Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur David A. COLLIER |
Documents disponibles écrits par cet auteur (1)
Faire une suggestion Affiner la recherche
Predicting outcomes following cognitive behaviour therapy in child anxiety disorders: the influence of genetic, demographic and clinical information / Jennifer L. HUDSON in Journal of Child Psychology and Psychiatry, 54-10 (October 2013)
[article]
Titre : Predicting outcomes following cognitive behaviour therapy in child anxiety disorders: the influence of genetic, demographic and clinical information Type de document : Texte imprimé et/ou numérique Auteurs : Jennifer L. HUDSON, Auteur ; Kathryn J. LESTER, Auteur ; Cathryn M. LEWIS, Auteur ; Maria TROPEANO, Auteur ; Cathy CRESWELL, Auteur ; David A. COLLIER, Auteur ; Peter J. COOPER, Auteur ; Heidi J. LYNEHAM, Auteur ; Talia MORRIS, Auteur ; Ronald M. RAPEE, Auteur ; Susanna ROBERTS, Auteur ; Jennifer A. DONALD, Auteur ; Thalia C. ELEY, Auteur Article en page(s) : p.1086-1094 Langues : Anglais (eng) Mots-clés : CBT G × E anxiety disorders child anxiety disorders Index. décimale : PER Périodiques Résumé : Background Within a therapeutic gene by environment (G × E) framework, we recently demonstrated that variation in the Serotonin Transporter Promoter Polymorphism; 5HTTLPR and marker rs6330 in Nerve Growth Factor gene; NGF is associated with poorer outcomes following cognitive behaviour therapy (CBT) for child anxiety disorders. The aim of this study was to explore one potential means of extending the translational reach of G × E data in a way that may be clinically informative. We describe a ‘risk-index’ approach combining genetic, demographic and clinical data and test its ability to predict diagnostic outcome following CBT in anxious children. Method DNA and clinical data were collected from 384 children with a primary anxiety disorder undergoing CBT. We tested our risk model in five cross-validation training sets. Results In predicting treatment outcome, six variables had a minimum mean beta value of 0.5:5HTTLPR, NGF rs6330, gender, primary anxiety severity, comorbid mood disorder and comorbid externalising disorder. A risk index (range 0–8) constructed from these variables had moderate a predictive ability (AUC = .62–.69) in this study. Children scoring high on this index (5–8) were approximately three times as likely to retain their primary anxiety disorder at follow-up as compared with those children scoring 2 or less. Conclusion Significant genetic, demographic and clinical predictors of outcome following CBT for anxiety-disordered children were identified. Combining these predictors within a risk index could be used to identify which children are less likely to be diagnosis-free following CBT alone and require longer or enhanced treatment. The ‘risk-index’ approach represents one means of harnessing the translational potential of G × E data. En ligne : http://dx.doi.org/10.1111/jcpp.12092 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212
in Journal of Child Psychology and Psychiatry > 54-10 (October 2013) . - p.1086-1094[article] Predicting outcomes following cognitive behaviour therapy in child anxiety disorders: the influence of genetic, demographic and clinical information [Texte imprimé et/ou numérique] / Jennifer L. HUDSON, Auteur ; Kathryn J. LESTER, Auteur ; Cathryn M. LEWIS, Auteur ; Maria TROPEANO, Auteur ; Cathy CRESWELL, Auteur ; David A. COLLIER, Auteur ; Peter J. COOPER, Auteur ; Heidi J. LYNEHAM, Auteur ; Talia MORRIS, Auteur ; Ronald M. RAPEE, Auteur ; Susanna ROBERTS, Auteur ; Jennifer A. DONALD, Auteur ; Thalia C. ELEY, Auteur . - p.1086-1094.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 54-10 (October 2013) . - p.1086-1094
Mots-clés : CBT G × E anxiety disorders child anxiety disorders Index. décimale : PER Périodiques Résumé : Background Within a therapeutic gene by environment (G × E) framework, we recently demonstrated that variation in the Serotonin Transporter Promoter Polymorphism; 5HTTLPR and marker rs6330 in Nerve Growth Factor gene; NGF is associated with poorer outcomes following cognitive behaviour therapy (CBT) for child anxiety disorders. The aim of this study was to explore one potential means of extending the translational reach of G × E data in a way that may be clinically informative. We describe a ‘risk-index’ approach combining genetic, demographic and clinical data and test its ability to predict diagnostic outcome following CBT in anxious children. Method DNA and clinical data were collected from 384 children with a primary anxiety disorder undergoing CBT. We tested our risk model in five cross-validation training sets. Results In predicting treatment outcome, six variables had a minimum mean beta value of 0.5:5HTTLPR, NGF rs6330, gender, primary anxiety severity, comorbid mood disorder and comorbid externalising disorder. A risk index (range 0–8) constructed from these variables had moderate a predictive ability (AUC = .62–.69) in this study. Children scoring high on this index (5–8) were approximately three times as likely to retain their primary anxiety disorder at follow-up as compared with those children scoring 2 or less. Conclusion Significant genetic, demographic and clinical predictors of outcome following CBT for anxiety-disordered children were identified. Combining these predictors within a risk index could be used to identify which children are less likely to be diagnosis-free following CBT alone and require longer or enhanced treatment. The ‘risk-index’ approach represents one means of harnessing the translational potential of G × E data. En ligne : http://dx.doi.org/10.1111/jcpp.12092 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212