Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur Natasha N. LUDWIG |
Documents disponibles écrits par cet auteur (2)
Faire une suggestion Affiner la recherche
Prevalence of gastrointestinal symptoms among autistic individuals, with and without co-occurring intellectual disability / Calliope HOLINGUE in Autism Research, 16-8 (August 2023)
[article]
Titre : Prevalence of gastrointestinal symptoms among autistic individuals, with and without co-occurring intellectual disability Type de document : Texte imprimé et/ou numérique Auteurs : Calliope HOLINGUE, Auteur ; Danika PFEIFFER, Auteur ; Natasha N. LUDWIG, Auteur ; Rachel REETZKE, Auteur ; Ji Su HONG, Auteur ; Luther G. KALB, Auteur ; Rebecca LANDA, Auteur Article en page(s) : p.1609-1618 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Gastrointestinal symptoms (GI) are very common among individuals on the autism spectrum. Prior research reports mixed findings regarding whether individuals with autism and co-occurring intellectual disability (ID) have elevated risk of gastrointestinal symptoms relative to individuals with autism alone. GI symptoms can be challenging to assess in individuals with autism spectrum disorder (ASD) and/or ID given challenges with language, communication, and interoception. Prior research has tended to only include individuals with documented presence or absence of GI symptoms or conditions, that is, to exclude observations in which there is uncertainty regarding presence of GI symptoms. Therefore, none of the prior autism studies reported the association between ID and the certainty regarding presence or absence of GI symptoms. The objective of this study was to examine differences in parental certainty and odds of reporting gastrointestinal signs and symptoms among children on the autism spectrum, with and without intellectual disability. Participants were 308 children (36% ID) with a clinical diagnosis of autism spectrum disorder (6-17?years). Parents endorsed whether their child had experienced or displayed a range of signs or symptoms related to GI problems in the past 3 months. Parents of autistic children with ID were less certain about the presence of more subjective symptoms, including abdominal pain, nausea, and bloating. Conversely, certainty regarding more objective signs (e.g., constipation, diarrhea, spitting up, etc.) was not significantly different. More accurate measures for GI signs/symptoms are needed for this population. En ligne : https://doi.org/10.1002/aur.2972 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510
in Autism Research > 16-8 (August 2023) . - p.1609-1618[article] Prevalence of gastrointestinal symptoms among autistic individuals, with and without co-occurring intellectual disability [Texte imprimé et/ou numérique] / Calliope HOLINGUE, Auteur ; Danika PFEIFFER, Auteur ; Natasha N. LUDWIG, Auteur ; Rachel REETZKE, Auteur ; Ji Su HONG, Auteur ; Luther G. KALB, Auteur ; Rebecca LANDA, Auteur . - p.1609-1618.
Langues : Anglais (eng)
in Autism Research > 16-8 (August 2023) . - p.1609-1618
Index. décimale : PER Périodiques Résumé : Abstract Gastrointestinal symptoms (GI) are very common among individuals on the autism spectrum. Prior research reports mixed findings regarding whether individuals with autism and co-occurring intellectual disability (ID) have elevated risk of gastrointestinal symptoms relative to individuals with autism alone. GI symptoms can be challenging to assess in individuals with autism spectrum disorder (ASD) and/or ID given challenges with language, communication, and interoception. Prior research has tended to only include individuals with documented presence or absence of GI symptoms or conditions, that is, to exclude observations in which there is uncertainty regarding presence of GI symptoms. Therefore, none of the prior autism studies reported the association between ID and the certainty regarding presence or absence of GI symptoms. The objective of this study was to examine differences in parental certainty and odds of reporting gastrointestinal signs and symptoms among children on the autism spectrum, with and without intellectual disability. Participants were 308 children (36% ID) with a clinical diagnosis of autism spectrum disorder (6-17?years). Parents endorsed whether their child had experienced or displayed a range of signs or symptoms related to GI problems in the past 3 months. Parents of autistic children with ID were less certain about the presence of more subjective symptoms, including abdominal pain, nausea, and bloating. Conversely, certainty regarding more objective signs (e.g., constipation, diarrhea, spitting up, etc.) was not significantly different. More accurate measures for GI signs/symptoms are needed for this population. En ligne : https://doi.org/10.1002/aur.2972 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510 Replication study for ADOS-2 cut-offs to assist evaluation of autism spectrum disorder / Ji Su HONG in Autism Research, 15-11 (November 2022)
[article]
Titre : Replication study for ADOS-2 cut-offs to assist evaluation of autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Ji Su HONG, Auteur ; Vini SINGH, Auteur ; Luke G. KALB, Auteur ; Rachel REETZKE, Auteur ; Natasha N. LUDWIG, Auteur ; Danika PFEIFFER, Auteur ; Calliope HOLINGUE, Auteur ; Deepa MENON, Auteur ; Qing LU, Auteur ; Ahlam ASHKAR, Auteur ; Rebecca LANDA, Auteur Article en page(s) : p.2181-2191 Langues : Anglais (eng) Mots-clés : Child Humans Male Female Autism Spectrum Disorder/diagnosis Sensitivity and Specificity Predictive Value of Tests Algorithms Autistic Disorder autism spectrum disorder classification cut-off score diagnosis Index. décimale : PER Périodiques Résumé : The Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) has been widely used for ASD assessment. While prior studies investigated sensitivity and specificity of ADOS-2 Modules 1-3, there has been limited research addressing algorithm cut-off scores to optimize ADOS-2 classification. The goal of this study was to assess algorithm cut-off scores for diagnosing ASD with Modules 1-3, and to evaluate alignment of the ADOS-2 classification with the best estimate clinical diagnosis. Participants included 3144 children aged 31 months or older who received ADOS-2 Modules 1-3, as well as the best estimate clinical diagnosis. Five classification statistics were reported for each module: sensitivity, specificity, positive predictive value, negative predictive value, and accuracy (i.e., Receiver Operator Classification Statistic), and these statistics were calculated for the optimal cut-off score. Frequency tables were used to compare ADOS-2 classification and the best estimate clinical diagnosis. Half of the sample received Module 3, 21% received Module 2, and 29% received Module 1. The overall prevalence of ASD was 60%; the male-to-female ratio was 4:1, and half of the sample was non-White. Across all modules, the autism spectrum cut-off score from the ADOS-2 manual resulted in high sensitivity (95%+) and low specificity (63%-73%). The autism cut-off score resulted in better specificity (76%-86%) with favorable sensitivity (81%-94%). The optimal cut-off scores for all modules based on the current sample were within the autism spectrum classification range except Module 2 Algorithm 2. In the No ASD group, 29% had false positives (ADOS-2 autism spectrum classification or autism classification). The ADOS-2 autism spectrum classification did not indicate directionality for diagnostic outcome (ASD 56% vs. No ASD 44%). While cut-off scores of ADOS-2 Modules 1-3 in the manual yielded good clinical utility in ASD assessment, false positives and low predictability of the autism spectrum classification remain challenging for clinicians. En ligne : http://dx.doi.org/10.1002/aur.2801 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488
in Autism Research > 15-11 (November 2022) . - p.2181-2191[article] Replication study for ADOS-2 cut-offs to assist evaluation of autism spectrum disorder [Texte imprimé et/ou numérique] / Ji Su HONG, Auteur ; Vini SINGH, Auteur ; Luke G. KALB, Auteur ; Rachel REETZKE, Auteur ; Natasha N. LUDWIG, Auteur ; Danika PFEIFFER, Auteur ; Calliope HOLINGUE, Auteur ; Deepa MENON, Auteur ; Qing LU, Auteur ; Ahlam ASHKAR, Auteur ; Rebecca LANDA, Auteur . - p.2181-2191.
Langues : Anglais (eng)
in Autism Research > 15-11 (November 2022) . - p.2181-2191
Mots-clés : Child Humans Male Female Autism Spectrum Disorder/diagnosis Sensitivity and Specificity Predictive Value of Tests Algorithms Autistic Disorder autism spectrum disorder classification cut-off score diagnosis Index. décimale : PER Périodiques Résumé : The Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) has been widely used for ASD assessment. While prior studies investigated sensitivity and specificity of ADOS-2 Modules 1-3, there has been limited research addressing algorithm cut-off scores to optimize ADOS-2 classification. The goal of this study was to assess algorithm cut-off scores for diagnosing ASD with Modules 1-3, and to evaluate alignment of the ADOS-2 classification with the best estimate clinical diagnosis. Participants included 3144 children aged 31 months or older who received ADOS-2 Modules 1-3, as well as the best estimate clinical diagnosis. Five classification statistics were reported for each module: sensitivity, specificity, positive predictive value, negative predictive value, and accuracy (i.e., Receiver Operator Classification Statistic), and these statistics were calculated for the optimal cut-off score. Frequency tables were used to compare ADOS-2 classification and the best estimate clinical diagnosis. Half of the sample received Module 3, 21% received Module 2, and 29% received Module 1. The overall prevalence of ASD was 60%; the male-to-female ratio was 4:1, and half of the sample was non-White. Across all modules, the autism spectrum cut-off score from the ADOS-2 manual resulted in high sensitivity (95%+) and low specificity (63%-73%). The autism cut-off score resulted in better specificity (76%-86%) with favorable sensitivity (81%-94%). The optimal cut-off scores for all modules based on the current sample were within the autism spectrum classification range except Module 2 Algorithm 2. In the No ASD group, 29% had false positives (ADOS-2 autism spectrum classification or autism classification). The ADOS-2 autism spectrum classification did not indicate directionality for diagnostic outcome (ASD 56% vs. No ASD 44%). While cut-off scores of ADOS-2 Modules 1-3 in the manual yielded good clinical utility in ASD assessment, false positives and low predictability of the autism spectrum classification remain challenging for clinicians. En ligne : http://dx.doi.org/10.1002/aur.2801 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488