Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur R. E. GRUNAU |
Documents disponibles écrits par cet auteur (2)
Faire une suggestion Affiner la recherche
Atypical resting state neuromagnetic connectivity and spectral power in very preterm children / N. KOZHEMIAKO in Journal of Child Psychology and Psychiatry, 60-9 (September 2019)
[article]
Titre : Atypical resting state neuromagnetic connectivity and spectral power in very preterm children Type de document : Texte imprimé et/ou numérique Auteurs : N. KOZHEMIAKO, Auteur ; A. NUNES, Auteur ; V. A. VAKORIN, Auteur ; C. M. Y. CHAU, Auteur ; A. MOISEEV, Auteur ; U. RIBARY, Auteur ; R. E. GRUNAU, Auteur ; S. M. DOESBURG, Auteur Article en page(s) : p.975-987 Langues : Anglais (eng) Mots-clés : Very preterm children early adversity magnetoencephalography neonatal stress pain resting state connectivity Index. décimale : PER Périodiques Résumé : BACKGROUND: Children born very preterm often display selective cognitive difficulties at school age even in the absence of major brain injury. Alterations in neurophysiological activity underpinning such difficulties, as well as their relation to specific aspects of adverse neonatal experience, remain poorly understood. In the present study, we examined interregional connectivity and spectral power in very preterm children at school age, and their relationship with clinical neonatal variables and long-term outcomes (IQ, executive functions, externalizing/internalizing behavior, visual-motor integration). METHODS: We collected resting state magnetoencephalographic (MEG) and psychometric data from a cohort at the age of 8 years followed prospectively since birth, which included three groups: Extremely Low Gestational Age (ELGA, 24-28 weeks GA n = 24, age 7.7 +/- 0.38, 10 girls), Very Low Gestational Age (VLGA, 29-32 weeks GA n = 37, age 7.7 +/- 0.39, 24 girls), and full-term children (38-41 weeks GA n = 39, age 7.9 +/- 1.02, 24 girls). Interregional phase synchrony and spectral power were tested for group differences, and associations with neonatal and outcome variables were examined using mean-centered and behavioral Partial Least Squares (PLS) analyses, respectively. RESULTS: We found greater connectivity in the theta band in the ELGA group compared to VLGA and full-term groups, primarily involving frontal connections. Spectral power analysis demonstrated overall lower power in the ELGA and VLGA compared to full-term group. PLS indicated strong associations between neurophysiological connectivity at school age, adverse neonatal experience and cognitive performance, and behavior. Resting spectral power was associated only with behavioral scores. CONCLUSIONS: Our findings indicate significant atypicalities of neuromagnetic brain activity and connectivity in very preterm children at school age, with alterations in connectivity mainly observed only in the ELGA group. We demonstrate a significant relationship between connectivity, adverse neonatal experience, and long-term outcome, indicating that the disruption of developing neurophysiological networks may mediate relationships between neonatal events and cognitive and behavioral difficulties at school age. En ligne : http://dx.doi.org/10.1111/jcpp.13026 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405
in Journal of Child Psychology and Psychiatry > 60-9 (September 2019) . - p.975-987[article] Atypical resting state neuromagnetic connectivity and spectral power in very preterm children [Texte imprimé et/ou numérique] / N. KOZHEMIAKO, Auteur ; A. NUNES, Auteur ; V. A. VAKORIN, Auteur ; C. M. Y. CHAU, Auteur ; A. MOISEEV, Auteur ; U. RIBARY, Auteur ; R. E. GRUNAU, Auteur ; S. M. DOESBURG, Auteur . - p.975-987.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 60-9 (September 2019) . - p.975-987
Mots-clés : Very preterm children early adversity magnetoencephalography neonatal stress pain resting state connectivity Index. décimale : PER Périodiques Résumé : BACKGROUND: Children born very preterm often display selective cognitive difficulties at school age even in the absence of major brain injury. Alterations in neurophysiological activity underpinning such difficulties, as well as their relation to specific aspects of adverse neonatal experience, remain poorly understood. In the present study, we examined interregional connectivity and spectral power in very preterm children at school age, and their relationship with clinical neonatal variables and long-term outcomes (IQ, executive functions, externalizing/internalizing behavior, visual-motor integration). METHODS: We collected resting state magnetoencephalographic (MEG) and psychometric data from a cohort at the age of 8 years followed prospectively since birth, which included three groups: Extremely Low Gestational Age (ELGA, 24-28 weeks GA n = 24, age 7.7 +/- 0.38, 10 girls), Very Low Gestational Age (VLGA, 29-32 weeks GA n = 37, age 7.7 +/- 0.39, 24 girls), and full-term children (38-41 weeks GA n = 39, age 7.9 +/- 1.02, 24 girls). Interregional phase synchrony and spectral power were tested for group differences, and associations with neonatal and outcome variables were examined using mean-centered and behavioral Partial Least Squares (PLS) analyses, respectively. RESULTS: We found greater connectivity in the theta band in the ELGA group compared to VLGA and full-term groups, primarily involving frontal connections. Spectral power analysis demonstrated overall lower power in the ELGA and VLGA compared to full-term group. PLS indicated strong associations between neurophysiological connectivity at school age, adverse neonatal experience and cognitive performance, and behavior. Resting spectral power was associated only with behavioral scores. CONCLUSIONS: Our findings indicate significant atypicalities of neuromagnetic brain activity and connectivity in very preterm children at school age, with alterations in connectivity mainly observed only in the ELGA group. We demonstrate a significant relationship between connectivity, adverse neonatal experience, and long-term outcome, indicating that the disruption of developing neurophysiological networks may mediate relationships between neonatal events and cognitive and behavioral difficulties at school age. En ligne : http://dx.doi.org/10.1111/jcpp.13026 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 Children's stress regulation mediates the association between prenatal maternal mood and child executive functions for boys, but not girls / R. NEUENSCHWANDER in Development and Psychopathology, 30-3 (August 2018)
[article]
Titre : Children's stress regulation mediates the association between prenatal maternal mood and child executive functions for boys, but not girls Type de document : Texte imprimé et/ou numérique Auteurs : R. NEUENSCHWANDER, Auteur ; K. HOOKENSON, Auteur ; U. BRAIN, Auteur ; R. E. GRUNAU, Auteur ; A. M. DEVLIN, Auteur ; J. WEINBERG, Auteur ; A. DIAMOND, Auteur ; T. F. OBERLANDER, Auteur Article en page(s) : p.953-969 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Prenatal exposure to maternal mood disturbances shapes children's cognitive development reflected in the critical construct of executive functions (EFs). Little is known, however, about underlying mechanisms. By examining cortisol responses in both everyday and lab challenge settings, we tested whether the child/offspring hypothalamic-pituitary-adrenal axis mediates effects of prenatal maternal mood on child EFs at age 6. In 107 Canadian children born to women with a wide range of anxious and depressive symptoms during pregnancy, we found that in boys but not girls, depressed and/or anxious prenatal maternal mood is associated with heightened diurnal cortisol levels in everyday settings, as well as heightened cortisol reactivity to a lab challenge and that this heightened reactivity was associated with poorer EFs. Among boys we also observed that cortisol reactivity but not diurnal cortisol mediated the association between depressed and/or anxious prenatal maternal mood and EFs. Depressed and/or anxious prenatal maternal mood was related to child EFs for both girls and boys. To our knowledge, this is the first study to demonstrate a mediating role for child stress regulation in the association between prenatal maternal stress-related mood disturbances and child EFs, providing evidence of a mechanism contributing to fetal programming of cognition. En ligne : http://dx.doi.org/10.1017/s095457941800041x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366
in Development and Psychopathology > 30-3 (August 2018) . - p.953-969[article] Children's stress regulation mediates the association between prenatal maternal mood and child executive functions for boys, but not girls [Texte imprimé et/ou numérique] / R. NEUENSCHWANDER, Auteur ; K. HOOKENSON, Auteur ; U. BRAIN, Auteur ; R. E. GRUNAU, Auteur ; A. M. DEVLIN, Auteur ; J. WEINBERG, Auteur ; A. DIAMOND, Auteur ; T. F. OBERLANDER, Auteur . - p.953-969.
Langues : Anglais (eng)
in Development and Psychopathology > 30-3 (August 2018) . - p.953-969
Index. décimale : PER Périodiques Résumé : Prenatal exposure to maternal mood disturbances shapes children's cognitive development reflected in the critical construct of executive functions (EFs). Little is known, however, about underlying mechanisms. By examining cortisol responses in both everyday and lab challenge settings, we tested whether the child/offspring hypothalamic-pituitary-adrenal axis mediates effects of prenatal maternal mood on child EFs at age 6. In 107 Canadian children born to women with a wide range of anxious and depressive symptoms during pregnancy, we found that in boys but not girls, depressed and/or anxious prenatal maternal mood is associated with heightened diurnal cortisol levels in everyday settings, as well as heightened cortisol reactivity to a lab challenge and that this heightened reactivity was associated with poorer EFs. Among boys we also observed that cortisol reactivity but not diurnal cortisol mediated the association between depressed and/or anxious prenatal maternal mood and EFs. Depressed and/or anxious prenatal maternal mood was related to child EFs for both girls and boys. To our knowledge, this is the first study to demonstrate a mediating role for child stress regulation in the association between prenatal maternal stress-related mood disturbances and child EFs, providing evidence of a mechanism contributing to fetal programming of cognition. En ligne : http://dx.doi.org/10.1017/s095457941800041x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366