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Auteur Arturas PETRONIS |
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Pre- and peri-natal environmental risks for attention-deficit hyperactivity disorder (ADHD): the potential role of epigenetic processes in mediating susceptibility / Jonathan MILL in Journal of Child Psychology and Psychiatry, 49-10 (October 2008)
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Titre : Pre- and peri-natal environmental risks for attention-deficit hyperactivity disorder (ADHD): the potential role of epigenetic processes in mediating susceptibility Type de document : Texte imprimé et/ou numérique Auteurs : Jonathan MILL, Auteur ; Arturas PETRONIS, Auteur Année de publication : 2008 Article en page(s) : p.1020-1030 Langues : Anglais (eng) Mots-clés : Epigenetics DNA-methylation environment prenatal attention-deficit-hyperactivity-disorder-(ADHD) genetics psychiatry DOHaD fetal-programming Index. décimale : PER Périodiques Résumé : Attention-deficit hyperactivity disorder (ADHD) is a common childhood neurobehavioural disorder defined by symptoms of developmentally inappropriate inattention, impulsivity and hyperactivity. As is the norm for most psychiatric phenotypes, traditional aetiological studies have focused primarily on the interplay between genetic and environmental factors. It is likely that epigenetic factors, i.e., heritable, but reversible changes to genomic function that are independent of DNA sequence, are also important. It is known that epigenetic processes can be induced following exposure to a range of external factors, and thus provide a mechanism by which the environment can lead to long-term alterations in phenotype. In this article we hypothesise that epigenetic dysregulation may mediate the association observed between early-development environmental insults and ADHD. We propose that understanding the epigenetic processes involved in linking specific environmental pathogens to an increased risk for ADHD may offer new possibilities for preventative and therapeutic intervention. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01909.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=606
in Journal of Child Psychology and Psychiatry > 49-10 (October 2008) . - p.1020-1030[article] Pre- and peri-natal environmental risks for attention-deficit hyperactivity disorder (ADHD): the potential role of epigenetic processes in mediating susceptibility [Texte imprimé et/ou numérique] / Jonathan MILL, Auteur ; Arturas PETRONIS, Auteur . - 2008 . - p.1020-1030.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 49-10 (October 2008) . - p.1020-1030
Mots-clés : Epigenetics DNA-methylation environment prenatal attention-deficit-hyperactivity-disorder-(ADHD) genetics psychiatry DOHaD fetal-programming Index. décimale : PER Périodiques Résumé : Attention-deficit hyperactivity disorder (ADHD) is a common childhood neurobehavioural disorder defined by symptoms of developmentally inappropriate inattention, impulsivity and hyperactivity. As is the norm for most psychiatric phenotypes, traditional aetiological studies have focused primarily on the interplay between genetic and environmental factors. It is likely that epigenetic factors, i.e., heritable, but reversible changes to genomic function that are independent of DNA sequence, are also important. It is known that epigenetic processes can be induced following exposure to a range of external factors, and thus provide a mechanism by which the environment can lead to long-term alterations in phenotype. In this article we hypothesise that epigenetic dysregulation may mediate the association observed between early-development environmental insults and ADHD. We propose that understanding the epigenetic processes involved in linking specific environmental pathogens to an increased risk for ADHD may offer new possibilities for preventative and therapeutic intervention. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01909.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=606