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Auteur Zachary WARREN |
Documents disponibles écrits par cet auteur (60)
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The Behavioral Phenotype in MECP2 Duplication Syndrome: A Comparison With Idiopathic Autism / Sarika U. PETERS in Autism Research, 6-1 (February 2013)
[article]
Titre : The Behavioral Phenotype in MECP2 Duplication Syndrome: A Comparison With Idiopathic Autism Type de document : Texte imprimé et/ou numérique Auteurs : Sarika U. PETERS, Auteur ; Rachel J. HUNDLEY, Auteur ; Amy K. WILSON, Auteur ; Zachary WARREN, Auteur ; Alison VEHORN, Auteur ; Claudia M. B. CARVALHO, Auteur ; James R. LUPSKI, Auteur ; Melissa B. RAMOCKI, Auteur Année de publication : 2013 Article en page(s) : p.42-50 Langues : Anglais (eng) Mots-clés : autism MECP2 genetics phenotype social affect overexpression Index. décimale : PER Périodiques Résumé : Alterations in the X-linked gene MECP2 encoding the methyl-CpG-binding protein 2 have been linked to autism spectrum disorders (ASDs). Most recently, data suggest that overexpression of MECP2 may be related to ASD. To better characterize the relevance of MECP2 overexpression to ASD-related behaviors, we compared the core symptoms of ASD in MECP2 duplication syndrome to nonverbal mental age-matched boys with idiopathic ASD. Within the MECP2 duplication group, we further delineated aspects of the behavioral phenotype and also examined how duplication size and gene content corresponded to clinical severity. We compared ten males with MECP2 duplication syndrome (ages 3–10) with a chronological and mental age-matched sample of nine nonverbal males with idiopathic ASD. Our results indicate that boys with MECP2 duplication syndrome share the core behavioral features of ASD (e.g. social affect, restricted/repetitive behaviors). Direct comparisons of ASD profiles revealed that a majority of boys with MECP2 duplication syndrome are similar to idiopathic ASD; they have impairments in social affect (albeit to a lesser degree than idiopathic ASD) and similar severity in restricted/repetitive behaviors. Nonverbal mental age did not correlate with severity of social impairment or repetitive behaviors. Within the MECP2 duplication group, breakpoint size does not predict differences in clinical severity. In addition to social withdrawal and stereotyped behaviors, we also found that hyposensitivity to pain/temperature are part of the behavioral phenotype of MECP2 duplication syndrome. Our results illustrate that overexpression/increased dosage of MECP2 is related to core features of ASD. En ligne : http://dx.doi.org/10.1002/aur.1262 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192
in Autism Research > 6-1 (February 2013) . - p.42-50[article] The Behavioral Phenotype in MECP2 Duplication Syndrome: A Comparison With Idiopathic Autism [Texte imprimé et/ou numérique] / Sarika U. PETERS, Auteur ; Rachel J. HUNDLEY, Auteur ; Amy K. WILSON, Auteur ; Zachary WARREN, Auteur ; Alison VEHORN, Auteur ; Claudia M. B. CARVALHO, Auteur ; James R. LUPSKI, Auteur ; Melissa B. RAMOCKI, Auteur . - 2013 . - p.42-50.
Langues : Anglais (eng)
in Autism Research > 6-1 (February 2013) . - p.42-50
Mots-clés : autism MECP2 genetics phenotype social affect overexpression Index. décimale : PER Périodiques Résumé : Alterations in the X-linked gene MECP2 encoding the methyl-CpG-binding protein 2 have been linked to autism spectrum disorders (ASDs). Most recently, data suggest that overexpression of MECP2 may be related to ASD. To better characterize the relevance of MECP2 overexpression to ASD-related behaviors, we compared the core symptoms of ASD in MECP2 duplication syndrome to nonverbal mental age-matched boys with idiopathic ASD. Within the MECP2 duplication group, we further delineated aspects of the behavioral phenotype and also examined how duplication size and gene content corresponded to clinical severity. We compared ten males with MECP2 duplication syndrome (ages 3–10) with a chronological and mental age-matched sample of nine nonverbal males with idiopathic ASD. Our results indicate that boys with MECP2 duplication syndrome share the core behavioral features of ASD (e.g. social affect, restricted/repetitive behaviors). Direct comparisons of ASD profiles revealed that a majority of boys with MECP2 duplication syndrome are similar to idiopathic ASD; they have impairments in social affect (albeit to a lesser degree than idiopathic ASD) and similar severity in restricted/repetitive behaviors. Nonverbal mental age did not correlate with severity of social impairment or repetitive behaviors. Within the MECP2 duplication group, breakpoint size does not predict differences in clinical severity. In addition to social withdrawal and stereotyped behaviors, we also found that hyposensitivity to pain/temperature are part of the behavioral phenotype of MECP2 duplication syndrome. Our results illustrate that overexpression/increased dosage of MECP2 is related to core features of ASD. En ligne : http://dx.doi.org/10.1002/aur.1262 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192 The diagnosis of autism in community pediatric settings: Does advanced training facilitate practice change? / Amy R. SWANSON in Autism, 18-5 (July 2014)
[article]
Titre : The diagnosis of autism in community pediatric settings: Does advanced training facilitate practice change? Type de document : Texte imprimé et/ou numérique Auteurs : Amy R. SWANSON, Auteur ; Zachary WARREN, Auteur ; Wendy L. STONE, Auteur ; Alison C. VEHORN, Auteur ; Elizabeth DOHRMANN, Auteur ; Quentin HUMBERD, Auteur Article en page(s) : p.555-561 Langues : Anglais (eng) Mots-clés : autism spectrum disorders diagnosis screening Index. décimale : PER Périodiques Résumé : The increased prevalence of autism spectrum disorder and documented benefits of early intensive intervention have created a need for flexible systems for determining eligibility for autism-specific services. This study evaluated the effectiveness of a training program designed to enhance autism spectrum disorder identification and assessment within community pediatric settings across the state. Twenty-seven pediatric providers participated in regional trainings across a 3.5-year period. Trainings provided clinicians with strategies for conducting relatively brief within-practice interactive assessments following positive autism spectrum disorder screenings. Program evaluation was measured approximately 1.5 years following training through (a) clinician self-reports of practice change and (b) blind diagnostic verification of a subset of children assessed. Pediatric providers participating in the training reported significant changes in screening and consultation practices following training, with a reported 85% increase in diagnostic identification of children with autism spectrum disorder within their own practice setting. In addition, substantial agreement (86%–93%) was found between pediatrician diagnostic judgments and independent, comprehensive blinded diagnostic evaluations. Collaborative training methods that allow autism spectrum disorder identification within broader community pediatric settings may help translate enhanced screening initiatives into more effective and efficient diagnosis and treatment. En ligne : http://dx.doi.org/10.1177/1362361313481507 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233
in Autism > 18-5 (July 2014) . - p.555-561[article] The diagnosis of autism in community pediatric settings: Does advanced training facilitate practice change? [Texte imprimé et/ou numérique] / Amy R. SWANSON, Auteur ; Zachary WARREN, Auteur ; Wendy L. STONE, Auteur ; Alison C. VEHORN, Auteur ; Elizabeth DOHRMANN, Auteur ; Quentin HUMBERD, Auteur . - p.555-561.
Langues : Anglais (eng)
in Autism > 18-5 (July 2014) . - p.555-561
Mots-clés : autism spectrum disorders diagnosis screening Index. décimale : PER Périodiques Résumé : The increased prevalence of autism spectrum disorder and documented benefits of early intensive intervention have created a need for flexible systems for determining eligibility for autism-specific services. This study evaluated the effectiveness of a training program designed to enhance autism spectrum disorder identification and assessment within community pediatric settings across the state. Twenty-seven pediatric providers participated in regional trainings across a 3.5-year period. Trainings provided clinicians with strategies for conducting relatively brief within-practice interactive assessments following positive autism spectrum disorder screenings. Program evaluation was measured approximately 1.5 years following training through (a) clinician self-reports of practice change and (b) blind diagnostic verification of a subset of children assessed. Pediatric providers participating in the training reported significant changes in screening and consultation practices following training, with a reported 85% increase in diagnostic identification of children with autism spectrum disorder within their own practice setting. In addition, substantial agreement (86%–93%) was found between pediatrician diagnostic judgments and independent, comprehensive blinded diagnostic evaluations. Collaborative training methods that allow autism spectrum disorder identification within broader community pediatric settings may help translate enhanced screening initiatives into more effective and efficient diagnosis and treatment. En ligne : http://dx.doi.org/10.1177/1362361313481507 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233 The impact of robots on children with autism spectrum disorder / Zhi ZHENG
Titre : The impact of robots on children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Zhi ZHENG, Auteur ; Esubalew BEKELE, Auteur ; Amy SWANSON, Auteur ; Amy WEITLAUF, Auteur ; Zachary WARREN, Auteur ; Nilanjan SARKAR, Auteur Importance : p.397-417 Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=382 The impact of robots on children with autism spectrum disorder [Texte imprimé et/ou numérique] / Zhi ZHENG, Auteur ; Esubalew BEKELE, Auteur ; Amy SWANSON, Auteur ; Amy WEITLAUF, Auteur ; Zachary WARREN, Auteur ; Nilanjan SARKAR, Auteur . - [s.d.] . - p.397-417.
Langues : Anglais (eng)
Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=382 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire The Implications of Parent-Reported Emotional and Behavioral Problems on the Modified Checklist for Autism in Toddlers / Kourtney CHRISTOPHER in Journal of Autism and Developmental Disorders, 51-3 (March 2021)
[article]
Titre : The Implications of Parent-Reported Emotional and Behavioral Problems on the Modified Checklist for Autism in Toddlers Type de document : Texte imprimé et/ou numérique Auteurs : Kourtney CHRISTOPHER, Auteur ; Somer L. BISHOP, Auteur ; Laura ARNSTEIN CARPENTER, Auteur ; Zachary WARREN, Auteur ; Stephen M. KANNE, Auteur Article en page(s) : p.884-891 Langues : Anglais (eng) Mots-clés : Asd Autism Cbcl Ebp Emotional Behavioral Problems M-chat-r/f Screening measure Sensitivity Specificity Index. décimale : PER Périodiques Résumé : Studies have shown that Autism Spectrum Disorder (ASD) screening and diagnostic instruments may be affected by the presence of emotional and behavior problems (EBPs). This study assessed the impact of EBPs on the Modified Checklist for Autism in Toddlers, Revised with Follow-up (M-CHAT-R/F). Participants included 290 children, 18-48 months of age, referred for ASD-related concerns. Those diagnosed with ASD had significantly lower externalizing EBPs compared to those who were not diagnosed with ASD. More externalizing symptoms and younger age were significantly predictive of an M-CHAT-R/F final score. Sensitivity and specificity was impacted by the age of the child. These results suggest that combining measures that assess EBPs and autism core symptoms may improve accuracy in this referred population. En ligne : http://dx.doi.org/10.1007/s10803-020-04469-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443
in Journal of Autism and Developmental Disorders > 51-3 (March 2021) . - p.884-891[article] The Implications of Parent-Reported Emotional and Behavioral Problems on the Modified Checklist for Autism in Toddlers [Texte imprimé et/ou numérique] / Kourtney CHRISTOPHER, Auteur ; Somer L. BISHOP, Auteur ; Laura ARNSTEIN CARPENTER, Auteur ; Zachary WARREN, Auteur ; Stephen M. KANNE, Auteur . - p.884-891.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-3 (March 2021) . - p.884-891
Mots-clés : Asd Autism Cbcl Ebp Emotional Behavioral Problems M-chat-r/f Screening measure Sensitivity Specificity Index. décimale : PER Périodiques Résumé : Studies have shown that Autism Spectrum Disorder (ASD) screening and diagnostic instruments may be affected by the presence of emotional and behavior problems (EBPs). This study assessed the impact of EBPs on the Modified Checklist for Autism in Toddlers, Revised with Follow-up (M-CHAT-R/F). Participants included 290 children, 18-48 months of age, referred for ASD-related concerns. Those diagnosed with ASD had significantly lower externalizing EBPs compared to those who were not diagnosed with ASD. More externalizing symptoms and younger age were significantly predictive of an M-CHAT-R/F final score. Sensitivity and specificity was impacted by the age of the child. These results suggest that combining measures that assess EBPs and autism core symptoms may improve accuracy in this referred population. En ligne : http://dx.doi.org/10.1007/s10803-020-04469-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443 Toward Novel Tools for Autism Identification: Fusing Computational and Clinical Expertise / L. L. CORONA in Journal of Autism and Developmental Disorders, 51-11 (November 2021)
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Titre : Toward Novel Tools for Autism Identification: Fusing Computational and Clinical Expertise Type de document : Texte imprimé et/ou numérique Auteurs : L. L. CORONA, Auteur ; L. WAGNER, Auteur ; J. WADE, Auteur ; Amy S. WEITLAUF, Auteur ; J. HINE, Auteur ; A. NICHOLSON, Auteur ; C. STONE, Auteur ; A. VEHORN, Auteur ; Zachary WARREN, Auteur Article en page(s) : p.4003-4012 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis Autistic Disorder Child Child, Preschool Humans Mass Screening Outcome Assessment, Health Care Assessment Autism spectrum disorder Machine learning Young children has served as a Consultant for Adaptive Technology Consulting and Roche. Dr. Weitlauf has served as a Consultant for Adaptive Technology Consulting. Index. décimale : PER Périodiques Résumé : Barriers to identifying autism spectrum disorder (ASD) in young children in a timely manner have led to calls for novel screening and assessment strategies. Combining computational methods with clinical expertise presents an opportunity for identifying patterns within large clinical datasets that can inform new assessment paradigms. The present study describes an analytic approach used to identify key features predictive of ASD in young children, drawn from large amounts of data from comprehensive diagnostic evaluations. A team of expert clinicians used these predictive features to design a set of assessment activities allowing for observation of these core behaviors. The resulting brief assessment underlies several novel approaches to the identification of ASD that are the focus of ongoing research. En ligne : http://dx.doi.org/10.1007/s10803-020-04857-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454
in Journal of Autism and Developmental Disorders > 51-11 (November 2021) . - p.4003-4012[article] Toward Novel Tools for Autism Identification: Fusing Computational and Clinical Expertise [Texte imprimé et/ou numérique] / L. L. CORONA, Auteur ; L. WAGNER, Auteur ; J. WADE, Auteur ; Amy S. WEITLAUF, Auteur ; J. HINE, Auteur ; A. NICHOLSON, Auteur ; C. STONE, Auteur ; A. VEHORN, Auteur ; Zachary WARREN, Auteur . - p.4003-4012.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-11 (November 2021) . - p.4003-4012
Mots-clés : Autism Spectrum Disorder/diagnosis Autistic Disorder Child Child, Preschool Humans Mass Screening Outcome Assessment, Health Care Assessment Autism spectrum disorder Machine learning Young children has served as a Consultant for Adaptive Technology Consulting and Roche. Dr. Weitlauf has served as a Consultant for Adaptive Technology Consulting. Index. décimale : PER Périodiques Résumé : Barriers to identifying autism spectrum disorder (ASD) in young children in a timely manner have led to calls for novel screening and assessment strategies. Combining computational methods with clinical expertise presents an opportunity for identifying patterns within large clinical datasets that can inform new assessment paradigms. The present study describes an analytic approach used to identify key features predictive of ASD in young children, drawn from large amounts of data from comprehensive diagnostic evaluations. A team of expert clinicians used these predictive features to design a set of assessment activities allowing for observation of these core behaviors. The resulting brief assessment underlies several novel approaches to the identification of ASD that are the focus of ongoing research. En ligne : http://dx.doi.org/10.1007/s10803-020-04857-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454 Transitioning to Telemedicine During COVID-19: Impact on Perceptions and Use of Telemedicine Procedures for the Diagnosis of Autism in Toddlers / Liliana WAGNER in Journal of Autism and Developmental Disorders, 52-5 (May 2022)
PermalinkUnderstanding Performance and Verbal-Communication of Children with ASD in a Collaborative Virtual Environment / L. ZHANG in Journal of Autism and Developmental Disorders, 48-8 (August 2018)
PermalinkUse of the TELE-ASD-PEDS for Autism Evaluations in Response to COVID-19: Preliminary Outcomes and Clinician Acceptability / L. WAGNER in Journal of Autism and Developmental Disorders, 51-9 (September 2021)
PermalinkWhen Are We Sure? Predictors of Clinician Certainty in the Diagnosis of Autism Spectrum Disorder / C. G. MCDONNELL in Journal of Autism and Developmental Disorders, 49-4 (April 2019)
PermalinkWhy Is Early Intervention Important in ASC? / Zachary WARREN
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