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Auteur P. ADAK |
Documents disponibles écrits par cet auteur (1)
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An Association Study of Gamma-Aminobutyric Acid Type A Receptor Variants and Susceptibility to Autism Spectrum Disorders / P. ADAK in Journal of Autism and Developmental Disorders, 51-11 (November 2021)
[article]
Titre : An Association Study of Gamma-Aminobutyric Acid Type A Receptor Variants and Susceptibility to Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : P. ADAK, Auteur ; S. SINHA, Auteur ; N. BANERJEE, Auteur Article en page(s) : p.4043-4053 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/genetics Humans Pilot Projects Polymorphism, Single Nucleotide Receptors, GABA Receptors, GABA-A/genetics gamma-Aminobutyric Acid Autism spectrum disorders Cars Children Gabra5 Gabrb3 Gabrg3 Mdr Index. décimale : PER Périodiques Résumé : In this pilot study, we aim to identify the role of few genetic variants of GABA-receptor type A subunits GABRB3 (rs4906902, rs7171660), GABRG3 (rs208129, rs140679), GABRA5 (rs 140681) in the aetiology of autism spectrum disorders in a population of West Bengal. 192 ASD probands, their parents and 184 ethnically-matched healthy controls were recruited for the study. The rs4906902G and the rs140679T conferred significant risk towards ASD. rs7171660 and rs140679 had transmission bias in the family. Neither alleles of rs 208129 and rs 140681 showed significant over-representation in either groups. All these variants were associated with at least one deficit in ASD-associated phenotypes like 'relating to people', 'Imitation', 'emotional response', 'body use', 'taste, smell, touch response' and 'activity levels'. En ligne : http://dx.doi.org/10.1007/s10803-020-04865-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454
in Journal of Autism and Developmental Disorders > 51-11 (November 2021) . - p.4043-4053[article] An Association Study of Gamma-Aminobutyric Acid Type A Receptor Variants and Susceptibility to Autism Spectrum Disorders [Texte imprimé et/ou numérique] / P. ADAK, Auteur ; S. SINHA, Auteur ; N. BANERJEE, Auteur . - p.4043-4053.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-11 (November 2021) . - p.4043-4053
Mots-clés : Autism Spectrum Disorder/genetics Humans Pilot Projects Polymorphism, Single Nucleotide Receptors, GABA Receptors, GABA-A/genetics gamma-Aminobutyric Acid Autism spectrum disorders Cars Children Gabra5 Gabrb3 Gabrg3 Mdr Index. décimale : PER Périodiques Résumé : In this pilot study, we aim to identify the role of few genetic variants of GABA-receptor type A subunits GABRB3 (rs4906902, rs7171660), GABRG3 (rs208129, rs140679), GABRA5 (rs 140681) in the aetiology of autism spectrum disorders in a population of West Bengal. 192 ASD probands, their parents and 184 ethnically-matched healthy controls were recruited for the study. The rs4906902G and the rs140679T conferred significant risk towards ASD. rs7171660 and rs140679 had transmission bias in the family. Neither alleles of rs 208129 and rs 140681 showed significant over-representation in either groups. All these variants were associated with at least one deficit in ASD-associated phenotypes like 'relating to people', 'Imitation', 'emotional response', 'body use', 'taste, smell, touch response' and 'activity levels'. En ligne : http://dx.doi.org/10.1007/s10803-020-04865-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454