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Auteur X. KE |
Documents disponibles écrits par cet auteur (2)
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Alterations in hub organization in the white matter structural network in toddlers with autism spectrum disorder: A 2-year follow-up study / L. QIAN in Autism Research, 11-9 (September 2018)
[article]
Titre : Alterations in hub organization in the white matter structural network in toddlers with autism spectrum disorder: A 2-year follow-up study Type de document : Texte imprimé et/ou numérique Auteurs : L. QIAN, Auteur ; Y. WANG, Auteur ; K. CHU, Auteur ; Y. LI, Auteur ; C. XIAO, Auteur ; T. XIAO, Auteur ; X. XIAO, Auteur ; T. QIU, Auteur ; Y. XIAO, Auteur ; H. FANG, Auteur ; X. KE, Auteur Article en page(s) : p.1218-1228 Langues : Anglais (eng) Mots-clés : autism spectrum disorder brain network developmental trajectory hubs neuromechanism Index. décimale : PER Périodiques Résumé : Little is currently known about the longitudinal developmental patterns of hubs in the whole-brain white matter (WM) structural networks among toddlers with autism spectrum disorder (ASD). This study utilized diffusion tensor imaging (DTI) and deterministic tractography to map the WM structural networks in 37 ASD toddlers and 27 age-, gender- and developmental quotient-matched controls with developmental delay (DD) toddlers aged 2-3 years old at baseline (Time 1) and at 2-year follow-up (Time 2). Furthermore, graph-theoretical methods were applied to investigate alterations in the network hubs in these patients at the two time points. The results showed that after 2 years, 17 hubs were identified in the ASD subjects compared to the controls, including 13 hubs that had not changed from baseline and 4 hubs that were newly identified. In addition, alterations in the properties of the hubs of the right middle frontal gyrus, right insula, left median cingulate gyri, and bilateral precuneus were significantly correlated with alterations in the behavioral data for ASD patients. These results indicated that at the stage of 2-5 years of age, ASD children showed distributions of network hubs that were relatively stable, with minor differences. Abnormal developmental patterns in the five areas mentioned above in ASD may contribute to abnormalities in the social and nonsocial characteristics of this disorder. Autism Res 2018, 11: 1218-1228. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: This work studied the longitudinal developmental patterns of hubs in the whole-brain white matter (WM) structural network among toddlers with autism spectrum disorder (ASD). The findings of this study could have implications for understanding how the abnormalities in hub organization in ASD account for behavioral deficits in patients and may provide potential biomarkers for disease diagnosis and the subsequent monitoring of progression and treatment effects for patients with ASD. En ligne : http://dx.doi.org/10.1002/aur.1983 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369
in Autism Research > 11-9 (September 2018) . - p.1218-1228[article] Alterations in hub organization in the white matter structural network in toddlers with autism spectrum disorder: A 2-year follow-up study [Texte imprimé et/ou numérique] / L. QIAN, Auteur ; Y. WANG, Auteur ; K. CHU, Auteur ; Y. LI, Auteur ; C. XIAO, Auteur ; T. XIAO, Auteur ; X. XIAO, Auteur ; T. QIU, Auteur ; Y. XIAO, Auteur ; H. FANG, Auteur ; X. KE, Auteur . - p.1218-1228.
Langues : Anglais (eng)
in Autism Research > 11-9 (September 2018) . - p.1218-1228
Mots-clés : autism spectrum disorder brain network developmental trajectory hubs neuromechanism Index. décimale : PER Périodiques Résumé : Little is currently known about the longitudinal developmental patterns of hubs in the whole-brain white matter (WM) structural networks among toddlers with autism spectrum disorder (ASD). This study utilized diffusion tensor imaging (DTI) and deterministic tractography to map the WM structural networks in 37 ASD toddlers and 27 age-, gender- and developmental quotient-matched controls with developmental delay (DD) toddlers aged 2-3 years old at baseline (Time 1) and at 2-year follow-up (Time 2). Furthermore, graph-theoretical methods were applied to investigate alterations in the network hubs in these patients at the two time points. The results showed that after 2 years, 17 hubs were identified in the ASD subjects compared to the controls, including 13 hubs that had not changed from baseline and 4 hubs that were newly identified. In addition, alterations in the properties of the hubs of the right middle frontal gyrus, right insula, left median cingulate gyri, and bilateral precuneus were significantly correlated with alterations in the behavioral data for ASD patients. These results indicated that at the stage of 2-5 years of age, ASD children showed distributions of network hubs that were relatively stable, with minor differences. Abnormal developmental patterns in the five areas mentioned above in ASD may contribute to abnormalities in the social and nonsocial characteristics of this disorder. Autism Res 2018, 11: 1218-1228. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: This work studied the longitudinal developmental patterns of hubs in the whole-brain white matter (WM) structural network among toddlers with autism spectrum disorder (ASD). The findings of this study could have implications for understanding how the abnormalities in hub organization in ASD account for behavioral deficits in patients and may provide potential biomarkers for disease diagnosis and the subsequent monitoring of progression and treatment effects for patients with ASD. En ligne : http://dx.doi.org/10.1002/aur.1983 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 Prevalence of mental disorders in school children and adolescents in China: diagnostic data from detailed clinical assessments of 17,524 individuals / F. LI in Journal of Child Psychology and Psychiatry, 63-1 (January 2022)
[article]
Titre : Prevalence of mental disorders in school children and adolescents in China: diagnostic data from detailed clinical assessments of 17,524 individuals Type de document : Texte imprimé et/ou numérique Auteurs : F. LI, Auteur ; Y. CUI, Auteur ; Y. LI, Auteur ; L. GUO, Auteur ; X. KE, Auteur ; J. LIU, Auteur ; X. LUO, Auteur ; Y. ZHENG, Auteur ; J. F. LECKMAN, Auteur Article en page(s) : p.34-46 Langues : Anglais (eng) Mots-clés : Adolescent Attention Deficit and Disruptive Behavior Disorders Child China/epidemiology Comorbidity Depressive Disorder, Major Diagnostic and Statistical Manual of Mental Disorders Female Humans Male Mental Disorders/diagnosis/epidemiology Prevalence China adolescents children mental disorder prevalence Index. décimale : PER Périodiques Résumé : BACKGROUND: To date, no national-scale psychiatric epidemiological survey for children and adolescents has been conducted in China. In order to inform government officials and policymakers and to develop a comprehensive plan for service providers, there was a clear need to conduct an up-to-date systematic nationwide psychiatric epidemiological survey. METHODS: We conducted a two-stage large-scale psychiatric point prevalence survey. Multistage cluster stratified random sampling was used as the sampling strategy. Five provinces were selected by comprehensively considering geographical partition, economic development, and rural/urban factors. In Stage 1, the Child Behavior Checklist was used as the screening tool. In Stage 2, Mini-International Neuropsychiatric Interview for Children and Adolescents and a diagnostic process based on the Diagnostic and Statistical Manual were used to make the diagnoses. Sampling weights and poststratification weights were employed to match the population distributions. Exploratory analyses were also performed using socio-demographic factors. Prevalence in socio-demographic factor subgroups and overall were estimated. Rao-Scott adjusted chi-square tests were utilized to determine if between-group differences were present. Factor interactions were checked by logistic regression analyses. RESULTS: A total of 73,992 participants aged 6-16?years of age were selected in Stage 1. In Stage 2, 17,524 individuals were screened and diagnosed. The weighted prevalence of any disorder was 17.5% (95% CI: 17.2-18.0). Statistically significant differences in prevalence of any psychiatric disorder were observed between sexes [?(2) (1, N?=?71,929)?=?223.0, p?.001], age groups [?(2) (1, N?=?71,929)?=?18.6, p?.001] and developed vs. developing areas [?(2) (1, N?=?71,929)?=?2,129.6, p?.001], while no difference was found between rural and urban areas [?(2) (1, N?=?71,929)?=?1.4, p?=?.239]. Male, younger individuals, children, and adolescents from developed areas had higher prevalence of any psychiatric disorder. The prevalence of any psychiatric disorder was found to decrease with the age in the male group, while the female group increased with the age. Individuals diagnosed with attention-deficit hyperactivity disorder, oppositional defiant disorder, a tic disorder, conduct disorder, and major depression disorder had the highest rates of comorbidity. CONCLUSIONS: The prevalence of any psychiatric disorder we found is the highest ever reported in China. These results urgently need to be addressed by public mental health service providers and policymakers in order to provide access to the necessary treatments and to reduce the long-term negative impact of these conditions on families and the society as a whole. En ligne : http://dx.doi.org/10.1111/jcpp.13445 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456
in Journal of Child Psychology and Psychiatry > 63-1 (January 2022) . - p.34-46[article] Prevalence of mental disorders in school children and adolescents in China: diagnostic data from detailed clinical assessments of 17,524 individuals [Texte imprimé et/ou numérique] / F. LI, Auteur ; Y. CUI, Auteur ; Y. LI, Auteur ; L. GUO, Auteur ; X. KE, Auteur ; J. LIU, Auteur ; X. LUO, Auteur ; Y. ZHENG, Auteur ; J. F. LECKMAN, Auteur . - p.34-46.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-1 (January 2022) . - p.34-46
Mots-clés : Adolescent Attention Deficit and Disruptive Behavior Disorders Child China/epidemiology Comorbidity Depressive Disorder, Major Diagnostic and Statistical Manual of Mental Disorders Female Humans Male Mental Disorders/diagnosis/epidemiology Prevalence China adolescents children mental disorder prevalence Index. décimale : PER Périodiques Résumé : BACKGROUND: To date, no national-scale psychiatric epidemiological survey for children and adolescents has been conducted in China. In order to inform government officials and policymakers and to develop a comprehensive plan for service providers, there was a clear need to conduct an up-to-date systematic nationwide psychiatric epidemiological survey. METHODS: We conducted a two-stage large-scale psychiatric point prevalence survey. Multistage cluster stratified random sampling was used as the sampling strategy. Five provinces were selected by comprehensively considering geographical partition, economic development, and rural/urban factors. In Stage 1, the Child Behavior Checklist was used as the screening tool. In Stage 2, Mini-International Neuropsychiatric Interview for Children and Adolescents and a diagnostic process based on the Diagnostic and Statistical Manual were used to make the diagnoses. Sampling weights and poststratification weights were employed to match the population distributions. Exploratory analyses were also performed using socio-demographic factors. Prevalence in socio-demographic factor subgroups and overall were estimated. Rao-Scott adjusted chi-square tests were utilized to determine if between-group differences were present. Factor interactions were checked by logistic regression analyses. RESULTS: A total of 73,992 participants aged 6-16?years of age were selected in Stage 1. In Stage 2, 17,524 individuals were screened and diagnosed. The weighted prevalence of any disorder was 17.5% (95% CI: 17.2-18.0). Statistically significant differences in prevalence of any psychiatric disorder were observed between sexes [?(2) (1, N?=?71,929)?=?223.0, p?.001], age groups [?(2) (1, N?=?71,929)?=?18.6, p?.001] and developed vs. developing areas [?(2) (1, N?=?71,929)?=?2,129.6, p?.001], while no difference was found between rural and urban areas [?(2) (1, N?=?71,929)?=?1.4, p?=?.239]. Male, younger individuals, children, and adolescents from developed areas had higher prevalence of any psychiatric disorder. The prevalence of any psychiatric disorder was found to decrease with the age in the male group, while the female group increased with the age. Individuals diagnosed with attention-deficit hyperactivity disorder, oppositional defiant disorder, a tic disorder, conduct disorder, and major depression disorder had the highest rates of comorbidity. CONCLUSIONS: The prevalence of any psychiatric disorder we found is the highest ever reported in China. These results urgently need to be addressed by public mental health service providers and policymakers in order to provide access to the necessary treatments and to reduce the long-term negative impact of these conditions on families and the society as a whole. En ligne : http://dx.doi.org/10.1111/jcpp.13445 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456