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Détail de l'auteur
Auteur T. J. C. OPENNEER |
Documents disponibles écrits par cet auteur (2)
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Clinical precursors of tics: an EMTICS study / T. J. C. OPENNEER in Journal of Child Psychology and Psychiatry, 63-3 (March 2022)
[article]
Titre : Clinical precursors of tics: an EMTICS study Type de document : Texte imprimé et/ou numérique Auteurs : T. J. C. OPENNEER, Auteur ; C. HUYSER, Auteur ; D. MARTINO, Auteur ; A. SCHRAG, Auteur ; P. J. HOEKSTRA, Auteur ; A. DIETRICH, Auteur Article en page(s) : p.305-314 Langues : Anglais (eng) Mots-clés : Compulsions clinical precursors conduct problems sex differences tic onset Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with Tourette syndrome (TS) often have comorbid disorders, particularly attention-deficit/hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD). While subtle premorbid symptoms have been described in various psychiatric disorders, the presence of clinical precursors that may exist before the onset of tics is unknown. This longitudinal study aimed to find clinical precursors of tics by assessing a range of clinical characteristics prior to tic onset in comparison with children without onset of tics. METHODS: A sample of 187 3- to 10-year-old first-degree unaffected relatives of children with TS were followed up to 7?years in the European Multicentre Tics in Children Study (EMTICS). We investigated whether clinical characteristics assessed at baseline predicted tic onset, comparing 126 children without tic onset to 61 children who developed tics. We used the least absolute shrinkage and selection operator (LASSO) method, a penalised logistic regression approach. We also explored sex differences and repeated our analyses in an age- and sex-matched subsample. RESULTS: Children with tic onset were more frequently male (??=?-0.36), had higher baseline severity of conduct problems (??=?0.23), autism spectrum disorder symptoms (ASD; ??=?0.08), compulsions (??=?0.02) and emotional problems (??=?0.03) compared to children without tic onset. Conduct and ASD problems were male-specific predictors, whereas severity of compulsions and oppositional (??=?0.39) and emotional problems were female-specific predictors. CONCLUSION: This study supports the presence of clinical precursors prior to tic onset and highlights the need of sex-specific monitoring of children at risk of developing tics. This may aid in the earlier detection of tics, particularly in females. We moreover found that tics most often persisted one year after tic onset, in contrast to the common belief that tics are mostly transient. En ligne : http://dx.doi.org/10.1111/jcpp.13472 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457
in Journal of Child Psychology and Psychiatry > 63-3 (March 2022) . - p.305-314[article] Clinical precursors of tics: an EMTICS study [Texte imprimé et/ou numérique] / T. J. C. OPENNEER, Auteur ; C. HUYSER, Auteur ; D. MARTINO, Auteur ; A. SCHRAG, Auteur ; P. J. HOEKSTRA, Auteur ; A. DIETRICH, Auteur . - p.305-314.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-3 (March 2022) . - p.305-314
Mots-clés : Compulsions clinical precursors conduct problems sex differences tic onset Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with Tourette syndrome (TS) often have comorbid disorders, particularly attention-deficit/hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD). While subtle premorbid symptoms have been described in various psychiatric disorders, the presence of clinical precursors that may exist before the onset of tics is unknown. This longitudinal study aimed to find clinical precursors of tics by assessing a range of clinical characteristics prior to tic onset in comparison with children without onset of tics. METHODS: A sample of 187 3- to 10-year-old first-degree unaffected relatives of children with TS were followed up to 7?years in the European Multicentre Tics in Children Study (EMTICS). We investigated whether clinical characteristics assessed at baseline predicted tic onset, comparing 126 children without tic onset to 61 children who developed tics. We used the least absolute shrinkage and selection operator (LASSO) method, a penalised logistic regression approach. We also explored sex differences and repeated our analyses in an age- and sex-matched subsample. RESULTS: Children with tic onset were more frequently male (??=?-0.36), had higher baseline severity of conduct problems (??=?0.23), autism spectrum disorder symptoms (ASD; ??=?0.08), compulsions (??=?0.02) and emotional problems (??=?0.03) compared to children without tic onset. Conduct and ASD problems were male-specific predictors, whereas severity of compulsions and oppositional (??=?0.39) and emotional problems were female-specific predictors. CONCLUSION: This study supports the presence of clinical precursors prior to tic onset and highlights the need of sex-specific monitoring of children at risk of developing tics. This may aid in the earlier detection of tics, particularly in females. We moreover found that tics most often persisted one year after tic onset, in contrast to the common belief that tics are mostly transient. En ligne : http://dx.doi.org/10.1111/jcpp.13472 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 Effects of methylphenidate on executive functioning in children and adolescents with ADHD after long-term use: a randomized, placebo-controlled discontinuation study / P. T. ROSENAU in Journal of Child Psychology and Psychiatry, 62-12 (December 2021)
[article]
Titre : Effects of methylphenidate on executive functioning in children and adolescents with ADHD after long-term use: a randomized, placebo-controlled discontinuation study Type de document : Texte imprimé et/ou numérique Auteurs : P. T. ROSENAU, Auteur ; T. J. C. OPENNEER, Auteur ; A. M. MATTHIJSSEN, Auteur ; G. H. H. VAN DE LOO-NEUS, Auteur ; Jan K. BUITELAAR, Auteur ; B. J. VAN DEN HOOFDAKKER, Auteur ; P. J. HOEKSTRA, Auteur ; A. DIETRICH, Auteur Article en page(s) : p.1444-1452 Langues : Anglais (eng) Mots-clés : Adolescent Attention Deficit Disorder with Hyperactivity/drug therapy Central Nervous System Stimulants/adverse effects Child Double-Blind Method Executive Function Humans Methylphenidate/adverse effects Netherlands Treatment Outcome attention-deficit/hyperactivity disorder executive functioning long-term methylphenidate working memory Index. décimale : PER Périodiques Résumé : BACKGROUND: Methylphenidate may improve executive functioning in children with attention-deficit/hyperactivity disorder (ADHD). However, it is unclear if there are still acute effects of methylphenidate on executive functioning after long-term use. METHODS: In a randomized double-blind, placebo-controlled discontinuation study, 94 children and adolescents (ages 8-18?years) who used methylphenidate beyond two years were either assigned to seven weeks of continued treatment with 36 or 54?mg of extended-release methylphenidate or to gradual withdrawal over three weeks to placebo for four weeks. Performance on neuropsychological tasks, measuring working memory, response inhibition, attentional flexibility and psychomotor speed was compared between both groups using mixed models for repeated measures. Additionally, we investigated within the discontinuation group if a deterioration on the investigator-rated Clinical Global Impressions Improvement scale after withdrawing to placebo was related to a worse performance on the neuropsychological tasks. This study was registered in the Netherlands Trial Register (www. Trialregister.nl) with identifier 5252. RESULTS: After withdrawal of methylphenidate, the discontinuation group made more errors on working memory (??=?-1.62, SD?=?0.56, t?=?-2.88, p?=?.01, Cohen's f2?=?.14), independent from reaction time compared to baseline, in contrast to the continuation group. We did not find differences in changes in response inhibition, attentional flexibility and psychomotor speed between the two groups. Also, there were no significant differences in task measures between the participants who deteriorated clinically and those who did not. CONCLUSIONS: Our study shows that methylphenidate has a beneficial effect on working memory after two years of use. Future studies should explore whether cognitive outcomes may aid clinical decision-making on the continued use of methylphenidate, given dissociation between cognitive and behavioural effects of stimulant medication. En ligne : http://dx.doi.org/10.1111/jcpp.13419 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456
in Journal of Child Psychology and Psychiatry > 62-12 (December 2021) . - p.1444-1452[article] Effects of methylphenidate on executive functioning in children and adolescents with ADHD after long-term use: a randomized, placebo-controlled discontinuation study [Texte imprimé et/ou numérique] / P. T. ROSENAU, Auteur ; T. J. C. OPENNEER, Auteur ; A. M. MATTHIJSSEN, Auteur ; G. H. H. VAN DE LOO-NEUS, Auteur ; Jan K. BUITELAAR, Auteur ; B. J. VAN DEN HOOFDAKKER, Auteur ; P. J. HOEKSTRA, Auteur ; A. DIETRICH, Auteur . - p.1444-1452.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 62-12 (December 2021) . - p.1444-1452
Mots-clés : Adolescent Attention Deficit Disorder with Hyperactivity/drug therapy Central Nervous System Stimulants/adverse effects Child Double-Blind Method Executive Function Humans Methylphenidate/adverse effects Netherlands Treatment Outcome attention-deficit/hyperactivity disorder executive functioning long-term methylphenidate working memory Index. décimale : PER Périodiques Résumé : BACKGROUND: Methylphenidate may improve executive functioning in children with attention-deficit/hyperactivity disorder (ADHD). However, it is unclear if there are still acute effects of methylphenidate on executive functioning after long-term use. METHODS: In a randomized double-blind, placebo-controlled discontinuation study, 94 children and adolescents (ages 8-18?years) who used methylphenidate beyond two years were either assigned to seven weeks of continued treatment with 36 or 54?mg of extended-release methylphenidate or to gradual withdrawal over three weeks to placebo for four weeks. Performance on neuropsychological tasks, measuring working memory, response inhibition, attentional flexibility and psychomotor speed was compared between both groups using mixed models for repeated measures. Additionally, we investigated within the discontinuation group if a deterioration on the investigator-rated Clinical Global Impressions Improvement scale after withdrawing to placebo was related to a worse performance on the neuropsychological tasks. This study was registered in the Netherlands Trial Register (www. Trialregister.nl) with identifier 5252. RESULTS: After withdrawal of methylphenidate, the discontinuation group made more errors on working memory (??=?-1.62, SD?=?0.56, t?=?-2.88, p?=?.01, Cohen's f2?=?.14), independent from reaction time compared to baseline, in contrast to the continuation group. We did not find differences in changes in response inhibition, attentional flexibility and psychomotor speed between the two groups. Also, there were no significant differences in task measures between the participants who deteriorated clinically and those who did not. CONCLUSIONS: Our study shows that methylphenidate has a beneficial effect on working memory after two years of use. Future studies should explore whether cognitive outcomes may aid clinical decision-making on the continued use of methylphenidate, given dissociation between cognitive and behavioural effects of stimulant medication. En ligne : http://dx.doi.org/10.1111/jcpp.13419 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456