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Auteur AUTISM GENETIC RESOURCE EXCHANGE CONSORTIUM |
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Genetic and environmental influences on symptom domains in twins and siblings with autism / Carla A. MAZEFSKY in Research in Autism Spectrum Disorders, 2-2 (April-June 2008)
[article]
Titre : Genetic and environmental influences on symptom domains in twins and siblings with autism Type de document : Texte imprimé et/ou numérique Auteurs : Carla A. MAZEFSKY, Auteur ; Robin P. GOIN-KOCHEL, Auteur ; AUTISM GENETIC RESOURCE EXCHANGE CONSORTIUM, Auteur ; Hermine H. MAES, Auteur ; Brien P. RILEY, Auteur Année de publication : 2008 Article en page(s) : p.320-331 Langues : Anglais (eng) Mots-clés : Autism Autism-diagnostic-interview Behavioral-genetics Twins Social-interaction Nonverbal-communication Index. décimale : PER Périodiques Résumé : Clarifying the sources of variation among autism symptom domains is important to the identification of homogenous subgroups for molecular genetic studies. This study explored the genetic and environmental bases of nonverbal communication and social interaction, two symptom domains that have also been related to treatment response, in 1294 child and adolescent twins and siblings with pervasive developmental disorders (PDDs) from the Autism Genetic Resource Exchange under the age of 18. Twin/sibling resemblance was assessed through correlations and behavior genetic modeling of autism diagnostic interview (ADI) nonverbal communication and social scores. Variation in these phenotypes was explained by additive genetic, dominant genetic, and unique environmental factors with no evidence for shared environmental factors. Broad heritability estimates were higher for nonverbal communication (45%) than social interaction (28%). Nonverbal communication and social scores were partially accounted for by the same underlying genetic and environmental factors. Gender differences were not supported. These results add to information on familial resemblance of these symptom domains based on correlational methods, and this study is one of the first to apply behavioral genetic modeling to a PDD population. The results have implications for molecular genetics as well as treatment. En ligne : http://dx.doi.org/10.1016/j.rasd.2007.08.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=425
in Research in Autism Spectrum Disorders > 2-2 (April-June 2008) . - p.320-331[article] Genetic and environmental influences on symptom domains in twins and siblings with autism [Texte imprimé et/ou numérique] / Carla A. MAZEFSKY, Auteur ; Robin P. GOIN-KOCHEL, Auteur ; AUTISM GENETIC RESOURCE EXCHANGE CONSORTIUM, Auteur ; Hermine H. MAES, Auteur ; Brien P. RILEY, Auteur . - 2008 . - p.320-331.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 2-2 (April-June 2008) . - p.320-331
Mots-clés : Autism Autism-diagnostic-interview Behavioral-genetics Twins Social-interaction Nonverbal-communication Index. décimale : PER Périodiques Résumé : Clarifying the sources of variation among autism symptom domains is important to the identification of homogenous subgroups for molecular genetic studies. This study explored the genetic and environmental bases of nonverbal communication and social interaction, two symptom domains that have also been related to treatment response, in 1294 child and adolescent twins and siblings with pervasive developmental disorders (PDDs) from the Autism Genetic Resource Exchange under the age of 18. Twin/sibling resemblance was assessed through correlations and behavior genetic modeling of autism diagnostic interview (ADI) nonverbal communication and social scores. Variation in these phenotypes was explained by additive genetic, dominant genetic, and unique environmental factors with no evidence for shared environmental factors. Broad heritability estimates were higher for nonverbal communication (45%) than social interaction (28%). Nonverbal communication and social scores were partially accounted for by the same underlying genetic and environmental factors. Gender differences were not supported. These results add to information on familial resemblance of these symptom domains based on correlational methods, and this study is one of the first to apply behavioral genetic modeling to a PDD population. The results have implications for molecular genetics as well as treatment. En ligne : http://dx.doi.org/10.1016/j.rasd.2007.08.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=425 Lack of evidence for increased genetic loading for autism among families of affected females: A replication from family history data in two large samples / Robin P. GOIN-KOCHEL in Autism, 11-3 (May 2007)
[article]
Titre : Lack of evidence for increased genetic loading for autism among families of affected females: A replication from family history data in two large samples Type de document : Texte imprimé et/ou numérique Auteurs : Robin P. GOIN-KOCHEL, Auteur ; John N. CONSTANTINO, Auteur ; Anna ABBACCHI, Auteur ; AUTISM GENETIC RESOURCE EXCHANGE CONSORTIUM, Auteur Année de publication : 2007 Article en page(s) : p.279-286 Langues : Anglais (eng) Mots-clés : Asperger's-disorder Autism Family-history Genetics Index. décimale : PER Périodiques Résumé : Both the broad and narrow phenotypes of autism have been consistently observed in family members of affected individuals. Additionally, autism spectrum disorders (ASDs) present four times more often in males than in females, for reasons that are currently unknown. In this study, we examined whether there were differences in familial loading of ASD among families of male versus female probands. Analyses were conducted with existing data from two distinct samples. The first sample contained 417 individuals with autism and Asperger's disorder and included information on the ASD diagnoses of their first- and second-degree relatives. The second sample consisted of 405 sibships participating in the Autism Genetic Resource Exchange, of which one or more siblings had an ASD diagnosis. Results from both samples did not suggest significant differences in the prevalence of ASD among relatives of affected males versus females. En ligne : http://dx.doi.org/10.1177/1362361307076857 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=112
in Autism > 11-3 (May 2007) . - p.279-286[article] Lack of evidence for increased genetic loading for autism among families of affected females: A replication from family history data in two large samples [Texte imprimé et/ou numérique] / Robin P. GOIN-KOCHEL, Auteur ; John N. CONSTANTINO, Auteur ; Anna ABBACCHI, Auteur ; AUTISM GENETIC RESOURCE EXCHANGE CONSORTIUM, Auteur . - 2007 . - p.279-286.
Langues : Anglais (eng)
in Autism > 11-3 (May 2007) . - p.279-286
Mots-clés : Asperger's-disorder Autism Family-history Genetics Index. décimale : PER Périodiques Résumé : Both the broad and narrow phenotypes of autism have been consistently observed in family members of affected individuals. Additionally, autism spectrum disorders (ASDs) present four times more often in males than in females, for reasons that are currently unknown. In this study, we examined whether there were differences in familial loading of ASD among families of male versus female probands. Analyses were conducted with existing data from two distinct samples. The first sample contained 417 individuals with autism and Asperger's disorder and included information on the ASD diagnoses of their first- and second-degree relatives. The second sample consisted of 405 sibships participating in the Autism Genetic Resource Exchange, of which one or more siblings had an ASD diagnosis. Results from both samples did not suggest significant differences in the prevalence of ASD among relatives of affected males versus females. En ligne : http://dx.doi.org/10.1177/1362361307076857 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=112