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Auteur Thomas BOURGERON |
Documents disponibles écrits par cet auteur (24)
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Alterations of the serotonin-melatonin pathway in autism spectrum disorders: Biological evidence and clinical consequences / Cecile PAGAN
Titre : Alterations of the serotonin-melatonin pathway in autism spectrum disorders: Biological evidence and clinical consequences Type de document : Texte imprimé et/ou numérique Auteurs : Cecile PAGAN, Auteur ; Richard DELORME, Auteur ; Jean-Marie LAUNAY, Auteur ; Thomas BOURGERON, Auteur Année de publication : 2013 Importance : p.240-273 Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 Alterations of the serotonin-melatonin pathway in autism spectrum disorders: Biological evidence and clinical consequences [Texte imprimé et/ou numérique] / Cecile PAGAN, Auteur ; Richard DELORME, Auteur ; Jean-Marie LAUNAY, Auteur ; Thomas BOURGERON, Auteur . - 2013 . - p.240-273.
Langues : Anglais (eng)
Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 Exemplaires
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Titre : Autisme, la piste génétique se confirme Type de document : Texte imprimé et/ou numérique Auteurs : Thomas BOURGERON, Auteur ; Marion LEBOYER, Auteur ; Richard DELORME, Auteur Année de publication : 2009 Article en page(s) : p.93-98 Langues : Français (fre) Mots-clés : autisme gènes synapses Index. décimale : AUT-D AUT-D - L'Autisme - Dépistage et Diagnostic Résumé : Coup sur coup, plusieurs études ont identifié des mutations génétiques en cause dans l’autisme. Les gènes impliqués jouent un rôle dans le fonctionnement des synapses. En accordant sa part à l’inné, cette découverte lève un pan du voile qui entoure ce syndrome très complexe. En ligne : http://dx.doi.org/10.4074/S0013754509001104 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=807
in Enfance > 2009-1 (janvier-mars 2009) . - p.93-98[article] Autisme, la piste génétique se confirme [Texte imprimé et/ou numérique] / Thomas BOURGERON, Auteur ; Marion LEBOYER, Auteur ; Richard DELORME, Auteur . - 2009 . - p.93-98.
Langues : Français (fre)
in Enfance > 2009-1 (janvier-mars 2009) . - p.93-98
Mots-clés : autisme gènes synapses Index. décimale : AUT-D AUT-D - L'Autisme - Dépistage et Diagnostic Résumé : Coup sur coup, plusieurs études ont identifié des mutations génétiques en cause dans l’autisme. Les gènes impliqués jouent un rôle dans le fonctionnement des synapses. En accordant sa part à l’inné, cette découverte lève un pan du voile qui entoure ce syndrome très complexe. En ligne : http://dx.doi.org/10.4074/S0013754509001104 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=807 Autisme : La recherche trouve! - Tous pour un / Isabelle MALO in Déclic, 164 (Mars-Avril 2015)
[article]
Titre : Autisme : La recherche trouve! - Tous pour un Type de document : Texte imprimé et/ou numérique Auteurs : Isabelle MALO, Auteur ; Danièle LANGLOYS, Auteur des citations ou des fragments textuels ; Thomas BOURGERON, Auteur des citations ou des fragments textuels Année de publication : 2015 Article en page(s) : p. 40-41 Langues : Français (fre) Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=250
in Déclic > 164 (Mars-Avril 2015) . - p. 40-41[article] Autisme : La recherche trouve! - Tous pour un [Texte imprimé et/ou numérique] / Isabelle MALO, Auteur ; Danièle LANGLOYS, Auteur des citations ou des fragments textuels ; Thomas BOURGERON, Auteur des citations ou des fragments textuels . - 2015 . - p. 40-41.
Langues : Français (fre)
in Déclic > 164 (Mars-Avril 2015) . - p. 40-41
Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=250 Behavioral profiles of mouse models for autism spectrum disorders / Elodie EY in Autism Research, 4-1 (February 2011)
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Titre : Behavioral profiles of mouse models for autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Elodie EY, Auteur ; Claire S. LEBLOND, Auteur ; Thomas BOURGERON, Auteur Année de publication : 2011 Article en page(s) : p.5-16 Langues : Anglais (eng) Mots-clés : autism spectrum disorder mouse model synaptic pathway mTOR/PI3K pathway behavior Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are characterized by impairments in reciprocal social communication, and stereotyped verbal and nonverbal behaviors. In approximately 10–25% of the affected individuals, a genetic mutation associated with the condition can be identified. Recently, mutations altering synapse formation, cellular/synaptic growth rate and regulation of excitatory and inhibitory currents were identified in patients with intellectual disability, typical autism, Asperger syndrome or neurological syndromes associated with autistic traits. Following these genetic findings, mouse models carrying mutations similar to those identified in patients have been generated. These models offer the opportunity to investigate in vivo the physiological and behavioral consequences of the mutations. Here, we review the existing data on the phenotypes of mice carrying mutations in genes associated with ASD including neuroligin, neurexin and Shank mutant mice as well as the Fmr1, Mecp2, Ube3a, Nf1, Pten and Tsc1/Tsc2 mutant mice. The diversity and complexity of the phenotype of these mouse models reflect the broad range of phenotypes observed in patients with ASD. Remarkably, results from therapeutic approaches (e.g., modulation of gene expression, administration of pharmacological and nonpharmacological substances, enriched environment) are encouraging since some behavioral alterations could be reversed even when treatment was performed on adult mice. These ongoing studies should therefore increase our understanding of the biological alterations associated with ASD as well as the development of knowledge-based treatments. En ligne : http://dx.doi.org/10.1002/aur.175 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118
in Autism Research > 4-1 (February 2011) . - p.5-16[article] Behavioral profiles of mouse models for autism spectrum disorders [Texte imprimé et/ou numérique] / Elodie EY, Auteur ; Claire S. LEBLOND, Auteur ; Thomas BOURGERON, Auteur . - 2011 . - p.5-16.
Langues : Anglais (eng)
in Autism Research > 4-1 (February 2011) . - p.5-16
Mots-clés : autism spectrum disorder mouse model synaptic pathway mTOR/PI3K pathway behavior Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are characterized by impairments in reciprocal social communication, and stereotyped verbal and nonverbal behaviors. In approximately 10–25% of the affected individuals, a genetic mutation associated with the condition can be identified. Recently, mutations altering synapse formation, cellular/synaptic growth rate and regulation of excitatory and inhibitory currents were identified in patients with intellectual disability, typical autism, Asperger syndrome or neurological syndromes associated with autistic traits. Following these genetic findings, mouse models carrying mutations similar to those identified in patients have been generated. These models offer the opportunity to investigate in vivo the physiological and behavioral consequences of the mutations. Here, we review the existing data on the phenotypes of mice carrying mutations in genes associated with ASD including neuroligin, neurexin and Shank mutant mice as well as the Fmr1, Mecp2, Ube3a, Nf1, Pten and Tsc1/Tsc2 mutant mice. The diversity and complexity of the phenotype of these mouse models reflect the broad range of phenotypes observed in patients with ASD. Remarkably, results from therapeutic approaches (e.g., modulation of gene expression, administration of pharmacological and nonpharmacological substances, enriched environment) are encouraging since some behavioral alterations could be reversed even when treatment was performed on adult mice. These ongoing studies should therefore increase our understanding of the biological alterations associated with ASD as well as the development of knowledge-based treatments. En ligne : http://dx.doi.org/10.1002/aur.175 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118 Discriminant value of repetitive behaviors in families with autism spectrum disorder and obsessional compulsive disorder probands / A. LEFEBVRE in Autism Research, 14-11 (November 2021)
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Titre : Discriminant value of repetitive behaviors in families with autism spectrum disorder and obsessional compulsive disorder probands Type de document : Texte imprimé et/ou numérique Auteurs : A. LEFEBVRE, Auteur ; A. COHEN, Auteur ; A. MARUANI, Auteur ; Frédérique AMSELLEM, Auteur ; Anita BEGGIATO, Auteur ; Anouck AMESTOY, Auteur ; M. L. MOAL, Auteur ; D. UMBRICHT, Auteur ; Christopher H. CHATHAM, Auteur ; L. MURTAGH, Auteur ; Manuel P. BOUVARD, Auteur ; M. LEBOYER, Auteur ; Thomas BOURGERON, Auteur ; R. DELORME, Auteur Article en page(s) : p.2373-2382 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/complications/genetics Cognition Humans Obsessive-Compulsive Disorder/genetics habits heritability neurodevelopment phenotype Index. décimale : PER Périodiques Résumé : Repetitive behaviors (RB) represent a wide spectrum of symptoms ranging from sensory-motor stereotypies to complex cognitive rituals, frequently dichotomized as low- and high-order sub-groups of symptoms. Even though these subgroups are considered as phenomenologically distinct in autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD), brain imaging and genetic studies suggest that they have common mechanisms and pathways. This discrepancy may be explained by the frequent intellectual disability reported in ASD, which blurs the RB expressivity. Given the high heritability of RB, that is, the diversity of symptoms expressed in the relatives are dependent on those expressed in their probands, we hypothesize that if RB expressed in ASD or OCD are two distinct entities, then the RB expressed in relatives will also reflect these two dimensions. We thus conduct a linear discriminant analysis on RB in both the relatives of probands with ASD and OCD and subjects from the general population (n = 1023). The discriminant analysis results in a classification of 81.1% of the controls (p?10(-4) ), but poorly differentiated the ASD and OCD relatives (?46%). The stepwise analysis reveals that five symptoms attributed to high-order RB and two related to low-order RB (including hypersensitivity) are the most discriminant. Our results support the idea that the difference of RB patterns in the relatives is mild compared with the distribution of symptoms in controls. Our findings reinforce the evidence of a common biological pattern of RB both in ASD and OCD but with minor differences, specific to each of these two neuro-developmental disorders. LAY SUMMARY: Repetitive behaviors (RB), a key symptom in the classification of both OCD and ASD, are phenomenologically considered as distinct in the two disorders, which is in contrast with brain imaging studies describing a common neural circuit. Intellectual disability, which is frequently associated with ASD, makes RB in ASD more difficult to understand as it affects the expression of the RB symptoms. To avoid this bias, we propose to consider the familial aggregation in ASD and OCD by exploring RB in the first-degree relatives of ASD and OCD. Our results highlight the existence of RB expressed in relatives compared to the general population, with a common pattern of symptoms in relatives of both ASD and OCD but also minor differences, specific to each of these two neuro-developmental disorders. En ligne : http://dx.doi.org/10.1002/aur.2570 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-11 (November 2021) . - p.2373-2382[article] Discriminant value of repetitive behaviors in families with autism spectrum disorder and obsessional compulsive disorder probands [Texte imprimé et/ou numérique] / A. LEFEBVRE, Auteur ; A. COHEN, Auteur ; A. MARUANI, Auteur ; Frédérique AMSELLEM, Auteur ; Anita BEGGIATO, Auteur ; Anouck AMESTOY, Auteur ; M. L. MOAL, Auteur ; D. UMBRICHT, Auteur ; Christopher H. CHATHAM, Auteur ; L. MURTAGH, Auteur ; Manuel P. BOUVARD, Auteur ; M. LEBOYER, Auteur ; Thomas BOURGERON, Auteur ; R. DELORME, Auteur . - p.2373-2382.
Langues : Anglais (eng)
in Autism Research > 14-11 (November 2021) . - p.2373-2382
Mots-clés : Autism Spectrum Disorder/complications/genetics Cognition Humans Obsessive-Compulsive Disorder/genetics habits heritability neurodevelopment phenotype Index. décimale : PER Périodiques Résumé : Repetitive behaviors (RB) represent a wide spectrum of symptoms ranging from sensory-motor stereotypies to complex cognitive rituals, frequently dichotomized as low- and high-order sub-groups of symptoms. Even though these subgroups are considered as phenomenologically distinct in autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD), brain imaging and genetic studies suggest that they have common mechanisms and pathways. This discrepancy may be explained by the frequent intellectual disability reported in ASD, which blurs the RB expressivity. Given the high heritability of RB, that is, the diversity of symptoms expressed in the relatives are dependent on those expressed in their probands, we hypothesize that if RB expressed in ASD or OCD are two distinct entities, then the RB expressed in relatives will also reflect these two dimensions. We thus conduct a linear discriminant analysis on RB in both the relatives of probands with ASD and OCD and subjects from the general population (n = 1023). The discriminant analysis results in a classification of 81.1% of the controls (p?10(-4) ), but poorly differentiated the ASD and OCD relatives (?46%). The stepwise analysis reveals that five symptoms attributed to high-order RB and two related to low-order RB (including hypersensitivity) are the most discriminant. Our results support the idea that the difference of RB patterns in the relatives is mild compared with the distribution of symptoms in controls. Our findings reinforce the evidence of a common biological pattern of RB both in ASD and OCD but with minor differences, specific to each of these two neuro-developmental disorders. LAY SUMMARY: Repetitive behaviors (RB), a key symptom in the classification of both OCD and ASD, are phenomenologically considered as distinct in the two disorders, which is in contrast with brain imaging studies describing a common neural circuit. Intellectual disability, which is frequently associated with ASD, makes RB in ASD more difficult to understand as it affects the expression of the RB symptoms. To avoid this bias, we propose to consider the familial aggregation in ASD and OCD by exploring RB in the first-degree relatives of ASD and OCD. Our results highlight the existence of RB expressed in relatives compared to the general population, with a common pattern of symptoms in relatives of both ASD and OCD but also minor differences, specific to each of these two neuro-developmental disorders. En ligne : http://dx.doi.org/10.1002/aur.2570 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 Exploring the multidimensional nature of repetitive and restricted behaviors and interests (RRBI) in autism: neuroanatomical correlates and clinical implications / Nicolas TRAUT ; Amandine PEDOUX ; Anna MARUANI ; Anita BEGGIATO ; Monique ELMALEH ; David GERMANAUD ; Anouck AMESTOY ; Myriam LY-LE MOAL ; Christopher CHATHAM ; Lorraine MURTAGH ; Manuel BOUVARD ; Marianne ALISSON ; Marion LEBOYER ; Thomas BOURGERON ; Roberto TORO ; Guillaume DUMAS ; Clara MOREAU ; Richard DELORME in Molecular Autism, 14 (2023)
PermalinkGender differences in autism spectrum disorders: Divergence among specific core symptoms / Anita BEGGIATO in Autism Research, 10-4 (April 2017)
PermalinkDes gènes, des synapses, des autismes / Thomas BOURGERON
PermalinkPermalinkLa génétique de l'autisme / Richard DELORME in Cerveau & Psycho, 51 (Mai-Juin 2012)
PermalinkGénétique et business / Bertrand JORDAN in Sésame, 163 (3ème trimestre 2007)
PermalinkHigh-functioning autism spectrum disorder and fragile X syndrome: report of two affected sisters / Pauline CHASTE in Molecular Autism, (June 2012)
PermalinkIdentification de mutations associées à l'autisme et au syndrome d'Asperger dans deux gènes du chromosome X codant les neuroligines NLGN3 et NLGN4 / Stéphane JAMAIN in Bulletin Scientifique de l'arapi (Le), 11 (automne 2003)
PermalinkLack of replication of previous autism spectrum disorder GWAS hits in European populations / Bàrbara TORRICO in Autism Research, 10-2 (February 2017)
PermalinkMélatonine et autisme / Thomas BOURGERON in Bulletin Scientifique de l'arapi (Le), 27 (juin 2011)
PermalinkMéthodologies génétiques et protéines synaptiques dans l’autisme infantile / Stéphane JAMAIN
PermalinkScreening, Intervention and Outcome in Autism and Other Developmental Disorders: The Role of Randomized Controlled Trials / Elisabeth FERNELL in Journal of Autism and Developmental Disorders, 44-8 (August 2014)
PermalinkTackling hypo and hyper sensory processing heterogeneity in autism: From clinical stratification to genetic pathways / Julian TILLMANN ; Freddy CLIQUET ; Frédérique AMSELLEM ; Anna MARUANI ; Claire LEBLOND ; Anita BEGGIATO ; David GERMANAUD ; Anouck AMESTOY ; Myriam LY-LE MOAL ; Daniel UMBRICHT ; Christopher CHATHAM ; Lorraine MURTAGH ; Manuel BOUVARD ; Marion LEBOYER ; Tony CHARMAN ; Thomas BOURGERON ; Richard DELORME ; Guillaume DUMAS ; EU-AIMS LEAP Group in Autism Research, 16-2 (February 2023)
PermalinkThe EU-AIMS Longitudinal European Autism Project (LEAP): clinical characterisation / Tony CHARMAN in Molecular Autism, 8 (2017)
PermalinkThe EU-AIMS Longitudinal European Autism Project (LEAP): design and methodologies to identify and validate stratification biomarkers for autism spectrum disorders / E. LOTH in Molecular Autism, 8 (2017)
PermalinkThe neuroanatomical substrates of autism and ADHD and their link to putative genomic underpinnings / Caroline GURR ; Johanna LEYHAUSEN ; Hanna SEELEMEYER ; Anke BLETSCH ; Tim SCHAEFER ; Charlotte M. PRETZSCH ; Bethany OAKLEY ; Eva LOTH ; Dorothea L. FLORIS ; Jan K. BUITELAAR ; Christian F. BECKMANN ; Tobias BANASCHEWSKI ; Tony CHARMAN ; Emily J. H. JONES ; Julian TILLMANN ; Chris H CHATHAM ; Thomas BOURGERON ; EU-AIMS LEAP Group ; Declan G. M. MURPHY ; Christine ECKER in Molecular Autism, 14 (2023)
PermalinkThe Neurobiology of Autism / Christopher GILLBERG
PermalinkThe role of cholesterol metabolism and various steroid abnormalities in autism spectrum disorders: A hypothesis paper / Christopher GILLBERG in Autism Research, 10-6 (June 2017)
PermalinkVitamin D in the General Population of Young Adults with Autism in the Faroe Islands / Eva KOCOVSKA in Journal of Autism and Developmental Disorders, 44-12 (December 2014)
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