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Détail de l'auteur
Auteur Patrick O. MCGOWAN |
Documents disponibles écrits par cet auteur (2)
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DNA methylation profiles in adults born at extremely low birth weight / Karen J. MATHEWSON in Development and Psychopathology, 34-1 (February 2022)
[article]
Titre : DNA methylation profiles in adults born at extremely low birth weight Type de document : Texte imprimé et/ou numérique Auteurs : Karen J. MATHEWSON, Auteur ; Patrick O. MCGOWAN, Auteur ; Wilfred C. DE VEGA, Auteur ; Ryan J. VAN LIESHOUT, Auteur ; Katherine M. MORRISON, Auteur ; Saroj SAIGAL, Auteur ; Louis A. SCHMIDT, Auteur Article en page(s) : p.19-36 Langues : Anglais (eng) Mots-clés : DNA methylation profiling epigenetic modification extremely low birth weight (ELBW) sex differences stress reactivity and vulnerability Index. décimale : PER Périodiques Résumé : Effects of stresses associated with extremely preterm birth may be biologically ?recorded? in the genomes of individuals born preterm via changes in DNA methylation (DNAm) patterns. Genome-wide DNAm profiles were examined in buccal epithelial cells from 45 adults born at extremely low birth weight (ELBW; ?1000 g) in the oldest known cohort of prospectively followed ELBW survivors (Mage = 32.35 years, 17 male), and 47 normal birth weight (NBW; ?2500 g) control adults (Mage = 32.43 years, 20 male). Sex differences in DNAm profiles were found in both birth weight groups, but they were greatly enhanced in the ELBW group (77,895 loci) versus the NBW group (3,424 loci), suggesting synergistic effects of extreme prenatal adversity and sex on adult DNAm profiles. In men, DNAm profiles differed by birth weight group at 1,354 loci on 694 unique genes. Only two loci on two genes distinguished between ELBW and NBW women. Gene ontology (GO) and network analyses indicated that loci differentiating between ELBW and NBW men were abundant in genes within biological pathways related to neuronal development, synaptic transportation, metabolic regulation, and cellular regulation. Findings suggest increased sensitivity of males to long-term epigenetic effects of extremely preterm birth. Group differences are discussed in relation to particular gene functions. En ligne : http://dx.doi.org/10.1017/s0954579420000899 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474
in Development and Psychopathology > 34-1 (February 2022) . - p.19-36[article] DNA methylation profiles in adults born at extremely low birth weight [Texte imprimé et/ou numérique] / Karen J. MATHEWSON, Auteur ; Patrick O. MCGOWAN, Auteur ; Wilfred C. DE VEGA, Auteur ; Ryan J. VAN LIESHOUT, Auteur ; Katherine M. MORRISON, Auteur ; Saroj SAIGAL, Auteur ; Louis A. SCHMIDT, Auteur . - p.19-36.
Langues : Anglais (eng)
in Development and Psychopathology > 34-1 (February 2022) . - p.19-36
Mots-clés : DNA methylation profiling epigenetic modification extremely low birth weight (ELBW) sex differences stress reactivity and vulnerability Index. décimale : PER Périodiques Résumé : Effects of stresses associated with extremely preterm birth may be biologically ?recorded? in the genomes of individuals born preterm via changes in DNA methylation (DNAm) patterns. Genome-wide DNAm profiles were examined in buccal epithelial cells from 45 adults born at extremely low birth weight (ELBW; ?1000 g) in the oldest known cohort of prospectively followed ELBW survivors (Mage = 32.35 years, 17 male), and 47 normal birth weight (NBW; ?2500 g) control adults (Mage = 32.43 years, 20 male). Sex differences in DNAm profiles were found in both birth weight groups, but they were greatly enhanced in the ELBW group (77,895 loci) versus the NBW group (3,424 loci), suggesting synergistic effects of extreme prenatal adversity and sex on adult DNAm profiles. In men, DNAm profiles differed by birth weight group at 1,354 loci on 694 unique genes. Only two loci on two genes distinguished between ELBW and NBW women. Gene ontology (GO) and network analyses indicated that loci differentiating between ELBW and NBW men were abundant in genes within biological pathways related to neuronal development, synaptic transportation, metabolic regulation, and cellular regulation. Findings suggest increased sensitivity of males to long-term epigenetic effects of extremely preterm birth. Group differences are discussed in relation to particular gene functions. En ligne : http://dx.doi.org/10.1017/s0954579420000899 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 Epigenetic pathways through which experiences become linked with biology / Patrick O. MCGOWAN in Development and Psychopathology, 27-2 (May 2015)
[article]
Titre : Epigenetic pathways through which experiences become linked with biology Type de document : Texte imprimé et/ou numérique Auteurs : Patrick O. MCGOWAN, Auteur ; Tania L. ROTH, Auteur Article en page(s) : p.637-648 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This article highlights the defining principles, progress, and future directions in epigenetics research in relation to this Special Issue. Exciting studies in the fields of neuroscience, psychology, and psychiatry have provided new insights into the epigenetic factors (e.g., DNA methylation) that are responsive to environmental input and serve as biological pathways in behavioral development. Here we highlight the experimental evidence, mainly from animal models, that factors such as psychosocial stress and environmental adversity can become encoded within epigenetic factors with functional consequences for brain plasticity and behavior. We also highlight evidence that epigenetic marking of genes in one generation can have consequences for future generations (i.e., inherited), and work with humans linking epigenetics, cognitive dysfunction, and psychiatric disorder. Though epigenetics has offered more of a beginning than an answer to the centuries-old nature–nurture debate, continued research is certain to yield substantial information regarding biological determinants of central nervous system changes and behavior with relevance for the study of developmental psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579415000206 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257
in Development and Psychopathology > 27-2 (May 2015) . - p.637-648[article] Epigenetic pathways through which experiences become linked with biology [Texte imprimé et/ou numérique] / Patrick O. MCGOWAN, Auteur ; Tania L. ROTH, Auteur . - p.637-648.
Langues : Anglais (eng)
in Development and Psychopathology > 27-2 (May 2015) . - p.637-648
Index. décimale : PER Périodiques Résumé : This article highlights the defining principles, progress, and future directions in epigenetics research in relation to this Special Issue. Exciting studies in the fields of neuroscience, psychology, and psychiatry have provided new insights into the epigenetic factors (e.g., DNA methylation) that are responsive to environmental input and serve as biological pathways in behavioral development. Here we highlight the experimental evidence, mainly from animal models, that factors such as psychosocial stress and environmental adversity can become encoded within epigenetic factors with functional consequences for brain plasticity and behavior. We also highlight evidence that epigenetic marking of genes in one generation can have consequences for future generations (i.e., inherited), and work with humans linking epigenetics, cognitive dysfunction, and psychiatric disorder. Though epigenetics has offered more of a beginning than an answer to the centuries-old nature–nurture debate, continued research is certain to yield substantial information regarding biological determinants of central nervous system changes and behavior with relevance for the study of developmental psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579415000206 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257