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Auteur Eric DUKU |
Documents disponibles écrits par cet auteur (40)
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Helping Children Adjust—a Tri-Ministry Study: II. Program Effects / Joel HUNDERT in Journal of Child Psychology and Psychiatry, 40-7 (October 1999)
[article]
Titre : Helping Children Adjust—a Tri-Ministry Study: II. Program Effects Type de document : Texte imprimé et/ou numérique Auteurs : Joel HUNDERT, Auteur ; Michael H. BOYLE, Auteur ; Charles E. CUNNINGHAM, Auteur ; Eric DUKU, Auteur ; JoAnn HEALE, Auteur ; Jan MCDONALD, Auteur ; David R. OFFORD, Auteur ; Yvonne RACINE, Auteur Année de publication : 1999 Article en page(s) : p.1061-1073 Langues : Anglais (eng) Mots-clés : Behaviour problems longitudinal studies prevention reading school social skills training Index. décimale : PER Périodiques Résumé : This report describes program effects of the Tri-Ministry Study—a school-based, longitudinal trial carried out over a 5-year period to assess the effectiveness of classwide social skills training (SS), partner reading (RE), and a combination of both (SS & RE) to reduce maladjustment among children in the primary division (up to grade 3) of Ontario schools. It also places these effects in the context of other school-based prevention studies and discusses them in view of important methodological and programmatic issues. The incremental effects attributable to the intervention programs were small and sporadic. There were statistically significant increases in prosocial behaviour observed in the playgrounds of intervention schools with no differentiation by program type. Furthermore, there was some evidence—a reduction in teacher and parent-rated externalising problems—that the combination of SS & RE and SS alone may have had modest beneficial effects. A review of nine other school-based studies, which evaluated universally delivered mental health prevention programs in general populations of students, revealed similar mixed results. There are both methodologic and programmatic issues implicated in the weak findings that have been reported to date. These issues need to be addressed to advance knowledge about the potential impact of mental-health prevention initiatives delivered universally through school-based programs. A companion paper gives the specific details on the programs, randomisation of schools, selection of subjects, measurements, and analysis. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=124
in Journal of Child Psychology and Psychiatry > 40-7 (October 1999) . - p.1061-1073[article] Helping Children Adjust—a Tri-Ministry Study: II. Program Effects [Texte imprimé et/ou numérique] / Joel HUNDERT, Auteur ; Michael H. BOYLE, Auteur ; Charles E. CUNNINGHAM, Auteur ; Eric DUKU, Auteur ; JoAnn HEALE, Auteur ; Jan MCDONALD, Auteur ; David R. OFFORD, Auteur ; Yvonne RACINE, Auteur . - 1999 . - p.1061-1073.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 40-7 (October 1999) . - p.1061-1073
Mots-clés : Behaviour problems longitudinal studies prevention reading school social skills training Index. décimale : PER Périodiques Résumé : This report describes program effects of the Tri-Ministry Study—a school-based, longitudinal trial carried out over a 5-year period to assess the effectiveness of classwide social skills training (SS), partner reading (RE), and a combination of both (SS & RE) to reduce maladjustment among children in the primary division (up to grade 3) of Ontario schools. It also places these effects in the context of other school-based prevention studies and discusses them in view of important methodological and programmatic issues. The incremental effects attributable to the intervention programs were small and sporadic. There were statistically significant increases in prosocial behaviour observed in the playgrounds of intervention schools with no differentiation by program type. Furthermore, there was some evidence—a reduction in teacher and parent-rated externalising problems—that the combination of SS & RE and SS alone may have had modest beneficial effects. A review of nine other school-based studies, which evaluated universally delivered mental health prevention programs in general populations of students, revealed similar mixed results. There are both methodologic and programmatic issues implicated in the weak findings that have been reported to date. These issues need to be addressed to advance knowledge about the potential impact of mental-health prevention initiatives delivered universally through school-based programs. A companion paper gives the specific details on the programs, randomisation of schools, selection of subjects, measurements, and analysis. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=124 Impact of personal and social resources on parenting stress in mothers of children with autism spectrum disorder / Anat ZAIDMAN-ZAIT in Autism, 21-2 (February 2017)
[article]
Titre : Impact of personal and social resources on parenting stress in mothers of children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Anat ZAIDMAN-ZAIT, Auteur ; Pat MIRENDA, Auteur ; Eric DUKU, Auteur ; Tracy VAILLANCOURT, Auteur ; Isabel M. SMITH, Auteur ; Peter SZATMARI, Auteur ; Susan E. BRYSON, Auteur ; Eric FOMBONNE, Auteur ; Joanne VOLDEN, Auteur ; Charlotte WADDELL, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Stelios GEORGIADES, Auteur ; Teresa BENNETT, Auteur ; Mayada ELSABAGGH, Auteur ; Ann THOMPSON, Auteur Article en page(s) : p.155-166 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study examined the longitudinal associations between child behavior problems, coping strategies, social resources, and parenting stress in mothers of young children with autism spectrum disorder. Participants were 283 mothers who completed self- and child-report measures at the time of diagnosis and 2?years later. Hierarchical multiple regression was conducted to predict overall parenting stress. At diagnosis, the final model indicated that high levels of social support and mothers? use of active engaged coping strategies were associated with lower levels of parenting stress. Conversely, high levels of child externalizing behavior problems, family dysfunction, and mothers? use of disengaged coping strategies were associated with higher parenting stress. Two years later, high levels of parenting stress at diagnosis predicted increased parenting stress. In addition, high or increasing levels of social support predicted a decrease in parenting stress, while high or increasing levels of family dysfunction predicted increased stress. Finally, increased use of disengaged coping strategies and decreased use of active coping strategies over time predicted higher levels of parenting stress. Results are discussed in terms of their implications for the provision of targeted supports that are designed to enhance the personal and social resources available to mothers of children with autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361316633033 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303
in Autism > 21-2 (February 2017) . - p.155-166[article] Impact of personal and social resources on parenting stress in mothers of children with autism spectrum disorder [Texte imprimé et/ou numérique] / Anat ZAIDMAN-ZAIT, Auteur ; Pat MIRENDA, Auteur ; Eric DUKU, Auteur ; Tracy VAILLANCOURT, Auteur ; Isabel M. SMITH, Auteur ; Peter SZATMARI, Auteur ; Susan E. BRYSON, Auteur ; Eric FOMBONNE, Auteur ; Joanne VOLDEN, Auteur ; Charlotte WADDELL, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Stelios GEORGIADES, Auteur ; Teresa BENNETT, Auteur ; Mayada ELSABAGGH, Auteur ; Ann THOMPSON, Auteur . - p.155-166.
Langues : Anglais (eng)
in Autism > 21-2 (February 2017) . - p.155-166
Index. décimale : PER Périodiques Résumé : This study examined the longitudinal associations between child behavior problems, coping strategies, social resources, and parenting stress in mothers of young children with autism spectrum disorder. Participants were 283 mothers who completed self- and child-report measures at the time of diagnosis and 2?years later. Hierarchical multiple regression was conducted to predict overall parenting stress. At diagnosis, the final model indicated that high levels of social support and mothers? use of active engaged coping strategies were associated with lower levels of parenting stress. Conversely, high levels of child externalizing behavior problems, family dysfunction, and mothers? use of disengaged coping strategies were associated with higher parenting stress. Two years later, high levels of parenting stress at diagnosis predicted increased parenting stress. In addition, high or increasing levels of social support predicted a decrease in parenting stress, while high or increasing levels of family dysfunction predicted increased stress. Finally, increased use of disengaged coping strategies and decreased use of active coping strategies over time predicted higher levels of parenting stress. Results are discussed in terms of their implications for the provision of targeted supports that are designed to enhance the personal and social resources available to mothers of children with autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361316633033 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 Inattention and hyperactive/impulsive component scores do not differentiate between autism spectrum disorder and attention-deficit/hyperactivity disorder in a clinical sample / Aneta D. KRAKOWSKI in Molecular Autism, 11 (2020)
[article]
Titre : Inattention and hyperactive/impulsive component scores do not differentiate between autism spectrum disorder and attention-deficit/hyperactivity disorder in a clinical sample Type de document : Texte imprimé et/ou numérique Auteurs : Aneta D. KRAKOWSKI, Auteur ; Katherine Tombeau COST, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Meng-Chuan LAI, Auteur ; Jennifer CROSBIE, Auteur ; Russell SCHACHAR, Auteur ; Stelios GEORGIADES, Auteur ; Eric DUKU, Auteur ; Peter SZATMARI, Auteur Année de publication : 2020 Article en page(s) : 28 p. Langues : Anglais (eng) Mots-clés : adhd asd Co-morbidity Gender Principle component analysis Symptoms scientific advisory board for ehave (psychological software company). RS also has equity in ehave. EA has received consultation fees from Roche and Takeda, royalties from APPI and Springer, and funding from SynapDx and Sanofi-Aventis. PS has received royalties from Guilford Press. AK, KTC, MCL, JC, ED, and SG have no conflicts of interest to declare. Index. décimale : PER Périodiques Résumé : BACKGROUND: Although there is high co-occurrence between ASD and ADHD, the nature of this co-occurrence remains unclear. Our study aimed to examine the underlying relationship between ASD and ADHD symptoms in a combined sample of children with a primary clinical diagnosis of ASD or ADHD. METHODS: Participants included children and youth (aged 3-20?years) with a clinical diagnosis of ASD (n = 303) or ADHD (n = 319) for a total of 622 participants. Parents of these children completed the social communication questionnaire (SCQ), a measure of autism symptoms, and the strengths and weaknesses of ADHD and normal behavior (SWAN) questionnaire, a measure of ADHD symptoms. A principal component analysis (PCA) was performed on combined SCQ and SWAN items, followed by a profile analysis comparing normalized component scores between diagnostic groups and gender. RESULTS: PCA revealed a four-component solution (inattention, hyperactivity/impulsivity, social-communication, and restricted, repetitive, behaviors, and interests (RRBI)), with no overlap between SCQ and SWAN items in the components. Children with ASD had higher component scores in social-communication and RRBI than children with ADHD, while there was no difference in inattentive and hyperactive/impulsive scores between diagnostic groups. Males had higher scores than females in social-communication, RRBI, and hyperactivity/impulsivity components in each diagnostic group. LIMITATIONS: We did not formally assess children with ASD for ADHD using our research-criteria for ADHD, and vice versa. High rates of co-occurring ADHD in ASD, for example, may have inflated component scores in inattention and hyperactivity/impulsivity. A disadvantage with using single informant-based reports (i.e., parent-rated questionnaires) is that ASD and ADHD symptoms may be difficult to distinguish by parents, and may be interpreted differently between parents and clinicians. CONCLUSIONS: ASD and ADHD items loaded on separate components in our sample, suggesting that the measurement structure cannot explain the covariation between the two disorders in clinical samples. High levels of inattention and hyperactivity/impulsivity were seen in both ASD and ADHD in our clinical sample. This supports the need for a dimensional framework that examines neurodevelopmental domains across traditional diagnostic boundaries. Females also had lower component scores across social-communication, RRBI, and hyperactivity/impulsivity than males, suggesting that there may be gender-specific phenotypes related to the two conditions. En ligne : http://dx.doi.org/10.1186/s13229-020-00338-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427
in Molecular Autism > 11 (2020) . - 28 p.[article] Inattention and hyperactive/impulsive component scores do not differentiate between autism spectrum disorder and attention-deficit/hyperactivity disorder in a clinical sample [Texte imprimé et/ou numérique] / Aneta D. KRAKOWSKI, Auteur ; Katherine Tombeau COST, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Meng-Chuan LAI, Auteur ; Jennifer CROSBIE, Auteur ; Russell SCHACHAR, Auteur ; Stelios GEORGIADES, Auteur ; Eric DUKU, Auteur ; Peter SZATMARI, Auteur . - 2020 . - 28 p.
Langues : Anglais (eng)
in Molecular Autism > 11 (2020) . - 28 p.
Mots-clés : adhd asd Co-morbidity Gender Principle component analysis Symptoms scientific advisory board for ehave (psychological software company). RS also has equity in ehave. EA has received consultation fees from Roche and Takeda, royalties from APPI and Springer, and funding from SynapDx and Sanofi-Aventis. PS has received royalties from Guilford Press. AK, KTC, MCL, JC, ED, and SG have no conflicts of interest to declare. Index. décimale : PER Périodiques Résumé : BACKGROUND: Although there is high co-occurrence between ASD and ADHD, the nature of this co-occurrence remains unclear. Our study aimed to examine the underlying relationship between ASD and ADHD symptoms in a combined sample of children with a primary clinical diagnosis of ASD or ADHD. METHODS: Participants included children and youth (aged 3-20?years) with a clinical diagnosis of ASD (n = 303) or ADHD (n = 319) for a total of 622 participants. Parents of these children completed the social communication questionnaire (SCQ), a measure of autism symptoms, and the strengths and weaknesses of ADHD and normal behavior (SWAN) questionnaire, a measure of ADHD symptoms. A principal component analysis (PCA) was performed on combined SCQ and SWAN items, followed by a profile analysis comparing normalized component scores between diagnostic groups and gender. RESULTS: PCA revealed a four-component solution (inattention, hyperactivity/impulsivity, social-communication, and restricted, repetitive, behaviors, and interests (RRBI)), with no overlap between SCQ and SWAN items in the components. Children with ASD had higher component scores in social-communication and RRBI than children with ADHD, while there was no difference in inattentive and hyperactive/impulsive scores between diagnostic groups. Males had higher scores than females in social-communication, RRBI, and hyperactivity/impulsivity components in each diagnostic group. LIMITATIONS: We did not formally assess children with ASD for ADHD using our research-criteria for ADHD, and vice versa. High rates of co-occurring ADHD in ASD, for example, may have inflated component scores in inattention and hyperactivity/impulsivity. A disadvantage with using single informant-based reports (i.e., parent-rated questionnaires) is that ASD and ADHD symptoms may be difficult to distinguish by parents, and may be interpreted differently between parents and clinicians. CONCLUSIONS: ASD and ADHD items loaded on separate components in our sample, suggesting that the measurement structure cannot explain the covariation between the two disorders in clinical samples. High levels of inattention and hyperactivity/impulsivity were seen in both ASD and ADHD in our clinical sample. This supports the need for a dimensional framework that examines neurodevelopmental domains across traditional diagnostic boundaries. Females also had lower component scores across social-communication, RRBI, and hyperactivity/impulsivity than males, suggesting that there may be gender-specific phenotypes related to the two conditions. En ligne : http://dx.doi.org/10.1186/s13229-020-00338-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 Influence of reporting effects on the association between maternal depression and child autism spectrum disorder behaviors / Teresa BENNETT in Journal of Child Psychology and Psychiatry, 53-1 (January 2012)
[article]
Titre : Influence of reporting effects on the association between maternal depression and child autism spectrum disorder behaviors Type de document : Texte imprimé et/ou numérique Auteurs : Teresa BENNETT, Auteur ; Michael H. BOYLE, Auteur ; Katholiki GEORGIADES, Auteur ; Stelios GEORGIADES, Auteur ; Ann THOMPSON, Auteur ; Eric DUKU, Auteur ; Susan E. BRYSON, Auteur ; Eric FOMBONNE, Auteur ; Tracy VAILLANCOURT, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Isabel M. SMITH, Auteur ; Pat MIRENDA, Auteur ; Wendy ROBERTS, Auteur ; Joanne VOLDEN, Auteur ; Charlotte WADDELL, Auteur ; THE PATHWAYS IN ASD STUDY TEAM, Auteur ; Peter SZATMARI, Auteur Année de publication : 2012 Article en page(s) : p.89-96 Langues : Anglais (eng) Mots-clés : Autistic disorder Asperger’s disorder methodology maternal depression structural equation modeling Index. décimale : PER Périodiques Résumé : Background: Maximizing measurement accuracy is an important aim in child development assessment and research. Parents are essential informants in the diagnostic process, and past research suggests that certain parental characteristics may influence how they report information about their children. This has not been studied in autism spectrum disorders (ASD) to date. We aimed, therefore, to investigate the possible effect that maternal depression might have on a mother’s reports of her child’s ASD behaviors. Using structural equation modeling, we disaggregated shared from unique variation in the association between latent variable measures of maternal depression and ASD behaviors. Methods: Data were obtained from a study of preschoolers aged 2–4 newly diagnosed with ASD (n = 214). Information from a parent questionnaire, a semi-structured parent interview, and a semi-structured observational assessment was used to develop a latent variable measure of child ASD behaviors. Mothers reported on their own depression symptoms. We first modeled the covariance between maternal depression and child ASD behavior. Then, to quantify unique variation, we added covariance terms between maternal depression and the residual variation associated with the individual measures of child ASD behaviors. Results: The model demonstrated excellent fit to the underlying data. Maternal self-report of depression symptoms exhibited a significant association with the unique variance of the questionnaire report but not with the latent variable measure of child ASD behavior. A gradient pattern of association was demonstrated between maternal depression and the unique variance of the ASD measures: most strongly for the maternal questionnaire report, more weakly for the maternal semi-structured interview, and to a trivial extent for the observational interview. Conclusions: Parental depression may influence reporting of ASD behaviors in preschoolers. Shared method effects may also contribute to bias. This finding highlights the importance of obtaining multimethod reports of child ASD symptoms. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02451.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=148
in Journal of Child Psychology and Psychiatry > 53-1 (January 2012) . - p.89-96[article] Influence of reporting effects on the association between maternal depression and child autism spectrum disorder behaviors [Texte imprimé et/ou numérique] / Teresa BENNETT, Auteur ; Michael H. BOYLE, Auteur ; Katholiki GEORGIADES, Auteur ; Stelios GEORGIADES, Auteur ; Ann THOMPSON, Auteur ; Eric DUKU, Auteur ; Susan E. BRYSON, Auteur ; Eric FOMBONNE, Auteur ; Tracy VAILLANCOURT, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Isabel M. SMITH, Auteur ; Pat MIRENDA, Auteur ; Wendy ROBERTS, Auteur ; Joanne VOLDEN, Auteur ; Charlotte WADDELL, Auteur ; THE PATHWAYS IN ASD STUDY TEAM, Auteur ; Peter SZATMARI, Auteur . - 2012 . - p.89-96.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 53-1 (January 2012) . - p.89-96
Mots-clés : Autistic disorder Asperger’s disorder methodology maternal depression structural equation modeling Index. décimale : PER Périodiques Résumé : Background: Maximizing measurement accuracy is an important aim in child development assessment and research. Parents are essential informants in the diagnostic process, and past research suggests that certain parental characteristics may influence how they report information about their children. This has not been studied in autism spectrum disorders (ASD) to date. We aimed, therefore, to investigate the possible effect that maternal depression might have on a mother’s reports of her child’s ASD behaviors. Using structural equation modeling, we disaggregated shared from unique variation in the association between latent variable measures of maternal depression and ASD behaviors. Methods: Data were obtained from a study of preschoolers aged 2–4 newly diagnosed with ASD (n = 214). Information from a parent questionnaire, a semi-structured parent interview, and a semi-structured observational assessment was used to develop a latent variable measure of child ASD behaviors. Mothers reported on their own depression symptoms. We first modeled the covariance between maternal depression and child ASD behavior. Then, to quantify unique variation, we added covariance terms between maternal depression and the residual variation associated with the individual measures of child ASD behaviors. Results: The model demonstrated excellent fit to the underlying data. Maternal self-report of depression symptoms exhibited a significant association with the unique variance of the questionnaire report but not with the latent variable measure of child ASD behavior. A gradient pattern of association was demonstrated between maternal depression and the unique variance of the ASD measures: most strongly for the maternal questionnaire report, more weakly for the maternal semi-structured interview, and to a trivial extent for the observational interview. Conclusions: Parental depression may influence reporting of ASD behaviors in preschoolers. Shared method effects may also contribute to bias. This finding highlights the importance of obtaining multimethod reports of child ASD symptoms. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02451.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=148 Investigating phenotypic heterogeneity in children with autism spectrum disorder: a factor mixture modeling approach / Stelios GEORGIADES in Journal of Child Psychology and Psychiatry, 54-2 (February 2013)
[article]
Titre : Investigating phenotypic heterogeneity in children with autism spectrum disorder: a factor mixture modeling approach Type de document : Texte imprimé et/ou numérique Auteurs : Stelios GEORGIADES, Auteur ; Peter SZATMARI, Auteur ; Michael H. BOYLE, Auteur ; Steven HANNA, Auteur ; Eric DUKU, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Susan E. BRYSON, Auteur ; Eric FOMBONNE, Auteur ; Joanne VOLDEN, Auteur ; Pat MIRENDA, Auteur ; Isabel M. SMITH, Auteur ; Wendy ROBERTS, Auteur ; Tracy VAILLANCOURT, Auteur ; Charlotte WADDELL, Auteur ; Teresa BENNETT, Auteur ; Ann THOMPSON, Auteur ; PATHWAYS IN A. S. D. STUDY TEAM, Auteur Année de publication : 2013 Article en page(s) : p.206-215 Langues : Anglais (eng) Mots-clés : Symptomatology Autistic disorder Classification Diagnosis DSM Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorder (ASD) is characterized by notable phenotypic heterogeneity, which is often viewed as an obstacle to the study of its etiology, diagnosis, treatment, and prognosis. On the basis of empirical evidence, instead of three binary categories, the upcoming edition of the DSM 5 will use two dimensions – social communication deficits (SCD) and fixated interests and repetitive behaviors (FIRB) – for the ASD diagnostic criteria. Building on this proposed DSM 5 model, it would be useful to consider whether empirical data on the SCD and FIRB dimensions can be used within the novel methodological framework of Factor Mixture Modeling (FMM) to stratify children with ASD into more homogeneous subgroups. Methods: The study sample consisted of 391 newly diagnosed children (mean age 38.3 months; 330 males) with ASD. To derive subgroups, data from the Autism Diagnostic Interview-Revised indexing SCD and FIRB were used in FMM; FMM allows the examination of continuous dimensions and latent classes (i.e., categories) using both factor analysis (FA) and latent class analysis (LCA) as part of a single analytic framework. Results: Competing LCA, FA, and FMM models were fit to the data. On the basis of a set of goodness-of-fit criteria, a ‘two-factor/three-class' factor mixture model provided the overall best fit to the data. This model describes ASD using three subgroups/classes (Class 1: 34%, Class 2: 10%, Class 3: 56% of the sample) based on differential severity gradients on the SCD and FIRB symptom dimensions. In addition to having different symptom severity levels, children from these subgroups were diagnosed at different ages and were functioning at different adaptive, language, and cognitive levels. Conclusions: Study findings suggest that the two symptom dimensions of SCD and FIRB proposed for the DSM 5 can be used in FMM to stratify children with ASD empirically into three relatively homogeneous subgroups. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02588.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=188
in Journal of Child Psychology and Psychiatry > 54-2 (February 2013) . - p.206-215[article] Investigating phenotypic heterogeneity in children with autism spectrum disorder: a factor mixture modeling approach [Texte imprimé et/ou numérique] / Stelios GEORGIADES, Auteur ; Peter SZATMARI, Auteur ; Michael H. BOYLE, Auteur ; Steven HANNA, Auteur ; Eric DUKU, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Susan E. BRYSON, Auteur ; Eric FOMBONNE, Auteur ; Joanne VOLDEN, Auteur ; Pat MIRENDA, Auteur ; Isabel M. SMITH, Auteur ; Wendy ROBERTS, Auteur ; Tracy VAILLANCOURT, Auteur ; Charlotte WADDELL, Auteur ; Teresa BENNETT, Auteur ; Ann THOMPSON, Auteur ; PATHWAYS IN A. S. D. STUDY TEAM, Auteur . - 2013 . - p.206-215.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 54-2 (February 2013) . - p.206-215
Mots-clés : Symptomatology Autistic disorder Classification Diagnosis DSM Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorder (ASD) is characterized by notable phenotypic heterogeneity, which is often viewed as an obstacle to the study of its etiology, diagnosis, treatment, and prognosis. On the basis of empirical evidence, instead of three binary categories, the upcoming edition of the DSM 5 will use two dimensions – social communication deficits (SCD) and fixated interests and repetitive behaviors (FIRB) – for the ASD diagnostic criteria. Building on this proposed DSM 5 model, it would be useful to consider whether empirical data on the SCD and FIRB dimensions can be used within the novel methodological framework of Factor Mixture Modeling (FMM) to stratify children with ASD into more homogeneous subgroups. Methods: The study sample consisted of 391 newly diagnosed children (mean age 38.3 months; 330 males) with ASD. To derive subgroups, data from the Autism Diagnostic Interview-Revised indexing SCD and FIRB were used in FMM; FMM allows the examination of continuous dimensions and latent classes (i.e., categories) using both factor analysis (FA) and latent class analysis (LCA) as part of a single analytic framework. Results: Competing LCA, FA, and FMM models were fit to the data. On the basis of a set of goodness-of-fit criteria, a ‘two-factor/three-class' factor mixture model provided the overall best fit to the data. This model describes ASD using three subgroups/classes (Class 1: 34%, Class 2: 10%, Class 3: 56% of the sample) based on differential severity gradients on the SCD and FIRB symptom dimensions. In addition to having different symptom severity levels, children from these subgroups were diagnosed at different ages and were functioning at different adaptive, language, and cognitive levels. Conclusions: Study findings suggest that the two symptom dimensions of SCD and FIRB proposed for the DSM 5 can be used in FMM to stratify children with ASD empirically into three relatively homogeneous subgroups. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02588.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=188 Investigating the Measurement Properties of the Social Responsiveness Scale in Preschool Children with Autism Spectrum Disorders / Eric DUKU in Journal of Autism and Developmental Disorders, 43-4 (April 2013)
PermalinkJoint trajectories of internalizing and externalizing problems in preschool children with autism spectrum disorder / Tracy VAILLANCOURT in Development and Psychopathology, 29-1 (February 2017)
PermalinkLongitudinal associations between early childhood irritability and adolescent depression symptoms in autistic children are mediated by peer relationships but not educational engagement / Virginia CARTER LENO in Development and Psychopathology, 36-1 (February 2024)
PermalinkMeasurement equivalence of the autism symptom phenotype in children and youth / Eric DUKU in Journal of Child Psychology and Psychiatry, 54-12 (December 2013)
PermalinkMiddle-childhood executive functioning mediates associations between early-childhood autism symptoms and adolescent mental health, academic and functional outcomes in autistic children / Stephanie H. AMEIS in Journal of Child Psychology and Psychiatry, 63-5 (May 2022)
PermalinkModeling the Phenotypic Architecture of Autism Symptoms from Time of Diagnosis to Age 6 / Stelios GEORGIADES in Journal of Autism and Developmental Disorders, 44-12 (December 2014)
PermalinkParent-Reported Rates and Clinical Correlates of Suicidality in Children with Autism Spectrum Disorder: A Longitudinal Study / Michelle C. HUNSCHE in Journal of Autism and Developmental Disorders, 50-10 (October 2020)
PermalinkPhenotypic Overlap Between Core Diagnostic Features and Emotional/Behavioral Problems in Preschool Children with Autism Spectrum Disorder / Stelios GEORGIADES in Journal of Autism and Developmental Disorders, 41-10 (October 2011)
PermalinkPredicting borderline personality disorder symptoms in adolescents from childhood physical and relational aggression, depression, and attention-deficit/hyperactivity disorder / Tracy VAILLANCOURT in Development and Psychopathology, 26-3 (August 2014)
PermalinkPredictors of language regression and its association with subsequent communication development in children with autism / Andrew PICKLES in Journal of Child Psychology and Psychiatry, 63-11 (November 2022)
Permalink