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Auteur Luise POUSTKA |
Documents disponibles écrits par cet auteur (17)
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Using machine learning to improve diagnostic assessment of ASD in the light of specific differential and co-occurring diagnoses / Martin SCHULTE-RUTHER in Journal of Child Psychology and Psychiatry, 64-1 (January 2023)
[article]
Titre : Using machine learning to improve diagnostic assessment of ASD in the light of specific differential and co-occurring diagnoses Type de document : Texte imprimé et/ou numérique Auteurs : Martin SCHULTE-RUTHER, Auteur ; Tomas KULVICIUS, Auteur ; Sanna STROTH, Auteur ; Nicole WOLFF, Auteur ; Veit ROESSNER, Auteur ; Peter B. MARSCHIK, Auteur ; Inge KAMP-BECKER, Auteur ; Luise POUSTKA, Auteur Article en page(s) : p.16-26 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Diagnostic assessment of ASD requires substantial clinical experience and is particularly difficult in the context of other disorders with behavioral symptoms in the domain of social interaction and communication. Observation measures such as the Autism Diagnostic Observation Schedule (ADOS) do not take into account such co-occurring disorders. Method We used a well-characterized clinical sample of individuals (n=1,251) that had received detailed outpatient evaluation for the presence of an ASD diagnosis (n=481) and covered a range of additional overlapping diagnoses, including anxiety-related disorders (ANX, n=122), ADHD (n=439), and conduct disorder (CD, n=194). We focused on ADOS module 3, covering the age range with particular high prevalence of such differential diagnoses. We used machine learning (ML) and trained random forest models on ADOS single item scores to predict a clinical best-estimate diagnosis of ASD in the context of these differential diagnoses (ASD vs. ANX, ASD vs. ADHD, ASD vs. CD), in the context of co-occurring ADHD, and an unspecific model using all available data. We employed nested cross-validation for an unbiased estimate of classification performance and made available a Webapp to showcase the results and feasibility for translation into clinical practice. Results We obtained very good overall sensitivity (0.89-0.94) and specificity (0.87-0.89). In particular for individuals with less severe symptoms, our models showed increases of up to 35% in sensitivity or specificity. Furthermore, we analyzed item importance profiles of the ANX, ADHD, and CD models in comparison with the unspecific model revealing distinct patterns of importance for specific ADOS items with respect to differential diagnoses. Conclusions ML-based diagnostic classification may improve clinical decisions by utilizing the full range of information from detailed diagnostic observation instruments such as the ADOS. Importantly, this strategy might be of particular relevance for older children with less severe symptoms for whom the diagnostic decision is often particularly difficult. En ligne : https://doi.org/10.1111/jcpp.13650 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490
in Journal of Child Psychology and Psychiatry > 64-1 (January 2023) . - p.16-26[article] Using machine learning to improve diagnostic assessment of ASD in the light of specific differential and co-occurring diagnoses [Texte imprimé et/ou numérique] / Martin SCHULTE-RUTHER, Auteur ; Tomas KULVICIUS, Auteur ; Sanna STROTH, Auteur ; Nicole WOLFF, Auteur ; Veit ROESSNER, Auteur ; Peter B. MARSCHIK, Auteur ; Inge KAMP-BECKER, Auteur ; Luise POUSTKA, Auteur . - p.16-26.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 64-1 (January 2023) . - p.16-26
Index. décimale : PER Périodiques Résumé : Background Diagnostic assessment of ASD requires substantial clinical experience and is particularly difficult in the context of other disorders with behavioral symptoms in the domain of social interaction and communication. Observation measures such as the Autism Diagnostic Observation Schedule (ADOS) do not take into account such co-occurring disorders. Method We used a well-characterized clinical sample of individuals (n=1,251) that had received detailed outpatient evaluation for the presence of an ASD diagnosis (n=481) and covered a range of additional overlapping diagnoses, including anxiety-related disorders (ANX, n=122), ADHD (n=439), and conduct disorder (CD, n=194). We focused on ADOS module 3, covering the age range with particular high prevalence of such differential diagnoses. We used machine learning (ML) and trained random forest models on ADOS single item scores to predict a clinical best-estimate diagnosis of ASD in the context of these differential diagnoses (ASD vs. ANX, ASD vs. ADHD, ASD vs. CD), in the context of co-occurring ADHD, and an unspecific model using all available data. We employed nested cross-validation for an unbiased estimate of classification performance and made available a Webapp to showcase the results and feasibility for translation into clinical practice. Results We obtained very good overall sensitivity (0.89-0.94) and specificity (0.87-0.89). In particular for individuals with less severe symptoms, our models showed increases of up to 35% in sensitivity or specificity. Furthermore, we analyzed item importance profiles of the ANX, ADHD, and CD models in comparison with the unspecific model revealing distinct patterns of importance for specific ADOS items with respect to differential diagnoses. Conclusions ML-based diagnostic classification may improve clinical decisions by utilizing the full range of information from detailed diagnostic observation instruments such as the ADOS. Importantly, this strategy might be of particular relevance for older children with less severe symptoms for whom the diagnostic decision is often particularly difficult. En ligne : https://doi.org/10.1111/jcpp.13650 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 Validation of the Movie for the Assessment of Social Cognition in Adolescents with ASD: Fixation Duration and Pupil Dilation as Predictors of Performance / Nico MÜLLER in Journal of Autism and Developmental Disorders, 46-9 (September 2016)
[article]
Titre : Validation of the Movie for the Assessment of Social Cognition in Adolescents with ASD: Fixation Duration and Pupil Dilation as Predictors of Performance Type de document : Texte imprimé et/ou numérique Auteurs : Nico MÜLLER, Auteur ; Sarah BAUMEISTER, Auteur ; Isabel DZIOBEK, Auteur ; Tobias BANASCHEWSKI, Auteur ; Luise POUSTKA, Auteur Article en page(s) : p.2831-2844 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Eye-tracking Adolescence Pupil dilation Social cognition Ecological validity Index. décimale : PER Périodiques Résumé : Impaired social cognition is one of the core characteristics of autism spectrum disorders (ASD). Appropriate measures of social cognition for high-functioning adolescents with ASD are, however, lacking. The Movie for the Assessment of Social Cognition (MASC) uses dynamic social stimuli, ensuring ecological validity, and has proven to be a sensitive measure in adulthood. In the current study, 33 adolescents with ASD and 23 controls were administered the MASC, while concurrent eye tracking was used to relate gaze behavior to performance levels. The ASD group exhibited reduced MASC scores, with social cognition performance being explained by shorter fixation duration on eyes and decreased pupil dilation. These potential diagnostic markers are discussed as indicators of different processing of social information in ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-2828-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292
in Journal of Autism and Developmental Disorders > 46-9 (September 2016) . - p.2831-2844[article] Validation of the Movie for the Assessment of Social Cognition in Adolescents with ASD: Fixation Duration and Pupil Dilation as Predictors of Performance [Texte imprimé et/ou numérique] / Nico MÜLLER, Auteur ; Sarah BAUMEISTER, Auteur ; Isabel DZIOBEK, Auteur ; Tobias BANASCHEWSKI, Auteur ; Luise POUSTKA, Auteur . - p.2831-2844.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 46-9 (September 2016) . - p.2831-2844
Mots-clés : Autism spectrum disorder Eye-tracking Adolescence Pupil dilation Social cognition Ecological validity Index. décimale : PER Périodiques Résumé : Impaired social cognition is one of the core characteristics of autism spectrum disorders (ASD). Appropriate measures of social cognition for high-functioning adolescents with ASD are, however, lacking. The Movie for the Assessment of Social Cognition (MASC) uses dynamic social stimuli, ensuring ecological validity, and has proven to be a sensitive measure in adulthood. In the current study, 33 adolescents with ASD and 23 controls were administered the MASC, while concurrent eye tracking was used to relate gaze behavior to performance levels. The ASD group exhibited reduced MASC scores, with social cognition performance being explained by shorter fixation duration on eyes and decreased pupil dilation. These potential diagnostic markers are discussed as indicators of different processing of social information in ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-2828-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292