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Auteur Hildigunnur Anna HALL |
Documents disponibles écrits par cet auteur (2)
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Polygenic risks for joint developmental trajectories of internalizing and externalizing problems: findings from the ALSPAC cohort / Lydia Gabriela SPEYER in Journal of Child Psychology and Psychiatry, 63-8 (August 2022)
[article]
Titre : Polygenic risks for joint developmental trajectories of internalizing and externalizing problems: findings from the ALSPAC cohort Type de document : Texte imprimé et/ou numérique Auteurs : Lydia Gabriela SPEYER, Auteur ; Samuel NEAVES, Auteur ; Hildigunnur Anna HALL, Auteur ; Gibran HEMANI, Auteur ; Michael Vincent LOMBARDO, Auteur ; Aja Louise MURRAY, Auteur ; Bonnie AUYEUNG, Auteur ; Michelle LUCIANO, Auteur Article en page(s) : p.948-956 Langues : Anglais (eng) Mots-clés : Adolescent Child Child, Preschool Female Humans Longitudinal Studies Male Mothers Multifactorial Inheritance Pregnancy Risk Factors Smoking Alspac Joint mental health trajectories externalizing internalizing polygenic risk Index. décimale : PER Périodiques Résumé : BACKGROUND: Joint developmental trajectories of internalizing and externalizing problems show considerable heterogeneity; however, this can be parsed into a small number of meaningful subgroups. Doing so offered insights into risk factors that lead to different patterns of internalizing/externalizing trajectories. However, despite both domains of problems showing strong heritability, no study has yet considered genetic risks as predictors of joint internalizing/externalizing problem trajectories. METHODS: Using parallel process latent class growth analysis, we estimated joint developmental trajectories of internalizing and externalizing difficulties assessed across ages 4 to 16 using the Strengths and Difficulties Questionnaire. Multinomial logistic regression was used to evaluate a range of demographic, perinatal, maternal mental health, and child and maternal polygenic predictors of group membership. Participants included 11,049 children taking part in the Avon Longitudinal Study of Parents and Children. Polygenic data were available for 7,127 children and 6,836 mothers. RESULTS: A 5-class model was judged optimal: Unaffected, Moderate Externalizing Symptoms, High Externalizing Symptoms, Moderate Internalizing and Externalizing Symptoms and High Internalizing and Externalizing Symptoms. Male sex, lower maternal age, maternal mental health problems, maternal smoking during pregnancy, higher child polygenic risk scores for ADHD and lower polygenic scores for IQ distinguished affected classes from the unaffected class. CONCLUSIONS: While affected classes could be relatively well separated from the unaffected class, phenotypic and polygenic predictors were limited in their ability to distinguish between different affected classes. Results thus add to existing evidence that internalizing and externalizing problems have mostly shared risk factors. En ligne : http://dx.doi.org/10.1111/jcpp.13549 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486
in Journal of Child Psychology and Psychiatry > 63-8 (August 2022) . - p.948-956[article] Polygenic risks for joint developmental trajectories of internalizing and externalizing problems: findings from the ALSPAC cohort [Texte imprimé et/ou numérique] / Lydia Gabriela SPEYER, Auteur ; Samuel NEAVES, Auteur ; Hildigunnur Anna HALL, Auteur ; Gibran HEMANI, Auteur ; Michael Vincent LOMBARDO, Auteur ; Aja Louise MURRAY, Auteur ; Bonnie AUYEUNG, Auteur ; Michelle LUCIANO, Auteur . - p.948-956.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-8 (August 2022) . - p.948-956
Mots-clés : Adolescent Child Child, Preschool Female Humans Longitudinal Studies Male Mothers Multifactorial Inheritance Pregnancy Risk Factors Smoking Alspac Joint mental health trajectories externalizing internalizing polygenic risk Index. décimale : PER Périodiques Résumé : BACKGROUND: Joint developmental trajectories of internalizing and externalizing problems show considerable heterogeneity; however, this can be parsed into a small number of meaningful subgroups. Doing so offered insights into risk factors that lead to different patterns of internalizing/externalizing trajectories. However, despite both domains of problems showing strong heritability, no study has yet considered genetic risks as predictors of joint internalizing/externalizing problem trajectories. METHODS: Using parallel process latent class growth analysis, we estimated joint developmental trajectories of internalizing and externalizing difficulties assessed across ages 4 to 16 using the Strengths and Difficulties Questionnaire. Multinomial logistic regression was used to evaluate a range of demographic, perinatal, maternal mental health, and child and maternal polygenic predictors of group membership. Participants included 11,049 children taking part in the Avon Longitudinal Study of Parents and Children. Polygenic data were available for 7,127 children and 6,836 mothers. RESULTS: A 5-class model was judged optimal: Unaffected, Moderate Externalizing Symptoms, High Externalizing Symptoms, Moderate Internalizing and Externalizing Symptoms and High Internalizing and Externalizing Symptoms. Male sex, lower maternal age, maternal mental health problems, maternal smoking during pregnancy, higher child polygenic risk scores for ADHD and lower polygenic scores for IQ distinguished affected classes from the unaffected class. CONCLUSIONS: While affected classes could be relatively well separated from the unaffected class, phenotypic and polygenic predictors were limited in their ability to distinguish between different affected classes. Results thus add to existing evidence that internalizing and externalizing problems have mostly shared risk factors. En ligne : http://dx.doi.org/10.1111/jcpp.13549 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 Within-family relations of mental health problems across childhood and adolescence / Lydia Gabriela SPEYER in Journal of Child Psychology and Psychiatry, 63-11 (November 2022)
[article]
Titre : Within-family relations of mental health problems across childhood and adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Lydia Gabriela SPEYER, Auteur ; Hildigunnur Anna HALL, Auteur ; Yuzhan HANG, Auteur ; Claire HUGHES, Auteur ; Aja Louise MURRAY, Auteur Article en page(s) : p.1288-1296 Langues : Anglais (eng) Mots-clés : Child Male Child, Preschool Adolescent Humans Female Child Behavior Disorders/psychology Family Relations Child Behavior/psychology Cohort Studies Mental Health Longitudinal Studies Millennium Cohort Study Parental mental health externalising internalising within-family Index. décimale : PER Périodiques Résumé : BACKGROUND: While transactional models suggest that parent and child mental health reciprocally influence one another over development, research has largely focused on parent-to-child effects. Additionally, it is not known whether observed associations hold when appropriate statistical tools are used to operationalise within-family dynamics. METHODS: We investigated within-family mental health dynamics using autoregressive latent trajectory models with structured residuals, stratified by child gender. Parental psychological distress was assessed using the Kessler (K6) scale, and children's internalising and externalising problems were assessed using the Strengths and Difficulties Questionnaire. Both measures were administered at the age 3, 5, 7, 11, 14 and 17 waves of the Millennium Cohort Study (N=10,746, ~50% female). RESULTS: Maternal psychological distress was positively associated with subsequent internalising and externalising problems for girls but only with internalising problems for boys. Paternal psychological distress was associated with boys' later internalising and externalising problems during early adolescence. Among boys, internalising problems were associated with later maternal psychological distress, while externalising problems were associated with later paternal psychological distress. Among girls, internalising problems were associated with subsequent paternal psychological distress, while externalising problems were associated with later maternal psychological distress. Finally, maternal and paternal psychological distress showed negative bidirectional associations in early childhood but positive associations in middle childhood and early adolescence. CONCLUSIONS: Findings support a transactional model of family mental health, with both child-to-parent and parent-to-child effects playing a role in the development of mental health difficulties. Mental health intervention efforts should, therefore, target the whole family system. En ligne : http://dx.doi.org/10.1111/jcpp.13572 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490
in Journal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1288-1296[article] Within-family relations of mental health problems across childhood and adolescence [Texte imprimé et/ou numérique] / Lydia Gabriela SPEYER, Auteur ; Hildigunnur Anna HALL, Auteur ; Yuzhan HANG, Auteur ; Claire HUGHES, Auteur ; Aja Louise MURRAY, Auteur . - p.1288-1296.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1288-1296
Mots-clés : Child Male Child, Preschool Adolescent Humans Female Child Behavior Disorders/psychology Family Relations Child Behavior/psychology Cohort Studies Mental Health Longitudinal Studies Millennium Cohort Study Parental mental health externalising internalising within-family Index. décimale : PER Périodiques Résumé : BACKGROUND: While transactional models suggest that parent and child mental health reciprocally influence one another over development, research has largely focused on parent-to-child effects. Additionally, it is not known whether observed associations hold when appropriate statistical tools are used to operationalise within-family dynamics. METHODS: We investigated within-family mental health dynamics using autoregressive latent trajectory models with structured residuals, stratified by child gender. Parental psychological distress was assessed using the Kessler (K6) scale, and children's internalising and externalising problems were assessed using the Strengths and Difficulties Questionnaire. Both measures were administered at the age 3, 5, 7, 11, 14 and 17 waves of the Millennium Cohort Study (N=10,746, ~50% female). RESULTS: Maternal psychological distress was positively associated with subsequent internalising and externalising problems for girls but only with internalising problems for boys. Paternal psychological distress was associated with boys' later internalising and externalising problems during early adolescence. Among boys, internalising problems were associated with later maternal psychological distress, while externalising problems were associated with later paternal psychological distress. Among girls, internalising problems were associated with subsequent paternal psychological distress, while externalising problems were associated with later maternal psychological distress. Finally, maternal and paternal psychological distress showed negative bidirectional associations in early childhood but positive associations in middle childhood and early adolescence. CONCLUSIONS: Findings support a transactional model of family mental health, with both child-to-parent and parent-to-child effects playing a role in the development of mental health difficulties. Mental health intervention efforts should, therefore, target the whole family system. En ligne : http://dx.doi.org/10.1111/jcpp.13572 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490