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Détail de l'auteur
Auteur P. C. FLETCHER |
Documents disponibles écrits par cet auteur (2)
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An Examination of Handedness and Footedness in Children with High Functioning Autism and Asperger Syndrome / R. MARKOULAKIS in Journal of Autism and Developmental Disorders, 42-10 (October 2012)
[article]
Titre : An Examination of Handedness and Footedness in Children with High Functioning Autism and Asperger Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : R. MARKOULAKIS, Auteur ; S. M. SCHAROUN, Auteur ; P.J. BRYDEN, Auteur ; P. C. FLETCHER, Auteur Année de publication : 2012 Article en page(s) : p.2192-2201 Langues : Anglais (eng) Mots-clés : Motor control Footedness High functioning autism Asperger’s syndrome Index. décimale : PER Périodiques Résumé : Motor control deficits have been documented in children with high functioning autism and Asperger syndrome (HFA/AS), but the extent to which these disorders affect the children’s footedness must be delineated. Twelve typically developing (TD) children and 12 children with HFA/AS, ages 6–9 years, were recruited. Motor control skills were assessed through a variety of footedness tasks to determine location and nature of impairment, regarding motor dominance. Overall, greater inconsistencies in dominance arose in children with HFA/AS, through disparities in measures of preference. Results will have broader implications for understanding motor impairments in children with HFA/AS as determined by comparing performance on footedness tasks, as well as for the design of interventions to account for these deficits. En ligne : http://dx.doi.org/10.1007/s10803-012-1469-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180
in Journal of Autism and Developmental Disorders > 42-10 (October 2012) . - p.2192-2201[article] An Examination of Handedness and Footedness in Children with High Functioning Autism and Asperger Syndrome [Texte imprimé et/ou numérique] / R. MARKOULAKIS, Auteur ; S. M. SCHAROUN, Auteur ; P.J. BRYDEN, Auteur ; P. C. FLETCHER, Auteur . - 2012 . - p.2192-2201.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-10 (October 2012) . - p.2192-2201
Mots-clés : Motor control Footedness High functioning autism Asperger’s syndrome Index. décimale : PER Périodiques Résumé : Motor control deficits have been documented in children with high functioning autism and Asperger syndrome (HFA/AS), but the extent to which these disorders affect the children’s footedness must be delineated. Twelve typically developing (TD) children and 12 children with HFA/AS, ages 6–9 years, were recruited. Motor control skills were assessed through a variety of footedness tasks to determine location and nature of impairment, regarding motor dominance. Overall, greater inconsistencies in dominance arose in children with HFA/AS, through disparities in measures of preference. Results will have broader implications for understanding motor impairments in children with HFA/AS as determined by comparing performance on footedness tasks, as well as for the design of interventions to account for these deficits. En ligne : http://dx.doi.org/10.1007/s10803-012-1469-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180 Psychopathology and cognitive performance in individuals with membrane-associated guanylate kinase mutations: a functional network phenotyping study / K. BAKER in Journal of Neurodevelopmental Disorders, 7-1 (December 2015)
[article]
Titre : Psychopathology and cognitive performance in individuals with membrane-associated guanylate kinase mutations: a functional network phenotyping study Type de document : Texte imprimé et/ou numérique Auteurs : K. BAKER, Auteur ; G. SCERIF, Auteur ; Duncan E. ASTLE, Auteur ; P. C. FLETCHER, Auteur ; F. L. RAYMOND, Auteur Article en page(s) : p.8 Langues : Anglais (eng) Mots-clés : Cognition Dlg3 Genetics Intellectual disability Maguk Psychiatric disorders Index. décimale : PER Périodiques Résumé : BACKGROUND: Rare pathogenic variants in membrane-associated guanylate kinase (MAGUK) genes cause intellectual disability (ID) and have recently been associated with neuropsychiatric risk in the non-ID population. However, it is not known whether risk for psychiatric symptoms amongst individuals with ID due to MAGUK gene mutations is higher than expected for the degree of general intellectual impairment, nor whether specific cognitive differences are associated with disruption to this gene functional network. METHODS: This study addresses these two questions via behavioural questionnaires and cognitive testing, applying quantitative methods previously validated in populations with ID. We compared males with X-linked ID caused by mutations in three MAGUK genes (PAK3, DLG3, OPHN1; n = 9) to males with ID caused by mutations in other X chromosome genes (n = 17). Non-parametric and parametric analyses were applied as appropriate to data. RESULTS: Groups did not differ in age, global cognitive impairment, adaptive function or epilepsy prevalence. However, individuals with MAGUK gene mutations demonstrated significantly higher psychopathology risks, comprising elevated total problem behaviours, prominent hyperactivity and elevated scores on an autism screening checklist. Despite these overt difficulties, individuals in the MAGUK group performed more accurately than expected for age and intelligence quotient (IQ) on computerised tests of visual attention, convergent with mouse models of MAGUK loss-of-function. CONCLUSIONS: Our findings support a role for MAGUK genes in influencing cognitive parameters relevant to psychiatric risk. In addition to establishing clear patterns of impairment for this group, our findings highlight the importance of careful phenotyping after genetic diagnosis, showing that gene functional network disruptions can be associated with specific psychopathological risks and cognitive differences within the context of ID. En ligne : http://dx.doi.org/10.1186/s11689-015-9105-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347
in Journal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.8[article] Psychopathology and cognitive performance in individuals with membrane-associated guanylate kinase mutations: a functional network phenotyping study [Texte imprimé et/ou numérique] / K. BAKER, Auteur ; G. SCERIF, Auteur ; Duncan E. ASTLE, Auteur ; P. C. FLETCHER, Auteur ; F. L. RAYMOND, Auteur . - p.8.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.8
Mots-clés : Cognition Dlg3 Genetics Intellectual disability Maguk Psychiatric disorders Index. décimale : PER Périodiques Résumé : BACKGROUND: Rare pathogenic variants in membrane-associated guanylate kinase (MAGUK) genes cause intellectual disability (ID) and have recently been associated with neuropsychiatric risk in the non-ID population. However, it is not known whether risk for psychiatric symptoms amongst individuals with ID due to MAGUK gene mutations is higher than expected for the degree of general intellectual impairment, nor whether specific cognitive differences are associated with disruption to this gene functional network. METHODS: This study addresses these two questions via behavioural questionnaires and cognitive testing, applying quantitative methods previously validated in populations with ID. We compared males with X-linked ID caused by mutations in three MAGUK genes (PAK3, DLG3, OPHN1; n = 9) to males with ID caused by mutations in other X chromosome genes (n = 17). Non-parametric and parametric analyses were applied as appropriate to data. RESULTS: Groups did not differ in age, global cognitive impairment, adaptive function or epilepsy prevalence. However, individuals with MAGUK gene mutations demonstrated significantly higher psychopathology risks, comprising elevated total problem behaviours, prominent hyperactivity and elevated scores on an autism screening checklist. Despite these overt difficulties, individuals in the MAGUK group performed more accurately than expected for age and intelligence quotient (IQ) on computerised tests of visual attention, convergent with mouse models of MAGUK loss-of-function. CONCLUSIONS: Our findings support a role for MAGUK genes in influencing cognitive parameters relevant to psychiatric risk. In addition to establishing clear patterns of impairment for this group, our findings highlight the importance of careful phenotyping after genetic diagnosis, showing that gene functional network disruptions can be associated with specific psychopathological risks and cognitive differences within the context of ID. En ligne : http://dx.doi.org/10.1186/s11689-015-9105-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347