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Atypical resting state neuromagnetic connectivity and spectral power in very preterm children / N. KOZHEMIAKO in Journal of Child Psychology and Psychiatry, 60-9 (September 2019)
[article]
Titre : Atypical resting state neuromagnetic connectivity and spectral power in very preterm children Type de document : Texte imprimé et/ou numérique Auteurs : N. KOZHEMIAKO, Auteur ; A. NUNES, Auteur ; V. A. VAKORIN, Auteur ; C. M. Y. CHAU, Auteur ; A. MOISEEV, Auteur ; U. RIBARY, Auteur ; R. E. GRUNAU, Auteur ; S. M. DOESBURG, Auteur Article en page(s) : p.975-987 Langues : Anglais (eng) Mots-clés : Very preterm children early adversity magnetoencephalography neonatal stress pain resting state connectivity Index. décimale : PER Périodiques Résumé : BACKGROUND: Children born very preterm often display selective cognitive difficulties at school age even in the absence of major brain injury. Alterations in neurophysiological activity underpinning such difficulties, as well as their relation to specific aspects of adverse neonatal experience, remain poorly understood. In the present study, we examined interregional connectivity and spectral power in very preterm children at school age, and their relationship with clinical neonatal variables and long-term outcomes (IQ, executive functions, externalizing/internalizing behavior, visual-motor integration). METHODS: We collected resting state magnetoencephalographic (MEG) and psychometric data from a cohort at the age of 8 years followed prospectively since birth, which included three groups: Extremely Low Gestational Age (ELGA, 24-28 weeks GA n = 24, age 7.7 +/- 0.38, 10 girls), Very Low Gestational Age (VLGA, 29-32 weeks GA n = 37, age 7.7 +/- 0.39, 24 girls), and full-term children (38-41 weeks GA n = 39, age 7.9 +/- 1.02, 24 girls). Interregional phase synchrony and spectral power were tested for group differences, and associations with neonatal and outcome variables were examined using mean-centered and behavioral Partial Least Squares (PLS) analyses, respectively. RESULTS: We found greater connectivity in the theta band in the ELGA group compared to VLGA and full-term groups, primarily involving frontal connections. Spectral power analysis demonstrated overall lower power in the ELGA and VLGA compared to full-term group. PLS indicated strong associations between neurophysiological connectivity at school age, adverse neonatal experience and cognitive performance, and behavior. Resting spectral power was associated only with behavioral scores. CONCLUSIONS: Our findings indicate significant atypicalities of neuromagnetic brain activity and connectivity in very preterm children at school age, with alterations in connectivity mainly observed only in the ELGA group. We demonstrate a significant relationship between connectivity, adverse neonatal experience, and long-term outcome, indicating that the disruption of developing neurophysiological networks may mediate relationships between neonatal events and cognitive and behavioral difficulties at school age. En ligne : http://dx.doi.org/10.1111/jcpp.13026 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405
in Journal of Child Psychology and Psychiatry > 60-9 (September 2019) . - p.975-987[article] Atypical resting state neuromagnetic connectivity and spectral power in very preterm children [Texte imprimé et/ou numérique] / N. KOZHEMIAKO, Auteur ; A. NUNES, Auteur ; V. A. VAKORIN, Auteur ; C. M. Y. CHAU, Auteur ; A. MOISEEV, Auteur ; U. RIBARY, Auteur ; R. E. GRUNAU, Auteur ; S. M. DOESBURG, Auteur . - p.975-987.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 60-9 (September 2019) . - p.975-987
Mots-clés : Very preterm children early adversity magnetoencephalography neonatal stress pain resting state connectivity Index. décimale : PER Périodiques Résumé : BACKGROUND: Children born very preterm often display selective cognitive difficulties at school age even in the absence of major brain injury. Alterations in neurophysiological activity underpinning such difficulties, as well as their relation to specific aspects of adverse neonatal experience, remain poorly understood. In the present study, we examined interregional connectivity and spectral power in very preterm children at school age, and their relationship with clinical neonatal variables and long-term outcomes (IQ, executive functions, externalizing/internalizing behavior, visual-motor integration). METHODS: We collected resting state magnetoencephalographic (MEG) and psychometric data from a cohort at the age of 8 years followed prospectively since birth, which included three groups: Extremely Low Gestational Age (ELGA, 24-28 weeks GA n = 24, age 7.7 +/- 0.38, 10 girls), Very Low Gestational Age (VLGA, 29-32 weeks GA n = 37, age 7.7 +/- 0.39, 24 girls), and full-term children (38-41 weeks GA n = 39, age 7.9 +/- 1.02, 24 girls). Interregional phase synchrony and spectral power were tested for group differences, and associations with neonatal and outcome variables were examined using mean-centered and behavioral Partial Least Squares (PLS) analyses, respectively. RESULTS: We found greater connectivity in the theta band in the ELGA group compared to VLGA and full-term groups, primarily involving frontal connections. Spectral power analysis demonstrated overall lower power in the ELGA and VLGA compared to full-term group. PLS indicated strong associations between neurophysiological connectivity at school age, adverse neonatal experience and cognitive performance, and behavior. Resting spectral power was associated only with behavioral scores. CONCLUSIONS: Our findings indicate significant atypicalities of neuromagnetic brain activity and connectivity in very preterm children at school age, with alterations in connectivity mainly observed only in the ELGA group. We demonstrate a significant relationship between connectivity, adverse neonatal experience, and long-term outcome, indicating that the disruption of developing neurophysiological networks may mediate relationships between neonatal events and cognitive and behavioral difficulties at school age. En ligne : http://dx.doi.org/10.1111/jcpp.13026 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 Neonatal cerebral morphometry and later risk of persistent inattention/hyperactivity in children born very preterm / Samudragupta BORA in Journal of Child Psychology and Psychiatry, 55-7 (July 2014)
[article]
Titre : Neonatal cerebral morphometry and later risk of persistent inattention/hyperactivity in children born very preterm Type de document : Texte imprimé et/ou numérique Auteurs : Samudragupta BORA, Auteur ; Verena E. PRITCHARD, Auteur ; Zhe CHEN, Auteur ; Terrie E. INDER, Auteur ; Lianne J. WOODWARD, Auteur Article en page(s) : p.828-838 Langues : Anglais (eng) Mots-clés : Attention brain development low birth weight magnetic resonance imaging very preterm white matter injury Index. décimale : PER Périodiques Résumé : Background Attention problems are among the most prevalent neurobehavioral morbidities affecting very preterm (VPT) born children. The first study aim was to document rates of persistent attention/hyperactivity problems from ages 4 to 9 years in a regional cohort of VPT born children. The second aim was to examine the extent to which persistent problems were related to cerebral white matter abnormality and structural development on neonatal MRI. Methods Data were drawn from a prospective longitudinal study of 110 VPT (?32 weeks gestation) and 113 full-term (FT) children born from 1998 to 2000. At term equivalent, all VPT and 10 FT children underwent cerebral structural MRI, with scans analyzed qualitatively for white matter abnormalities and quantitatively for cortical and subcortical gray matter, myelinated and unmyelinated white matter, and cerebrospinal fluid volumes. At ages 4, 6, and 9 years, each child's parent and teacher completed the Inattention/Hyperactivity subscale of the Strengths and Difficulties Questionnaire. Results VPT born children had a fivefold increased risk of persistent attention/hyperactivity problems compared with FT children (13.1% vs. 2.8%; p = .002). No association was found between neonatal white matter abnormalities and later persistent inattention/hyperactivity risk (p ? .24). In contrast, measures of cerebral structural development including volumetric estimates of total cerebral tissue and cerebrospinal fluid relative to intracranial volume were associated with an increased risk of persistent attention/hyperactivity problems in VPT born children (p = .001). The dorsal prefrontal region showed the largest volumetric reduction (?3.2–8.2 mL). These brain-behavior associations persisted and in some cases, strengthened after covariate adjustment for postmenstrual age at MRI, gender, and family socioeconomic status. Conclusions Just over one in 10 VPT born children are subject to early onset and persistent attention/hyperactivity problems during childhood. These problems appear to reflect, at least in part, neonatal disturbances in cerebral growth and development rather than the effects of white matter injury. En ligne : http://dx.doi.org/10.1111/jcpp.12200 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=235
in Journal of Child Psychology and Psychiatry > 55-7 (July 2014) . - p.828-838[article] Neonatal cerebral morphometry and later risk of persistent inattention/hyperactivity in children born very preterm [Texte imprimé et/ou numérique] / Samudragupta BORA, Auteur ; Verena E. PRITCHARD, Auteur ; Zhe CHEN, Auteur ; Terrie E. INDER, Auteur ; Lianne J. WOODWARD, Auteur . - p.828-838.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 55-7 (July 2014) . - p.828-838
Mots-clés : Attention brain development low birth weight magnetic resonance imaging very preterm white matter injury Index. décimale : PER Périodiques Résumé : Background Attention problems are among the most prevalent neurobehavioral morbidities affecting very preterm (VPT) born children. The first study aim was to document rates of persistent attention/hyperactivity problems from ages 4 to 9 years in a regional cohort of VPT born children. The second aim was to examine the extent to which persistent problems were related to cerebral white matter abnormality and structural development on neonatal MRI. Methods Data were drawn from a prospective longitudinal study of 110 VPT (?32 weeks gestation) and 113 full-term (FT) children born from 1998 to 2000. At term equivalent, all VPT and 10 FT children underwent cerebral structural MRI, with scans analyzed qualitatively for white matter abnormalities and quantitatively for cortical and subcortical gray matter, myelinated and unmyelinated white matter, and cerebrospinal fluid volumes. At ages 4, 6, and 9 years, each child's parent and teacher completed the Inattention/Hyperactivity subscale of the Strengths and Difficulties Questionnaire. Results VPT born children had a fivefold increased risk of persistent attention/hyperactivity problems compared with FT children (13.1% vs. 2.8%; p = .002). No association was found between neonatal white matter abnormalities and later persistent inattention/hyperactivity risk (p ? .24). In contrast, measures of cerebral structural development including volumetric estimates of total cerebral tissue and cerebrospinal fluid relative to intracranial volume were associated with an increased risk of persistent attention/hyperactivity problems in VPT born children (p = .001). The dorsal prefrontal region showed the largest volumetric reduction (?3.2–8.2 mL). These brain-behavior associations persisted and in some cases, strengthened after covariate adjustment for postmenstrual age at MRI, gender, and family socioeconomic status. Conclusions Just over one in 10 VPT born children are subject to early onset and persistent attention/hyperactivity problems during childhood. These problems appear to reflect, at least in part, neonatal disturbances in cerebral growth and development rather than the effects of white matter injury. En ligne : http://dx.doi.org/10.1111/jcpp.12200 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=235