Dépouillements

Epigenetic correlates of neonatal contact in humans / Sarah R. MOORE in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1517-1538 Titre : Epigenetic correlates of neonatal contact in humans Type de document : Texte imprimé et/ou numérique Auteurs : Sarah R. MOORE, Auteur ; Lisa M. MCEWEN, Auteur ; Jill QUIRT, Auteur ; Alex MORIN, Auteur ; Sarah M. MAH, Auteur ; Ronald G. BARR, Auteur ; W. Thomas BOYCE, Auteur ; Michael S. KOBOR, Auteur Article en page(s) : p.1517-1538 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Animal models of early postnatal mother–infant interactions have highlighted the importance of tactile contact for biobehavioral outcomes via the modification of DNA methylation (DNAm). The role of normative variation in contact in early human development has yet to be explored. In an effort to translate the animal work on tactile contact to humans, we applied a naturalistic daily diary strategy to assess the link between maternal contact with infants and epigenetic signatures in children 4–5 years later, with respect to multiple levels of child-level factors, including genetic variation and infant distress. We first investigated DNAm at four candidate genes: the glucocorticoid receptor gene, nuclear receptor subfamily 3, group C, member 1 (NR3C1), ?-opioid receptor M1 (OPRM1) and oxytocin receptor (OXTR; related to the neurobiology of social bonds), and brain-derived neurotrophic factor (BDNF; involved in postnatal plasticity). Although no candidate gene DNAm sites significantly associated with early postnatal contact, when we next examined DNAm across the genome, differentially methylated regions were identified between high and low contact groups. Using a different application of epigenomic information, we also quantified epigenetic age, and report that for infants who received low contact from caregivers, greater infant distress was associated with younger epigenetic age. These results suggested that early postnatal contact has lasting associations with child biology. En ligne : http://dx.doi.org/10.1017/S0954579417001213 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Epigenetic correlates of neonatal contact in humans [Texte imprimé et/ou numérique] / Sarah R. MOORE, Auteur ; Lisa M. MCEWEN, Auteur ; Jill QUIRT, Auteur ; Alex MORIN, Auteur ; Sarah M. MAH, Auteur ; Ronald G. BARR, Auteur ; W. Thomas BOYCE, Auteur ; Michael S. KOBOR, Auteur . - p.1517-1538. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1517-1538 Index. décimale : PER Périodiques Résumé : Animal models of early postnatal mother–infant interactions have highlighted the importance of tactile contact for biobehavioral outcomes via the modification of DNA methylation (DNAm). The role of normative variation in contact in early human development has yet to be explored. In an effort to translate the animal work on tactile contact to humans, we applied a naturalistic daily diary strategy to assess the link between maternal contact with infants and epigenetic signatures in children 4–5 years later, with respect to multiple levels of child-level factors, including genetic variation and infant distress. We first investigated DNAm at four candidate genes: the glucocorticoid receptor gene, nuclear receptor subfamily 3, group C, member 1 (NR3C1), ?-opioid receptor M1 (OPRM1) and oxytocin receptor (OXTR; related to the neurobiology of social bonds), and brain-derived neurotrophic factor (BDNF; involved in postnatal plasticity). Although no candidate gene DNAm sites significantly associated with early postnatal contact, when we next examined DNAm across the genome, differentially methylated regions were identified between high and low contact groups. Using a different application of epigenomic information, we also quantified epigenetic age, and report that for infants who received low contact from caregivers, greater infant distress was associated with younger epigenetic age. These results suggested that early postnatal contact has lasting associations with child biology. En ligne : http://dx.doi.org/10.1017/S0954579417001213 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

Shaping long-term primate development: Telomere length trajectory as an indicator of early maternal maltreatment and predictor of future physiologic regulation / Stacy S. DRURY in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1539-1551 Titre : Shaping long-term primate development: Telomere length trajectory as an indicator of early maternal maltreatment and predictor of future physiologic regulation Type de document : Texte imprimé et/ou numérique Auteurs : Stacy S. DRURY, Auteur ; Brittany R. HOWELL, Auteur ; Christopher JONES, Auteur ; Kyle ESTEVES, Auteur ; Elyse MORIN, Auteur ; Reid SCHLESINGER, Auteur ; Jerrold S. MEYER, Auteur ; Kate BAKER, Auteur ; Mar M. SANCHEZ, Auteur Article en page(s) : p.1539-1551 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The molecular, neurobiological, and physical health impacts of child maltreatment are well established, yet mechanistic pathways remain inadequately defined. Telomere length (TL) decline is an emerging molecular indicator of stress exposure with definitive links to negative health outcomes in maltreated individuals. The multiple confounders endemic to human maltreatment research impede the identification of causal pathways. This study leverages a unique randomized, cross-foster, study design in a naturalistic translational nonhuman primate model of infant maltreatment. At birth, newborn macaques were randomly assigned to either a maltreating or a competent control mother, balancing for sex, biological mother parenting history, and social rank. Offspring TL was measured longitudinally across the first 6 months of life (infancy) from peripheral blood. Hair cortisol accumulation was also determined at 6, 12, and 18 months of age. TL decline was greater in animals randomized to maltreatment, but also interacted with biological mother group. Shorter TL at 6 months was associated with higher mean cortisol levels through 18 months (juvenile period) when controlling for relevant covariates. These results suggest that even under the equivalent social, nutritional, and environmental conditions feasible in naturalistic translational nonhuman primate models, early adverse caregiving results in lasting molecular scars that foreshadow elevated health risk and physiologic dysregulation. En ligne : http://dx.doi.org/10.1017/S0954579417001225 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Shaping long-term primate development: Telomere length trajectory as an indicator of early maternal maltreatment and predictor of future physiologic regulation [Texte imprimé et/ou numérique] / Stacy S. DRURY, Auteur ; Brittany R. HOWELL, Auteur ; Christopher JONES, Auteur ; Kyle ESTEVES, Auteur ; Elyse MORIN, Auteur ; Reid SCHLESINGER, Auteur ; Jerrold S. MEYER, Auteur ; Kate BAKER, Auteur ; Mar M. SANCHEZ, Auteur . - p.1539-1551. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1539-1551 Index. décimale : PER Périodiques Résumé : The molecular, neurobiological, and physical health impacts of child maltreatment are well established, yet mechanistic pathways remain inadequately defined. Telomere length (TL) decline is an emerging molecular indicator of stress exposure with definitive links to negative health outcomes in maltreated individuals. The multiple confounders endemic to human maltreatment research impede the identification of causal pathways. This study leverages a unique randomized, cross-foster, study design in a naturalistic translational nonhuman primate model of infant maltreatment. At birth, newborn macaques were randomly assigned to either a maltreating or a competent control mother, balancing for sex, biological mother parenting history, and social rank. Offspring TL was measured longitudinally across the first 6 months of life (infancy) from peripheral blood. Hair cortisol accumulation was also determined at 6, 12, and 18 months of age. TL decline was greater in animals randomized to maltreatment, but also interacted with biological mother group. Shorter TL at 6 months was associated with higher mean cortisol levels through 18 months (juvenile period) when controlling for relevant covariates. These results suggest that even under the equivalent social, nutritional, and environmental conditions feasible in naturalistic translational nonhuman primate models, early adverse caregiving results in lasting molecular scars that foreshadow elevated health risk and physiologic dysregulation. En ligne : http://dx.doi.org/10.1017/S0954579417001225 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

Effects of pre- and postnatal maternal stress on infant temperament and autonomic nervous system reactivity and regulation in a diverse, low-income population / Nicole R. BUSH in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1553-1571 Titre : Effects of pre- and postnatal maternal stress on infant temperament and autonomic nervous system reactivity and regulation in a diverse, low-income population Type de document : Texte imprimé et/ou numérique Auteurs : Nicole R. BUSH, Auteur ; Karen JONES-MASON, Auteur ; Michael COCCIA, Auteur ; Zoe CARON, Auteur ; Abbey ALKON, Auteur ; Melanie THOMAS, Auteur ; Kim COLEMAN-PHOX, Auteur ; Pathik D. WADHWA, Auteur ; Barbara A. LARAIA, Auteur ; Nancy E. ADLER, Auteur ; Elissa S. EPEL, Auteur Article en page(s) : p.1553-1571 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We examined the prospective associations of objective and subjective measures of stress during pregnancy with infant stress reactivity and regulation, an early-life predictor of psychopathology. In a racially and ethnically diverse low-income sample of 151 mother–infant dyads, maternal reports of stressful life events (SLE) and perceived stress (PS) were collected serially over gestation and the early postpartum period. Infant reactivity and regulation at 6 months of age was assessed via maternal report of temperament (negativity, surgency, and regulation) and infant parasympathetic nervous system physiology (respiratory sinus arrhythmia [RSA]) during the Still Face Paradigm. Regression models predicting infant temperament showed higher maternal prenatal PS predicted lower surgency and self-regulation but not negativity. Regression models predicting infant physiology showed higher numbers of SLE during gestation predicted greater RSA reactivity and weaker recovery. Tests of interactions revealed SLE predicted RSA reactivity only at moderate to high levels of PS. Thus, findings suggest objective and subjective measures of maternal prenatal stress uniquely predict infant behavior and physiology, adjusting for key pre- and postnatal covariates, and advance the limited evidence for such prenatal programming within high-risk populations. Assessing multiple levels of maternal stress and offspring stress reactivity and regulation provides a richer picture of intergenerational transmission of adversity. En ligne : http://dx.doi.org/10.1017/S0954579417001237 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Effects of pre- and postnatal maternal stress on infant temperament and autonomic nervous system reactivity and regulation in a diverse, low-income population [Texte imprimé et/ou numérique] / Nicole R. BUSH, Auteur ; Karen JONES-MASON, Auteur ; Michael COCCIA, Auteur ; Zoe CARON, Auteur ; Abbey ALKON, Auteur ; Melanie THOMAS, Auteur ; Kim COLEMAN-PHOX, Auteur ; Pathik D. WADHWA, Auteur ; Barbara A. LARAIA, Auteur ; Nancy E. ADLER, Auteur ; Elissa S. EPEL, Auteur . - p.1553-1571. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1553-1571 Index. décimale : PER Périodiques Résumé : We examined the prospective associations of objective and subjective measures of stress during pregnancy with infant stress reactivity and regulation, an early-life predictor of psychopathology. In a racially and ethnically diverse low-income sample of 151 mother–infant dyads, maternal reports of stressful life events (SLE) and perceived stress (PS) were collected serially over gestation and the early postpartum period. Infant reactivity and regulation at 6 months of age was assessed via maternal report of temperament (negativity, surgency, and regulation) and infant parasympathetic nervous system physiology (respiratory sinus arrhythmia [RSA]) during the Still Face Paradigm. Regression models predicting infant temperament showed higher maternal prenatal PS predicted lower surgency and self-regulation but not negativity. Regression models predicting infant physiology showed higher numbers of SLE during gestation predicted greater RSA reactivity and weaker recovery. Tests of interactions revealed SLE predicted RSA reactivity only at moderate to high levels of PS. Thus, findings suggest objective and subjective measures of maternal prenatal stress uniquely predict infant behavior and physiology, adjusting for key pre- and postnatal covariates, and advance the limited evidence for such prenatal programming within high-risk populations. Assessing multiple levels of maternal stress and offspring stress reactivity and regulation provides a richer picture of intergenerational transmission of adversity. En ligne : http://dx.doi.org/10.1017/S0954579417001237 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

Positive maternal mental health during pregnancy associated with specific forms of adaptive development in early childhood: Evidence from a longitudinal study / Desiree Y. PHUA in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1573-1587 Titre : Positive maternal mental health during pregnancy associated with specific forms of adaptive development in early childhood: Evidence from a longitudinal study Type de document : Texte imprimé et/ou numérique Auteurs : Desiree Y. PHUA, Auteur ; Michelle K. Z. L. KEE, Auteur ; Dawn X. P. KOH, Auteur ; Anne RIFKIN-GRABOI, Auteur ; Mary DANIELS, Auteur ; Helen CHEN, Auteur ; Yap Seng CHONG, Auteur ; Birit F. P. BROEKMAN, Auteur ; Iliana MAGIATI, Auteur ; Neerja KARNANI, Auteur ; Michael PLUESS, Auteur ; Michael J. MEANEY, Auteur Article en page(s) : p.1573-1587 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The quality of prenatal maternal mental health, from psychological stress and depressive symptoms to anxiety and other nonpsychotic mental disorders, profoundly affects fetal neurodevelopment. Despite the evidence for the influence of positive mental well-being on health, there is, to our knowledge, no research examining the possible effects of positive antenatal mental health on the development of the offspring. Using exploratory bifactor analysis, this prospective study (n = 1,066) demonstrated the feasibility of using common psychiatric screening tools to examine the effect of positive maternal mental health. Antenatal mental health was assessed during 26th week of pregnancy. The effects on offspring were assessed when the child was 12, 18, and 24 months old. Results showed that positive antenatal mental health was uniquely associated with the offspring's cognitive, language and parentally rated competences. This study shows that the effects of positive maternal mental health are likely to be specific and distinct from the sheer absence of symptoms of depression or anxiety. En ligne : http://dx.doi.org/10.1017/S0954579417001249 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Positive maternal mental health during pregnancy associated with specific forms of adaptive development in early childhood: Evidence from a longitudinal study [Texte imprimé et/ou numérique] / Desiree Y. PHUA, Auteur ; Michelle K. Z. L. KEE, Auteur ; Dawn X. P. KOH, Auteur ; Anne RIFKIN-GRABOI, Auteur ; Mary DANIELS, Auteur ; Helen CHEN, Auteur ; Yap Seng CHONG, Auteur ; Birit F. P. BROEKMAN, Auteur ; Iliana MAGIATI, Auteur ; Neerja KARNANI, Auteur ; Michael PLUESS, Auteur ; Michael J. MEANEY, Auteur . - p.1573-1587. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1573-1587 Index. décimale : PER Périodiques Résumé : The quality of prenatal maternal mental health, from psychological stress and depressive symptoms to anxiety and other nonpsychotic mental disorders, profoundly affects fetal neurodevelopment. Despite the evidence for the influence of positive mental well-being on health, there is, to our knowledge, no research examining the possible effects of positive antenatal mental health on the development of the offspring. Using exploratory bifactor analysis, this prospective study (n = 1,066) demonstrated the feasibility of using common psychiatric screening tools to examine the effect of positive maternal mental health. Antenatal mental health was assessed during 26th week of pregnancy. The effects on offspring were assessed when the child was 12, 18, and 24 months old. Results showed that positive antenatal mental health was uniquely associated with the offspring's cognitive, language and parentally rated competences. This study shows that the effects of positive maternal mental health are likely to be specific and distinct from the sheer absence of symptoms of depression or anxiety. En ligne : http://dx.doi.org/10.1017/S0954579417001249 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

Immune and neuroendocrine correlates of temperament in infancy / Thomas G. O'CONNOR in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1589-1600 Titre : Immune and neuroendocrine correlates of temperament in infancy Type de document : Texte imprimé et/ou numérique Auteurs : Thomas G. O'CONNOR, Auteur ; Kristin SCHEIBLE, Auteur ; Ana Vallejo SEFAIR, Auteur ; Michelle GILCHRIST, Auteur ; Emma Robertson BLACKMORE, Auteur ; Marcia A. WINTER, Auteur ; Megan R. GUNNAR, Auteur ; Claire WYMAN, Auteur ; Jennifer CARNAHAN, Auteur ; Jan A. MOYNIHAN, Auteur ; Mary T. CASERTA, Auteur Article en page(s) : p.1589-1600 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : There is now a clear focus on incorporating, and integrating, multiple levels of analysis in developmental science. The current study adds to research in this area by including markers of the immune and neuroendocrine systems in a longitudinal study of temperament in infants. Observational and parent-reported ratings of infant temperament, serum markers of the innate immune system, and cortisol reactivity from repeated salivary collections were examined in a sample of 123 infants who were assessed at 6 months and again when they were, on average, 17 months old. Blood from venipuncture was collected for analyses of nine select innate immune cytokines; salivary cortisol collected prior to and 15 min and 30 min following a physical exam including blood draw was used as an index of neuroendocrine functioning. Analyses indicated fairly minimal significant associations between biological markers and temperament at 6 months. However, by 17 months of age, we found reliable and nonoverlapping associations between observed fearful temperament and biological markers of the immune and neuroendocrine systems. The findings provide some of the earliest evidence of robust biological correlates of fear behavior with the immune system, and identify possible immune and neuroendocrine mechanisms for understanding the origins of behavioral development. En ligne : http://dx.doi.org/10.1017/S0954579417001250 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Immune and neuroendocrine correlates of temperament in infancy [Texte imprimé et/ou numérique] / Thomas G. O'CONNOR, Auteur ; Kristin SCHEIBLE, Auteur ; Ana Vallejo SEFAIR, Auteur ; Michelle GILCHRIST, Auteur ; Emma Robertson BLACKMORE, Auteur ; Marcia A. WINTER, Auteur ; Megan R. GUNNAR, Auteur ; Claire WYMAN, Auteur ; Jennifer CARNAHAN, Auteur ; Jan A. MOYNIHAN, Auteur ; Mary T. CASERTA, Auteur . - p.1589-1600. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1589-1600 Index. décimale : PER Périodiques Résumé : There is now a clear focus on incorporating, and integrating, multiple levels of analysis in developmental science. The current study adds to research in this area by including markers of the immune and neuroendocrine systems in a longitudinal study of temperament in infants. Observational and parent-reported ratings of infant temperament, serum markers of the innate immune system, and cortisol reactivity from repeated salivary collections were examined in a sample of 123 infants who were assessed at 6 months and again when they were, on average, 17 months old. Blood from venipuncture was collected for analyses of nine select innate immune cytokines; salivary cortisol collected prior to and 15 min and 30 min following a physical exam including blood draw was used as an index of neuroendocrine functioning. Analyses indicated fairly minimal significant associations between biological markers and temperament at 6 months. However, by 17 months of age, we found reliable and nonoverlapping associations between observed fearful temperament and biological markers of the immune and neuroendocrine systems. The findings provide some of the earliest evidence of robust biological correlates of fear behavior with the immune system, and identify possible immune and neuroendocrine mechanisms for understanding the origins of behavioral development. En ligne : http://dx.doi.org/10.1017/S0954579417001250 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression / Patricia P. SILVEIRA in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1601-1617 Titre : Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression Type de document : Texte imprimé et/ou numérique Auteurs : Patricia P. SILVEIRA, Auteur ; Irina POKHVISNEVA, Auteur ; Carine PARENT, Auteur ; Shirong CAI, Auteur ; Anu Sathyan Sathyapalan REMA, Auteur ; Birit F. P. BROEKMAN, Auteur ; Anne RIFKIN-GRABOI, Auteur ; Michael PLUESS, Auteur ; Kieran J. O'DONNELL, Auteur ; Michael J. MEANEY, Auteur Article en page(s) : p.1601-1617 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : While many studies focus on the association between early life adversity and the later risk for psychopathology, few simultaneously explore diverse forms of environmental adversity. Moreover, those studies that examined the cumulative impact of early life adversity focus uniquely on postnatal influences. The objective of this study was to focus on the fetal period of development to construct and validate a cumulative prenatal adversity score in relation to a wide range of neurodevelopmental outcomes. We also examined the interaction of this adversity score with a biologically informed genetic score based on the serotonin transporter gene. Prenatal adversities were computed in two community birth cohorts using information on health during pregnancy, birth weight, gestational age, income, domestic violence/sexual abuse, marital strain, as well as maternal smoking, anxiety, and depression. A genetic score based on genes coexpressed with the serotonin transporter in the amygdala, hippocampus, and prefrontal cortex during prenatal life was constructed with an emphasis on functionally relevant single nucleotide polymorphisms, that is, expression quantitative trait loci. Prenatal adversities predicted a wide range of developmental and behavioral alterations in children as young as 2 years of age in both cohorts. There were interactions between the genetic score and adversities for several domains of the Child Behavior Checklist (CBCL), with pervasive developmental problems remaining significant adjustment for multiple comparisons. Scores combining different prenatal adverse exposures predict childhood behavior and interact with the genetic background to influence the risk for psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579417001262 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression [Texte imprimé et/ou numérique] / Patricia P. SILVEIRA, Auteur ; Irina POKHVISNEVA, Auteur ; Carine PARENT, Auteur ; Shirong CAI, Auteur ; Anu Sathyan Sathyapalan REMA, Auteur ; Birit F. P. BROEKMAN, Auteur ; Anne RIFKIN-GRABOI, Auteur ; Michael PLUESS, Auteur ; Kieran J. O'DONNELL, Auteur ; Michael J. MEANEY, Auteur . - p.1601-1617. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1601-1617 Index. décimale : PER Périodiques Résumé : While many studies focus on the association between early life adversity and the later risk for psychopathology, few simultaneously explore diverse forms of environmental adversity. Moreover, those studies that examined the cumulative impact of early life adversity focus uniquely on postnatal influences. The objective of this study was to focus on the fetal period of development to construct and validate a cumulative prenatal adversity score in relation to a wide range of neurodevelopmental outcomes. We also examined the interaction of this adversity score with a biologically informed genetic score based on the serotonin transporter gene. Prenatal adversities were computed in two community birth cohorts using information on health during pregnancy, birth weight, gestational age, income, domestic violence/sexual abuse, marital strain, as well as maternal smoking, anxiety, and depression. A genetic score based on genes coexpressed with the serotonin transporter in the amygdala, hippocampus, and prefrontal cortex during prenatal life was constructed with an emphasis on functionally relevant single nucleotide polymorphisms, that is, expression quantitative trait loci. Prenatal adversities predicted a wide range of developmental and behavioral alterations in children as young as 2 years of age in both cohorts. There were interactions between the genetic score and adversities for several domains of the Child Behavior Checklist (CBCL), with pervasive developmental problems remaining significant adjustment for multiple comparisons. Scores combining different prenatal adverse exposures predict childhood behavior and interact with the genetic background to influence the risk for psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579417001262 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

Stress exposure and psychopathology alter methylation of the serotonin receptor 2A (HTR2A) gene in preschoolers / Stephanie H. PARADE in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1619-1626 Titre : Stress exposure and psychopathology alter methylation of the serotonin receptor 2A (HTR2A) gene in preschoolers Type de document : Texte imprimé et/ou numérique Auteurs : Stephanie H. PARADE, Auteur ; Andrew M. NOVICK, Auteur ; Justin PARENT, Auteur ; Ronald SEIFER, Auteur ; Samantha J. KLAVER, Auteur ; Carmen J. MARSIT, Auteur ; Asi Polly GOBIN, Auteur ; Bao-Zhu YANG, Auteur ; Audrey R. TYRKA, Auteur Article en page(s) : p.1619-1626 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Serotonin signaling pathways play a key role in brain development, stress reactivity, and mental health. Epigenetic alterations in the serotonin system may underlie the effect of early life stress on psychopathology. The current study examined methylation of the serotonin receptor 2A (HTR2A) gene in a sample of 228 children including 119 with child welfare documentation of moderate to severe maltreatment within the last 6 months. Child protection records, semistructured interviews in the home, and parent reports were used to assess child stress exposure, psychiatric symptoms, and behavior. The HTR2A genotype and methylation of HTR2A were measured at two CpG sites (–1420 and –1224) from saliva DNA. HTR2A genotype was associated with HTR2A methylation at both CpG sites. HTR2A genotype also moderated associations of contextual stress exposure and HTR2A methylation at site –1420. Contextual stress was positively associated with –1420 methylation among A homozygotes, but negatively associated with –1420 methylation among G homozygotes. Posttraumatic stress disorder and major depressive disorder symptoms were negatively associated with methylation at –1420, but positively associated with methylation at –1224. Results support the view that the serotonin system is sensitive to stress exposure and psychopathology, and HTR2A methylation may be a mechanism by which early adversity is biologically encoded. En ligne : http://dx.doi.org/10.1017/S0954579417001274 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Stress exposure and psychopathology alter methylation of the serotonin receptor 2A (HTR2A) gene in preschoolers [Texte imprimé et/ou numérique] / Stephanie H. PARADE, Auteur ; Andrew M. NOVICK, Auteur ; Justin PARENT, Auteur ; Ronald SEIFER, Auteur ; Samantha J. KLAVER, Auteur ; Carmen J. MARSIT, Auteur ; Asi Polly GOBIN, Auteur ; Bao-Zhu YANG, Auteur ; Audrey R. TYRKA, Auteur . - p.1619-1626. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1619-1626 Index. décimale : PER Périodiques Résumé : Serotonin signaling pathways play a key role in brain development, stress reactivity, and mental health. Epigenetic alterations in the serotonin system may underlie the effect of early life stress on psychopathology. The current study examined methylation of the serotonin receptor 2A (HTR2A) gene in a sample of 228 children including 119 with child welfare documentation of moderate to severe maltreatment within the last 6 months. Child protection records, semistructured interviews in the home, and parent reports were used to assess child stress exposure, psychiatric symptoms, and behavior. The HTR2A genotype and methylation of HTR2A were measured at two CpG sites (–1420 and –1224) from saliva DNA. HTR2A genotype was associated with HTR2A methylation at both CpG sites. HTR2A genotype also moderated associations of contextual stress exposure and HTR2A methylation at site –1420. Contextual stress was positively associated with –1420 methylation among A homozygotes, but negatively associated with –1420 methylation among G homozygotes. Posttraumatic stress disorder and major depressive disorder symptoms were negatively associated with methylation at –1420, but positively associated with methylation at –1224. Results support the view that the serotonin system is sensitive to stress exposure and psychopathology, and HTR2A methylation may be a mechanism by which early adversity is biologically encoded. En ligne : http://dx.doi.org/10.1017/S0954579417001274 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

Change in FK506 binding protein 5 (FKBP5) methylation over time among preschoolers with adversity / Stephanie H. PARADE in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1627-1634 Titre : Change in FK506 binding protein 5 (FKBP5) methylation over time among preschoolers with adversity Type de document : Texte imprimé et/ou numérique Auteurs : Stephanie H. PARADE, Auteur ; Justin PARENT, Auteur ; Kantoniony RABEMANANJARA, Auteur ; Ronald SEIFER, Auteur ; Carmen J. MARSIT, Auteur ; Bao-Zhu YANG, Auteur ; Huiping ZHANG, Auteur ; Audrey R. TYRKA, Auteur Article en page(s) : p.1627-1634 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : FK506 binding protein 5 (FKBP5) alters stress response system functioning, and childhood maltreatment is associated with methylation of the FKBP5 gene. Yet it is unknown if maltreatment contributes to change in FKBP5 methylation over time. The current study draws upon a sample of 231 preschoolers, including 123 with child welfare documentation of moderate to severe maltreatment in the past 6 months, to understand if maltreatment contributes to change in FKBP5 methylation over a 6-month period. Review of child protection records and semistructured interviews in the home were used to assess maltreatment and exposure to other contextual stressors, as well as service utilization. Methylation of FKBP5 at two CpG sites in intron 7 was measured from saliva DNA at the time of initial study enrollment, and 6 months following enrollment. Child maltreatment was associated with change in FKBP5 methylation over time, but only when children were exposed to high levels of other contextual stressors. Service utilization was associated with increases in methylation over time, but only among children with the FKPB5 rs1360780 protective CC genotype. Methylation of FKBP5 is sensitive to stress exposure and may be a mechanism linking early adversity to long-term health and developmental outcomes. En ligne : http://dx.doi.org/10.1017/S0954579417001286 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Change in FK506 binding protein 5 (FKBP5) methylation over time among preschoolers with adversity [Texte imprimé et/ou numérique] / Stephanie H. PARADE, Auteur ; Justin PARENT, Auteur ; Kantoniony RABEMANANJARA, Auteur ; Ronald SEIFER, Auteur ; Carmen J. MARSIT, Auteur ; Bao-Zhu YANG, Auteur ; Huiping ZHANG, Auteur ; Audrey R. TYRKA, Auteur . - p.1627-1634. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1627-1634 Index. décimale : PER Périodiques Résumé : FK506 binding protein 5 (FKBP5) alters stress response system functioning, and childhood maltreatment is associated with methylation of the FKBP5 gene. Yet it is unknown if maltreatment contributes to change in FKBP5 methylation over time. The current study draws upon a sample of 231 preschoolers, including 123 with child welfare documentation of moderate to severe maltreatment in the past 6 months, to understand if maltreatment contributes to change in FKBP5 methylation over a 6-month period. Review of child protection records and semistructured interviews in the home were used to assess maltreatment and exposure to other contextual stressors, as well as service utilization. Methylation of FKBP5 at two CpG sites in intron 7 was measured from saliva DNA at the time of initial study enrollment, and 6 months following enrollment. Child maltreatment was associated with change in FKBP5 methylation over time, but only when children were exposed to high levels of other contextual stressors. Service utilization was associated with increases in methylation over time, but only among children with the FKPB5 rs1360780 protective CC genotype. Methylation of FKBP5 is sensitive to stress exposure and may be a mechanism linking early adversity to long-term health and developmental outcomes. En ligne : http://dx.doi.org/10.1017/S0954579417001286 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

Dynamic stress-related epigenetic regulation of the glucocorticoid receptor gene promoter during early development: The role of child maltreatment / Justin PARENT in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1635-1648 Titre : Dynamic stress-related epigenetic regulation of the glucocorticoid receptor gene promoter during early development: The role of child maltreatment Type de document : Texte imprimé et/ou numérique Auteurs : Justin PARENT, Auteur ; Stephanie H. PARADE, Auteur ; Laura E. LAUMANN, Auteur ; Kathryn K. RIDOUT, Auteur ; Bao-Zhu YANG, Auteur ; Carmen J. MARSIT, Auteur ; Ronald SEIFER, Auteur ; Audrey R. TYRKA, Auteur Article en page(s) : p.1635-1648 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Epigenetics processes may play a vital role in the biological embedding of early environmental adversity and the development of psychopathology. Accumulating evidence suggests that maltreatment is linked to methylation of the glucocorticoid receptor gene, nuclear receptor subfamily 3, group C, member 1 (NR3C1), which is a key regulator of the hypothalamus–pituitary–adrenal axis. However, prior work has been exclusively cross-sectional, greatly constraining our understanding of stress-related epigenetic processes over time. In the current study, we examined the effect of maltreatment and other adversity on change in NR3C1 methylation among at-risk preschoolers to begin to characterize within-child epigenetic changes during this sensitive developmental period. Participants were 260 preschoolers (3–5 years old, 53.8% female), including 51.5% with moderate to severe maltreatment in the past 6 months. Child protection records, semistructured interviews, and parent reports were used to assess child stress exposure. Methylation of exons 1D and 1F of NR3C1 via saliva DNA were measured at two time points approximately 6 months apart. Results indicate that maltreated children evidence higher baseline levels of NR3C1 methylation, significant decreases in methylation over time, and then at follow-up, lower levels of methylation, relative to nonmaltreated preschoolers. Findings from the current study highlight the complex nature of stress-related epigenetic processes during early development. En ligne : http://dx.doi.org/10.1017/S0954579417001298 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Dynamic stress-related epigenetic regulation of the glucocorticoid receptor gene promoter during early development: The role of child maltreatment [Texte imprimé et/ou numérique] / Justin PARENT, Auteur ; Stephanie H. PARADE, Auteur ; Laura E. LAUMANN, Auteur ; Kathryn K. RIDOUT, Auteur ; Bao-Zhu YANG, Auteur ; Carmen J. MARSIT, Auteur ; Ronald SEIFER, Auteur ; Audrey R. TYRKA, Auteur . - p.1635-1648. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1635-1648 Index. décimale : PER Périodiques Résumé : Epigenetics processes may play a vital role in the biological embedding of early environmental adversity and the development of psychopathology. Accumulating evidence suggests that maltreatment is linked to methylation of the glucocorticoid receptor gene, nuclear receptor subfamily 3, group C, member 1 (NR3C1), which is a key regulator of the hypothalamus–pituitary–adrenal axis. However, prior work has been exclusively cross-sectional, greatly constraining our understanding of stress-related epigenetic processes over time. In the current study, we examined the effect of maltreatment and other adversity on change in NR3C1 methylation among at-risk preschoolers to begin to characterize within-child epigenetic changes during this sensitive developmental period. Participants were 260 preschoolers (3–5 years old, 53.8% female), including 51.5% with moderate to severe maltreatment in the past 6 months. Child protection records, semistructured interviews, and parent reports were used to assess child stress exposure. Methylation of exons 1D and 1F of NR3C1 via saliva DNA were measured at two time points approximately 6 months apart. Results indicate that maltreated children evidence higher baseline levels of NR3C1 methylation, significant decreases in methylation over time, and then at follow-up, lower levels of methylation, relative to nonmaltreated preschoolers. Findings from the current study highlight the complex nature of stress-related epigenetic processes during early development. En ligne : http://dx.doi.org/10.1017/S0954579417001298 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

Exploring longitudinal associations between neighborhood disadvantage and cortisol levels in early childhood / Eric D. FINEGOOD in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1649-1662 Titre : Exploring longitudinal associations between neighborhood disadvantage and cortisol levels in early childhood Type de document : Texte imprimé et/ou numérique Auteurs : Eric D. FINEGOOD, Auteur ; Jason R. D. RARICK, Auteur ; Clancy BLAIR, Auteur Article en page(s) : p.1649-1662 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Children who grow up in poverty are more likely to experience chronic stressors that generate “wear” on stress regulatory systems including the hypothalamus–pituitary–adrenal (HPA) axis. This can have long-term consequences for health and well-being. Prior research has examined the role of proximal family and home contributions to HPA axis functioning. However, there is evidence to suggest that more distal levels of context, including neighborhoods, also matter. Prior evidence has primarily focused on adolescents and adults, with little evidence linking the neighborhood context with HPA activity in infancy and toddlerhood. We tested whether neighborhood disadvantage (indexed by US Census data) was associated with basal salivary cortisol levels at 7, 15, and 24 months of child age in a large sample of families (N = 1,292) residing in predominately low-income and rural communities in the United States. Multilevel models indicated that neighborhood disadvantage was positively associated with salivary cortisol levels and that this effect emerged across time. This effect was moderated by the race/ethnicity of children such that the association was only observed in White children in our sample. Findings provide preliminary evidence that the neighborhood context is associated with stress regulation during toddlerhood, elucidating a need for future work to address possible mechanisms. En ligne : http://dx.doi.org/10.1017/S0954579417001304 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Exploring longitudinal associations between neighborhood disadvantage and cortisol levels in early childhood [Texte imprimé et/ou numérique] / Eric D. FINEGOOD, Auteur ; Jason R. D. RARICK, Auteur ; Clancy BLAIR, Auteur . - p.1649-1662. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1649-1662 Index. décimale : PER Périodiques Résumé : Children who grow up in poverty are more likely to experience chronic stressors that generate “wear” on stress regulatory systems including the hypothalamus–pituitary–adrenal (HPA) axis. This can have long-term consequences for health and well-being. Prior research has examined the role of proximal family and home contributions to HPA axis functioning. However, there is evidence to suggest that more distal levels of context, including neighborhoods, also matter. Prior evidence has primarily focused on adolescents and adults, with little evidence linking the neighborhood context with HPA activity in infancy and toddlerhood. We tested whether neighborhood disadvantage (indexed by US Census data) was associated with basal salivary cortisol levels at 7, 15, and 24 months of child age in a large sample of families (N = 1,292) residing in predominately low-income and rural communities in the United States. Multilevel models indicated that neighborhood disadvantage was positively associated with salivary cortisol levels and that this effect emerged across time. This effect was moderated by the race/ethnicity of children such that the association was only observed in White children in our sample. Findings provide preliminary evidence that the neighborhood context is associated with stress regulation during toddlerhood, elucidating a need for future work to address possible mechanisms. En ligne : http://dx.doi.org/10.1017/S0954579417001304 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

Variation in DNA methylation of the oxytocin receptor gene predicts children's resilience to prenatal stress / Izabela MILANIAK in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1663-1674 Titre : Variation in DNA methylation of the oxytocin receptor gene predicts children's resilience to prenatal stress Type de document : Texte imprimé et/ou numérique Auteurs : Izabela MILANIAK, Auteur ; Charlotte A. M. CECIL, Auteur ; Edward D. BARKER, Auteur ; Caroline L. RELTON, Auteur ; Tom R. GAUNT, Auteur ; Wendy MCARDLE, Auteur ; Sara R. JAFFEE, Auteur Article en page(s) : p.1663-1674 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Emerging research in epigenetics has shown that there is variability in how environmental exposures “get under the skin” through mechanisms like DNA methylation to influence gene expression that may lead to differential adaptations to stress. This is the first study to examine prospectively the relationship between DNA methylation at birth and resilience to prenatal environmental stressors in several domains (conduct, hyperactivity, emotional problems, and global symptomatology) in middle childhood. We focused on DNA methylation in the vicinity of the oxytocin receptor (OXTR) gene as it has been previously associated with impairments in social–cognitive processes that may underlie a wide range of childhood psychopathology. Participants were 91 youth exposed to pre- and postnatal adversity with established conduct problem trajectories drawn from the Avon Longitudinal Study of Parents and Children. Consistent with our hypothesis, OXTR DNA methylation was predictive of resilience in the conduct problems domain in middle childhood. DNA methylation profiles did not predict resilience in domains of emotional, hyperactivity, and global symptomatology, suggesting a potential role for OXTR in the development of conduct problems in particular. However, individuals who were resilient to conduct problems were also broadly resilient across multiple domains. Therefore, future research should elucidate the biological pathways between OXTR DNA methylation and gene expression and its relation to impairments in social behavior. En ligne : http://dx.doi.org/10.1017/S0954579417001316 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Variation in DNA methylation of the oxytocin receptor gene predicts children's resilience to prenatal stress [Texte imprimé et/ou numérique] / Izabela MILANIAK, Auteur ; Charlotte A. M. CECIL, Auteur ; Edward D. BARKER, Auteur ; Caroline L. RELTON, Auteur ; Tom R. GAUNT, Auteur ; Wendy MCARDLE, Auteur ; Sara R. JAFFEE, Auteur . - p.1663-1674. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1663-1674 Index. décimale : PER Périodiques Résumé : Emerging research in epigenetics has shown that there is variability in how environmental exposures “get under the skin” through mechanisms like DNA methylation to influence gene expression that may lead to differential adaptations to stress. This is the first study to examine prospectively the relationship between DNA methylation at birth and resilience to prenatal environmental stressors in several domains (conduct, hyperactivity, emotional problems, and global symptomatology) in middle childhood. We focused on DNA methylation in the vicinity of the oxytocin receptor (OXTR) gene as it has been previously associated with impairments in social–cognitive processes that may underlie a wide range of childhood psychopathology. Participants were 91 youth exposed to pre- and postnatal adversity with established conduct problem trajectories drawn from the Avon Longitudinal Study of Parents and Children. Consistent with our hypothesis, OXTR DNA methylation was predictive of resilience in the conduct problems domain in middle childhood. DNA methylation profiles did not predict resilience in domains of emotional, hyperactivity, and global symptomatology, suggesting a potential role for OXTR in the development of conduct problems in particular. However, individuals who were resilient to conduct problems were also broadly resilient across multiple domains. Therefore, future research should elucidate the biological pathways between OXTR DNA methylation and gene expression and its relation to impairments in social behavior. En ligne : http://dx.doi.org/10.1017/S0954579417001316 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

Reward sensitivity, impulse control, and social cognition as mediators of the link between childhood family adversity and externalizing behavior in eight countries / Jennifer E. LANSFORD in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1675-1688 Titre : Reward sensitivity, impulse control, and social cognition as mediators of the link between childhood family adversity and externalizing behavior in eight countries Type de document : Texte imprimé et/ou numérique Auteurs : Jennifer E. LANSFORD, Auteur ; Jennifer GODWIN, Auteur ; Marc H. BORNSTEIN, Auteur ; Lei CHANG, Auteur ; Kirby DEATER-DECKARD, Auteur ; Laura DI GIUNTA, Auteur ; Kenneth A. DODGE, Auteur ; Patrick S. MALONE, Auteur ; Paul OBURU, Auteur ; Concetta PASTORELLI, Auteur ; Ann T. SKINNER, Auteur ; Emma SORBRING, Auteur ; Laurence STEINBERG, Auteur ; Sombat TAPANYA, Auteur ; Liane Peña ALAMPAY, Auteur ; Liliana Maria URIBE TIRADO, Auteur ; Suha M. AL-HASSAN, Auteur ; Dario BACCHINI, Auteur Article en page(s) : p.1675-1688 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Using data from 1,177 families in eight countries (Colombia, Italy, Jordan, Kenya, the Philippines, Sweden, Thailand, and the United States), we tested a conceptual model of direct effects of childhood family adversity on subsequent externalizing behaviors as well as indirect effects through psychological mediators. When children were 9 years old, mothers and fathers reported on financial difficulties and their use of corporal punishment, and children reported perceptions of their parents’ rejection. When children were 10 years old, they completed a computerized battery of tasks assessing reward sensitivity and impulse control and responded to questions about hypothetical social provocations to assess their hostile attributions and proclivity for aggressive responding. When children were 12 years old, they reported on their externalizing behavior. Multigroup structural equation models revealed that across all eight countries, childhood family adversity had direct effects on externalizing behaviors 3 years later, and childhood family adversity had indirect effects on externalizing behavior through psychological mediators. The findings suggest ways in which family-level adversity poses risk for children's subsequent development of problems at psychological and behavioral levels, situated within diverse cultural contexts. En ligne : http://dx.doi.org/10.1017/S0954579417001328 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Reward sensitivity, impulse control, and social cognition as mediators of the link between childhood family adversity and externalizing behavior in eight countries [Texte imprimé et/ou numérique] / Jennifer E. LANSFORD, Auteur ; Jennifer GODWIN, Auteur ; Marc H. BORNSTEIN, Auteur ; Lei CHANG, Auteur ; Kirby DEATER-DECKARD, Auteur ; Laura DI GIUNTA, Auteur ; Kenneth A. DODGE, Auteur ; Patrick S. MALONE, Auteur ; Paul OBURU, Auteur ; Concetta PASTORELLI, Auteur ; Ann T. SKINNER, Auteur ; Emma SORBRING, Auteur ; Laurence STEINBERG, Auteur ; Sombat TAPANYA, Auteur ; Liane Peña ALAMPAY, Auteur ; Liliana Maria URIBE TIRADO, Auteur ; Suha M. AL-HASSAN, Auteur ; Dario BACCHINI, Auteur . - p.1675-1688. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1675-1688 Index. décimale : PER Périodiques Résumé : Using data from 1,177 families in eight countries (Colombia, Italy, Jordan, Kenya, the Philippines, Sweden, Thailand, and the United States), we tested a conceptual model of direct effects of childhood family adversity on subsequent externalizing behaviors as well as indirect effects through psychological mediators. When children were 9 years old, mothers and fathers reported on financial difficulties and their use of corporal punishment, and children reported perceptions of their parents’ rejection. When children were 10 years old, they completed a computerized battery of tasks assessing reward sensitivity and impulse control and responded to questions about hypothetical social provocations to assess their hostile attributions and proclivity for aggressive responding. When children were 12 years old, they reported on their externalizing behavior. Multigroup structural equation models revealed that across all eight countries, childhood family adversity had direct effects on externalizing behaviors 3 years later, and childhood family adversity had indirect effects on externalizing behavior through psychological mediators. The findings suggest ways in which family-level adversity poses risk for children's subsequent development of problems at psychological and behavioral levels, situated within diverse cultural contexts. En ligne : http://dx.doi.org/10.1017/S0954579417001328 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

A neurocomputational investigation of reinforcement-based decision making as a candidate latent vulnerability mechanism in maltreated children / Mattia I. GERIN in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1689-1705 Titre : A neurocomputational investigation of reinforcement-based decision making as a candidate latent vulnerability mechanism in maltreated children Type de document : Texte imprimé et/ou numérique Auteurs : Mattia I. GERIN, Auteur ; Vanessa B. PUETZ, Auteur ; James R. BLAIR, Auteur ; Stuart F. WHITE, Auteur ; Arjun SETHI, Auteur ; Ferdinand HOFFMANN, Auteur ; Amy L. PALMER, Auteur ; Essi VIDING, Auteur ; Eamon J. MCCRORY, Auteur Article en page(s) : p.1689-1705 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Alterations in reinforcement-based decision making may be associated with increased psychiatric vulnerability in children who have experienced maltreatment. A probabilistic passive avoidance task and a model-based functional magnetic resonance imaging analytic approach were implemented to assess the neurocomputational components underlying decision making: (a) reinforcement expectancies (the representation of the outcomes associated with a stimulus) and (b) prediction error signaling (the ability to detect the differences between expected and actual outcomes). There were three main findings. First, the maltreated group (n = 18; mean age = 13), relative to nonmaltreated peers (n = 19; mean age = 13), showed decreased activity during expected value processing in a widespread network commonly associated with reinforcement expectancies representation, including the striatum (especially the caudate), the orbitofrontal cortex, and medial temporal structures including the hippocampus and insula. Second, consistent with previously reported hyperresponsiveness to negative cues in the context of childhood abuse, the maltreated group showed increased prediction error signaling in the middle cingulate gyrus, somatosensory cortex, superior temporal gyrus, and thalamus. Third, the maltreated group showed increased activity in frontodorsal regions and in the putamen during expected value representation. These findings suggest that early adverse environments disrupt the development of decision-making processes, which in turn may compromise psychosocial functioning in ways that increase latent vulnerability to psychiatric disorder. En ligne : http://dx.doi.org/10.1017/S095457941700133X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] A neurocomputational investigation of reinforcement-based decision making as a candidate latent vulnerability mechanism in maltreated children [Texte imprimé et/ou numérique] / Mattia I. GERIN, Auteur ; Vanessa B. PUETZ, Auteur ; James R. BLAIR, Auteur ; Stuart F. WHITE, Auteur ; Arjun SETHI, Auteur ; Ferdinand HOFFMANN, Auteur ; Amy L. PALMER, Auteur ; Essi VIDING, Auteur ; Eamon J. MCCRORY, Auteur . - p.1689-1705. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1689-1705 Index. décimale : PER Périodiques Résumé : Alterations in reinforcement-based decision making may be associated with increased psychiatric vulnerability in children who have experienced maltreatment. A probabilistic passive avoidance task and a model-based functional magnetic resonance imaging analytic approach were implemented to assess the neurocomputational components underlying decision making: (a) reinforcement expectancies (the representation of the outcomes associated with a stimulus) and (b) prediction error signaling (the ability to detect the differences between expected and actual outcomes). There were three main findings. First, the maltreated group (n = 18; mean age = 13), relative to nonmaltreated peers (n = 19; mean age = 13), showed decreased activity during expected value processing in a widespread network commonly associated with reinforcement expectancies representation, including the striatum (especially the caudate), the orbitofrontal cortex, and medial temporal structures including the hippocampus and insula. Second, consistent with previously reported hyperresponsiveness to negative cues in the context of childhood abuse, the maltreated group showed increased prediction error signaling in the middle cingulate gyrus, somatosensory cortex, superior temporal gyrus, and thalamus. Third, the maltreated group showed increased activity in frontodorsal regions and in the putamen during expected value representation. These findings suggest that early adverse environments disrupt the development of decision-making processes, which in turn may compromise psychosocial functioning in ways that increase latent vulnerability to psychiatric disorder. En ligne : http://dx.doi.org/10.1017/S095457941700133X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

Using an adoption–biological family design to examine associations between maternal trauma, maternal depressive symptoms, and child internalizing and externalizing behaviors / Aleksandria Perez GRABOW in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1707-1720 Titre : Using an adoption–biological family design to examine associations between maternal trauma, maternal depressive symptoms, and child internalizing and externalizing behaviors Type de document : Texte imprimé et/ou numérique Auteurs : Aleksandria Perez GRABOW, Auteur ; Atika KHURANA, Auteur ; Misaki N. NATSUAKI, Auteur ; Jenae M. NEIDERHISER, Auteur ; Gordon T. HAROLD, Auteur ; Daniel S. SHAW, Auteur ; Jody M. GANIBAN, Auteur ; David REISS, Auteur ; Leslie D. LEVE, Auteur Article en page(s) : p.1707-1720 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Maternal trauma is a complex risk factor that has been linked to adverse child outcomes, yet the mechanisms underlying this association are not well understood. This study, which included adoptive and biological families, examined the heritable and environmental mechanisms by which maternal trauma and associated depressive symptoms are linked to child internalizing and externalizing behaviors. Path analyses were used to analyze data from 541 adoptive mother–adopted child (AM–AC) dyads and 126 biological mother–biological child (BM–BC) dyads; the two family types were linked through the same biological mother. Rearing mother's trauma was associated with child internalizing and externalizing behaviors in AM–AC and BM–BC dyads, and this association was mediated by rearing mothers’ depressive symptoms, with the exception of biological child externalizing behavior, for which biological mother trauma had a direct influence only. Significant associations between maternal trauma and child behavior in dyads that share only environment (i.e., AM–AC dyads) suggest an environmental mechanism of influence for maternal trauma. Significant associations were also observed between maternal depressive symptoms and child internalizing and externalizing behavior in dyads that were only genetically related, with no shared environment (i.e., BM–AC dyads), suggesting a heritable pathway of influence via maternal depressive symptoms. En ligne : http://dx.doi.org/10.1017/S0954579417001341 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Using an adoption–biological family design to examine associations between maternal trauma, maternal depressive symptoms, and child internalizing and externalizing behaviors [Texte imprimé et/ou numérique] / Aleksandria Perez GRABOW, Auteur ; Atika KHURANA, Auteur ; Misaki N. NATSUAKI, Auteur ; Jenae M. NEIDERHISER, Auteur ; Gordon T. HAROLD, Auteur ; Daniel S. SHAW, Auteur ; Jody M. GANIBAN, Auteur ; David REISS, Auteur ; Leslie D. LEVE, Auteur . - p.1707-1720. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1707-1720 Index. décimale : PER Périodiques Résumé : Maternal trauma is a complex risk factor that has been linked to adverse child outcomes, yet the mechanisms underlying this association are not well understood. This study, which included adoptive and biological families, examined the heritable and environmental mechanisms by which maternal trauma and associated depressive symptoms are linked to child internalizing and externalizing behaviors. Path analyses were used to analyze data from 541 adoptive mother–adopted child (AM–AC) dyads and 126 biological mother–biological child (BM–BC) dyads; the two family types were linked through the same biological mother. Rearing mother's trauma was associated with child internalizing and externalizing behaviors in AM–AC and BM–BC dyads, and this association was mediated by rearing mothers’ depressive symptoms, with the exception of biological child externalizing behavior, for which biological mother trauma had a direct influence only. Significant associations between maternal trauma and child behavior in dyads that share only environment (i.e., AM–AC dyads) suggest an environmental mechanism of influence for maternal trauma. Significant associations were also observed between maternal depressive symptoms and child internalizing and externalizing behavior in dyads that were only genetically related, with no shared environment (i.e., BM–AC dyads), suggesting a heritable pathway of influence via maternal depressive symptoms. En ligne : http://dx.doi.org/10.1017/S0954579417001341 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

Threat vigilance and socioeconomic disparities in metabolic health / Camelia E. HOSTINAR in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1721-1733 Titre : Threat vigilance and socioeconomic disparities in metabolic health Type de document : Texte imprimé et/ou numérique Auteurs : Camelia E. HOSTINAR, Auteur ; Kharah M. ROSS, Auteur ; Meanne CHAN, Auteur ; Edith CHEN, Auteur ; Gregory E. MILLER, Auteur Article en page(s) : p.1721-1733 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : A quarter of the global population meets diagnostic criteria for metabolic syndrome (MetS). MetS prevalence stratifies by socioeconomic status (SES), such that low SES is associated with higher MetS risk starting in childhood. Despite this trend, some low-SES children maintain good metabolic health across the life span, but the factors responsible for their resilience are not well understood. This study examined the role of threat vigilance as either a moderator or a mediator of the effects of low early life SES on adult metabolic risk. Three hundred twenty-five Canadians aged 15–55 participated (M = 36.4 years, SD = 10.7; 55.4% female). We coded parental occupational status between the ages of 0 and 5 to index early life SES. We used the International Diabetes Federation case definition for MetS based on waist circumference, blood pressure, triglyceride levels, HDL cholesterol, and glycosylated hemoglobin measures. Threat vigilance was assessed using the Weapons Identification Procedure, a visual discrimination paradigm that captures implicit perceptions of threat. Analyses supported the moderator hypothesis: low early life SES was associated with MetS diagnosis exclusively among those with high levels of threat vigilance. This suggests that low early life SES environments that heighten vigilance to threat might be particularly detrimental for metabolic health. Conversely, low threat vigilance may buffer against the metabolic risks associated with socioeconomic disadvantage. En ligne : http://dx.doi.org/10.1017/S0954579417001353 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Threat vigilance and socioeconomic disparities in metabolic health [Texte imprimé et/ou numérique] / Camelia E. HOSTINAR, Auteur ; Kharah M. ROSS, Auteur ; Meanne CHAN, Auteur ; Edith CHEN, Auteur ; Gregory E. MILLER, Auteur . - p.1721-1733. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1721-1733 Index. décimale : PER Périodiques Résumé : A quarter of the global population meets diagnostic criteria for metabolic syndrome (MetS). MetS prevalence stratifies by socioeconomic status (SES), such that low SES is associated with higher MetS risk starting in childhood. Despite this trend, some low-SES children maintain good metabolic health across the life span, but the factors responsible for their resilience are not well understood. This study examined the role of threat vigilance as either a moderator or a mediator of the effects of low early life SES on adult metabolic risk. Three hundred twenty-five Canadians aged 15–55 participated (M = 36.4 years, SD = 10.7; 55.4% female). We coded parental occupational status between the ages of 0 and 5 to index early life SES. We used the International Diabetes Federation case definition for MetS based on waist circumference, blood pressure, triglyceride levels, HDL cholesterol, and glycosylated hemoglobin measures. Threat vigilance was assessed using the Weapons Identification Procedure, a visual discrimination paradigm that captures implicit perceptions of threat. Analyses supported the moderator hypothesis: low early life SES was associated with MetS diagnosis exclusively among those with high levels of threat vigilance. This suggests that low early life SES environments that heighten vigilance to threat might be particularly detrimental for metabolic health. Conversely, low threat vigilance may buffer against the metabolic risks associated with socioeconomic disadvantage. En ligne : http://dx.doi.org/10.1017/S0954579417001353 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

Childhood maltreatment moderates the effect of combat exposure on cingulum structural integrity / Layla BANIHASHEMI in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1735-1747 Titre : Childhood maltreatment moderates the effect of combat exposure on cingulum structural integrity Type de document : Texte imprimé et/ou numérique Auteurs : Layla BANIHASHEMI, Auteur ; Meredith L. WALLACE, Auteur ; Lei K. SHEU, Auteur ; Michael C. LEE, Auteur ; Peter J. GIANAROS, Auteur ; Robert P. MACKENZIE, Auteur ; Salvatore P. INSANA, Auteur ; Anne GERMAIN, Auteur ; Ryan J. HERRINGA, Auteur Article en page(s) : p.1735-1747 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Limbic white matter pathways link emotion, cognition, and behavior and are potentially malleable to the influences of traumatic events throughout development. However, the impact of interactions between childhood and later life trauma on limbic white matter pathways has yet to be examined. Here, we examined whether childhood maltreatment moderated the effect of combat exposure on diffusion tensor imaging measures within a sample of military veterans (N = 28). We examined five limbic tracts of interest: two components of the cingulum (cingulum, cingulate gyrus, and cingulum hippocampus [CGH]), the uncinate fasciculus, the fornix/stria terminalis, and the anterior limb of the internal capsule. Using effect sizes, clinically meaningful moderator effects were found only within the CGH. Greater combat exposure was associated with decreased CGH fractional anisotropy (overall structural integrity) and increased CGH radial diffusivity (perpendicular water diffusivity) among individuals with more severe childhood maltreatment. Our findings provide preliminary evidence of the moderating effect of childhood maltreatment on the relationship between combat exposure and CGH structural integrity. These differences in CGH structural integrity could have maladaptive implications for emotion and memory, as well as provide a potential mechanism by which childhood maltreatment induces vulnerability to later life trauma exposure. En ligne : http://dx.doi.org/10.1017/S0954579417001365 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Childhood maltreatment moderates the effect of combat exposure on cingulum structural integrity [Texte imprimé et/ou numérique] / Layla BANIHASHEMI, Auteur ; Meredith L. WALLACE, Auteur ; Lei K. SHEU, Auteur ; Michael C. LEE, Auteur ; Peter J. GIANAROS, Auteur ; Robert P. MACKENZIE, Auteur ; Salvatore P. INSANA, Auteur ; Anne GERMAIN, Auteur ; Ryan J. HERRINGA, Auteur . - p.1735-1747. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1735-1747 Index. décimale : PER Périodiques Résumé : Limbic white matter pathways link emotion, cognition, and behavior and are potentially malleable to the influences of traumatic events throughout development. However, the impact of interactions between childhood and later life trauma on limbic white matter pathways has yet to be examined. Here, we examined whether childhood maltreatment moderated the effect of combat exposure on diffusion tensor imaging measures within a sample of military veterans (N = 28). We examined five limbic tracts of interest: two components of the cingulum (cingulum, cingulate gyrus, and cingulum hippocampus [CGH]), the uncinate fasciculus, the fornix/stria terminalis, and the anterior limb of the internal capsule. Using effect sizes, clinically meaningful moderator effects were found only within the CGH. Greater combat exposure was associated with decreased CGH fractional anisotropy (overall structural integrity) and increased CGH radial diffusivity (perpendicular water diffusivity) among individuals with more severe childhood maltreatment. Our findings provide preliminary evidence of the moderating effect of childhood maltreatment on the relationship between combat exposure and CGH structural integrity. These differences in CGH structural integrity could have maladaptive implications for emotion and memory, as well as provide a potential mechanism by which childhood maltreatment induces vulnerability to later life trauma exposure. En ligne : http://dx.doi.org/10.1017/S0954579417001365 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

Effects of early institutionalization on emotion processing in 12-year-old youth / Johanna BICK in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1749-1761 Titre : Effects of early institutionalization on emotion processing in 12-year-old youth Type de document : Texte imprimé et/ou numérique Auteurs : Johanna BICK, Auteur ; Rhiannon LUYSTER, Auteur ; Nathan A. FOX, Auteur ; Charles H. ZEANAH, Auteur ; Charles A. NELSON, Auteur Article en page(s) : p.1749-1761 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We examined facial emotion recognition in 12-year-olds in a longitudinally followed sample of children with and without exposure to early life psychosocial deprivation (institutional care). Half of the institutionally reared children were randomized into foster care homes during the first years of life. Facial emotion recognition was examined in a behavioral task using morphed images. This same task had been administered when children were 8 years old. Neutral facial expressions were morphed with happy, sad, angry, and fearful emotional facial expressions, and children were asked to identify the emotion of each face, which varied in intensity. Consistent with our previous report, we show that some areas of emotion processing, involving the recognition of happy and fearful faces, are affected by early deprivation, whereas other areas, involving the recognition of sad and angry faces, appear to be unaffected. We also show that early intervention can have a lasting positive impact, normalizing developmental trajectories of processing negative emotions (fear) into the late childhood/preadolescent period. En ligne : http://dx.doi.org/10.1017/S0954579417001377 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Effects of early institutionalization on emotion processing in 12-year-old youth [Texte imprimé et/ou numérique] / Johanna BICK, Auteur ; Rhiannon LUYSTER, Auteur ; Nathan A. FOX, Auteur ; Charles H. ZEANAH, Auteur ; Charles A. NELSON, Auteur . - p.1749-1761. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1749-1761 Index. décimale : PER Périodiques Résumé : We examined facial emotion recognition in 12-year-olds in a longitudinally followed sample of children with and without exposure to early life psychosocial deprivation (institutional care). Half of the institutionally reared children were randomized into foster care homes during the first years of life. Facial emotion recognition was examined in a behavioral task using morphed images. This same task had been administered when children were 8 years old. Neutral facial expressions were morphed with happy, sad, angry, and fearful emotional facial expressions, and children were asked to identify the emotion of each face, which varied in intensity. Consistent with our previous report, we show that some areas of emotion processing, involving the recognition of happy and fearful faces, are affected by early deprivation, whereas other areas, involving the recognition of sad and angry faces, appear to be unaffected. We also show that early intervention can have a lasting positive impact, normalizing developmental trajectories of processing negative emotions (fear) into the late childhood/preadolescent period. En ligne : http://dx.doi.org/10.1017/S0954579417001377 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

Child temperament and teacher relationship interactively predict cortisol expression: The prism of classroom climate / Danielle S. ROUBINOV in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1763-1775 Titre : Child temperament and teacher relationship interactively predict cortisol expression: The prism of classroom climate Type de document : Texte imprimé et/ou numérique Auteurs : Danielle S. ROUBINOV, Auteur ; Melissa J. HAGAN, Auteur ; W. Thomas BOYCE, Auteur ; Marilyn J. ESSEX, Auteur ; Nicole R. BUSH, Auteur Article en page(s) : p.1763-1775 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Entry into kindergarten is a developmental milestone that children may differentially experience as stressful, with implications for variability in neurobiological functioning. Guided by the goodness-of-fit framework, this study tested the hypothesis that kindergarten children's (N = 338) daily cortisol would be affected by the “match” or “mismatch” between children's temperament and qualities of the classroom relational context. The robustness of these associations was also explored among a separate sample of children in third grade (N = 165). Results among kindergarten children showed negative affectivity and overcontrolled temperament were positively related to cortisol expression within classrooms characterized by lower levels of teacher motivational support, but there was no relation between temperament and cortisol when motivational support was higher. Among third-grade children, negative affectivity was marginally positively related to cortisol at lower levels of teacher–child closeness and unrelated at higher levels of teacher–child closeness. Findings suggest children's cortisol expression depends on the extent to which specific temperamental characteristics “fit” within the relational and contextual qualities of the classroom environment, particularly as children navigate the new roles and relationships that emerge during the transition to formal schooling. Developmentally informed neurobiological research in classrooms may contribute to tailored programmatic efforts to support children's school adjustment. En ligne : http://dx.doi.org/10.1017/S0954579417001389 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Child temperament and teacher relationship interactively predict cortisol expression: The prism of classroom climate [Texte imprimé et/ou numérique] / Danielle S. ROUBINOV, Auteur ; Melissa J. HAGAN, Auteur ; W. Thomas BOYCE, Auteur ; Marilyn J. ESSEX, Auteur ; Nicole R. BUSH, Auteur . - p.1763-1775. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1763-1775 Index. décimale : PER Périodiques Résumé : Entry into kindergarten is a developmental milestone that children may differentially experience as stressful, with implications for variability in neurobiological functioning. Guided by the goodness-of-fit framework, this study tested the hypothesis that kindergarten children's (N = 338) daily cortisol would be affected by the “match” or “mismatch” between children's temperament and qualities of the classroom relational context. The robustness of these associations was also explored among a separate sample of children in third grade (N = 165). Results among kindergarten children showed negative affectivity and overcontrolled temperament were positively related to cortisol expression within classrooms characterized by lower levels of teacher motivational support, but there was no relation between temperament and cortisol when motivational support was higher. Among third-grade children, negative affectivity was marginally positively related to cortisol at lower levels of teacher–child closeness and unrelated at higher levels of teacher–child closeness. Findings suggest children's cortisol expression depends on the extent to which specific temperamental characteristics “fit” within the relational and contextual qualities of the classroom environment, particularly as children navigate the new roles and relationships that emerge during the transition to formal schooling. Developmentally informed neurobiological research in classrooms may contribute to tailored programmatic efforts to support children's school adjustment. En ligne : http://dx.doi.org/10.1017/S0954579417001389 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

Dimensions of childhood adversity have distinct associations with neural systems underlying executive functioning / Margaret A. SHERIDAN in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1777-1794 Titre : Dimensions of childhood adversity have distinct associations with neural systems underlying executive functioning Type de document : Texte imprimé et/ou numérique Auteurs : Margaret A. SHERIDAN, Auteur ; Matthew PEVERILL, Auteur ; Amy S. FINN, Auteur ; Katie A. MCLAUGHLIN, Auteur Article en page(s) : p.1777-1794 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Childhood adversity is associated with increased risk for psychopathology. Neurodevelopmental pathways underlying this risk remain poorly understood. A recent conceptual model posits that childhood adversity can be deconstructed into at least two underlying dimensions, deprivation and threat, that are associated with distinct neurocognitive consequences. This model argues that deprivation (i.e., a lack of cognitive stimulation and learning opportunities) is associated with poor executive function (EF), whereas threat is not. We examine this hypothesis in two studies measuring EF at multiple levels: performance on EF tasks, neural recruitment during EF, and problems with EF in daily life. In Study 1, deprivation (low parental education and child neglect) was associated with greater parent-reported problems with EF in adolescents (N = 169; 13–17 years) after adjustment for levels of threat (community violence and abuse), which were unrelated to EF. In Study 2, low parental education was associated with poor working memory (WM) performance and inefficient neural recruitment in the parietal and prefrontal cortex during high WM load among adolescents (N = 51, 13–20 years) after adjusting for abuse, which was unrelated to WM task performance and neural recruitment during WM. These findings constitute strong preliminary evidence for a novel model of the neurodevelopmental consequences of childhood adversity. En ligne : http://dx.doi.org/10.1017/S0954579417001390 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Dimensions of childhood adversity have distinct associations with neural systems underlying executive functioning [Texte imprimé et/ou numérique] / Margaret A. SHERIDAN, Auteur ; Matthew PEVERILL, Auteur ; Amy S. FINN, Auteur ; Katie A. MCLAUGHLIN, Auteur . - p.1777-1794. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1777-1794 Index. décimale : PER Périodiques Résumé : Childhood adversity is associated with increased risk for psychopathology. Neurodevelopmental pathways underlying this risk remain poorly understood. A recent conceptual model posits that childhood adversity can be deconstructed into at least two underlying dimensions, deprivation and threat, that are associated with distinct neurocognitive consequences. This model argues that deprivation (i.e., a lack of cognitive stimulation and learning opportunities) is associated with poor executive function (EF), whereas threat is not. We examine this hypothesis in two studies measuring EF at multiple levels: performance on EF tasks, neural recruitment during EF, and problems with EF in daily life. In Study 1, deprivation (low parental education and child neglect) was associated with greater parent-reported problems with EF in adolescents (N = 169; 13–17 years) after adjustment for levels of threat (community violence and abuse), which were unrelated to EF. In Study 2, low parental education was associated with poor working memory (WM) performance and inefficient neural recruitment in the parietal and prefrontal cortex during high WM load among adolescents (N = 51, 13–20 years) after adjusting for abuse, which was unrelated to WM task performance and neural recruitment during WM. These findings constitute strong preliminary evidence for a novel model of the neurodevelopmental consequences of childhood adversity. En ligne : http://dx.doi.org/10.1017/S0954579417001390 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

Methylation of the glucocorticoid receptor gene, nuclear receptor subfamily 3, group C, member 1 (NR3C1), in maltreated and nonmaltreated children: Associations with behavioral undercontrol, emotional lability/negativity, and externalizing and internalizing symptoms / Dante CICCHETTI in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1795-1806 Titre : Methylation of the glucocorticoid receptor gene, nuclear receptor subfamily 3, group C, member 1 (NR3C1), in maltreated and nonmaltreated children: Associations with behavioral undercontrol, emotional lability/negativity, and externalizing and internalizing symptoms Type de document : Texte imprimé et/ou numérique Auteurs : Dante CICCHETTI, Auteur ; Elizabeth D. HANDLEY, Auteur Article en page(s) : p.1795-1806 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The present study examined the effect of various dimensions of child maltreatment (i.e., developmental timing of maltreatment, number of maltreatment subtypes, and chronicity of maltreatment) on methylation of the glucocorticoid receptor gene, nuclear receptor subfamily 3, group C, member 1 (NR3C1), and investigated the associations between NR3C1 methylation and child outcomes. Participants included 534 children who attended a research summer camp program for school-aged maltreated (53.4%) and nonmaltreated (46.6%) children from low socioeconomic backgrounds. Results show that children with early onset maltreatment evidence significant hypermethylation compared to nonmaltreated children. Moreover, more maltreatment subtypes experienced and more chronic maltreatment are both related to greater NR3C1 hypermethylation. Findings also indicate that hypermethylation of NR3C1 is linked with a number of negative child outcomes including greater emotional lability–negativity, higher levels of ego undercontrol, more externalizing behavior, and greater depressive symptoms. Together, results highlight the role of methylation of NR3C1 in the effects of child maltreatment on the development of emotion dysregulation and psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579417001407 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Methylation of the glucocorticoid receptor gene, nuclear receptor subfamily 3, group C, member 1 (NR3C1), in maltreated and nonmaltreated children: Associations with behavioral undercontrol, emotional lability/negativity, and externalizing and internalizing symptoms [Texte imprimé et/ou numérique] / Dante CICCHETTI, Auteur ; Elizabeth D. HANDLEY, Auteur . - p.1795-1806. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1795-1806 Index. décimale : PER Périodiques Résumé : The present study examined the effect of various dimensions of child maltreatment (i.e., developmental timing of maltreatment, number of maltreatment subtypes, and chronicity of maltreatment) on methylation of the glucocorticoid receptor gene, nuclear receptor subfamily 3, group C, member 1 (NR3C1), and investigated the associations between NR3C1 methylation and child outcomes. Participants included 534 children who attended a research summer camp program for school-aged maltreated (53.4%) and nonmaltreated (46.6%) children from low socioeconomic backgrounds. Results show that children with early onset maltreatment evidence significant hypermethylation compared to nonmaltreated children. Moreover, more maltreatment subtypes experienced and more chronic maltreatment are both related to greater NR3C1 hypermethylation. Findings also indicate that hypermethylation of NR3C1 is linked with a number of negative child outcomes including greater emotional lability–negativity, higher levels of ego undercontrol, more externalizing behavior, and greater depressive symptoms. Together, results highlight the role of methylation of NR3C1 in the effects of child maltreatment on the development of emotion dysregulation and psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579417001407 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

From child maltreatment to emerging adult problem drinking: Identification of a multilevel internalizing pathway among African American youth / Elizabeth D. HANDLEY in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1807-1821 Titre : From child maltreatment to emerging adult problem drinking: Identification of a multilevel internalizing pathway among African American youth Type de document : Texte imprimé et/ou numérique Auteurs : Elizabeth D. HANDLEY, Auteur ; Fred A. ROGOSCH, Auteur ; Dante CICCHETTI, Auteur Article en page(s) : p.1807-1821 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The present study tested the role of FKBP5 binding protein 5 (FKBP5) genetic variation in an internalizing pathway from child maltreatment to emerging adult problem drinking among a sample of African American youth (N = 280) followed prospectively from ages 11 to 20. Specifically, whether childhood internalizing symptoms and emerging adult tension reduction alcohol expectancies sequentially mediate the effect of child maltreatment on emerging adult problem drinking and whether FKBP5 moderates these associations were investigated. The results indicate that individuals with at least one copy of the FKBP5 CATT haplotype (minor alleles) are more vulnerable to traversing the hypothesized internalizing pathway of risk than individuals without this genotypic profile. Taken together our findings highlight the importance of FKBP5 genetic variation in the context of early adversity; support the role of two prospective sequential mediators of an internalizing pathway to problematic drinking, namely, childhood internalizing symptoms and emerging adult tension reduction alcohol expectancies; and identify a subgroup of maltreated children most susceptible to progressing along this less common pathway of risk. En ligne : http://dx.doi.org/10.1017/S0954579417001419 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 [article] From child maltreatment to emerging adult problem drinking: Identification of a multilevel internalizing pathway among African American youth [Texte imprimé et/ou numérique] / Elizabeth D. HANDLEY, Auteur ; Fred A. ROGOSCH, Auteur ; Dante CICCHETTI, Auteur . - p.1807-1821. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1807-1821 Index. décimale : PER Périodiques Résumé : The present study tested the role of FKBP5 binding protein 5 (FKBP5) genetic variation in an internalizing pathway from child maltreatment to emerging adult problem drinking among a sample of African American youth (N = 280) followed prospectively from ages 11 to 20. Specifically, whether childhood internalizing symptoms and emerging adult tension reduction alcohol expectancies sequentially mediate the effect of child maltreatment on emerging adult problem drinking and whether FKBP5 moderates these associations were investigated. The results indicate that individuals with at least one copy of the FKBP5 CATT haplotype (minor alleles) are more vulnerable to traversing the hypothesized internalizing pathway of risk than individuals without this genotypic profile. Taken together our findings highlight the importance of FKBP5 genetic variation in the context of early adversity; support the role of two prospective sequential mediators of an internalizing pathway to problematic drinking, namely, childhood internalizing symptoms and emerging adult tension reduction alcohol expectancies; and identify a subgroup of maltreated children most susceptible to progressing along this less common pathway of risk. En ligne : http://dx.doi.org/10.1017/S0954579417001419 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324

In the eye of the beholder: Perceptions of neighborhood adversity and psychotic experiences in adolescence / Joanne B. NEWBURY in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1823-1837 Titre : In the eye of the beholder: Perceptions of neighborhood adversity and psychotic experiences in adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Joanne B. NEWBURY, Auteur ; Louise ARSENEAULT, Auteur ; Avshalom CASPI, Auteur ; Terrie E. MOFFITT, Auteur ; Candice L. ODGERS, Auteur ; Jessie R. BALDWIN, Auteur ; Helena M. S. ZAVOS, Auteur ; Helen L. FISHER, Auteur Article en page(s) : p.1823-1837 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Adolescent psychotic experiences increase risk for schizophrenia and other severe psychopathology in adulthood. Converging evidence implicates urban and adverse neighborhood conditions in the etiology of adolescent psychotic experiences, but the role of young people's personal perceptions of disorder (i.e., physical and social signs of threat) in their neighborhood is unknown. This was examined using data from the Environmental Risk Longitudinal Twin Study, a nationally representative birth cohort of 2,232 British twins. Participants were interviewed at age 18 about psychotic phenomena and perceptions of disorder in the neighborhood. Multilevel, longitudinal, and genetically sensitive analyses investigated the association between perceptions of neighborhood disorder and adolescent psychotic experiences. Adolescents who perceived higher levels of neighborhood disorder were significantly more likely to have psychotic experiences, even after accounting for objectively/independently measured levels of crime and disorder, neighborhood- and family-level socioeconomic status, family psychiatric history, adolescent substance and mood problems, and childhood psychotic symptoms: odds ratio = 1.62, 95% confidence interval [1.27, 2.05], p < .001. The phenotypic overlap between adolescent psychotic experiences and perceptions of neighborhood disorder was explained by overlapping common environmental influences, rC = .88, 95% confidence interval [0.26, 1.00]. Findings suggest that early psychological interventions to prevent adolescent psychotic experiences should explore the role of young people's (potentially modifiable) perceptions of threatening neighborhood conditions. En ligne : http://dx.doi.org/10.1017/S0954579417001420 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 [article] In the eye of the beholder: Perceptions of neighborhood adversity and psychotic experiences in adolescence [Texte imprimé et/ou numérique] / Joanne B. NEWBURY, Auteur ; Louise ARSENEAULT, Auteur ; Avshalom CASPI, Auteur ; Terrie E. MOFFITT, Auteur ; Candice L. ODGERS, Auteur ; Jessie R. BALDWIN, Auteur ; Helena M. S. ZAVOS, Auteur ; Helen L. FISHER, Auteur . - p.1823-1837. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1823-1837 Index. décimale : PER Périodiques Résumé : Adolescent psychotic experiences increase risk for schizophrenia and other severe psychopathology in adulthood. Converging evidence implicates urban and adverse neighborhood conditions in the etiology of adolescent psychotic experiences, but the role of young people's personal perceptions of disorder (i.e., physical and social signs of threat) in their neighborhood is unknown. This was examined using data from the Environmental Risk Longitudinal Twin Study, a nationally representative birth cohort of 2,232 British twins. Participants were interviewed at age 18 about psychotic phenomena and perceptions of disorder in the neighborhood. Multilevel, longitudinal, and genetically sensitive analyses investigated the association between perceptions of neighborhood disorder and adolescent psychotic experiences. Adolescents who perceived higher levels of neighborhood disorder were significantly more likely to have psychotic experiences, even after accounting for objectively/independently measured levels of crime and disorder, neighborhood- and family-level socioeconomic status, family psychiatric history, adolescent substance and mood problems, and childhood psychotic symptoms: odds ratio = 1.62, 95% confidence interval [1.27, 2.05], p < .001. The phenotypic overlap between adolescent psychotic experiences and perceptions of neighborhood disorder was explained by overlapping common environmental influences, rC = .88, 95% confidence interval [0.26, 1.00]. Findings suggest that early psychological interventions to prevent adolescent psychotic experiences should explore the role of young people's (potentially modifiable) perceptions of threatening neighborhood conditions. En ligne : http://dx.doi.org/10.1017/S0954579417001420 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324

External-environmental and internal-health early life predictors of adolescent development / Sarah HARTMAN in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1839-1849 Titre : External-environmental and internal-health early life predictors of adolescent development Type de document : Texte imprimé et/ou numérique Auteurs : Sarah HARTMAN, Auteur ; Zhi LI, Auteur ; Daniel NETTLE, Auteur ; Jay BELSKY, Auteur Article en page(s) : p.1839-1849 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : A wealth of evidence documents associations between various aspects of the rearing environment and later development. Two evolutionary-inspired models advance explanations for why and how such early experiences shape later functioning: (a) the external-prediction model, which highlights the role of the early environment (e.g., parenting) in regulating children's development, and (b) the internal-prediction model, which emphasizes internal state (i.e., health) as the critical regulator. Thus, by using data from the NICHD Study of Early Child Care and Youth Development, the current project draws from both models by investigating whether the effect of the early environment on later adolescent functioning is subject to an indirect effect by internal-health variables. Results showed a significant indirect effect of internal health on the relation between the early environment and adolescent behavior. Specifically, early environmental adversity during the first 5 years of life predicted lower quality health during childhood, which then led to problematic adolescent functioning and earlier age of menarche for girls. In addition, for girls, early adversity predicted lower quality health that forecasted earlier age of menarche leading to increased adolescent risk taking. The discussion highlights the importance of integrating both internal and external models to further understand the developmental processes that effect adolescent behavior. En ligne : http://dx.doi.org/10.1017/S0954579417001432 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 [article] External-environmental and internal-health early life predictors of adolescent development [Texte imprimé et/ou numérique] / Sarah HARTMAN, Auteur ; Zhi LI, Auteur ; Daniel NETTLE, Auteur ; Jay BELSKY, Auteur . - p.1839-1849. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1839-1849 Index. décimale : PER Périodiques Résumé : A wealth of evidence documents associations between various aspects of the rearing environment and later development. Two evolutionary-inspired models advance explanations for why and how such early experiences shape later functioning: (a) the external-prediction model, which highlights the role of the early environment (e.g., parenting) in regulating children's development, and (b) the internal-prediction model, which emphasizes internal state (i.e., health) as the critical regulator. Thus, by using data from the NICHD Study of Early Child Care and Youth Development, the current project draws from both models by investigating whether the effect of the early environment on later adolescent functioning is subject to an indirect effect by internal-health variables. Results showed a significant indirect effect of internal health on the relation between the early environment and adolescent behavior. Specifically, early environmental adversity during the first 5 years of life predicted lower quality health during childhood, which then led to problematic adolescent functioning and earlier age of menarche for girls. In addition, for girls, early adversity predicted lower quality health that forecasted earlier age of menarche leading to increased adolescent risk taking. The discussion highlights the importance of integrating both internal and external models to further understand the developmental processes that effect adolescent behavior. En ligne : http://dx.doi.org/10.1017/S0954579417001432 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324

The association between early life stress and prefrontal cortex activation during implicit emotion regulation is moderated by sex in early adolescence / Natalie L. COLICH in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1851-1864 Titre : The association between early life stress and prefrontal cortex activation during implicit emotion regulation is moderated by sex in early adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Natalie L. COLICH, Auteur ; Eileen S. WILLIAMS, Auteur ; Tiffany C. HO, Auteur ; Lucy S. KING, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Alexandria N. PRICE, Auteur ; Sarah J. ORDAZ, Auteur ; Ian H. GOTLIB, Auteur Article en page(s) : p.1851-1864 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Early life stress (ELS) is a significant risk factor for the emergence of internalizing problems in adolescence. Beginning in adolescence, females are twice as likely as males to experience internalizing disorders. The present study was designed to examine sex differences in the association between ELS and internalizing problems in early pubertal adolescents, and whether and how corticolimbic function and connectivity may underlie these associations. Fifty-nine early pubertal males and 78 early pubertal females, ages 9–13 years (all Tanner Stage 3 or below) underwent functional magnetic resonance imaging as they performed an emotion label task that robustly interrogates corticolimbic function. Participants were also interviewed about their experience of ELS. Females exhibited a positive association between ELS and internalizing problems, whereas males exhibited no such association. Whole-brain and amygdala region of interest analyses indicated that whereas females exhibited a positive association between ELS and the ventrolateral prefrontal cortex during implicit emotion regulation, males showed no such association. Activation in these regions was positively associated with internalizing problems in females but not males; however, activation in these regions did not mediate the association between ELS and internalizing problems. Finally, both boys and girls exhibited an association between ELS and increased negative connectivity between the right ventrolateral prefrontal cortex and bilateral amygdala. Using a carefully characterized sample of early pubertal adolescents, the current study highlights important sex differences in the development of corticolimbic circuitry during a critical period of brain development. These sex differences may play a significant role in subsequent risk for internalizing problems. En ligne : http://dx.doi.org/10.1017/S0954579417001444 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 [article] The association between early life stress and prefrontal cortex activation during implicit emotion regulation is moderated by sex in early adolescence [Texte imprimé et/ou numérique] / Natalie L. COLICH, Auteur ; Eileen S. WILLIAMS, Auteur ; Tiffany C. HO, Auteur ; Lucy S. KING, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Alexandria N. PRICE, Auteur ; Sarah J. ORDAZ, Auteur ; Ian H. GOTLIB, Auteur . - p.1851-1864. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1851-1864 Index. décimale : PER Périodiques Résumé : Early life stress (ELS) is a significant risk factor for the emergence of internalizing problems in adolescence. Beginning in adolescence, females are twice as likely as males to experience internalizing disorders. The present study was designed to examine sex differences in the association between ELS and internalizing problems in early pubertal adolescents, and whether and how corticolimbic function and connectivity may underlie these associations. Fifty-nine early pubertal males and 78 early pubertal females, ages 9–13 years (all Tanner Stage 3 or below) underwent functional magnetic resonance imaging as they performed an emotion label task that robustly interrogates corticolimbic function. Participants were also interviewed about their experience of ELS. Females exhibited a positive association between ELS and internalizing problems, whereas males exhibited no such association. Whole-brain and amygdala region of interest analyses indicated that whereas females exhibited a positive association between ELS and the ventrolateral prefrontal cortex during implicit emotion regulation, males showed no such association. Activation in these regions was positively associated with internalizing problems in females but not males; however, activation in these regions did not mediate the association between ELS and internalizing problems. Finally, both boys and girls exhibited an association between ELS and increased negative connectivity between the right ventrolateral prefrontal cortex and bilateral amygdala. Using a carefully characterized sample of early pubertal adolescents, the current study highlights important sex differences in the development of corticolimbic circuitry during a critical period of brain development. These sex differences may play a significant role in subsequent risk for internalizing problems. En ligne : http://dx.doi.org/10.1017/S0954579417001444 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324

Altered ventral striatal–medial prefrontal cortex resting-state connectivity mediates adolescent social problems after early institutional care / Dominic S. FARERI in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1865-1876 Titre : Altered ventral striatal–medial prefrontal cortex resting-state connectivity mediates adolescent social problems after early institutional care Type de document : Texte imprimé et/ou numérique Auteurs : Dominic S. FARERI, Auteur ; Laurel GABARD-DURNAM, Auteur ; Bonnie GOFF, Auteur ; Jessica FLANNERY, Auteur ; Dylan G. GEE, Auteur ; Daniel S. LUMIAN, Auteur ; Christina CALDERA, Auteur ; Nim TOTTENHAM, Auteur Article en page(s) : p.1865-1876 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Early caregiving adversity is associated with increased risk for social difficulties. The ventral striatum and associated corticostriatal circuitry, which have demonstrated vulnerability to early exposures to adversity, are implicated in many aspects of social behavior, including social play, aggression, and valuation of social stimuli across development. Here, we used resting-state functional magnetic resonance imaging to assess the degree to which early caregiving adversity was associated with altered coritocostriatal resting connectivity in previously institutionalized youth (n = 41) relative to youth who were raised with their biological families from birth (n = 47), and the degree to which this connectivity was associated with parent-reported social problems. Using a seed-based approach, we observed increased positive coupling between the ventral striatum and anterior regions of medial prefrontal cortex (mPFC) in previously institutionalized youth. Stronger ventral striatum–mPFC coupling was associated with parent reports of social problems. A moderated-mediation analysis showed that ventral striatal–mPFC connectivity mediated group differences in social problems, and more so with increasing age. These findings show that early institutional care is associated with differences in resting-state connectivity between the ventral striatum and the mPFC, and this connectivity seems to play an increasingly important role in social behaviors as youth enter adolescence. En ligne : http://dx.doi.org/10.1017/S0954579417001456 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 [article] Altered ventral striatal–medial prefrontal cortex resting-state connectivity mediates adolescent social problems after early institutional care [Texte imprimé et/ou numérique] / Dominic S. FARERI, Auteur ; Laurel GABARD-DURNAM, Auteur ; Bonnie GOFF, Auteur ; Jessica FLANNERY, Auteur ; Dylan G. GEE, Auteur ; Daniel S. LUMIAN, Auteur ; Christina CALDERA, Auteur ; Nim TOTTENHAM, Auteur . - p.1865-1876. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1865-1876 Index. décimale : PER Périodiques Résumé : Early caregiving adversity is associated with increased risk for social difficulties. The ventral striatum and associated corticostriatal circuitry, which have demonstrated vulnerability to early exposures to adversity, are implicated in many aspects of social behavior, including social play, aggression, and valuation of social stimuli across development. Here, we used resting-state functional magnetic resonance imaging to assess the degree to which early caregiving adversity was associated with altered coritocostriatal resting connectivity in previously institutionalized youth (n = 41) relative to youth who were raised with their biological families from birth (n = 47), and the degree to which this connectivity was associated with parent-reported social problems. Using a seed-based approach, we observed increased positive coupling between the ventral striatum and anterior regions of medial prefrontal cortex (mPFC) in previously institutionalized youth. Stronger ventral striatum–mPFC coupling was associated with parent reports of social problems. A moderated-mediation analysis showed that ventral striatal–mPFC connectivity mediated group differences in social problems, and more so with increasing age. These findings show that early institutional care is associated with differences in resting-state connectivity between the ventral striatum and the mPFC, and this connectivity seems to play an increasingly important role in social behaviors as youth enter adolescence. En ligne : http://dx.doi.org/10.1017/S0954579417001456 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324

Childhood adversity moderates the influence of proximal episodic stress on the cortisol awakening response and depressive symptoms in adolescents / Lisa R. STARR in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1877-1893 Titre : Childhood adversity moderates the influence of proximal episodic stress on the cortisol awakening response and depressive symptoms in adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Lisa R. STARR, Auteur ; Kimberly DIENES, Auteur ; Catherine B. STROUD, Auteur ; Zoey A. SHAW, Auteur ; Y. Irina LI, Auteur ; Fanny MLAWER, Auteur ; Meghan HUANG, Auteur Article en page(s) : p.1877-1893 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Childhood adversity (CA) is known to predict sensitization to proximal stressors. Researchers have suggested that disruptions in hypothalamus–pituitary–adrenal axis functioning may be a biological mechanism. If so, CA may predict altered associations between proximal life stress and markers of cortisol secretion. We examined whether CA moderates associations between recent episodic stress and (a) the cortisol awakening response (CAR), and (b) depressive symptoms, in 241 adolescents aged 14–17 years (cortisol n = 196). Salivary cortisol was sampled at 0, 30, and 60 min postawakening for 2 days. The CAR was calculated as the area under the curve with respect to increase and waking cortisol. CA and episodic stress were assessed using contextual-threat-method-coded objective interviews. CA significantly interacted with episodic stress to predict both the CAR and depression. Among those with low CA, episodic stress predicted increased CAR but did not predict depression. For adolescents with high CA, episodic stress predicted lower CAR and higher depression. These interactions were found only for independent (uncontrollable, fateful) events, and not for dependent (self-generated) stress. Increased allostatic load resulting from CA exposure may interfere with adolescents' ability to optimally regulate their CAR in relation to recent stress, contributing to increased depression risk. En ligne : http://dx.doi.org/10.1017/S0954579417001468 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 [article] Childhood adversity moderates the influence of proximal episodic stress on the cortisol awakening response and depressive symptoms in adolescents [Texte imprimé et/ou numérique] / Lisa R. STARR, Auteur ; Kimberly DIENES, Auteur ; Catherine B. STROUD, Auteur ; Zoey A. SHAW, Auteur ; Y. Irina LI, Auteur ; Fanny MLAWER, Auteur ; Meghan HUANG, Auteur . - p.1877-1893. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1877-1893 Index. décimale : PER Périodiques Résumé : Childhood adversity (CA) is known to predict sensitization to proximal stressors. Researchers have suggested that disruptions in hypothalamus–pituitary–adrenal axis functioning may be a biological mechanism. If so, CA may predict altered associations between proximal life stress and markers of cortisol secretion. We examined whether CA moderates associations between recent episodic stress and (a) the cortisol awakening response (CAR), and (b) depressive symptoms, in 241 adolescents aged 14–17 years (cortisol n = 196). Salivary cortisol was sampled at 0, 30, and 60 min postawakening for 2 days. The CAR was calculated as the area under the curve with respect to increase and waking cortisol. CA and episodic stress were assessed using contextual-threat-method-coded objective interviews. CA significantly interacted with episodic stress to predict both the CAR and depression. Among those with low CA, episodic stress predicted increased CAR but did not predict depression. For adolescents with high CA, episodic stress predicted lower CAR and higher depression. These interactions were found only for independent (uncontrollable, fateful) events, and not for dependent (self-generated) stress. Increased allostatic load resulting from CA exposure may interfere with adolescents' ability to optimally regulate their CAR in relation to recent stress, contributing to increased depression risk. En ligne : http://dx.doi.org/10.1017/S0954579417001468 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324

Early life stress, FK506 binding protein 5 gene (FKBP5) methylation, and inhibition-related prefrontal function: A prospective longitudinal study / Madeline B. HARMS in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1895-1903 Titre : Early life stress, FK506 binding protein 5 gene (FKBP5) methylation, and inhibition-related prefrontal function: A prospective longitudinal study Type de document : Texte imprimé et/ou numérique Auteurs : Madeline B. HARMS, Auteur ; Rasmus BIRN, Auteur ; Nadine PROVENCAL, Auteur ; Tobias WIECHMANN, Auteur ; Elisabeth B. BINDER, Auteur ; Sebastian W. GIAKAS, Auteur ; Barbara J. ROEBER, Auteur ; Seth D. POLLAK, Auteur Article en page(s) : p.1895-1903 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Individuals who have experienced high levels of childhood stress are at increased risk for a wide range of behavioral problems that persist into adulthood, yet the neurobiological and molecular mechanisms underlying these associations remain poorly understood. Many of the difficulties observed in stress-exposed children involve problems with learning and inhibitory control. This experiment was designed to test individuals' ability to learn to inhibit responding during a laboratory task. To do so, we measured stress exposure among a community sample of school-aged children, and then followed these children for a decade. Those from the highest and lowest quintiles of childhood stress exposure were invited to return to our laboratory as young adults. At that time, we reassessed their life stress exposure, acquired functional magnetic resonance imaging data during an inhibitory control task, and assayed these individuals' levels of methylation in the FK506 binding protein 5 (FKBP5) gene. We found that individuals who experienced high levels of stress in childhood showed less differentiation in the dorsolateral prefrontal cortex between error and correct trials during inhibition. This effect was associated only with childhood stress exposure and not by current levels of stress in adulthood. In addition, FKBP5 methylation mediated the association between early life stress and inhibition-related prefrontal activity. These findings are discussed in terms of using multiple levels of analyses to understand the ways in which adversity in early development may affect adult behavioral adaptation. En ligne : http://dx.doi.org/10.1017/S095457941700147X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 [article] Early life stress, FK506 binding protein 5 gene (FKBP5) methylation, and inhibition-related prefrontal function: A prospective longitudinal study [Texte imprimé et/ou numérique] / Madeline B. HARMS, Auteur ; Rasmus BIRN, Auteur ; Nadine PROVENCAL, Auteur ; Tobias WIECHMANN, Auteur ; Elisabeth B. BINDER, Auteur ; Sebastian W. GIAKAS, Auteur ; Barbara J. ROEBER, Auteur ; Seth D. POLLAK, Auteur . - p.1895-1903. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1895-1903 Index. décimale : PER Périodiques Résumé : Individuals who have experienced high levels of childhood stress are at increased risk for a wide range of behavioral problems that persist into adulthood, yet the neurobiological and molecular mechanisms underlying these associations remain poorly understood. Many of the difficulties observed in stress-exposed children involve problems with learning and inhibitory control. This experiment was designed to test individuals' ability to learn to inhibit responding during a laboratory task. To do so, we measured stress exposure among a community sample of school-aged children, and then followed these children for a decade. Those from the highest and lowest quintiles of childhood stress exposure were invited to return to our laboratory as young adults. At that time, we reassessed their life stress exposure, acquired functional magnetic resonance imaging data during an inhibitory control task, and assayed these individuals' levels of methylation in the FK506 binding protein 5 (FKBP5) gene. We found that individuals who experienced high levels of stress in childhood showed less differentiation in the dorsolateral prefrontal cortex between error and correct trials during inhibition. This effect was associated only with childhood stress exposure and not by current levels of stress in adulthood. In addition, FKBP5 methylation mediated the association between early life stress and inhibition-related prefrontal activity. These findings are discussed in terms of using multiple levels of analyses to understand the ways in which adversity in early development may affect adult behavioral adaptation. En ligne : http://dx.doi.org/10.1017/S095457941700147X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324

Does striving to succeed come at a physiological or psychosocial cost for adults who experienced child maltreatment? / Jenalee R. DOOM in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1905-1919 Titre : Does striving to succeed come at a physiological or psychosocial cost for adults who experienced child maltreatment? Type de document : Texte imprimé et/ou numérique Auteurs : Jenalee R. DOOM, Auteur ; Vivienne M. HAZZARD, Auteur ; Katherine W. BAUER, Auteur ; Cari Jo CLARK, Auteur ; Alison L. MILLER, Auteur Article en page(s) : p.1905-1919 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : While striving to succeed in the face of adversity may provide individuals with outward benefits, it may come at a cost to individuals’ physical health. The current study examines whether striving predicts greater physiological or psychosocial costs among those who experienced child maltreatment, a stressor that disrupts the caregiving environment and threatens relationship security. Using data from the National Longitudinal Study of Adolescent to Adult Health, we tested whether greater striving after childhood maltreatment would come at a cost, increasing underlying cardiovascular disease (CVD) risk and depressive symptoms despite showing outward success via income and college degree attainment. The study included 13,341 Black, Hispanic, and White adolescents who self-reported striving and their experiences of childhood neglect, physical abuse, and sexual abuse. As young adults, participants reported depressive symptoms, income, and college degree attainment and completed a health assessment from which a 30-year Framingham-based CVD risk score was calculated. Higher striving was associated with lower CVD risk and depressive symptoms, and higher income and college degree attainment, regardless of maltreatment history. These findings highlight the potential for striving as a target for interventions and support the need to examine multiple biological and behavioral outcomes to understand the multifaceted nature of resilience. En ligne : http://dx.doi.org/10.1017/S0954579417001481 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 [article] Does striving to succeed come at a physiological or psychosocial cost for adults who experienced child maltreatment? [Texte imprimé et/ou numérique] / Jenalee R. DOOM, Auteur ; Vivienne M. HAZZARD, Auteur ; Katherine W. BAUER, Auteur ; Cari Jo CLARK, Auteur ; Alison L. MILLER, Auteur . - p.1905-1919. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1905-1919 Index. décimale : PER Périodiques Résumé : While striving to succeed in the face of adversity may provide individuals with outward benefits, it may come at a cost to individuals’ physical health. The current study examines whether striving predicts greater physiological or psychosocial costs among those who experienced child maltreatment, a stressor that disrupts the caregiving environment and threatens relationship security. Using data from the National Longitudinal Study of Adolescent to Adult Health, we tested whether greater striving after childhood maltreatment would come at a cost, increasing underlying cardiovascular disease (CVD) risk and depressive symptoms despite showing outward success via income and college degree attainment. The study included 13,341 Black, Hispanic, and White adolescents who self-reported striving and their experiences of childhood neglect, physical abuse, and sexual abuse. As young adults, participants reported depressive symptoms, income, and college degree attainment and completed a health assessment from which a 30-year Framingham-based CVD risk score was calculated. Higher striving was associated with lower CVD risk and depressive symptoms, and higher income and college degree attainment, regardless of maltreatment history. These findings highlight the potential for striving as a target for interventions and support the need to examine multiple biological and behavioral outcomes to understand the multifaceted nature of resilience. En ligne : http://dx.doi.org/10.1017/S0954579417001481 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324

Childhood quality influences genetic sensitivity to environmental influences across adulthood: A life-course Gene × Environment interaction study / Robert KEERS in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1921-1933 Titre : Childhood quality influences genetic sensitivity to environmental influences across adulthood: A life-course Gene × Environment interaction study Type de document : Texte imprimé et/ou numérique Auteurs : Robert KEERS, Auteur ; Michael PLUESS, Auteur Article en page(s) : p.1921-1933 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : While environmental adversity has been shown to increase risk for psychopathology, individuals differ in their sensitivity to these effects. Both genes and childhood experiences are thought to influence sensitivity to the environment, and these factors may operate synergistically such that the effects of childhood experiences on later sensitivity are greater in individuals who are more genetically sensitive. In line with this hypothesis, several recent studies have reported a significant three-way interaction (Gene × Environment × Environment) between two candidate genes and childhood and adult environment on adult psychopathology. We aimed to replicate and extend these findings in a large, prospective multiwave longitudinal study using a polygenic score of environmental sensitivity and objectively measured childhood and adult material environmental quality. We found evidence for both Environment × Environment and Gene × Environment × Environment effects on psychological distress. Children with a poor-quality material environment were more sensitive to the negative effects of a poor environment as adults, reporting significantly higher psychological distress scores. These effects were further moderated by a polygenic score of environmental sensitivity. Genetically sensitive children were more vulnerable to adversity as adults, if they had experienced a poor childhood environment but were significantly less vulnerable if their childhood environment was positive. These findings are in line with the differential susceptibility hypothesis and suggest that a life course approach is necessary to elucidate the role of Gene × Environment in the development of mental illnesses. En ligne : http://dx.doi.org/10.1017/S0954579417001493 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 [article] Childhood quality influences genetic sensitivity to environmental influences across adulthood: A life-course Gene × Environment interaction study [Texte imprimé et/ou numérique] / Robert KEERS, Auteur ; Michael PLUESS, Auteur . - p.1921-1933. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1921-1933 Index. décimale : PER Périodiques Résumé : While environmental adversity has been shown to increase risk for psychopathology, individuals differ in their sensitivity to these effects. Both genes and childhood experiences are thought to influence sensitivity to the environment, and these factors may operate synergistically such that the effects of childhood experiences on later sensitivity are greater in individuals who are more genetically sensitive. In line with this hypothesis, several recent studies have reported a significant three-way interaction (Gene × Environment × Environment) between two candidate genes and childhood and adult environment on adult psychopathology. We aimed to replicate and extend these findings in a large, prospective multiwave longitudinal study using a polygenic score of environmental sensitivity and objectively measured childhood and adult material environmental quality. We found evidence for both Environment × Environment and Gene × Environment × Environment effects on psychological distress. Children with a poor-quality material environment were more sensitive to the negative effects of a poor environment as adults, reporting significantly higher psychological distress scores. These effects were further moderated by a polygenic score of environmental sensitivity. Genetically sensitive children were more vulnerable to adversity as adults, if they had experienced a poor childhood environment but were significantly less vulnerable if their childhood environment was positive. These findings are in line with the differential susceptibility hypothesis and suggest that a life course approach is necessary to elucidate the role of Gene × Environment in the development of mental illnesses. En ligne : http://dx.doi.org/10.1017/S0954579417001493 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324

Childhood abuse and neglect and physical health at midlife: Prospective, longitudinal evidence / William F. JOHNSON in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1935-1946 Titre : Childhood abuse and neglect and physical health at midlife: Prospective, longitudinal evidence Type de document : Texte imprimé et/ou numérique Auteurs : William F. JOHNSON, Auteur ; Chloe O. HUELSNITZ, Auteur ; Elizabeth A. CARLSON, Auteur ; Glenn I. ROISMAN, Auteur ; Michelle M. ENGLUND, Auteur ; Gregory E. MILLER, Auteur ; Jeffry A. SIMPSON, Auteur Article en page(s) : p.1935-1946 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Previous research suggests that the experience of abuse and neglect in childhood has negative implications for physical health in adulthood. Using data from the Minnesota Longitudinal Study of Risk and Adaptation (N = 115), the present research examined the predictive significance of childhood physical abuse, sexual abuse, and physical/cognitive neglect for multilevel assessments of physical health at midlife (age 37–39 years), including biomarkers of cardiometabolic risk, self-reports of quality of health, and a number of health problems. Analyses revealed that childhood physical/cognitive neglect, but not physical or sexual abuse, predicted all three health outcomes in middle adulthood, even when controlling for demographic risk factors and adult health maintenance behaviors. We discuss possible explanations for the unique significance of neglect in this study and suggest future research that could clarify previous findings regarding the differential impact of different types of abuse and neglect on adult health. En ligne : http://dx.doi.org/10.1017/S095457941700150X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 [article] Childhood abuse and neglect and physical health at midlife: Prospective, longitudinal evidence [Texte imprimé et/ou numérique] / William F. JOHNSON, Auteur ; Chloe O. HUELSNITZ, Auteur ; Elizabeth A. CARLSON, Auteur ; Glenn I. ROISMAN, Auteur ; Michelle M. ENGLUND, Auteur ; Gregory E. MILLER, Auteur ; Jeffry A. SIMPSON, Auteur . - p.1935-1946. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1935-1946 Index. décimale : PER Périodiques Résumé : Previous research suggests that the experience of abuse and neglect in childhood has negative implications for physical health in adulthood. Using data from the Minnesota Longitudinal Study of Risk and Adaptation (N = 115), the present research examined the predictive significance of childhood physical abuse, sexual abuse, and physical/cognitive neglect for multilevel assessments of physical health at midlife (age 37–39 years), including biomarkers of cardiometabolic risk, self-reports of quality of health, and a number of health problems. Analyses revealed that childhood physical/cognitive neglect, but not physical or sexual abuse, predicted all three health outcomes in middle adulthood, even when controlling for demographic risk factors and adult health maintenance behaviors. We discuss possible explanations for the unique significance of neglect in this study and suggest future research that could clarify previous findings regarding the differential impact of different types of abuse and neglect on adult health. En ligne : http://dx.doi.org/10.1017/S095457941700150X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324

Assessing the interplay between multigenic and environmental influences on adolescent to adult pathways of antisocial behaviors / James J. LI in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1947-1967 Titre : Assessing the interplay between multigenic and environmental influences on adolescent to adult pathways of antisocial behaviors Type de document : Texte imprimé et/ou numérique Auteurs : James J. LI, Auteur Article en page(s) : p.1947-1967 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The current investigation utilized a developmental psychopathology approach to test the hypothesis that multigenic (i.e., dopaminergic and serotonergic genes) and multienvironmental factors interactively contribute to developmental pathways of antisocial behavior (ASB). A sample of 8,834 Caucasian individuals from the National Longitudinal Study of Adolescent to Adult Health (Add Health) were used to (a) examine the developmental pathways of ASB from age 13 to 32 using growth mixture modeling, (b) compute weighted multigenic risk scores (Add Health MRS) for ASB from six well-characterized polymorphisms in dopamine and serotonin genes, and (c) test the interaction between the Add Health MRS and a measures of support (incorporating indicators of both positive and negative support from parents and schools). Four pathways of adolescent to adult ASB emerged from the growth mixture models: low, adolescence-peaked, high decline, and persistent. Add Health MRS predicted the persistent ASB pathway, but not other ASB pathways. Males with high Add Health MRS, but not low MRS, had significantly greater odds of being in the adolescence-peaked pathway relative to the low pathway at low levels of school connectedness. Nonfamilial environmental influences during adolescence may have a cumulative impact on the development of ASB, particularly among males with greater underlying genetic risks. En ligne : http://dx.doi.org/10.1017/S0954579417001511 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 [article] Assessing the interplay between multigenic and environmental influences on adolescent to adult pathways of antisocial behaviors [Texte imprimé et/ou numérique] / James J. LI, Auteur . - p.1947-1967. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1947-1967 Index. décimale : PER Périodiques Résumé : The current investigation utilized a developmental psychopathology approach to test the hypothesis that multigenic (i.e., dopaminergic and serotonergic genes) and multienvironmental factors interactively contribute to developmental pathways of antisocial behavior (ASB). A sample of 8,834 Caucasian individuals from the National Longitudinal Study of Adolescent to Adult Health (Add Health) were used to (a) examine the developmental pathways of ASB from age 13 to 32 using growth mixture modeling, (b) compute weighted multigenic risk scores (Add Health MRS) for ASB from six well-characterized polymorphisms in dopamine and serotonin genes, and (c) test the interaction between the Add Health MRS and a measures of support (incorporating indicators of both positive and negative support from parents and schools). Four pathways of adolescent to adult ASB emerged from the growth mixture models: low, adolescence-peaked, high decline, and persistent. Add Health MRS predicted the persistent ASB pathway, but not other ASB pathways. Males with high Add Health MRS, but not low MRS, had significantly greater odds of being in the adolescence-peaked pathway relative to the low pathway at low levels of school connectedness. Nonfamilial environmental influences during adolescence may have a cumulative impact on the development of ASB, particularly among males with greater underlying genetic risks. En ligne : http://dx.doi.org/10.1017/S0954579417001511 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324

When inflammation and depression go together: The longitudinal effects of parent–child relationships / Steven R. H. BEACH in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1969-1986 Titre : When inflammation and depression go together: The longitudinal effects of parent–child relationships Type de document : Texte imprimé et/ou numérique Auteurs : Steven R. H. BEACH, Auteur ; Man Kit LEI, Auteur ; Ronald L. SIMONS, Auteur ; Ashley B. BARR, Auteur ; Leslie G. SIMONS, Auteur ; Katherine EHRLICH, Auteur ; Gene H. BRODY, Auteur ; Robert A. PHILIBERT, Auteur Article en page(s) : p.1969-1986 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Parent–child relationships have long-term effects on health, particularly later inflammation and depression. We hypothesized that these effects would be mediated by later romantic partner relationships and elevated stressors in young adulthood, helping promote chronic, low grade, inflammation as well as depressive symptoms, and driving their covariation. It has been proposed recently that youth experiencing harsher parenting may also develop a stronger association between inflammation and depressive symptoms in adulthood and altered effects of stressors on outcomes. In the current investigation, we test these ideas using an 18-year longitudinal study of N = 413 African American youth that provides assessment of the parent–child relationship (at age 10), pro-inflammatory cytokine profile and depressive symptoms (at age 28), and potential mediators in early young adulthood (assessed at ages 21 and 24). As predicted, the effect of harsher parent–child relationships (age 10) on pro-inflammatory state and increased depressive symptoms at age 28 were fully mediated through young adult stress and romantic partner relationships. In addition, beyond these mediated effects, parent–child relationships at age 10 moderated the concurrent association between inflammation and depressive symptoms, as well as the prospective association between romantic partner relationships and inflammation, and resulted in substantially different patterns of indirect effects from young adult mediators to outcomes. The results support theorizing that the association of depression and inflammation in young adulthood is conditional on earlier parenting, and suggest incorporating this perspective into models predicting long-term health outcomes. En ligne : http://dx.doi.org/10.1017/S0954579417001523 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 [article] When inflammation and depression go together: The longitudinal effects of parent–child relationships [Texte imprimé et/ou numérique] / Steven R. H. BEACH, Auteur ; Man Kit LEI, Auteur ; Ronald L. SIMONS, Auteur ; Ashley B. BARR, Auteur ; Leslie G. SIMONS, Auteur ; Katherine EHRLICH, Auteur ; Gene H. BRODY, Auteur ; Robert A. PHILIBERT, Auteur . - p.1969-1986. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1969-1986 Index. décimale : PER Périodiques Résumé : Parent–child relationships have long-term effects on health, particularly later inflammation and depression. We hypothesized that these effects would be mediated by later romantic partner relationships and elevated stressors in young adulthood, helping promote chronic, low grade, inflammation as well as depressive symptoms, and driving their covariation. It has been proposed recently that youth experiencing harsher parenting may also develop a stronger association between inflammation and depressive symptoms in adulthood and altered effects of stressors on outcomes. In the current investigation, we test these ideas using an 18-year longitudinal study of N = 413 African American youth that provides assessment of the parent–child relationship (at age 10), pro-inflammatory cytokine profile and depressive symptoms (at age 28), and potential mediators in early young adulthood (assessed at ages 21 and 24). As predicted, the effect of harsher parent–child relationships (age 10) on pro-inflammatory state and increased depressive symptoms at age 28 were fully mediated through young adult stress and romantic partner relationships. In addition, beyond these mediated effects, parent–child relationships at age 10 moderated the concurrent association between inflammation and depressive symptoms, as well as the prospective association between romantic partner relationships and inflammation, and resulted in substantially different patterns of indirect effects from young adult mediators to outcomes. The results support theorizing that the association of depression and inflammation in young adulthood is conditional on earlier parenting, and suggest incorporating this perspective into models predicting long-term health outcomes. En ligne : http://dx.doi.org/10.1017/S0954579417001523 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324