Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur Frederick W. CARVER |
Documents disponibles écrits par cet auteur (1)
Faire une suggestion Affiner la recherche
Isolating neural components of threat bias in pediatric anxiety / Jennifer C. BRITTON in Journal of Child Psychology and Psychiatry, 53-6 (June 2012)
[article]
Titre : Isolating neural components of threat bias in pediatric anxiety Type de document : Texte imprimé et/ou numérique Auteurs : Jennifer C. BRITTON, Auteur ; Yair BAR-HAIM, Auteur ; Frederick W. CARVER, Auteur ; Tom HOLROYD, Auteur ; Maxine A. NORCROSS, Auteur ; Allison DETLOFF, Auteur ; Ellen LEIBENLUFT, Auteur ; Monique ERNST, Auteur ; Daniel Samuel PINE, Auteur Année de publication : 2012 Article en page(s) : p.678–686 Langues : Anglais (eng) Mots-clés : magnetoencephalography ventrolateral prefrontal cortex attention Index. décimale : PER Périodiques Résumé : Background: Attention biases toward threat are often detected in individuals with anxiety disorders. Threat biases can be measured experimentally through dot-probe paradigms, in which individuals detect a probe following a stimulus pair including a threat. On these tasks, individuals with anxiety tend to detect probes that occur in a location previously occupied by a threat (i.e., congruent) faster than when opposite threats (i.e., incongruent). In pediatric anxiety disorders, dot-probe paradigms detect abnormal attention biases toward threat and abnormal ventrolateral prefrontal cortex (vlPFC) function. However, it remains unclear if this aberrant vlPFC activation occurs while subjects process threats (e.g., angry faces) or, alternatively, while they process and respond to probes. This magnetoencephalography (MEG) study was designed to answer this question.
Methods: Adolescents with either generalized anxiety disorder (GAD, n = 17) or no psychiatric diagnosis (n = 25) performed a dot-probe task involving angry and neutral faces while MEG data were collected. Synthetic Aperture Magnetometry (SAM) beamformer technique was used to determine whether there were group differences in power ratios while subjects processed threats (i.e., angry vs. neutral faces) or when subjects responded to incongruent versus. congruent probes.
Results: Group differences in vlPFC activation during the response period emerged with a 1–30 Hz frequency band. No group differences in vlPFC activation were detected in response to angry-face cues.
Conclusions: In the dot-probe task, anxiety-related perturbations in vlPFC activation reflect abnormal attention control when responding to behaviorally relevant probes, but not to angry faces. Given that motor responses to these probes are used to calculate threat bias, this study provides insight into the pathophysiology reflected in this commonly used marker of anxiety. In addition, this finding may inform the development of novel anxiety-disorder treatments targeting the vlPFC to enhance attention control to task-relevant demands.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02503.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=157
in Journal of Child Psychology and Psychiatry > 53-6 (June 2012) . - p.678–686[article] Isolating neural components of threat bias in pediatric anxiety [Texte imprimé et/ou numérique] / Jennifer C. BRITTON, Auteur ; Yair BAR-HAIM, Auteur ; Frederick W. CARVER, Auteur ; Tom HOLROYD, Auteur ; Maxine A. NORCROSS, Auteur ; Allison DETLOFF, Auteur ; Ellen LEIBENLUFT, Auteur ; Monique ERNST, Auteur ; Daniel Samuel PINE, Auteur . - 2012 . - p.678–686.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 53-6 (June 2012) . - p.678–686
Mots-clés : magnetoencephalography ventrolateral prefrontal cortex attention Index. décimale : PER Périodiques Résumé : Background: Attention biases toward threat are often detected in individuals with anxiety disorders. Threat biases can be measured experimentally through dot-probe paradigms, in which individuals detect a probe following a stimulus pair including a threat. On these tasks, individuals with anxiety tend to detect probes that occur in a location previously occupied by a threat (i.e., congruent) faster than when opposite threats (i.e., incongruent). In pediatric anxiety disorders, dot-probe paradigms detect abnormal attention biases toward threat and abnormal ventrolateral prefrontal cortex (vlPFC) function. However, it remains unclear if this aberrant vlPFC activation occurs while subjects process threats (e.g., angry faces) or, alternatively, while they process and respond to probes. This magnetoencephalography (MEG) study was designed to answer this question.
Methods: Adolescents with either generalized anxiety disorder (GAD, n = 17) or no psychiatric diagnosis (n = 25) performed a dot-probe task involving angry and neutral faces while MEG data were collected. Synthetic Aperture Magnetometry (SAM) beamformer technique was used to determine whether there were group differences in power ratios while subjects processed threats (i.e., angry vs. neutral faces) or when subjects responded to incongruent versus. congruent probes.
Results: Group differences in vlPFC activation during the response period emerged with a 1–30 Hz frequency band. No group differences in vlPFC activation were detected in response to angry-face cues.
Conclusions: In the dot-probe task, anxiety-related perturbations in vlPFC activation reflect abnormal attention control when responding to behaviorally relevant probes, but not to angry faces. Given that motor responses to these probes are used to calculate threat bias, this study provides insight into the pathophysiology reflected in this commonly used marker of anxiety. In addition, this finding may inform the development of novel anxiety-disorder treatments targeting the vlPFC to enhance attention control to task-relevant demands.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02503.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=157