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Détail de l'auteur
Auteur Robin A. LIBOVE |
Documents disponibles écrits par cet auteur (2)
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Brief Report: An Open-Label Study of the Neurosteroid Pregnenolone in Adults with Autism Spectrum Disorder / Lawrence K. FUNG in Journal of Autism and Developmental Disorders, 44-11 (November 2014)
[article]
Titre : Brief Report: An Open-Label Study of the Neurosteroid Pregnenolone in Adults with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Lawrence K. FUNG, Auteur ; Robin A. LIBOVE, Auteur ; Jennifer PHILLIPS, Auteur ; Francois HADDAD, Auteur ; Antonio Y. HARDAN, Auteur Article en page(s) : p.2971-2977 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Pregnenolone Neurosteroids Irritability Open-label trial Index. décimale : PER Périodiques Résumé : The objective of this study was to assess the tolerability and efficacy of pregnenolone in reducing irritability in adults with autism spectrum disorder (ASD). This was a pilot, open-label, 12-week trial that included twelve subjects with a mean age of 22.5 ± 5.8 years. Two participants dropped out of the study due to reasons unrelated to adverse effects. Pregnenolone yielded a statistically significant improvement in the primary measure, Aberrant Behavior Checklist (ABC)-Irritability [from 17.4 ± 7.4 at baseline to 11.2 ± 7.0 at 12 weeks (p = 0.028)]. Secondary measures were not statistically significant with the exception of ABC-lethargy (p = 0.046) and total Short Sensory Profile score (p = 0.009). No significant vital sign changes occurred during this study. Pregnenolone was not associated with any severe side effects. Single episodes of tiredness, diarrhea and depressive affect that could be related to pregnenolone were reported. Overall, pregnenolone was modestly effective and well-tolerated in individuals with ASD. En ligne : http://dx.doi.org/10.1007/s10803-014-2144-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241
in Journal of Autism and Developmental Disorders > 44-11 (November 2014) . - p.2971-2977[article] Brief Report: An Open-Label Study of the Neurosteroid Pregnenolone in Adults with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Lawrence K. FUNG, Auteur ; Robin A. LIBOVE, Auteur ; Jennifer PHILLIPS, Auteur ; Francois HADDAD, Auteur ; Antonio Y. HARDAN, Auteur . - p.2971-2977.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 44-11 (November 2014) . - p.2971-2977
Mots-clés : Autism spectrum disorder Pregnenolone Neurosteroids Irritability Open-label trial Index. décimale : PER Périodiques Résumé : The objective of this study was to assess the tolerability and efficacy of pregnenolone in reducing irritability in adults with autism spectrum disorder (ASD). This was a pilot, open-label, 12-week trial that included twelve subjects with a mean age of 22.5 ± 5.8 years. Two participants dropped out of the study due to reasons unrelated to adverse effects. Pregnenolone yielded a statistically significant improvement in the primary measure, Aberrant Behavior Checklist (ABC)-Irritability [from 17.4 ± 7.4 at baseline to 11.2 ± 7.0 at 12 weeks (p = 0.028)]. Secondary measures were not statistically significant with the exception of ABC-lethargy (p = 0.046) and total Short Sensory Profile score (p = 0.009). No significant vital sign changes occurred during this study. Pregnenolone was not associated with any severe side effects. Single episodes of tiredness, diarrhea and depressive affect that could be related to pregnenolone were reported. Overall, pregnenolone was modestly effective and well-tolerated in individuals with ASD. En ligne : http://dx.doi.org/10.1007/s10803-014-2144-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 A randomized controlled trial of Pivotal Response Treatment Group for parents of children with autism / Antonio Y. HARDAN in Journal of Child Psychology and Psychiatry, 56-8 (August 2015)
[article]
Titre : A randomized controlled trial of Pivotal Response Treatment Group for parents of children with autism Type de document : Texte imprimé et/ou numérique Auteurs : Antonio Y. HARDAN, Auteur ; Grace W. GENGOUX, Auteur ; Kari L. BERQUIST, Auteur ; Robin A. LIBOVE, Auteur ; Christina M. ARDEL, Auteur ; Jennifer PHILLIPS, Auteur ; Thomas W. FRAZIER, Auteur ; Mendy B. MINJAREZ, Auteur Article en page(s) : p.884-892 Langues : Anglais (eng) Mots-clés : Language deficits treatment fidelity group parent training social communication naturalistic developmental behavior intervention Index. décimale : PER Périodiques Résumé : Background With rates of autism diagnosis continuing to rise, there is an urgent need for effective and efficient service delivery models. Pivotal Response Treatment (PRT) is considered an established treatment for autism spectrum disorder (ASD); however, there have been few well-controlled studies with adequate sample size. The aim of this study was to conduct a randomized controlled trial to evaluate PRT parent training group (PRTG) for targeting language deficits in young children with ASD. Methods Fifty-three children with autism and significant language delay between 2 and 6 years old were randomized to PRTG (N = 27) or psychoeducation group (PEG; N = 26) for 12 weeks. The PRTG taught parents behavioral techniques to facilitate language development. The PEG taught general information about ASD (clinical trial NCT01881750; http://www.clinicaltrials.gov). Results Analysis of child utterances during the structured laboratory observation (primary outcome) indicated that, compared with children in the PEG, children in the PRTG demonstrated greater improvement in frequency of utterances (F(2, 43) = 3.53, p = .038, d = 0.42). Results indicated that parents were able to learn PRT in a group format, as the majority of parents in the PRTG (84%) met fidelity of implementation criteria after 12 weeks. Children also demonstrated greater improvement in adaptive communication skills (Vineland-II) following PRTG and baseline Mullen visual reception scores predicted treatment response to PRTG. Conclusions This is the first randomized controlled trial of group-delivered PRT and one of the largest experimental investigations of the PRT model to date. The findings suggest that specific instruction in PRT results in greater skill acquisition for both parents and children, especially in functional and adaptive communication skills. Further research in PRT is warranted to replicate the observed results and address other core ASD symptoms. En ligne : http://dx.doi.org/10.1111/jcpp.12354 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263
in Journal of Child Psychology and Psychiatry > 56-8 (August 2015) . - p.884-892[article] A randomized controlled trial of Pivotal Response Treatment Group for parents of children with autism [Texte imprimé et/ou numérique] / Antonio Y. HARDAN, Auteur ; Grace W. GENGOUX, Auteur ; Kari L. BERQUIST, Auteur ; Robin A. LIBOVE, Auteur ; Christina M. ARDEL, Auteur ; Jennifer PHILLIPS, Auteur ; Thomas W. FRAZIER, Auteur ; Mendy B. MINJAREZ, Auteur . - p.884-892.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 56-8 (August 2015) . - p.884-892
Mots-clés : Language deficits treatment fidelity group parent training social communication naturalistic developmental behavior intervention Index. décimale : PER Périodiques Résumé : Background With rates of autism diagnosis continuing to rise, there is an urgent need for effective and efficient service delivery models. Pivotal Response Treatment (PRT) is considered an established treatment for autism spectrum disorder (ASD); however, there have been few well-controlled studies with adequate sample size. The aim of this study was to conduct a randomized controlled trial to evaluate PRT parent training group (PRTG) for targeting language deficits in young children with ASD. Methods Fifty-three children with autism and significant language delay between 2 and 6 years old were randomized to PRTG (N = 27) or psychoeducation group (PEG; N = 26) for 12 weeks. The PRTG taught parents behavioral techniques to facilitate language development. The PEG taught general information about ASD (clinical trial NCT01881750; http://www.clinicaltrials.gov). Results Analysis of child utterances during the structured laboratory observation (primary outcome) indicated that, compared with children in the PEG, children in the PRTG demonstrated greater improvement in frequency of utterances (F(2, 43) = 3.53, p = .038, d = 0.42). Results indicated that parents were able to learn PRT in a group format, as the majority of parents in the PRTG (84%) met fidelity of implementation criteria after 12 weeks. Children also demonstrated greater improvement in adaptive communication skills (Vineland-II) following PRTG and baseline Mullen visual reception scores predicted treatment response to PRTG. Conclusions This is the first randomized controlled trial of group-delivered PRT and one of the largest experimental investigations of the PRT model to date. The findings suggest that specific instruction in PRT results in greater skill acquisition for both parents and children, especially in functional and adaptive communication skills. Further research in PRT is warranted to replicate the observed results and address other core ASD symptoms. En ligne : http://dx.doi.org/10.1111/jcpp.12354 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263