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Auteur Christine JENNEN-STEINMETZ |
Documents disponibles écrits par cet auteur (2)
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Catechol-O-methyltransferase Val158Met genotype, parenting practices and adolescent alcohol use: testing the differential susceptibility hypothesis / Manfred LAUCHT in Journal of Child Psychology and Psychiatry, 53-4 (April 2012)
[article]
Titre : Catechol-O-methyltransferase Val158Met genotype, parenting practices and adolescent alcohol use: testing the differential susceptibility hypothesis Type de document : Texte imprimé et/ou numérique Auteurs : Manfred LAUCHT, Auteur ; Dorothea BLOMEYER, Auteur ; Arlette F. BUCHMANN, Auteur ; Jens TREUTLEIN, Auteur ; Martin H. SCHMIDT, Auteur ; Günter ESSER, Auteur ; Christine JENNEN-STEINMETZ, Auteur ; Marcella RIETSCHEL, Auteur ; Ulrich S. ZIMMERMANN, Auteur ; Tobias BANASCHEWSKI, Auteur Année de publication : 2012 Article en page(s) : p.351-359 Langues : Anglais (eng) Mots-clés : Catechol-O-methyltransferase gene alcohol use adolescentsparenting gene–environment interaction Index. décimale : PER Périodiques Résumé : Background: Recently, first evidence has been reported for a gene–parenting interaction (G × E) with regard to adolescent alcohol use. The present investigation set out to extend this research using the catechol-O-methyltransferase (COMT) Val158Met polymorphism as a genetic susceptibility factor. Moreover, the current study examined whether a potential G×E would be consistent with one of two models of gene–environment interplay (genetic vulnerability vs. differential susceptibility). Methods: Data were collected as part of an ongoing epidemiological cohort study following the outcome of early risk factors from birth into adulthood. Two hundred and eighty-five participants (130 males, 155 females) were genotyped for the COMT Val158Met polymorphism and were administered an alcohol interview, providing measures of current frequency and amount of drinking at ages 15 and 19 years. Information on three dimensions of perceived parenting behavior was obtained from the 15-year-olds. Results: Adolescents homozygous for the Met allele showed higher drinking activity at age 19 years when their parents had engaged in less supervision or were less involved, while their drinking activity was reduced under conditions of favorable parenting. No such relationship was found in individuals carrying the Val allele. Conclusions: The present findings correspond with the pattern of results predicted by the differential susceptibility hypothesis, suggesting that environmental variation would have a greater impact in individuals carrying a genetic susceptibility such that, in this group, exposure to negative environmental conditions would result in more adverse outcomes and the experience of favorable conditions would lead to more positive outcomes. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02408.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152
in Journal of Child Psychology and Psychiatry > 53-4 (April 2012) . - p.351-359[article] Catechol-O-methyltransferase Val158Met genotype, parenting practices and adolescent alcohol use: testing the differential susceptibility hypothesis [Texte imprimé et/ou numérique] / Manfred LAUCHT, Auteur ; Dorothea BLOMEYER, Auteur ; Arlette F. BUCHMANN, Auteur ; Jens TREUTLEIN, Auteur ; Martin H. SCHMIDT, Auteur ; Günter ESSER, Auteur ; Christine JENNEN-STEINMETZ, Auteur ; Marcella RIETSCHEL, Auteur ; Ulrich S. ZIMMERMANN, Auteur ; Tobias BANASCHEWSKI, Auteur . - 2012 . - p.351-359.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 53-4 (April 2012) . - p.351-359
Mots-clés : Catechol-O-methyltransferase gene alcohol use adolescentsparenting gene–environment interaction Index. décimale : PER Périodiques Résumé : Background: Recently, first evidence has been reported for a gene–parenting interaction (G × E) with regard to adolescent alcohol use. The present investigation set out to extend this research using the catechol-O-methyltransferase (COMT) Val158Met polymorphism as a genetic susceptibility factor. Moreover, the current study examined whether a potential G×E would be consistent with one of two models of gene–environment interplay (genetic vulnerability vs. differential susceptibility). Methods: Data were collected as part of an ongoing epidemiological cohort study following the outcome of early risk factors from birth into adulthood. Two hundred and eighty-five participants (130 males, 155 females) were genotyped for the COMT Val158Met polymorphism and were administered an alcohol interview, providing measures of current frequency and amount of drinking at ages 15 and 19 years. Information on three dimensions of perceived parenting behavior was obtained from the 15-year-olds. Results: Adolescents homozygous for the Met allele showed higher drinking activity at age 19 years when their parents had engaged in less supervision or were less involved, while their drinking activity was reduced under conditions of favorable parenting. No such relationship was found in individuals carrying the Val allele. Conclusions: The present findings correspond with the pattern of results predicted by the differential susceptibility hypothesis, suggesting that environmental variation would have a greater impact in individuals carrying a genetic susceptibility such that, in this group, exposure to negative environmental conditions would result in more adverse outcomes and the experience of favorable conditions would lead to more positive outcomes. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02408.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152 Neuropsychological correlates of emotional lability in children with ADHD / Tobias BANASCHEWSKI in Journal of Child Psychology and Psychiatry, 53-11 (November 2012)
[article]
Titre : Neuropsychological correlates of emotional lability in children with ADHD Type de document : Texte imprimé et/ou numérique Auteurs : Tobias BANASCHEWSKI, Auteur ; Christine JENNEN-STEINMETZ, Auteur ; Daniel BRANDEIS, Auteur ; Jan K. BUITELAAR, Auteur ; Jonna KUNTSI, Auteur ; Luise POUSTKA, Auteur ; Joseph A. SERGEANT, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Alexis C. FRAZIER-WOOD, Auteur ; Björn ALBRECHT, Auteur ; Wai CHEN, Auteur ; Henrik UEBEL, Auteur ; Wolff SCHLOTZ, Auteur ; Jaap VAN DER MEERE, Auteur ; Michael GILL, Auteur ; Iris MANOR, Auteur ; Ana MIRANDA, Auteur ; Fernando MULAS, Auteur ; Robert D. OADES, Auteur ; Herbert ROEYERS, Auteur ; Aribert ROTHENBERGER, Auteur ; Hans-Christoph STEINHAUSEN, Auteur ; Stephen V. FARAONE, Auteur ; Philip ASHERSON, Auteur Année de publication : 2012 Article en page(s) : p.1139-1148 Langues : Anglais (eng) Mots-clés : ADHD neuropsychological performance emotional lability executive functions delay aversion Index. décimale : PER Périodiques Résumé : Background: Emotional lability (EL) is commonly seen in patients with attention-deficit/hyperactivity disorder (ADHD). The reasons for this association remain currently unknown. To address this question, we examined the relationship between ADHD and EL symptoms, and performance on a range of neuropsychological tasks to clarify whether EL symptoms are predicted by particular cognitive and/or motivational dysfunctions and whether these associations are mediated by the presence of ADHD symptoms. Methods: A large multi-site sample of 424 carefully diagnosed ADHD cases and 564 unaffected siblings and controls aged 6–18 years performed a broad neuropsychological test battery, including a Go/No-Go Task, a warned four-choice Reaction Time task, the Maudsley Index of Childhood Delay Aversion and Digit span backwards. Neuropsychological variables were aggregated as indices of processing speed, response variability, executive functions, choice impulsivity and the influence of energetic and/or motivational factors. EL and ADHD symptoms were regressed on each neuropsychological variable in separate analyses controlling for age, gender and IQ, and, in subsequent regression analyses, for ADHD and EL symptoms respectively. Results: Neuropsychological variables significantly predicted ADHD and EL symptoms with moderate-to-low regression coefficients. However, the association between neuropsychological parameters on EL disappeared entirely when the effect of ADHD symptoms was taken into account, revealing that the association between the neuropsychological performance measures and EL is completely mediated statistically by variations in ADHD symptoms. Conversely, neuropsychological effects on ADHD symptoms remained after EL symptom severity was taken into account. Conclusions: The neuropsychological parameters examined, herein, predict ADHD more strongly than EL. They cannot explain EL symptoms beyond what is already accounted for by ADHD symptom severity. The association between EL and ADHD cannot be explained by these cognitive or motivational deficits. Alternative mechanisms, including overlapping genetic influences (pleiotropic effects) and/or alternative neuropsychological processes need to be considered. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02596.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182
in Journal of Child Psychology and Psychiatry > 53-11 (November 2012) . - p.1139-1148[article] Neuropsychological correlates of emotional lability in children with ADHD [Texte imprimé et/ou numérique] / Tobias BANASCHEWSKI, Auteur ; Christine JENNEN-STEINMETZ, Auteur ; Daniel BRANDEIS, Auteur ; Jan K. BUITELAAR, Auteur ; Jonna KUNTSI, Auteur ; Luise POUSTKA, Auteur ; Joseph A. SERGEANT, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Alexis C. FRAZIER-WOOD, Auteur ; Björn ALBRECHT, Auteur ; Wai CHEN, Auteur ; Henrik UEBEL, Auteur ; Wolff SCHLOTZ, Auteur ; Jaap VAN DER MEERE, Auteur ; Michael GILL, Auteur ; Iris MANOR, Auteur ; Ana MIRANDA, Auteur ; Fernando MULAS, Auteur ; Robert D. OADES, Auteur ; Herbert ROEYERS, Auteur ; Aribert ROTHENBERGER, Auteur ; Hans-Christoph STEINHAUSEN, Auteur ; Stephen V. FARAONE, Auteur ; Philip ASHERSON, Auteur . - 2012 . - p.1139-1148.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 53-11 (November 2012) . - p.1139-1148
Mots-clés : ADHD neuropsychological performance emotional lability executive functions delay aversion Index. décimale : PER Périodiques Résumé : Background: Emotional lability (EL) is commonly seen in patients with attention-deficit/hyperactivity disorder (ADHD). The reasons for this association remain currently unknown. To address this question, we examined the relationship between ADHD and EL symptoms, and performance on a range of neuropsychological tasks to clarify whether EL symptoms are predicted by particular cognitive and/or motivational dysfunctions and whether these associations are mediated by the presence of ADHD symptoms. Methods: A large multi-site sample of 424 carefully diagnosed ADHD cases and 564 unaffected siblings and controls aged 6–18 years performed a broad neuropsychological test battery, including a Go/No-Go Task, a warned four-choice Reaction Time task, the Maudsley Index of Childhood Delay Aversion and Digit span backwards. Neuropsychological variables were aggregated as indices of processing speed, response variability, executive functions, choice impulsivity and the influence of energetic and/or motivational factors. EL and ADHD symptoms were regressed on each neuropsychological variable in separate analyses controlling for age, gender and IQ, and, in subsequent regression analyses, for ADHD and EL symptoms respectively. Results: Neuropsychological variables significantly predicted ADHD and EL symptoms with moderate-to-low regression coefficients. However, the association between neuropsychological parameters on EL disappeared entirely when the effect of ADHD symptoms was taken into account, revealing that the association between the neuropsychological performance measures and EL is completely mediated statistically by variations in ADHD symptoms. Conversely, neuropsychological effects on ADHD symptoms remained after EL symptom severity was taken into account. Conclusions: The neuropsychological parameters examined, herein, predict ADHD more strongly than EL. They cannot explain EL symptoms beyond what is already accounted for by ADHD symptom severity. The association between EL and ADHD cannot be explained by these cognitive or motivational deficits. Alternative mechanisms, including overlapping genetic influences (pleiotropic effects) and/or alternative neuropsychological processes need to be considered. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02596.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182