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Auteur Lindita IMERAJ |
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Time-of-day effects in arousal: disrupted diurnal cortisol profiles in children with ADHD / Lindita IMERAJ in Journal of Child Psychology and Psychiatry, 53-7 (July 2012)
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Titre : Time-of-day effects in arousal: disrupted diurnal cortisol profiles in children with ADHD Type de document : Texte imprimé et/ou numérique Auteurs : Lindita IMERAJ, Auteur ; Inge ANTROP, Auteur ; Herbert ROEYERS, Auteur ; James D. SWANSON, Auteur ; Ellen DESCHEPPE, Auteur ; Sarah BAL, Auteur ; Dirk DEBOUTTE, Auteur Année de publication : 2012 Article en page(s) : p.782-789 Langues : Anglais (eng) Mots-clés : ADHD ODD circadian HPA axis cortisol arousal Index. décimale : PER Périodiques Résumé : Background: Fluctuations in attention-deficit hyperactivity disorder (ADHD) symptoms related to regulatory deficits in arousal states are themselves characterized by circadian rhythms. Although cortisol is an important circadian arousal-related marker, studies focusing on across-the-day cortisol variations in ADHD are scarce. There is no study with multiple measurements to take into account interday and intraday variability.
Methods: Salivary cortisol was sampled five times a day (awakening, 30 min after awakening, noon, 4 p.m., 8 p.m.) across five consecutive days in 33 children with ADHD (22 with and 11 without oppositional defiant disorder; ODD) and 33 class- and sex-matched controls (aged 6–12). The cortisol awakening response (increase from awakening to 30 min after awakening) and the diurnal cortisol profile (across-the-day variations) were compared for ADHD with ODD (ADHD + ODD) and without ODD (ADHD) subgroups and the control group.
Results: The cortisol awakening response was not significantly different between groups. However, longitudinal analyses to evaluate cortisol profiles across the day revealed a significant Group × Time effect (p < .001). More specifically, compared to each other, the ADHD subgroup showed a flatter slope with relative morning hypo-arousal and evening hyperarousal, whereas the ADHD + ODD subgroup showed a steeper slope with relative morning hyperarousal and evening hypo-arousal (p < .001).
Conclusions: Findings support time-related arousal disruptions in children with ADHD associated with the presence or absence of ODD comorbidity. We recommend research on cortisol in larger samples for a better understanding of arousal mechanisms involved in ADHD not only with and without ODD but also with other comorbidities which may have implications for timing of arousal-based treatments.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02526.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166
in Journal of Child Psychology and Psychiatry > 53-7 (July 2012) . - p.782-789[article] Time-of-day effects in arousal: disrupted diurnal cortisol profiles in children with ADHD [Texte imprimé et/ou numérique] / Lindita IMERAJ, Auteur ; Inge ANTROP, Auteur ; Herbert ROEYERS, Auteur ; James D. SWANSON, Auteur ; Ellen DESCHEPPE, Auteur ; Sarah BAL, Auteur ; Dirk DEBOUTTE, Auteur . - 2012 . - p.782-789.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 53-7 (July 2012) . - p.782-789
Mots-clés : ADHD ODD circadian HPA axis cortisol arousal Index. décimale : PER Périodiques Résumé : Background: Fluctuations in attention-deficit hyperactivity disorder (ADHD) symptoms related to regulatory deficits in arousal states are themselves characterized by circadian rhythms. Although cortisol is an important circadian arousal-related marker, studies focusing on across-the-day cortisol variations in ADHD are scarce. There is no study with multiple measurements to take into account interday and intraday variability.
Methods: Salivary cortisol was sampled five times a day (awakening, 30 min after awakening, noon, 4 p.m., 8 p.m.) across five consecutive days in 33 children with ADHD (22 with and 11 without oppositional defiant disorder; ODD) and 33 class- and sex-matched controls (aged 6–12). The cortisol awakening response (increase from awakening to 30 min after awakening) and the diurnal cortisol profile (across-the-day variations) were compared for ADHD with ODD (ADHD + ODD) and without ODD (ADHD) subgroups and the control group.
Results: The cortisol awakening response was not significantly different between groups. However, longitudinal analyses to evaluate cortisol profiles across the day revealed a significant Group × Time effect (p < .001). More specifically, compared to each other, the ADHD subgroup showed a flatter slope with relative morning hypo-arousal and evening hyperarousal, whereas the ADHD + ODD subgroup showed a steeper slope with relative morning hyperarousal and evening hypo-arousal (p < .001).
Conclusions: Findings support time-related arousal disruptions in children with ADHD associated with the presence or absence of ODD comorbidity. We recommend research on cortisol in larger samples for a better understanding of arousal mechanisms involved in ADHD not only with and without ODD but also with other comorbidities which may have implications for timing of arousal-based treatments.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02526.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166