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Détail de l'auteur
Auteur L. THOMPSON |
Documents disponibles écrits par cet auteur (2)
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Autism With and Without Regression: A Two-Year Prospective Longitudinal Study in Two Population-Derived Swedish Cohorts / L. THOMPSON in Journal of Autism and Developmental Disorders, 49-6 (June 2019)
[article]
Titre : Autism With and Without Regression: A Two-Year Prospective Longitudinal Study in Two Population-Derived Swedish Cohorts Type de document : Texte imprimé et/ou numérique Auteurs : L. THOMPSON, Auteur ; C. GILLBERG, Auteur ; S. LANDBERG, Auteur ; A. K. KANTZER, Auteur ; C. MINISCALCO, Auteur ; M. BARNEVIK OLSSON, Auteur ; M. A. ERIKSSON, Auteur ; E. FERNELL, Auteur Article en page(s) : p.2281-2290 Langues : Anglais (eng) Mots-clés : Asd Autism Developmental language disorder Intellectual developmental disorder Non-regressive autism Regressive autism Index. décimale : PER Périodiques Résumé : Two community-based cohorts of children with autism spectrum disorder, examined using similar assessment protocols, were pooled (n = 301) and subdivided according to history of regression. Those with regression (n = 62), 20.5% of the combined cohort, were contrasted with those without regression (n = 241) at first assessment (age range 19-60 months) and at 2-year follow-up on a range of measures. The regression group was significantly more functionally impaired, with regard to intellectual function (p < .001), language development (p < .001), and to severity of autism (p < .01) at both T1 and T2. Only 14 (23.3%) had a clearly identified underlying etiology [24 (18.6%) in the non-regressive group]. There were no significant differences between those who had regressed 'from normal' and those who had regressed 'from low' functioning. En ligne : https://dx.doi.org/10.1007/s10803-018-03871-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400
in Journal of Autism and Developmental Disorders > 49-6 (June 2019) . - p.2281-2290[article] Autism With and Without Regression: A Two-Year Prospective Longitudinal Study in Two Population-Derived Swedish Cohorts [Texte imprimé et/ou numérique] / L. THOMPSON, Auteur ; C. GILLBERG, Auteur ; S. LANDBERG, Auteur ; A. K. KANTZER, Auteur ; C. MINISCALCO, Auteur ; M. BARNEVIK OLSSON, Auteur ; M. A. ERIKSSON, Auteur ; E. FERNELL, Auteur . - p.2281-2290.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-6 (June 2019) . - p.2281-2290
Mots-clés : Asd Autism Developmental language disorder Intellectual developmental disorder Non-regressive autism Regressive autism Index. décimale : PER Périodiques Résumé : Two community-based cohorts of children with autism spectrum disorder, examined using similar assessment protocols, were pooled (n = 301) and subdivided according to history of regression. Those with regression (n = 62), 20.5% of the combined cohort, were contrasted with those without regression (n = 241) at first assessment (age range 19-60 months) and at 2-year follow-up on a range of measures. The regression group was significantly more functionally impaired, with regard to intellectual function (p < .001), language development (p < .001), and to severity of autism (p < .01) at both T1 and T2. Only 14 (23.3%) had a clearly identified underlying etiology [24 (18.6%) in the non-regressive group]. There were no significant differences between those who had regressed 'from normal' and those who had regressed 'from low' functioning. En ligne : https://dx.doi.org/10.1007/s10803-018-03871-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400 Inbred strain preference in the BTBR T(+) Itpr3(tf) /J mouse model of autism spectrum disorder: Does the stranger mouse matter in social approach? / K. RYAN in Autism Research, 12-8 (August 2019)
[article]
Titre : Inbred strain preference in the BTBR T(+) Itpr3(tf) /J mouse model of autism spectrum disorder: Does the stranger mouse matter in social approach? Type de document : Texte imprimé et/ou numérique Auteurs : K. RYAN, Auteur ; L. THOMPSON, Auteur ; P. A. MENDOZA, Auteur ; Kathryn K. CHADMAN, Auteur Article en page(s) : p.1184-1191 Langues : Anglais (eng) Mots-clés : Asd Btbr C57bl/6j female male mice social behavior social preference Index. décimale : PER Périodiques Résumé : BTBR T(+) Itpr3(tf) /J (BTBR) mice have been used as a model of autism spectrum disorder (ASD) due to their low levels of sociability and high levels of repetitive grooming. These experiments explored social behavior in the BTBR and C57BL/6J mice using variations of the three-chambered social approach test. In the first test, the subject mice had a choice between a stranger mouse of the same strain or from a strain with a different level of sociability. The BTBR male mice demonstrated a strong preference for the more social C57BL/6J stranger mouse, as did the C57BL/6J male mice, although more moderately with sniff time only. The C57BL/6J female mice showed a moderate preference, sniff time only, for the BTBR stranger mouse, whereas the BTBR female mice did not show a preference. The second experiment examined whether the subject mouse preferred a stranger mouse or bedding from the stranger mouse home cage. Male BTBR mice always preferred bedding, whereas the C57BL/6J male mice did not show a preference. Both BTBR and C57BL/6J female mice preferred bedding when the stranger mouse was a different strain but not when the stranger mouse was the same strain. Therefore, the stranger mouse strain seems to influence the preference of the female mice more than the male mice. The mice preferred spending time in the chamber with the social smell but not the actual stranger mouse although not always significantly. This suggests that contact with a stranger mouse is more stressful or anxiety provoking than the smell. Autism Res 2019, 12: 1184-1191. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: BTBR T(+) Itpr3(tf) /J (BTBR) mice have been used as a model of autism spectrum disorder (ASD) due to their low levels of sociability and high levels of repetitive grooming. These experiments explored social behavior in the BTBR and C57BL/6J mice using variations of the three-chambered social approach test. These experiments examined how the sociability level of the stranger mouse affected the subject mouse's preference and if social odor was preferable to a social situation in the BTBR mice. The BTBR male mice demonstrated a strong preference for the more social C57BL/6J stranger mouse, as did the C57BL/6J male mice. The C57BL/6J female mice showed a moderate preference for the BTBR stranger mouse, whereas the BTBR female mice did not show a preference for either stranger mouse. The second modification let the subject mouse have a choice between a stranger mouse or bedding. Male BTBR mice preferred bedding, regardless of the strain of the stranger mouse, whereas the C57BL/6J male mice did not show a preference. Both BTBR and C57BL/6J female mice preferred bedding when the stranger mouse was a different strain but showed no preference when the stranger mouse was from the same strain. The stranger mouse strain seems to influence the female mice more. Male BTBR mice preferred spending time in the chamber with the social smell but not the actual mouse, suggesting that actual contact with a stranger mouse is more stressful or anxiety provoking. En ligne : http://dx.doi.org/10.1002/aur.2158 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405
in Autism Research > 12-8 (August 2019) . - p.1184-1191[article] Inbred strain preference in the BTBR T(+) Itpr3(tf) /J mouse model of autism spectrum disorder: Does the stranger mouse matter in social approach? [Texte imprimé et/ou numérique] / K. RYAN, Auteur ; L. THOMPSON, Auteur ; P. A. MENDOZA, Auteur ; Kathryn K. CHADMAN, Auteur . - p.1184-1191.
Langues : Anglais (eng)
in Autism Research > 12-8 (August 2019) . - p.1184-1191
Mots-clés : Asd Btbr C57bl/6j female male mice social behavior social preference Index. décimale : PER Périodiques Résumé : BTBR T(+) Itpr3(tf) /J (BTBR) mice have been used as a model of autism spectrum disorder (ASD) due to their low levels of sociability and high levels of repetitive grooming. These experiments explored social behavior in the BTBR and C57BL/6J mice using variations of the three-chambered social approach test. In the first test, the subject mice had a choice between a stranger mouse of the same strain or from a strain with a different level of sociability. The BTBR male mice demonstrated a strong preference for the more social C57BL/6J stranger mouse, as did the C57BL/6J male mice, although more moderately with sniff time only. The C57BL/6J female mice showed a moderate preference, sniff time only, for the BTBR stranger mouse, whereas the BTBR female mice did not show a preference. The second experiment examined whether the subject mouse preferred a stranger mouse or bedding from the stranger mouse home cage. Male BTBR mice always preferred bedding, whereas the C57BL/6J male mice did not show a preference. Both BTBR and C57BL/6J female mice preferred bedding when the stranger mouse was a different strain but not when the stranger mouse was the same strain. Therefore, the stranger mouse strain seems to influence the preference of the female mice more than the male mice. The mice preferred spending time in the chamber with the social smell but not the actual stranger mouse although not always significantly. This suggests that contact with a stranger mouse is more stressful or anxiety provoking than the smell. Autism Res 2019, 12: 1184-1191. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: BTBR T(+) Itpr3(tf) /J (BTBR) mice have been used as a model of autism spectrum disorder (ASD) due to their low levels of sociability and high levels of repetitive grooming. These experiments explored social behavior in the BTBR and C57BL/6J mice using variations of the three-chambered social approach test. These experiments examined how the sociability level of the stranger mouse affected the subject mouse's preference and if social odor was preferable to a social situation in the BTBR mice. The BTBR male mice demonstrated a strong preference for the more social C57BL/6J stranger mouse, as did the C57BL/6J male mice. The C57BL/6J female mice showed a moderate preference for the BTBR stranger mouse, whereas the BTBR female mice did not show a preference for either stranger mouse. The second modification let the subject mouse have a choice between a stranger mouse or bedding. Male BTBR mice preferred bedding, regardless of the strain of the stranger mouse, whereas the C57BL/6J male mice did not show a preference. Both BTBR and C57BL/6J female mice preferred bedding when the stranger mouse was a different strain but showed no preference when the stranger mouse was from the same strain. The stranger mouse strain seems to influence the female mice more. Male BTBR mice preferred spending time in the chamber with the social smell but not the actual mouse, suggesting that actual contact with a stranger mouse is more stressful or anxiety provoking. En ligne : http://dx.doi.org/10.1002/aur.2158 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405