Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur Kara Gross MARGOLIS |
Documents disponibles écrits par cet auteur (2)
Faire une suggestion Affiner la recherche
Brief Report: Whole Blood Serotonin Levels and Gastrointestinal Symptoms in Autism Spectrum Disorder / Sarah MARLER in Journal of Autism and Developmental Disorders, 46-3 (March 2016)
[article]
Titre : Brief Report: Whole Blood Serotonin Levels and Gastrointestinal Symptoms in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Sarah MARLER, Auteur ; Bradley J. FERGUSON, Auteur ; Evon BATEY LEE, Auteur ; Brittany PETERS, Auteur ; Kent C. WILLIAMS, Auteur ; Erin MCDONNELL, Auteur ; Eric A. MACKLIN, Auteur ; Pat LEVITT, Auteur ; Catherine HAGAN GILLESPIE, Auteur ; George M. ANDERSON, Auteur ; Kara Gross MARGOLIS, Auteur ; David Q. BEVERSDORF, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur Article en page(s) : p.1124-1130 Langues : Anglais (eng) Mots-clés : Serotonin 5-HT Gastrointestinal (GI) IL-6 Medical comorbidities Autism Treatment Network Index. décimale : PER Périodiques Résumé : Elevated whole blood serotonin levels are observed in more than 25 % of children with autism spectrum disorder (ASD). Co-occurring gastrointestinal (GI) symptoms are also common in ASD but have not previously been examined in relationship with hyperserotonemia, despite the synthesis of serotonin in the gut. In 82 children and adolescents with ASD, we observed a correlation between a quantitative measure of lower GI symptoms and whole blood serotonin levels. No significant association was seen between functional constipation diagnosis and serotonin levels in the hyperserotonemia range, suggesting that this correlation is not driven by a single subgroup. More specific assessment of gut function, including the microbiome, will be necessary to evaluate the contribution of gut physiology to serotonin levels in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2646-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282
in Journal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.1124-1130[article] Brief Report: Whole Blood Serotonin Levels and Gastrointestinal Symptoms in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Sarah MARLER, Auteur ; Bradley J. FERGUSON, Auteur ; Evon BATEY LEE, Auteur ; Brittany PETERS, Auteur ; Kent C. WILLIAMS, Auteur ; Erin MCDONNELL, Auteur ; Eric A. MACKLIN, Auteur ; Pat LEVITT, Auteur ; Catherine HAGAN GILLESPIE, Auteur ; George M. ANDERSON, Auteur ; Kara Gross MARGOLIS, Auteur ; David Q. BEVERSDORF, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur . - p.1124-1130.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.1124-1130
Mots-clés : Serotonin 5-HT Gastrointestinal (GI) IL-6 Medical comorbidities Autism Treatment Network Index. décimale : PER Périodiques Résumé : Elevated whole blood serotonin levels are observed in more than 25 % of children with autism spectrum disorder (ASD). Co-occurring gastrointestinal (GI) symptoms are also common in ASD but have not previously been examined in relationship with hyperserotonemia, despite the synthesis of serotonin in the gut. In 82 children and adolescents with ASD, we observed a correlation between a quantitative measure of lower GI symptoms and whole blood serotonin levels. No significant association was seen between functional constipation diagnosis and serotonin levels in the hyperserotonemia range, suggesting that this correlation is not driven by a single subgroup. More specific assessment of gut function, including the microbiome, will be necessary to evaluate the contribution of gut physiology to serotonin levels in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2646-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 Psychophysiological Associations with Gastrointestinal Symptomatology in Autism Spectrum Disorder / Bradley J. FERGUSON in Autism Research, 10-2 (February 2017)
[article]
Titre : Psychophysiological Associations with Gastrointestinal Symptomatology in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Bradley J. FERGUSON, Auteur ; Sarah MARLER, Auteur ; Lily L. ALTSTEIN, Auteur ; Evon BATEY LEE, Auteur ; Jill AKERS, Auteur ; Kristin SOHL, Auteur ; Aaron MCLAUGHLIN, Auteur ; Kaitlyn HARTNETT, Auteur ; Briana KILLE, Auteur ; Micah MAZUREK, Auteur ; Eric A. MACKLIN, Auteur ; Erin MCDONNELL, Auteur ; Mariah BARSTOW, Auteur ; Margaret L. BAUMAN, Auteur ; Kara Gross MARGOLIS, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur ; David Q. BEVERSDORF, Auteur Article en page(s) : p.276-288 Langues : Anglais (eng) Mots-clés : autism spectrum disorder gastrointestinal autonomic nervous system sympathetic parasympathetic anxiety constipation Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is often accompanied by gastrointestinal disturbances, which also may impact behavior. Alterations in autonomic nervous system functioning are also frequently observed in ASD. The relationship between these findings in ASD is not known. We examined the relationship between gastrointestinal symptomatology, examining upper and lower gastrointestinal tract symptomatology separately, and autonomic nervous system functioning, as assessed by heart rate variability and skin conductance level, in a sample of 120 individuals with ASD. Relationships with co-occurring medical and psychiatric symptoms were also examined. While the number of participants with significant upper gastrointestinal tract problems was small in this sample, 42.5% of participants met criteria for functional constipation, a disorder of the lower gastrointestinal tract. Heart rate variability, a measure of parasympathetic modulation of cardiac activity, was found to be positively associated with lower gastrointestinal tract symptomatology at baseline. This relationship was particularly strong for participants with co-occurring diagnoses of anxiety disorder and for those with a history of regressive ASD or loss of previously acquired skills. These findings suggest that autonomic function and gastrointestinal problems are intertwined in children with ASD; although it is not possible to assess causality in this data set. Future work should examine the impact of treatment of gastrointestinal problems on autonomic function and anxiety, as well as the impact of anxiety treatment on gastrointestinal problems. Clinicians should be aware that gastrointestinal problems, anxiety, and autonomic dysfunction may cluster in children with ASD and should be addressed in a multidisciplinary treatment plan. En ligne : http://dx.doi.org/10.1002/aur.1646 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303
in Autism Research > 10-2 (February 2017) . - p.276-288[article] Psychophysiological Associations with Gastrointestinal Symptomatology in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Bradley J. FERGUSON, Auteur ; Sarah MARLER, Auteur ; Lily L. ALTSTEIN, Auteur ; Evon BATEY LEE, Auteur ; Jill AKERS, Auteur ; Kristin SOHL, Auteur ; Aaron MCLAUGHLIN, Auteur ; Kaitlyn HARTNETT, Auteur ; Briana KILLE, Auteur ; Micah MAZUREK, Auteur ; Eric A. MACKLIN, Auteur ; Erin MCDONNELL, Auteur ; Mariah BARSTOW, Auteur ; Margaret L. BAUMAN, Auteur ; Kara Gross MARGOLIS, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur ; David Q. BEVERSDORF, Auteur . - p.276-288.
Langues : Anglais (eng)
in Autism Research > 10-2 (February 2017) . - p.276-288
Mots-clés : autism spectrum disorder gastrointestinal autonomic nervous system sympathetic parasympathetic anxiety constipation Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is often accompanied by gastrointestinal disturbances, which also may impact behavior. Alterations in autonomic nervous system functioning are also frequently observed in ASD. The relationship between these findings in ASD is not known. We examined the relationship between gastrointestinal symptomatology, examining upper and lower gastrointestinal tract symptomatology separately, and autonomic nervous system functioning, as assessed by heart rate variability and skin conductance level, in a sample of 120 individuals with ASD. Relationships with co-occurring medical and psychiatric symptoms were also examined. While the number of participants with significant upper gastrointestinal tract problems was small in this sample, 42.5% of participants met criteria for functional constipation, a disorder of the lower gastrointestinal tract. Heart rate variability, a measure of parasympathetic modulation of cardiac activity, was found to be positively associated with lower gastrointestinal tract symptomatology at baseline. This relationship was particularly strong for participants with co-occurring diagnoses of anxiety disorder and for those with a history of regressive ASD or loss of previously acquired skills. These findings suggest that autonomic function and gastrointestinal problems are intertwined in children with ASD; although it is not possible to assess causality in this data set. Future work should examine the impact of treatment of gastrointestinal problems on autonomic function and anxiety, as well as the impact of anxiety treatment on gastrointestinal problems. Clinicians should be aware that gastrointestinal problems, anxiety, and autonomic dysfunction may cluster in children with ASD and should be addressed in a multidisciplinary treatment plan. En ligne : http://dx.doi.org/10.1002/aur.1646 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303