and age in a 1:1 ratio. In children with ASD, the severity of symptomology and autistic behaviors were assessed using the child autism rating scale (CARS) and the autism behavior checklist (ABC). We found that urinary levels of nine of the hydroxy-PAHs were statistically significantly higher in the ASD group, with the exception of 2-hydroxynaphthalene (2-OHNap) and 4-hydroxyphenanthrene (4-OHPhe). Moreover, urinary hydroxy-PAH levels were associated with ASD risk, with odds ratios ranging from 1.86 to 17.19. Exposures to 1-hydroxynaphthalene (1-OHNap,Î2 = 3.32), hydroxyphenanthrenes (1/2/3 + 9-OHPhes,Î2 = 3.41-5.12), 1-hydroxypyrene (1-OH-Pyr;Î2 = 3.91), 2-hydroxybenzofuran (2-OHDBF;Î2 = 3.93), and â‘OH-PAHs (Î2 = 4.67) were positively associated with CARS scores after adjusting for covariates (all p< 0.05). When applying the ABC scale, 1-OHPyr levels were positively associated with ABC total scores (Î2 = 18.54), with the strongest associations evidenced in regard to the social relatedness (Î2 = 6.51) and language domains (Î2 = 6.51) (all p< 0.05). Bayesian kernel machine regression (BKMR) showed consistent positive exposure responses for 1-OHNap, 1-OHPhe, and 3 + 9-OHPhe levels in regard to CARS scores, and for 1-OHPyr levels in regard to ABC total scores. Our findings suggest that children with ASD may have higher urinary levels of hydroxy-PAHs, and that these biomarker levels are associated with an increased odds of ASD, an increased severity of autism symptomology, and increased autistic behaviors in children with autism. LAY SUMMARY: We conducted an epidemiologic study evaluating the associations of urinary hydroxy-PAH levels with autism spectrum disorder (ASD), autism symptomology, and autistic behaviors. We found that urinary hydroxy-PAHs were statistically significantly associated with ASD. We note strong statistically significant associations between 1-OHNap, 1-OHPhe, and 3 + 9-OHPhe levels and increased severity of autism symptomology, as well as a strong statistically significant association between 1-OHPyr levels and behavioral characteristics within the social and linguistic domains. This work, if confirmed, will contribute to the future development of diagnostics for children with mild autism, as well as to environmental measures to promote the health and wellbeing of children with autism spectrum disorders. En ligne : http://dx.doi.org/10.1002/aur.2788 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 Erratum to: Prenatal and Perinatal Risk Factors for Autism in China / Xin ZHANG in Journal of Autism and Developmental Disorders, 40-11 (November 2010)
[article]
Titre : Erratum to: Prenatal and Perinatal Risk Factors for Autism in China Type de document : Texte imprimé et/ou numérique Auteurs : Xin ZHANG, Auteur ; Cong-Chao LV, Auteur ; Jiang TIAN, Auteur ; Ru-Juan MIAO, Auteur ; Wei XI, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Lihong QI, Auteur Année de publication : 2010 Article en page(s) : p.1322 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-010-1020-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=113
in Journal of Autism and Developmental Disorders > 40-11 (November 2010) . - p.1322[article] Erratum to: Prenatal and Perinatal Risk Factors for Autism in China [Texte imprimé et/ou numérique] / Xin ZHANG, Auteur ; Cong-Chao LV, Auteur ; Jiang TIAN, Auteur ; Ru-Juan MIAO, Auteur ; Wei XI, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Lihong QI, Auteur . - 2010 . - p.1322.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 40-11 (November 2010) . - p.1322
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-010-1020-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=113 Prenatal and Perinatal Risk Factors for Autism in China / Xin ZHANG in Journal of Autism and Developmental Disorders, 40-11 (November 2010)
[article]
Titre : Prenatal and Perinatal Risk Factors for Autism in China Type de document : Texte imprimé et/ou numérique Auteurs : Xin ZHANG, Auteur ; Cong-Chao LV, Auteur ; Jiang TIAN, Auteur ; Ru-Juan MIAO, Auteur ; Wei XI, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Lihong QI, Auteur Année de publication : 2010 Article en page(s) : p.1311-1321 Langues : Anglais (eng) Mots-clés : Autism China Prenatal Perinatal Risk factors Index. décimale : PER Périodiques Résumé : We conducted a case–control study using 190 Han children with and without autism to investigate prenatal and perinatal risk factors for autism in China. Cases were recruited through public special education schools and controls from regular public schools in the same region (Tianjin), with frequency matching on sex and birth year. Unadjusted analyses identified seven prenatal and seven perinatal risk factors significantly associated with autism. In the adjusted analysis, nine risk factors showed significant association with autism: maternal second-hand smoke exposure, maternal chronic or acute medical conditions unrelated to pregnancy, maternal unhappy emotional state, gestational complications, edema, abnormal gestational age (<35 or >42 weeks), nuchal cord, gravidity >1, and advanced paternal age at delivery (>30 year-old). En ligne : http://dx.doi.org/10.1007/s10803-010-0992-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=113
in Journal of Autism and Developmental Disorders > 40-11 (November 2010) . - p.1311-1321[article] Prenatal and Perinatal Risk Factors for Autism in China [Texte imprimé et/ou numérique] / Xin ZHANG, Auteur ; Cong-Chao LV, Auteur ; Jiang TIAN, Auteur ; Ru-Juan MIAO, Auteur ; Wei XI, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Lihong QI, Auteur . - 2010 . - p.1311-1321.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 40-11 (November 2010) . - p.1311-1321
Mots-clés : Autism China Prenatal Perinatal Risk factors Index. décimale : PER Périodiques Résumé : We conducted a case–control study using 190 Han children with and without autism to investigate prenatal and perinatal risk factors for autism in China. Cases were recruited through public special education schools and controls from regular public schools in the same region (Tianjin), with frequency matching on sex and birth year. Unadjusted analyses identified seven prenatal and seven perinatal risk factors significantly associated with autism. In the adjusted analysis, nine risk factors showed significant association with autism: maternal second-hand smoke exposure, maternal chronic or acute medical conditions unrelated to pregnancy, maternal unhappy emotional state, gestational complications, edema, abnormal gestational age (<35 or >42 weeks), nuchal cord, gravidity >1, and advanced paternal age at delivery (>30 year-old). En ligne : http://dx.doi.org/10.1007/s10803-010-0992-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=113