Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur Marie-Laure BONTE |
Documents disponibles écrits par cet auteur (1)
Faire une suggestion Affiner la recherche
Oxytocin receptor gene (OXTR) DNA methylation is associated with autism and related social traits – A systematic review / Matthijs MOERKERKE in Research in Autism Spectrum Disorders, 85 (July 2021)
[article]
Titre : Oxytocin receptor gene (OXTR) DNA methylation is associated with autism and related social traits – A systematic review Type de document : Texte imprimé et/ou numérique Auteurs : Matthijs MOERKERKE, Auteur ; Marie-Laure BONTE, Auteur ; Nicky DANIELS, Auteur ; Viktoria CHUBAR, Auteur ; Kaat ALAERTS, Auteur ; Jean STEYAERT, Auteur ; Bart BOETS, Auteur Article en page(s) : 101785 Langues : Anglais (eng) Mots-clés : Oxytocin receptor gene Epigenetics DNA methylation Autism Social behaviour Index. décimale : PER Périodiques Résumé : There is emerging evidence implicating oxytocin receptor gene (OXTR) DNA methylation (DNAm) in social behaviour. This review investigated its association with autism spectrum disorder (ASD) characteristics and related social dimensions, both in individuals with and without ASD. Twelve articles investigating OXTR DNAm in relation to ASD, social perception/cognition and social anxiety were included. We found that hypermethylation is associated with (i) higher quantitative autism traits in adults, reflecting a higher incidence of autism characteristics, (ii) increased brain activity while performing social tasks (indicating a higher need for resources) and (iii) decreased functional connectivity. (iv) Contradictory, hypomethylation was found to be present in children (especially boys) with ASD and was also associated with more social anxiety. While the included studies displayed a large variability, for example in terms of population characteristics, analysed OXTR DNAm regions, and adopted scales/questionnaires, an initial developmental pattern of results emerged, suggesting an association between hypermethylation of OXTR and autism traits in adults. Nonetheless, future studies are warranted to corroborate these initial conclusions. En ligne : https://doi.org/10.1016/j.rasd.2021.101785 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458
in Research in Autism Spectrum Disorders > 85 (July 2021) . - 101785[article] Oxytocin receptor gene (OXTR) DNA methylation is associated with autism and related social traits – A systematic review [Texte imprimé et/ou numérique] / Matthijs MOERKERKE, Auteur ; Marie-Laure BONTE, Auteur ; Nicky DANIELS, Auteur ; Viktoria CHUBAR, Auteur ; Kaat ALAERTS, Auteur ; Jean STEYAERT, Auteur ; Bart BOETS, Auteur . - 101785.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 85 (July 2021) . - 101785
Mots-clés : Oxytocin receptor gene Epigenetics DNA methylation Autism Social behaviour Index. décimale : PER Périodiques Résumé : There is emerging evidence implicating oxytocin receptor gene (OXTR) DNA methylation (DNAm) in social behaviour. This review investigated its association with autism spectrum disorder (ASD) characteristics and related social dimensions, both in individuals with and without ASD. Twelve articles investigating OXTR DNAm in relation to ASD, social perception/cognition and social anxiety were included. We found that hypermethylation is associated with (i) higher quantitative autism traits in adults, reflecting a higher incidence of autism characteristics, (ii) increased brain activity while performing social tasks (indicating a higher need for resources) and (iii) decreased functional connectivity. (iv) Contradictory, hypomethylation was found to be present in children (especially boys) with ASD and was also associated with more social anxiety. While the included studies displayed a large variability, for example in terms of population characteristics, analysed OXTR DNAm regions, and adopted scales/questionnaires, an initial developmental pattern of results emerged, suggesting an association between hypermethylation of OXTR and autism traits in adults. Nonetheless, future studies are warranted to corroborate these initial conclusions. En ligne : https://doi.org/10.1016/j.rasd.2021.101785 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458