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Auteur Andrew J. O. WHITEHOUSE |
Documents disponibles écrits par cet auteur (81)
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Maternal pre-pregnancy weight and autistic-like traits among offspring in the general population / Kandice J. VARCIN in Autism Research, 12-1 (January 2019)
[article]
Titre : Maternal pre-pregnancy weight and autistic-like traits among offspring in the general population Type de document : Texte imprimé et/ou numérique Auteurs : Kandice J. VARCIN, Auteur ; J. P. NEWNHAM, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : p.80-88 Langues : Anglais (eng) Mots-clés : autism spectrum disorder body mass index maternal obesity prenatal Index. décimale : PER Périodiques Résumé : There is an emerging body of evidence demonstrating that maternal obesity at the time of conception increases the risk for Autism Spectrum Disorders (ASD) among offspring. We explored whether pre-pregnancy weight was related to autistic-like traits among offspring not diagnosed with ASD. A large sample of women, recruited during the second trimester of pregnancy, had their height measured and reported their pre-pregnancy weight. These measurements were then converted to a Body Mass Index (BMI) using the formula: (weight in kilograms)/(height in metres(2) ). At 19-20 years of age, 1238 offspring of these women completed a measure of autistic-like traits, the Autism-Spectrum Quotient (AQ). Regression analyses identified a positive association between increasing maternal pre-pregnancy BMI and increasing AQ Total Score amongst offspring; this association was maintained even after controlling for a range of variables including maternal/obstetric factors (age at conception, education, smoking, alcohol consumption, hypertensive diseases, diabetes, threatened abortion), paternal BMI at pregnancy, and child factors (parity, sex) (P < .01, R(2) =.03). Chi-square analyses found that women with pre-pregnancy obesity (BMI >/= 30) were more likely to have offspring with high scores (>/=26) on the AQ (P = .01). Follow-up binary logistic regression analyses also accounting for the same obstetric and sociodemographic variables found that the offspring of women with pre-pregnancy obesity were at a statistically significantly increased risk of having high scores (>/=26) on the AQ (OR: 2.80; 95% CI: 1.06, 7.43). This study provides further evidence that maternal pre-pregnancy obesity is associated with autism-like behaviors in offspring. Autism Research 2019, 12: 80-88. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The current study explored whether pre-pregnancy weight was related to autistic-like traits among offspring not diagnosed with ASD. We found that pre-pregnancy body mass index in women is associated with the amount of autistic-like traits in their children in early adulthood. Specifically, women who were obese at the time of conception were more likely to have a child who had high levels of autistic-like traits in early adulthood. En ligne : http://dx.doi.org/10.1002/aur.1973 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376
in Autism Research > 12-1 (January 2019) . - p.80-88[article] Maternal pre-pregnancy weight and autistic-like traits among offspring in the general population [Texte imprimé et/ou numérique] / Kandice J. VARCIN, Auteur ; J. P. NEWNHAM, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.80-88.
Langues : Anglais (eng)
in Autism Research > 12-1 (January 2019) . - p.80-88
Mots-clés : autism spectrum disorder body mass index maternal obesity prenatal Index. décimale : PER Périodiques Résumé : There is an emerging body of evidence demonstrating that maternal obesity at the time of conception increases the risk for Autism Spectrum Disorders (ASD) among offspring. We explored whether pre-pregnancy weight was related to autistic-like traits among offspring not diagnosed with ASD. A large sample of women, recruited during the second trimester of pregnancy, had their height measured and reported their pre-pregnancy weight. These measurements were then converted to a Body Mass Index (BMI) using the formula: (weight in kilograms)/(height in metres(2) ). At 19-20 years of age, 1238 offspring of these women completed a measure of autistic-like traits, the Autism-Spectrum Quotient (AQ). Regression analyses identified a positive association between increasing maternal pre-pregnancy BMI and increasing AQ Total Score amongst offspring; this association was maintained even after controlling for a range of variables including maternal/obstetric factors (age at conception, education, smoking, alcohol consumption, hypertensive diseases, diabetes, threatened abortion), paternal BMI at pregnancy, and child factors (parity, sex) (P < .01, R(2) =.03). Chi-square analyses found that women with pre-pregnancy obesity (BMI >/= 30) were more likely to have offspring with high scores (>/=26) on the AQ (P = .01). Follow-up binary logistic regression analyses also accounting for the same obstetric and sociodemographic variables found that the offspring of women with pre-pregnancy obesity were at a statistically significantly increased risk of having high scores (>/=26) on the AQ (OR: 2.80; 95% CI: 1.06, 7.43). This study provides further evidence that maternal pre-pregnancy obesity is associated with autism-like behaviors in offspring. Autism Research 2019, 12: 80-88. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The current study explored whether pre-pregnancy weight was related to autistic-like traits among offspring not diagnosed with ASD. We found that pre-pregnancy body mass index in women is associated with the amount of autistic-like traits in their children in early adulthood. Specifically, women who were obese at the time of conception were more likely to have a child who had high levels of autistic-like traits in early adulthood. En ligne : http://dx.doi.org/10.1002/aur.1973 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376 Maternal Vitamin D Levels and the Autism Phenotype Among Offspring / Andrew J. O. WHITEHOUSE in Journal of Autism and Developmental Disorders, 43-7 (July 2013)
[article]
Titre : Maternal Vitamin D Levels and the Autism Phenotype Among Offspring Type de document : Texte imprimé et/ou numérique Auteurs : Andrew J. O. WHITEHOUSE, Auteur ; Barbara J. HOLT, Auteur ; Michael SERRALHA, Auteur ; Patrick G HOLT, Auteur ; Prue H. HART, Auteur ; Merci M. H. KUSEL, Auteur Année de publication : 2013 Article en page(s) : p.1495-1504 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Autistic-like traits Vitamin D Prenatal Pregnancy Environment Index. décimale : PER Périodiques Résumé : We tested whether maternal vitamin D insufficiency during pregnancy is related to the autism phenotype. Serum 25(OH)-vitamin D concentrations of 929 women were measured at 18 weeks’ pregnancy. The mothers of the three children with a clinical diagnosis of autism spectrum disorder had 25(OH)-vitamin D concentrations above the population mean. The offspring of 406 women completed the Autism-Spectrum Quotient in early adulthood. Maternal 25(OH)-vitamin D concentrations were unrelated to offspring scores on the majority of scales. However, offspring of mothers with low 25(OH)-vitamin D concentrations (49 nmol/L) were at increased risk for ‘high’ scores (?2SD above mean) on the Attention Switching subscale (odds ratio: 5.46, 95 % confidence interval: 1.29, 23.05). The involvement of maternal vitamin D during pregnancy in autism requires continued investigation. En ligne : http://dx.doi.org/10.1007/s10803-012-1676-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202
in Journal of Autism and Developmental Disorders > 43-7 (July 2013) . - p.1495-1504[article] Maternal Vitamin D Levels and the Autism Phenotype Among Offspring [Texte imprimé et/ou numérique] / Andrew J. O. WHITEHOUSE, Auteur ; Barbara J. HOLT, Auteur ; Michael SERRALHA, Auteur ; Patrick G HOLT, Auteur ; Prue H. HART, Auteur ; Merci M. H. KUSEL, Auteur . - 2013 . - p.1495-1504.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 43-7 (July 2013) . - p.1495-1504
Mots-clés : Autism spectrum disorder Autistic-like traits Vitamin D Prenatal Pregnancy Environment Index. décimale : PER Périodiques Résumé : We tested whether maternal vitamin D insufficiency during pregnancy is related to the autism phenotype. Serum 25(OH)-vitamin D concentrations of 929 women were measured at 18 weeks’ pregnancy. The mothers of the three children with a clinical diagnosis of autism spectrum disorder had 25(OH)-vitamin D concentrations above the population mean. The offspring of 406 women completed the Autism-Spectrum Quotient in early adulthood. Maternal 25(OH)-vitamin D concentrations were unrelated to offspring scores on the majority of scales. However, offspring of mothers with low 25(OH)-vitamin D concentrations (49 nmol/L) were at increased risk for ‘high’ scores (?2SD above mean) on the Attention Switching subscale (odds ratio: 5.46, 95 % confidence interval: 1.29, 23.05). The involvement of maternal vitamin D during pregnancy in autism requires continued investigation. En ligne : http://dx.doi.org/10.1007/s10803-012-1676-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202 Mothers of Children with Autism have Different Rates of Cancer According to the Presence of Intellectual Disability in Their Child / Jennifer C. FAIRTHORNE in Journal of Autism and Developmental Disorders, 46-9 (September 2016)
[article]
Titre : Mothers of Children with Autism have Different Rates of Cancer According to the Presence of Intellectual Disability in Their Child Type de document : Texte imprimé et/ou numérique Auteurs : Jennifer C. FAIRTHORNE, Auteur ; Nicholas H. DE KLERK, Auteur ; Helen M. LEONARD, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : p.3106-3114 Langues : Anglais (eng) Mots-clés : Autism Intellectual disability Cancer Parents Genetics Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) and intellectual disability (ID) are neurodevelopmental disorders with strong genetic components. Increasingly, research attention has focused on whether genetic factors conveying susceptibility for these conditions, also influence the risk of other health conditions, such as cancer. We examined the occurrence of hospital admissions and treatment/services for cancer in mothers of children with ASD with or without ID compared with other mothers. After linking Western Australian administrative health databases, we used Cox regression to estimate the hazard ratios (HRs) of any hospitalisations and treatment/services for cancer in these groups of mothers. Mothers of children with ASD without ID had greater risk of admissions for cancer (HR 1.29 [95 % CI 1.1, 1.7]), and for treatment/services in particular (HR 1.41 [95 % CI 1.0, 2.0]), than mothers of children with no ASD/ID, while mothers of children with ASD with ID were no more likely to have a cancer-related hospital admission than other mothers. Mothers of children with autism without ID had increased risk of cancer, which may relate to common genetic pathways. En ligne : http://dx.doi.org/10.1007/s10803-016-2847-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292
in Journal of Autism and Developmental Disorders > 46-9 (September 2016) . - p.3106-3114[article] Mothers of Children with Autism have Different Rates of Cancer According to the Presence of Intellectual Disability in Their Child [Texte imprimé et/ou numérique] / Jennifer C. FAIRTHORNE, Auteur ; Nicholas H. DE KLERK, Auteur ; Helen M. LEONARD, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.3106-3114.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 46-9 (September 2016) . - p.3106-3114
Mots-clés : Autism Intellectual disability Cancer Parents Genetics Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) and intellectual disability (ID) are neurodevelopmental disorders with strong genetic components. Increasingly, research attention has focused on whether genetic factors conveying susceptibility for these conditions, also influence the risk of other health conditions, such as cancer. We examined the occurrence of hospital admissions and treatment/services for cancer in mothers of children with ASD with or without ID compared with other mothers. After linking Western Australian administrative health databases, we used Cox regression to estimate the hazard ratios (HRs) of any hospitalisations and treatment/services for cancer in these groups of mothers. Mothers of children with ASD without ID had greater risk of admissions for cancer (HR 1.29 [95 % CI 1.1, 1.7]), and for treatment/services in particular (HR 1.41 [95 % CI 1.0, 2.0]), than mothers of children with no ASD/ID, while mothers of children with ASD with ID were no more likely to have a cancer-related hospital admission than other mothers. Mothers of children with autism without ID had increased risk of cancer, which may relate to common genetic pathways. En ligne : http://dx.doi.org/10.1007/s10803-016-2847-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292 Narrowing the broader autism phenotype: A study using the Communication Checklist - Adult Version (CC-A) / Andrew J. O. WHITEHOUSE in Autism, 14-6 (November 2010)
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Titre : Narrowing the broader autism phenotype: A study using the Communication Checklist - Adult Version (CC-A) Type de document : Texte imprimé et/ou numérique Auteurs : Andrew J. O. WHITEHOUSE, Auteur ; Hilary H. COON, Auteur ; Judith N. MILLER, Auteur ; Bryanna SALISBURY, Auteur ; Dorothy V. M. BISHOP, Auteur Année de publication : 2010 Article en page(s) : p.559-574 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study investigated whether the Communication Checklist — Adult (CC-A) could identify subtypes of social and communication dysfunction in autism probands and their parents. The CC-A is divided into subscales measuring linguistic ability as well as two aspects of social communication: the Pragmatic Skills subscale assesses the level of pragmatic oddities (e.g. excessive talking), while the Social Engagement subscale picks up on those behaviours that reflect a more passive communication style (e.g. failure to engage in social interactions). CC-A data were collected for 69 autism probands, 238 parents of autism probands and 187 typical participants. The CC-A proved sensitive to the communication difficulties of autism probands and a proportion of their parents. The majority of parents who demonstrated the broader phenotype scored poorly on either the Pragmatic Skills or Social Engagement scale only. The Social Engagement scale was particularly sensitive to the difficulties of the parents, indicating that social-communicative passivity may be an important part of the broader autism phenotype. The findings provide evidence for the existence of more constrained pragmatic phenotypes in autism. Molecular genetic studies in this area may benefit from stratifying samples according to these phenotypes. En ligne : http://dx.doi.org/10.1177/1362361310382107 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114
in Autism > 14-6 (November 2010) . - p.559-574[article] Narrowing the broader autism phenotype: A study using the Communication Checklist - Adult Version (CC-A) [Texte imprimé et/ou numérique] / Andrew J. O. WHITEHOUSE, Auteur ; Hilary H. COON, Auteur ; Judith N. MILLER, Auteur ; Bryanna SALISBURY, Auteur ; Dorothy V. M. BISHOP, Auteur . - 2010 . - p.559-574.
Langues : Anglais (eng)
in Autism > 14-6 (November 2010) . - p.559-574
Index. décimale : PER Périodiques Résumé : This study investigated whether the Communication Checklist — Adult (CC-A) could identify subtypes of social and communication dysfunction in autism probands and their parents. The CC-A is divided into subscales measuring linguistic ability as well as two aspects of social communication: the Pragmatic Skills subscale assesses the level of pragmatic oddities (e.g. excessive talking), while the Social Engagement subscale picks up on those behaviours that reflect a more passive communication style (e.g. failure to engage in social interactions). CC-A data were collected for 69 autism probands, 238 parents of autism probands and 187 typical participants. The CC-A proved sensitive to the communication difficulties of autism probands and a proportion of their parents. The majority of parents who demonstrated the broader phenotype scored poorly on either the Pragmatic Skills or Social Engagement scale only. The Social Engagement scale was particularly sensitive to the difficulties of the parents, indicating that social-communicative passivity may be an important part of the broader autism phenotype. The findings provide evidence for the existence of more constrained pragmatic phenotypes in autism. Molecular genetic studies in this area may benefit from stratifying samples according to these phenotypes. En ligne : http://dx.doi.org/10.1177/1362361310382107 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114 Non-pharmacological interventions for autistic children: An umbrella review / David TREMBATH in Autism, 27-2 (February 2023)
[article]
Titre : Non-pharmacological interventions for autistic children: An umbrella review Type de document : Texte imprimé et/ou numérique Auteurs : David TREMBATH, Auteur ; Kandice J. VARCIN, Auteur ; Hannah WADDINGTON, Auteur ; Rhylee SULEK, Auteur ; Cathy BENT, Auteur ; Jill ASHBURNER, Auteur ; Valsamma EAPEN, Auteur ; Emma GOODALL, Auteur ; Kristelle HUDRY, Auteur ; Jacqueline ROBERTS, Auteur ; Natalie SILOVE, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : p.275-295 Langues : Anglais (eng) Mots-clés : autism evidence intervention non-pharmacological review Index. décimale : PER Périodiques Résumé : The breadth of available non-pharmacological interventions for autistic children, with varying evidence for efficacy summarised in multiple systematic reviews, creates challenges for parents, practitioners, and policymakers in navigating the research evidence. In this article, we report the findings of an umbrella review of 58 systematic reviews of non-pharmacological interventions for autistic children (aged 0 “12 years). Positive therapeutic effects were identified for Behavioural interventions, Developmental interventions, Naturalistic Developmental Behavioural Interventions, Technology-based interventions, and Cognitive Behaviour Therapy across several child and family outcomes. Positive effects for certain practices within Sensory-based interventions and ˜other’ interventions were limited to select child and family outcomes. Both inconsistent and null intervention effects were found for Treatment and Education of Autistic and related Communication-handicapped Children, and Animal-assisted interventions across outcomes. The possible influence of child (chronological age, core autism characteristics, and related skills) and delivery (agent, mode, format, and amount) characteristics on intervention effects was rarely examined, and inconsistent where reported. Twenty-seven systematic reviews (47%) were rated as ˜high’ quality. Few systematic reviews examined children’s participation and quality of life or adverse effects. The findings highlight the need for individualised evidence-based decision-making when selecting interventions for autistic children. En ligne : http://dx.doi.org/10.1177/13623613221119368 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493
in Autism > 27-2 (February 2023) . - p.275-295[article] Non-pharmacological interventions for autistic children: An umbrella review [Texte imprimé et/ou numérique] / David TREMBATH, Auteur ; Kandice J. VARCIN, Auteur ; Hannah WADDINGTON, Auteur ; Rhylee SULEK, Auteur ; Cathy BENT, Auteur ; Jill ASHBURNER, Auteur ; Valsamma EAPEN, Auteur ; Emma GOODALL, Auteur ; Kristelle HUDRY, Auteur ; Jacqueline ROBERTS, Auteur ; Natalie SILOVE, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.275-295.
Langues : Anglais (eng)
in Autism > 27-2 (February 2023) . - p.275-295
Mots-clés : autism evidence intervention non-pharmacological review Index. décimale : PER Périodiques Résumé : The breadth of available non-pharmacological interventions for autistic children, with varying evidence for efficacy summarised in multiple systematic reviews, creates challenges for parents, practitioners, and policymakers in navigating the research evidence. In this article, we report the findings of an umbrella review of 58 systematic reviews of non-pharmacological interventions for autistic children (aged 0 “12 years). Positive therapeutic effects were identified for Behavioural interventions, Developmental interventions, Naturalistic Developmental Behavioural Interventions, Technology-based interventions, and Cognitive Behaviour Therapy across several child and family outcomes. Positive effects for certain practices within Sensory-based interventions and ˜other’ interventions were limited to select child and family outcomes. Both inconsistent and null intervention effects were found for Treatment and Education of Autistic and related Communication-handicapped Children, and Animal-assisted interventions across outcomes. The possible influence of child (chronological age, core autism characteristics, and related skills) and delivery (agent, mode, format, and amount) characteristics on intervention effects was rarely examined, and inconsistent where reported. Twenty-seven systematic reviews (47%) were rated as ˜high’ quality. Few systematic reviews examined children’s participation and quality of life or adverse effects. The findings highlight the need for individualised evidence-based decision-making when selecting interventions for autistic children. En ligne : http://dx.doi.org/10.1177/13623613221119368 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493 Obesity and associated factors in youth with an autism spectrum disorder / Joanna GRANICH in Autism, 20-8 (November 2016)
PermalinkParent-observed thematic data on quality of life in children with autism spectrum disorder / A. EPSTEIN in Autism, 23-1 (January 2019)
PermalinkParent-reported atypical development in the first year of life and age of autism diagnosis / Hannah WADDINGTON in Journal of Autism and Developmental Disorders, 53-7 (July 2023)
PermalinkParent-reported Early Atypical Development and Age of Diagnosis for Children with Co-occurring Autism and ADHD / Willow J. Sainsbury ; Kelly CARRASCO ; Andrew J. O. WHITEHOUSE ; Hannah WADDINGTON in Journal of Autism and Developmental Disorders, 53-6 (June 2023)
PermalinkPatterns of sensory modulation by age and sex in young people on the autism spectrum / Alison E. LANE in Autism Research, 15-10 (October 2022)
PermalinkPerformance of the Autism Observation Scale for Infants with community-ascertained infants showing early signs of autism / Kristelle HUDRY in Autism, 25-2 (February 2021)
PermalinkPerinatal testosterone exposure and autistic-like traits in the general population: a longitudinal pregnancy-cohort study / Andrew J. O. WHITEHOUSE in Journal of Neurodevelopmental Disorders, 4-1 (December 2012)
PermalinkPotential role for immune-related genes in autism spectrum disorders: Evidence from genome-wide association meta-analysis of autistic traits / M. ARENELLA in Autism, 26-2 (February 2022)
PermalinkPrenatal maternal stress events and phenotypic outcomes in Autism Spectrum Disorder / Kandice J. VARCIN in Autism Research, 10-11 (November 2017)
PermalinkPrevalence of Motor Difficulties in Autism Spectrum Disorder: Analysis of a Population-Based Cohort / Melissa K. LICARI in Autism Research, 13-2 (February 2020)
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