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Auteur Dubravka HRANILOVIC |
Documents disponibles écrits par cet auteur (2)
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DNA Methylation Analysis of HTR2A Regulatory Region in Leukocytes of Autistic Subjects / Dubravka HRANILOVIC in Autism Research, 9-2 (February 2016)
[article]
Titre : DNA Methylation Analysis of HTR2A Regulatory Region in Leukocytes of Autistic Subjects Type de document : Texte imprimé et/ou numérique Auteurs : Dubravka HRANILOVIC, Auteur ; Sofia BLAZEVIC, Auteur ; Jasminka STEFULJ, Auteur ; Peter ZILL, Auteur Article en page(s) : p.204-209 Langues : Anglais (eng) Mots-clés : autism serotonin HTR2A DNA methylation epigenetics Index. décimale : PER Périodiques Résumé : Disturbed brain and peripheral serotonin homeostasis is often found in subjects with autism spectrum disorder (ASD). The role of the serotonin receptor 2A (HTR2A) in the regulation of central and peripheral serotonin homeostasis, as well as its altered expression in autistic subjects, have implicated the HTR2A gene as a major candidate for the serotonin disturbance seen in autism. Several studies, yielding so far inconclusive results, have attempted to associate autism with a functional SNP ?1438 G/A (rs6311) in the HTR2A promoter region, while possible contribution of epigenetic mechanisms, such as DNA methylation, to HTR2A dysregulation in autism has not yet been investigated. In this study, we compared the mean DNA methylation within the regulatory region of the HTR2A gene between autistic and control subjects. DNA methylation was analysed in peripheral blood leukocytes using bisulfite conversion and sequencing of the HTR2A region containing rs6311 polymorphism. Autistic subjects of rs6311 AG genotype displayed higher mean methylation levels within the analysed region than the corresponding controls (P?0.05), while there was no statistically significant difference for AA and GG carriers. Our study provides preliminary evidence for increased HTR2A promoter methylation in leukocytes of a portion of adult autistic subjects, indicating that epigenetic mechanisms might contribute to HTR2A dysregulation observed in individuals with ASD. En ligne : http://dx.doi.org/10.1002/aur.1519 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282
in Autism Research > 9-2 (February 2016) . - p.204-209[article] DNA Methylation Analysis of HTR2A Regulatory Region in Leukocytes of Autistic Subjects [Texte imprimé et/ou numérique] / Dubravka HRANILOVIC, Auteur ; Sofia BLAZEVIC, Auteur ; Jasminka STEFULJ, Auteur ; Peter ZILL, Auteur . - p.204-209.
Langues : Anglais (eng)
in Autism Research > 9-2 (February 2016) . - p.204-209
Mots-clés : autism serotonin HTR2A DNA methylation epigenetics Index. décimale : PER Périodiques Résumé : Disturbed brain and peripheral serotonin homeostasis is often found in subjects with autism spectrum disorder (ASD). The role of the serotonin receptor 2A (HTR2A) in the regulation of central and peripheral serotonin homeostasis, as well as its altered expression in autistic subjects, have implicated the HTR2A gene as a major candidate for the serotonin disturbance seen in autism. Several studies, yielding so far inconclusive results, have attempted to associate autism with a functional SNP ?1438 G/A (rs6311) in the HTR2A promoter region, while possible contribution of epigenetic mechanisms, such as DNA methylation, to HTR2A dysregulation in autism has not yet been investigated. In this study, we compared the mean DNA methylation within the regulatory region of the HTR2A gene between autistic and control subjects. DNA methylation was analysed in peripheral blood leukocytes using bisulfite conversion and sequencing of the HTR2A region containing rs6311 polymorphism. Autistic subjects of rs6311 AG genotype displayed higher mean methylation levels within the analysed region than the corresponding controls (P?0.05), while there was no statistically significant difference for AA and GG carriers. Our study provides preliminary evidence for increased HTR2A promoter methylation in leukocytes of a portion of adult autistic subjects, indicating that epigenetic mechanisms might contribute to HTR2A dysregulation observed in individuals with ASD. En ligne : http://dx.doi.org/10.1002/aur.1519 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 Hyperserotonemia in Adults with Autistic Disorder / Dubravka HRANILOVIC in Journal of Autism and Developmental Disorders, 37-10 (November 2007)
[article]
Titre : Hyperserotonemia in Adults with Autistic Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Dubravka HRANILOVIC, Auteur ; Zorana BUJAS-PETKOVIC, Auteur ; Renata VRAGOVIC, Auteur ; Tomislav VUK, Auteur ; Karlo HOCK, Auteur ; Branimir JERNEJ, Auteur Année de publication : 2007 Article en page(s) : p.1934-1940 Langues : Anglais (eng) Mots-clés : Autism Hyperserotonemia Platelet-serotonin-level Speech-development Verbal-communication Index. décimale : PER Périodiques Résumé : Hyperserotonemia is the most consistent serotonin-related finding in autism. The basis of this phenomenon, and its relationship to the central serotonergic dysfunction remains unclear. Platelet serotonin level (PSL) in 53 autistic adults and 45 healthy controls was measured. Mean PSL in autistic group (75.7 ± 37.4 ng/μL) was significantly higher than the control sample (59.2 ± 16.2 ng/μL) due to a presence of hyperserotonemic subjects which comprised 32% of the patients. PSL of autistic subjects did not correlate with the severity of symptoms, as measured by total CARS score, or the degree of mental retardation. However, significant negative relationship was observed between PSL and speech development, indicating the relationship between the peripheral 5HT concentrations and verbal abilities in autistic subjects.
En ligne : http://dx.doi.org/10.1007/s10803-006-0324-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219
in Journal of Autism and Developmental Disorders > 37-10 (November 2007) . - p.1934-1940[article] Hyperserotonemia in Adults with Autistic Disorder [Texte imprimé et/ou numérique] / Dubravka HRANILOVIC, Auteur ; Zorana BUJAS-PETKOVIC, Auteur ; Renata VRAGOVIC, Auteur ; Tomislav VUK, Auteur ; Karlo HOCK, Auteur ; Branimir JERNEJ, Auteur . - 2007 . - p.1934-1940.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 37-10 (November 2007) . - p.1934-1940
Mots-clés : Autism Hyperserotonemia Platelet-serotonin-level Speech-development Verbal-communication Index. décimale : PER Périodiques Résumé : Hyperserotonemia is the most consistent serotonin-related finding in autism. The basis of this phenomenon, and its relationship to the central serotonergic dysfunction remains unclear. Platelet serotonin level (PSL) in 53 autistic adults and 45 healthy controls was measured. Mean PSL in autistic group (75.7 ± 37.4 ng/μL) was significantly higher than the control sample (59.2 ± 16.2 ng/μL) due to a presence of hyperserotonemic subjects which comprised 32% of the patients. PSL of autistic subjects did not correlate with the severity of symptoms, as measured by total CARS score, or the degree of mental retardation. However, significant negative relationship was observed between PSL and speech development, indicating the relationship between the peripheral 5HT concentrations and verbal abilities in autistic subjects.
En ligne : http://dx.doi.org/10.1007/s10803-006-0324-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219