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HPA-axis multilocus genetic profile score moderates the association between maternal prenatal perceived stress and offspring depression in early adulthood / Brooke G. MCKENNA in Development and Psychopathology, 33-1 (February 2021)
[article]
Titre : HPA-axis multilocus genetic profile score moderates the association between maternal prenatal perceived stress and offspring depression in early adulthood Type de document : Texte imprimé et/ou numérique Auteurs : Brooke G. MCKENNA, Auteur ; Constance HAMMEN, Auteur ; Patricia A. BRENNAN, Auteur Article en page(s) : p.122-134 Langues : Anglais (eng) Mots-clés : HPA Axis depression fetal programming polygenic risk Index. décimale : PER Périodiques Résumé : Maternal stress during pregnancy can cause alterations to the fetal hypothalamus-pituitary-adrenal (HPA) axis, a phenomenon known as fetal programming that may have lasting effects on offspring outcomes, including depression. Evidence suggests that these effects may vary with respect to the offspring's genetic risk. Nonetheless, few studies have examined these effects into adulthood, when risk for depression onset is highest. The present study builds upon the extant literature by examining the interaction of maternal prenatal perceived stress (MPPS) and offspring HPA-axis polygenic risk to predict offspring depression in early adulthood. A total of 381 mother-child dyads participated in a prospective, longitudinal study that spanned from pregnancy until offspring were 20 years of age. Polygenic risk was defined by a multilocus genetic profile score (MGPS) that reflected the additive risk of three HPA-axis candidate genes. The results indicated that the interaction of MPPS and HPA-axis MGPS confers risk for offspring depression at age 20, in line with the differential susceptibility model. This interaction may be specific to prenatal stress, as maternal stress during early childhood did not interact with genetic risk to predict depression. These findings provide the first evidence that genetic variants that are associated with the HPA axis may act in a polygenic, additive fashion to moderate the association between fetal programming and adult depression. En ligne : http://dx.doi.org/10.1017/s0954579419001639 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442
in Development and Psychopathology > 33-1 (February 2021) . - p.122-134[article] HPA-axis multilocus genetic profile score moderates the association between maternal prenatal perceived stress and offspring depression in early adulthood [Texte imprimé et/ou numérique] / Brooke G. MCKENNA, Auteur ; Constance HAMMEN, Auteur ; Patricia A. BRENNAN, Auteur . - p.122-134.
Langues : Anglais (eng)
in Development and Psychopathology > 33-1 (February 2021) . - p.122-134
Mots-clés : HPA Axis depression fetal programming polygenic risk Index. décimale : PER Périodiques Résumé : Maternal stress during pregnancy can cause alterations to the fetal hypothalamus-pituitary-adrenal (HPA) axis, a phenomenon known as fetal programming that may have lasting effects on offspring outcomes, including depression. Evidence suggests that these effects may vary with respect to the offspring's genetic risk. Nonetheless, few studies have examined these effects into adulthood, when risk for depression onset is highest. The present study builds upon the extant literature by examining the interaction of maternal prenatal perceived stress (MPPS) and offspring HPA-axis polygenic risk to predict offspring depression in early adulthood. A total of 381 mother-child dyads participated in a prospective, longitudinal study that spanned from pregnancy until offspring were 20 years of age. Polygenic risk was defined by a multilocus genetic profile score (MGPS) that reflected the additive risk of three HPA-axis candidate genes. The results indicated that the interaction of MPPS and HPA-axis MGPS confers risk for offspring depression at age 20, in line with the differential susceptibility model. This interaction may be specific to prenatal stress, as maternal stress during early childhood did not interact with genetic risk to predict depression. These findings provide the first evidence that genetic variants that are associated with the HPA axis may act in a polygenic, additive fashion to moderate the association between fetal programming and adult depression. En ligne : http://dx.doi.org/10.1017/s0954579419001639 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442 HPA-axis multilocus genetic variation moderates associations between environmental stress and depressive symptoms among adolescents / L. R. STARR in Development and Psychopathology, 31-4 (October 2019)
[article]
Titre : HPA-axis multilocus genetic variation moderates associations between environmental stress and depressive symptoms among adolescents Type de document : Texte imprimé et/ou numérique Auteurs : L. R. STARR, Auteur ; M. HUANG, Auteur Article en page(s) : p.1339-1352 Langues : Anglais (eng) Mots-clés : HPA axis depression gene-environment interaction genetic stress Index. décimale : PER Périodiques Résumé : Research suggests that genetic variants linked to hypothalamic-pituitary-adrenal (HPA)-axis functioning moderate the association between environmental stressors and depression, but examining gene-environment interactions with single polymorphisms limits power. The current study used a multilocus genetic profile score (MGPS) approach to measuring HPA-axis-related genetic variation and examined interactions with acute stress, chronic stress, and childhood adversity (assessed using contextual threat interview methods) with depressive symptoms as outcomes in an adolescent sample (ages 14-17, N = 241; White subsample n = 192). Additive MGPSs were calculated using 10 single nucleotide polymorphisms within HPA-axis genes (CRHR1, NR3C2, NR3C1, FKBP5). Higher MGPS directly correlated with adolescent depressive symptoms. Moreover, MGPS predicted stronger associations between acute and chronic stress and adolescent depressive symptoms and also moderated the effect of interpersonal, but not noninterpersonal, childhood adversity. Gene-environment interactions individually accounted for 5%-8% of depressive symptom variation. All results were retained following multiple test correction and stratification by race. Results suggest that using MGPSs provides substantial power to examine gene-environmental interactions linked to affective outcomes among adolescents. En ligne : http://dx.doi.org/10.1017/s0954579418000779 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406
in Development and Psychopathology > 31-4 (October 2019) . - p.1339-1352[article] HPA-axis multilocus genetic variation moderates associations between environmental stress and depressive symptoms among adolescents [Texte imprimé et/ou numérique] / L. R. STARR, Auteur ; M. HUANG, Auteur . - p.1339-1352.
Langues : Anglais (eng)
in Development and Psychopathology > 31-4 (October 2019) . - p.1339-1352
Mots-clés : HPA axis depression gene-environment interaction genetic stress Index. décimale : PER Périodiques Résumé : Research suggests that genetic variants linked to hypothalamic-pituitary-adrenal (HPA)-axis functioning moderate the association between environmental stressors and depression, but examining gene-environment interactions with single polymorphisms limits power. The current study used a multilocus genetic profile score (MGPS) approach to measuring HPA-axis-related genetic variation and examined interactions with acute stress, chronic stress, and childhood adversity (assessed using contextual threat interview methods) with depressive symptoms as outcomes in an adolescent sample (ages 14-17, N = 241; White subsample n = 192). Additive MGPSs were calculated using 10 single nucleotide polymorphisms within HPA-axis genes (CRHR1, NR3C2, NR3C1, FKBP5). Higher MGPS directly correlated with adolescent depressive symptoms. Moreover, MGPS predicted stronger associations between acute and chronic stress and adolescent depressive symptoms and also moderated the effect of interpersonal, but not noninterpersonal, childhood adversity. Gene-environment interactions individually accounted for 5%-8% of depressive symptom variation. All results were retained following multiple test correction and stratification by race. Results suggest that using MGPSs provides substantial power to examine gene-environmental interactions linked to affective outcomes among adolescents. En ligne : http://dx.doi.org/10.1017/s0954579418000779 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406 Interpersonal childhood adversity and stress generation in adolescence: Moderation by HPA axis multilocus genetic variation / Meghan HUANG in Development and Psychopathology, 32-3 (August 2020)
[article]
Titre : Interpersonal childhood adversity and stress generation in adolescence: Moderation by HPA axis multilocus genetic variation Type de document : Texte imprimé et/ou numérique Auteurs : Meghan HUANG, Auteur ; Lisa R. STARR, Auteur Article en page(s) : p.865-878 Langues : Anglais (eng) Mots-clés : HPA axis childhood adversity gene–environment interaction stress generation Index. décimale : PER Périodiques Résumé : Research suggests that childhood adversity (CA) is associated with a wide range of repercussions, including an increased likelihood of interpersonal stress generation. This may be particularly true following interpersonal childhood adversity (ICA) and for youth with high hypothalamic-pituitary-adrenal (HPA) axis-related genetic risk. In the current study, we applied a multilocus genetic profile score (MGPS) approach to measuring HPA axis-related genetic variation and examined its interaction with ICA to predict interpersonal stress generation in a sample of adolescents aged 14-17 (N = 241, Caucasian subsample n = 192). MGPSs were computed using 10 single nucleotide polymorphisms from HPA axis-related genes (CRHR1, NRC31, NRC32, and FKBP5). ICA significantly predicted greater adolescent interpersonal dependent stress. Additionally, MGPS predicted a stronger association between ICA and interpersonal dependent (but not independent or noninterpersonal dependent) stress. No gene-environment interaction (G×E) effects were found for noninterpersonal CA and MGPS in predicting adolescent interpersonal dependent stress. Effects remained after controlling for current depressive symptoms and following stratification by race. Findings extend existing G×E research on stress generation to HPA axis-related genetic variation and demonstrate effects specific to the interpersonal domain. En ligne : http://dx.doi.org/10.1017/s0954579419001123 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429
in Development and Psychopathology > 32-3 (August 2020) . - p.865-878[article] Interpersonal childhood adversity and stress generation in adolescence: Moderation by HPA axis multilocus genetic variation [Texte imprimé et/ou numérique] / Meghan HUANG, Auteur ; Lisa R. STARR, Auteur . - p.865-878.
Langues : Anglais (eng)
in Development and Psychopathology > 32-3 (August 2020) . - p.865-878
Mots-clés : HPA axis childhood adversity gene–environment interaction stress generation Index. décimale : PER Périodiques Résumé : Research suggests that childhood adversity (CA) is associated with a wide range of repercussions, including an increased likelihood of interpersonal stress generation. This may be particularly true following interpersonal childhood adversity (ICA) and for youth with high hypothalamic-pituitary-adrenal (HPA) axis-related genetic risk. In the current study, we applied a multilocus genetic profile score (MGPS) approach to measuring HPA axis-related genetic variation and examined its interaction with ICA to predict interpersonal stress generation in a sample of adolescents aged 14-17 (N = 241, Caucasian subsample n = 192). MGPSs were computed using 10 single nucleotide polymorphisms from HPA axis-related genes (CRHR1, NRC31, NRC32, and FKBP5). ICA significantly predicted greater adolescent interpersonal dependent stress. Additionally, MGPS predicted a stronger association between ICA and interpersonal dependent (but not independent or noninterpersonal dependent) stress. No gene-environment interaction (G×E) effects were found for noninterpersonal CA and MGPS in predicting adolescent interpersonal dependent stress. Effects remained after controlling for current depressive symptoms and following stratification by race. Findings extend existing G×E research on stress generation to HPA axis-related genetic variation and demonstrate effects specific to the interpersonal domain. En ligne : http://dx.doi.org/10.1017/s0954579419001123 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429 Non-linear associations between HPA axis activity during infancy and mental health difficulties during early childhood among children in rural Pakistan / Ashley HAGAMAN ; Victoria BARANOV ; Esther O. CHUNG ; Sonia BHALOTRA ; Siham SIKANDER ; Joanna MASELKO in Development and Psychopathology, 35-4 (October 2023)
[article]
Titre : Non-linear associations between HPA axis activity during infancy and mental health difficulties during early childhood among children in rural Pakistan Type de document : Texte imprimé et/ou numérique Auteurs : Ashley HAGAMAN, Auteur ; Victoria BARANOV, Auteur ; Esther O. CHUNG, Auteur ; Sonia BHALOTRA, Auteur ; Siham SIKANDER, Auteur ; Joanna MASELKO, Auteur Article en page(s) : p.2086-2095 Langues : Anglais (eng) Mots-clés : cortisol DHEA early childhood HPA axis mental health difficulties Index. décimale : PER Périodiques Résumé : Hypothalamic pituitary adrenal (HPA) axis activity may be a mechanism linking early adversity to child mental health difficulties. However, there is a dearth of longitudinal evidence for the association between HPA axis activity and mental health among children in low-resource contexts. The goal of this study is to examine linear and curvilinear associations between HPA axis activity during infancy and mental health difficulties in early childhood among children in rural Pakistan. Participants included 104 children (46% male) from the Bachpan study, a longitudinal cohort embedded within a maternal depression trial in Pakistan. We examined the associations between hair-derived cortisol and dehydroepiandosterone (DHEA) at 12 months old and mental health difficulties, measured with the Strengths and Difficulties Questionnaire (SDQ), at 36 months old. There was a significant quadratic association between hair cortisol and SDQ scores, with results showing a U-shaped relationship (i.e., having relatively high or low cortisol predicted increased mental health difficulties). DHEA showed a quadratic association with SDQ scores with an inverted U-shaped relationship (i.e., high and low DHEA was associated with decreased mental health difficulties). Results provide evidence of longitudinal and curvilinear effects of cortisol and DHEA during infancy on mental health difficulties in early childhood. En ligne : https://dx.doi.org/10.1017/S0954579422000773 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=515
in Development and Psychopathology > 35-4 (October 2023) . - p.2086-2095[article] Non-linear associations between HPA axis activity during infancy and mental health difficulties during early childhood among children in rural Pakistan [Texte imprimé et/ou numérique] / Ashley HAGAMAN, Auteur ; Victoria BARANOV, Auteur ; Esther O. CHUNG, Auteur ; Sonia BHALOTRA, Auteur ; Siham SIKANDER, Auteur ; Joanna MASELKO, Auteur . - p.2086-2095.
Langues : Anglais (eng)
in Development and Psychopathology > 35-4 (October 2023) . - p.2086-2095
Mots-clés : cortisol DHEA early childhood HPA axis mental health difficulties Index. décimale : PER Périodiques Résumé : Hypothalamic pituitary adrenal (HPA) axis activity may be a mechanism linking early adversity to child mental health difficulties. However, there is a dearth of longitudinal evidence for the association between HPA axis activity and mental health among children in low-resource contexts. The goal of this study is to examine linear and curvilinear associations between HPA axis activity during infancy and mental health difficulties in early childhood among children in rural Pakistan. Participants included 104 children (46% male) from the Bachpan study, a longitudinal cohort embedded within a maternal depression trial in Pakistan. We examined the associations between hair-derived cortisol and dehydroepiandosterone (DHEA) at 12 months old and mental health difficulties, measured with the Strengths and Difficulties Questionnaire (SDQ), at 36 months old. There was a significant quadratic association between hair cortisol and SDQ scores, with results showing a U-shaped relationship (i.e., having relatively high or low cortisol predicted increased mental health difficulties). DHEA showed a quadratic association with SDQ scores with an inverted U-shaped relationship (i.e., high and low DHEA was associated with decreased mental health difficulties). Results provide evidence of longitudinal and curvilinear effects of cortisol and DHEA during infancy on mental health difficulties in early childhood. En ligne : https://dx.doi.org/10.1017/S0954579422000773 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=515 Stress-induced activation of the HPA axis predicts connectivity between subgenual cingulate and salience network during rest in adolescents / Moriah E. THOMASON in Journal of Child Psychology and Psychiatry, 52-10 (October 2011)
[article]
Titre : Stress-induced activation of the HPA axis predicts connectivity between subgenual cingulate and salience network during rest in adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Moriah E. THOMASON, Auteur ; J. Paul HAMILTON, Auteur ; Ian H. GOTLIB, Auteur Année de publication : 2011 Article en page(s) : p.1026-1034 Langues : Anglais (eng) Mots-clés : Resting-state adolescents HPA axis stress subgenual cingulate fMRI salience network connectivity Index. décimale : PER Périodiques Résumé : Background: Responses to stress vary greatly in young adolescents, and little is known about neural correlates of the stress response in youth. The purpose of this study was to examine whether variability in cortisol responsivity following a social stress test in young adolescents is associated with altered neural functional connectivity (FC) of the salience network (SN) measured during resting-state functional magnetic resonance imaging (rs-fMRI).
Methods: Forty-nine typically developing young adolescents participated in a social stress test during which they contributed salivary cortisol samples. Following this, they underwent rs-fMRI scanning. We examined the association of FC of the SN [composed of anterior cingulate cortex and bilateral anterior insula regions] with cortisol responsivity.
Results: Greater cortisol responsivity was significantly positively correlated with higher FC between subgenual anterior cingulate cortex (Cg25) and the SN, controlling for participant age. There were no regions of the brain that showed an inverse relation.
Conclusions: Brain systems that have been implicated in autonomic arousal and that influence subjective feeling states show altered FC associated with stress responsivity in early life.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02422.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=142
in Journal of Child Psychology and Psychiatry > 52-10 (October 2011) . - p.1026-1034[article] Stress-induced activation of the HPA axis predicts connectivity between subgenual cingulate and salience network during rest in adolescents [Texte imprimé et/ou numérique] / Moriah E. THOMASON, Auteur ; J. Paul HAMILTON, Auteur ; Ian H. GOTLIB, Auteur . - 2011 . - p.1026-1034.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 52-10 (October 2011) . - p.1026-1034
Mots-clés : Resting-state adolescents HPA axis stress subgenual cingulate fMRI salience network connectivity Index. décimale : PER Périodiques Résumé : Background: Responses to stress vary greatly in young adolescents, and little is known about neural correlates of the stress response in youth. The purpose of this study was to examine whether variability in cortisol responsivity following a social stress test in young adolescents is associated with altered neural functional connectivity (FC) of the salience network (SN) measured during resting-state functional magnetic resonance imaging (rs-fMRI).
Methods: Forty-nine typically developing young adolescents participated in a social stress test during which they contributed salivary cortisol samples. Following this, they underwent rs-fMRI scanning. We examined the association of FC of the SN [composed of anterior cingulate cortex and bilateral anterior insula regions] with cortisol responsivity.
Results: Greater cortisol responsivity was significantly positively correlated with higher FC between subgenual anterior cingulate cortex (Cg25) and the SN, controlling for participant age. There were no regions of the brain that showed an inverse relation.
Conclusions: Brain systems that have been implicated in autonomic arousal and that influence subjective feeling states show altered FC associated with stress responsivity in early life.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02422.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=142 The role of HPA-axis function during pregnancy in the intergenerational transmission of maternal adverse childhood experiences to child behavior problems / Jenna C. THOMAS-ARGYRIOU in Development and Psychopathology, 33-1 (February 2021)
PermalinkChildhood parenting and adolescent internalizing and externalizing symptoms: Moderation by multilocus hypothalamic-pituitary-adrenal axis-related genetic variation / Cong CAO in Development and Psychopathology, 35-2 (May 2023)
PermalinkAssociations between developmental trajectories of peer victimization, hair cortisol, and depressive symptoms: a longitudinal study / Isabelle OUELLET-MORIN in Journal of Child Psychology and Psychiatry, 62-1 (January 2021)
PermalinkDevelopmental consequences of early life stress on risk for psychopathology: Longitudinal associations with children's multisystem physiological regulation and executive functioning / Kristen L. RUDD in Development and Psychopathology, 33-5 (December 2021)
PermalinkDifferences in anticipatory versus reactive stress to social evaluative threat in adults versus adolescents with autism / Julie LOUNDS TAYLOR in Autism Research, 11-9 (September 2018)
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