Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur Cassandra L. HENDRIX |
Documents disponibles écrits par cet auteur (1)
Faire une suggestion Affiner la recherche
School-age social behavior and pragmatic language ability in children with prenatal serotonin reuptake inhibitor exposure / Erica L. SMEARMAN in Development and Psychopathology, 32-1 (February 2020)
[article]
Titre : School-age social behavior and pragmatic language ability in children with prenatal serotonin reuptake inhibitor exposure Type de document : Texte imprimé et/ou numérique Auteurs : Erica L. SMEARMAN, Auteur ; Cassandra L. HENDRIX, Auteur ; Dominika A. WINIARSKI, Auteur ; Katrina C. JOHNSON, Auteur ; Alicia K. SMITH, Auteur ; Opal Y. OUSLEY, Auteur ; Zachary N. STOWE, Auteur ; D. Jeffrey NEWPORT, Auteur ; Patricia A. BRENNAN, Auteur Article en page(s) : p.21-30 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder language neurodevelopment prenatal exposure serotonin Index. décimale : PER Périodiques Résumé : Studies examining associations between fetal serotonin reuptake inhibitor (SRI) exposure and child autism spectrum disorder (ASD) diagnoses or delayed language remain mixed and rarely prospectively follow children or employ gold-standard assessments. We prospectively followed a cohort of mother-child dyads from pregnancy through early elementary school (N = 178), and obtained maternal and alternate-caregiver ratings of behaviors related to ASD (N = 137), as well as direct, gold-standard assessments of child ASD symptoms and pragmatic language among dyads who experienced prenatal depression and either took SRIs or were medication free during pregnancy (N = 44). Prenatal SRI exposure was related to maternal ratings of ASD-related behaviors (beta = 0.24 95% confidence interval; CI [0.07, 0.48]), and, among boys, alternative caregiver ratings (males-only beta = 0.28 95% CI [0.02, 0.55], females-only beta = -0.21 95% CI [-0.63, 0.08]). However, results of our direct assessments suggest an association between SRI exposure and reduced pragmatic language scores (beta = -0.27, 95% CI [-0.53, -0.01], but not ASD (Autism Diagnostic Observation Schedule beta = 0.14 95% CI [-0.15, 0.41]; Social Responsiveness Scale beta = 0.08 95% CI [-0.25, 0.40]). These discrepancies point to issues regarding how ASD is assessed, and the possibility that SRIs may be more strongly associated with language or other broader behaviors that coincide with ASD. Larger prospective studies that incorporate thorough, gold-standard assessments of ASD, language, and other ASD-related behaviors are needed. En ligne : http://dx.doi.org/10.1017/s0954579418001372 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415
in Development and Psychopathology > 32-1 (February 2020) . - p.21-30[article] School-age social behavior and pragmatic language ability in children with prenatal serotonin reuptake inhibitor exposure [Texte imprimé et/ou numérique] / Erica L. SMEARMAN, Auteur ; Cassandra L. HENDRIX, Auteur ; Dominika A. WINIARSKI, Auteur ; Katrina C. JOHNSON, Auteur ; Alicia K. SMITH, Auteur ; Opal Y. OUSLEY, Auteur ; Zachary N. STOWE, Auteur ; D. Jeffrey NEWPORT, Auteur ; Patricia A. BRENNAN, Auteur . - p.21-30.
Langues : Anglais (eng)
in Development and Psychopathology > 32-1 (February 2020) . - p.21-30
Mots-clés : Autism Spectrum Disorder language neurodevelopment prenatal exposure serotonin Index. décimale : PER Périodiques Résumé : Studies examining associations between fetal serotonin reuptake inhibitor (SRI) exposure and child autism spectrum disorder (ASD) diagnoses or delayed language remain mixed and rarely prospectively follow children or employ gold-standard assessments. We prospectively followed a cohort of mother-child dyads from pregnancy through early elementary school (N = 178), and obtained maternal and alternate-caregiver ratings of behaviors related to ASD (N = 137), as well as direct, gold-standard assessments of child ASD symptoms and pragmatic language among dyads who experienced prenatal depression and either took SRIs or were medication free during pregnancy (N = 44). Prenatal SRI exposure was related to maternal ratings of ASD-related behaviors (beta = 0.24 95% confidence interval; CI [0.07, 0.48]), and, among boys, alternative caregiver ratings (males-only beta = 0.28 95% CI [0.02, 0.55], females-only beta = -0.21 95% CI [-0.63, 0.08]). However, results of our direct assessments suggest an association between SRI exposure and reduced pragmatic language scores (beta = -0.27, 95% CI [-0.53, -0.01], but not ASD (Autism Diagnostic Observation Schedule beta = 0.14 95% CI [-0.15, 0.41]; Social Responsiveness Scale beta = 0.08 95% CI [-0.25, 0.40]). These discrepancies point to issues regarding how ASD is assessed, and the possibility that SRIs may be more strongly associated with language or other broader behaviors that coincide with ASD. Larger prospective studies that incorporate thorough, gold-standard assessments of ASD, language, and other ASD-related behaviors are needed. En ligne : http://dx.doi.org/10.1017/s0954579418001372 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415