Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur Asi Polly GOBIN |
Documents disponibles écrits par cet auteur (1)
Faire une suggestion Affiner la recherche
Stress exposure and psychopathology alter methylation of the serotonin receptor 2A (HTR2A) gene in preschoolers / Stephanie H. PARADE in Development and Psychopathology, 29-5 (December 2017)
[article]
Titre : Stress exposure and psychopathology alter methylation of the serotonin receptor 2A (HTR2A) gene in preschoolers Type de document : Texte imprimé et/ou numérique Auteurs : Stephanie H. PARADE, Auteur ; Andrew M. NOVICK, Auteur ; Justin PARENT, Auteur ; Ronald SEIFER, Auteur ; Samantha J. KLAVER, Auteur ; Carmen J. MARSIT, Auteur ; Asi Polly GOBIN, Auteur ; Bao-Zhu YANG, Auteur ; Audrey R. TYRKA, Auteur Article en page(s) : p.1619-1626 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Serotonin signaling pathways play a key role in brain development, stress reactivity, and mental health. Epigenetic alterations in the serotonin system may underlie the effect of early life stress on psychopathology. The current study examined methylation of the serotonin receptor 2A (HTR2A) gene in a sample of 228 children including 119 with child welfare documentation of moderate to severe maltreatment within the last 6 months. Child protection records, semistructured interviews in the home, and parent reports were used to assess child stress exposure, psychiatric symptoms, and behavior. The HTR2A genotype and methylation of HTR2A were measured at two CpG sites (–1420 and –1224) from saliva DNA. HTR2A genotype was associated with HTR2A methylation at both CpG sites. HTR2A genotype also moderated associations of contextual stress exposure and HTR2A methylation at site –1420. Contextual stress was positively associated with –1420 methylation among A homozygotes, but negatively associated with –1420 methylation among G homozygotes. Posttraumatic stress disorder and major depressive disorder symptoms were negatively associated with methylation at –1420, but positively associated with methylation at –1224. Results support the view that the serotonin system is sensitive to stress exposure and psychopathology, and HTR2A methylation may be a mechanism by which early adversity is biologically encoded. En ligne : http://dx.doi.org/10.1017/S0954579417001274 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323
in Development and Psychopathology > 29-5 (December 2017) . - p.1619-1626[article] Stress exposure and psychopathology alter methylation of the serotonin receptor 2A (HTR2A) gene in preschoolers [Texte imprimé et/ou numérique] / Stephanie H. PARADE, Auteur ; Andrew M. NOVICK, Auteur ; Justin PARENT, Auteur ; Ronald SEIFER, Auteur ; Samantha J. KLAVER, Auteur ; Carmen J. MARSIT, Auteur ; Asi Polly GOBIN, Auteur ; Bao-Zhu YANG, Auteur ; Audrey R. TYRKA, Auteur . - p.1619-1626.
Langues : Anglais (eng)
in Development and Psychopathology > 29-5 (December 2017) . - p.1619-1626
Index. décimale : PER Périodiques Résumé : Serotonin signaling pathways play a key role in brain development, stress reactivity, and mental health. Epigenetic alterations in the serotonin system may underlie the effect of early life stress on psychopathology. The current study examined methylation of the serotonin receptor 2A (HTR2A) gene in a sample of 228 children including 119 with child welfare documentation of moderate to severe maltreatment within the last 6 months. Child protection records, semistructured interviews in the home, and parent reports were used to assess child stress exposure, psychiatric symptoms, and behavior. The HTR2A genotype and methylation of HTR2A were measured at two CpG sites (–1420 and –1224) from saliva DNA. HTR2A genotype was associated with HTR2A methylation at both CpG sites. HTR2A genotype also moderated associations of contextual stress exposure and HTR2A methylation at site –1420. Contextual stress was positively associated with –1420 methylation among A homozygotes, but negatively associated with –1420 methylation among G homozygotes. Posttraumatic stress disorder and major depressive disorder symptoms were negatively associated with methylation at –1420, but positively associated with methylation at –1224. Results support the view that the serotonin system is sensitive to stress exposure and psychopathology, and HTR2A methylation may be a mechanism by which early adversity is biologically encoded. En ligne : http://dx.doi.org/10.1017/S0954579417001274 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323