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Auteur Phyllis KITTLER |
Documents disponibles écrits par cet auteur (1)
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Neonatal Brainstem Function and 4-Month Arousal-Modulated Attention Are Jointly Associated With Autism / Ira L. COHEN in Autism Research, 6-1 (February 2013)
[article]
Titre : Neonatal Brainstem Function and 4-Month Arousal-Modulated Attention Are Jointly Associated With Autism Type de document : Texte imprimé et/ou numérique Auteurs : Ira L. COHEN, Auteur ; Judith M. GARDNER, Auteur ; Bernard Z. KARMEL, Auteur ; Ha T. T. PHAN, Auteur ; Phyllis KITTLER, Auteur ; Tina Rovito GOMEZ, Auteur ; Maripaz G. GONZALEZ, Auteur ; Elizabeth M. LENNON, Auteur ; Santosh PARAB, Auteur ; Anthony BARONE, Auteur Année de publication : 2013 Article en page(s) : p.11-22 Langues : Anglais (eng) Mots-clés : auditory brainstem response infancy attention arousal repetitive and ritualistic behaviors autism spectrum disorder Index. décimale : PER Périodiques Résumé : The authors evaluated the contribution of initially abnormal neonatal auditory brainstem responses (ABRs) and 4-month arousal-modulated attention visual preference to later autism spectrum disorder (ASD) behaviors in neonatal intensive care unit (NICU) graduates. A longitudinal study design was used to compare NICU graduates with normal ABRs (n?=?28) to those with initially abnormal ABRs (n?=?46) that later resolved. At 4 months postterm age, visual preference (measured after feeding) for a random check pattern flashing at 1, 3, or 8?Hz and gestational age (GA) served as additional predictors. Outcome measures were PDD Behavior Inventory (PDDBI) scores at 3.4 years (standard deviation?=?1.2), and developmental quotients (DQ) obtained around the same age with the Griffiths Mental Development Scales (GMDS). Preferences for higher rates of stimulation at 4 months were highly correlated with PDDBI scores (all P-values??0.01) and the GMDS Hearing and Speech DQ, but only in those with initially abnormal ABRs. Effects were strongest for a PDDBI social competence measure most associated with a diagnosis of autism. For those with abnormal ABRs, increases in preference for higher rates of stimulation as infants were linked to nonlinear increases in severity of ASD at 3 years and to an ASD diagnosis. Abnormal ABRs were associated with later reports of repetitive and ritualistic behaviors irrespective of 4-month preference for stimulation. The joint occurrence of initially abnormal neonatal ABRs and preference for more stimulation at 4 months, both indices of early brainstem dysfunction, may be a marker for the development of autism in this cohort. En ligne : http://dx.doi.org/10.1002/aur.1259 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192
in Autism Research > 6-1 (February 2013) . - p.11-22[article] Neonatal Brainstem Function and 4-Month Arousal-Modulated Attention Are Jointly Associated With Autism [Texte imprimé et/ou numérique] / Ira L. COHEN, Auteur ; Judith M. GARDNER, Auteur ; Bernard Z. KARMEL, Auteur ; Ha T. T. PHAN, Auteur ; Phyllis KITTLER, Auteur ; Tina Rovito GOMEZ, Auteur ; Maripaz G. GONZALEZ, Auteur ; Elizabeth M. LENNON, Auteur ; Santosh PARAB, Auteur ; Anthony BARONE, Auteur . - 2013 . - p.11-22.
Langues : Anglais (eng)
in Autism Research > 6-1 (February 2013) . - p.11-22
Mots-clés : auditory brainstem response infancy attention arousal repetitive and ritualistic behaviors autism spectrum disorder Index. décimale : PER Périodiques Résumé : The authors evaluated the contribution of initially abnormal neonatal auditory brainstem responses (ABRs) and 4-month arousal-modulated attention visual preference to later autism spectrum disorder (ASD) behaviors in neonatal intensive care unit (NICU) graduates. A longitudinal study design was used to compare NICU graduates with normal ABRs (n?=?28) to those with initially abnormal ABRs (n?=?46) that later resolved. At 4 months postterm age, visual preference (measured after feeding) for a random check pattern flashing at 1, 3, or 8?Hz and gestational age (GA) served as additional predictors. Outcome measures were PDD Behavior Inventory (PDDBI) scores at 3.4 years (standard deviation?=?1.2), and developmental quotients (DQ) obtained around the same age with the Griffiths Mental Development Scales (GMDS). Preferences for higher rates of stimulation at 4 months were highly correlated with PDDBI scores (all P-values??0.01) and the GMDS Hearing and Speech DQ, but only in those with initially abnormal ABRs. Effects were strongest for a PDDBI social competence measure most associated with a diagnosis of autism. For those with abnormal ABRs, increases in preference for higher rates of stimulation as infants were linked to nonlinear increases in severity of ASD at 3 years and to an ASD diagnosis. Abnormal ABRs were associated with later reports of repetitive and ritualistic behaviors irrespective of 4-month preference for stimulation. The joint occurrence of initially abnormal neonatal ABRs and preference for more stimulation at 4 months, both indices of early brainstem dysfunction, may be a marker for the development of autism in this cohort. En ligne : http://dx.doi.org/10.1002/aur.1259 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192