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Détail de l'auteur
Auteur Ting CHENG |
Documents disponibles écrits par cet auteur (1)
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Corneal structural alterations in autism spectrum disorder: An in vivo confocal microscopy study / Po-Ying WU ; Jo-Hsuan WU ; Wei-Lun HUANG ; Chia-Chieh HSIAO ; Yi-Ting HSIEH ; Ting CHENG ; Susan Shur-Fen GAU ; Wei-Li CHEN in Autism Research, 16-12 (December 2023)
[article]
Titre : Corneal structural alterations in autism spectrum disorder: An in vivo confocal microscopy study Type de document : Texte imprimé et/ou numérique Auteurs : Po-Ying WU, Auteur ; Jo-Hsuan WU, Auteur ; Wei-Lun HUANG, Auteur ; Chia-Chieh HSIAO, Auteur ; Yi-Ting HSIEH, Auteur ; Ting CHENG, Auteur ; Susan Shur-Fen GAU, Auteur ; Wei-Li CHEN, Auteur Article en page(s) : p.2316-2325 Index. décimale : PER Périodiques Résumé : Abstract Individuals with autism spectrum disorder (ASD) often exhibit joint hypermobility and connective tissue disorders. However, it remains unclear if ASD individuals also have structural alterations in the connective tissue of the cornea. This study aims to determine whether the Kobayashi structure (K-structure) characteristics differ between adults with ASD and typically developing controls (TDC) and explore the clinical correlates of the K-structure abnormality. We recruited 30 ASD adults and 35 TDC. Corneal structures, particularly the K-structure in the Bowman's layer, of the participants were examined using in vivo confocal microscopy (IVCM), and a K-grading ranging from 1 to 4 was given to each eye based on the level of morphological mosaicism. The ASD participants' eyes received a significantly higher single-eye K-grading than that of the TDC eyes (p<0.001), and the medians [25th, 75th percentile] of bilateral-eye summed K-grading were 8 [7, 8] and 5 [4, 6] in ASD and TDC, respectively (p<0.001). A significantly higher K-grading in the ASD participants' eyes was still observed after adjusting for the within-subject inter-eye correlation (p<0.001). Youden Index showed the optimal cutoffs to differentiate ASD from TDC by bilateral-eye summed K-grading and single-eye K-grading was >6 and?>3, respectively. Additionally, a higher K-grading was associated with fewer visual sensation seeking in ASD (Spearman's correlation coefficient ? = ?0.518, p = 0.008) and low visual registration (i.e., higher sensory threshold) in TDC (? = 0.446, p = 0.023). This study provided novel evidence of corneal structural alterations in ASD by IVCM. Our findings may not only support the prior hypothesis of the association between ASD and connective tissue abnormalities but also shed light on the relationship between connective tissue disorder and neurodevelopmental disorders. En ligne : https://doi.org/10.1002/aur.3050 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518
in Autism Research > 16-12 (December 2023) . - p.2316-2325[article] Corneal structural alterations in autism spectrum disorder: An in vivo confocal microscopy study [Texte imprimé et/ou numérique] / Po-Ying WU, Auteur ; Jo-Hsuan WU, Auteur ; Wei-Lun HUANG, Auteur ; Chia-Chieh HSIAO, Auteur ; Yi-Ting HSIEH, Auteur ; Ting CHENG, Auteur ; Susan Shur-Fen GAU, Auteur ; Wei-Li CHEN, Auteur . - p.2316-2325.
in Autism Research > 16-12 (December 2023) . - p.2316-2325
Index. décimale : PER Périodiques Résumé : Abstract Individuals with autism spectrum disorder (ASD) often exhibit joint hypermobility and connective tissue disorders. However, it remains unclear if ASD individuals also have structural alterations in the connective tissue of the cornea. This study aims to determine whether the Kobayashi structure (K-structure) characteristics differ between adults with ASD and typically developing controls (TDC) and explore the clinical correlates of the K-structure abnormality. We recruited 30 ASD adults and 35 TDC. Corneal structures, particularly the K-structure in the Bowman's layer, of the participants were examined using in vivo confocal microscopy (IVCM), and a K-grading ranging from 1 to 4 was given to each eye based on the level of morphological mosaicism. The ASD participants' eyes received a significantly higher single-eye K-grading than that of the TDC eyes (p<0.001), and the medians [25th, 75th percentile] of bilateral-eye summed K-grading were 8 [7, 8] and 5 [4, 6] in ASD and TDC, respectively (p<0.001). A significantly higher K-grading in the ASD participants' eyes was still observed after adjusting for the within-subject inter-eye correlation (p<0.001). Youden Index showed the optimal cutoffs to differentiate ASD from TDC by bilateral-eye summed K-grading and single-eye K-grading was >6 and?>3, respectively. Additionally, a higher K-grading was associated with fewer visual sensation seeking in ASD (Spearman's correlation coefficient ? = ?0.518, p = 0.008) and low visual registration (i.e., higher sensory threshold) in TDC (? = 0.446, p = 0.023). This study provided novel evidence of corneal structural alterations in ASD by IVCM. Our findings may not only support the prior hypothesis of the association between ASD and connective tissue abnormalities but also shed light on the relationship between connective tissue disorder and neurodevelopmental disorders. En ligne : https://doi.org/10.1002/aur.3050 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518