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The gene in its natural habitat: The importance of gene–trait interactions / Colin G. DEYOUNG in Development and Psychopathology, 24-4 (November 2012)
[article]
Titre : The gene in its natural habitat: The importance of gene–trait interactions Type de document : Texte imprimé et/ou numérique Auteurs : Colin G. DEYOUNG, Auteur ; Rachel CLARK, Auteur Année de publication : 2012 Article en page(s) : p.1307-1318 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Despite the substantial heritability of nearly all psychological traits, it has been difficult to identify specific genetic variants that account for more than a tiny percentage of genetic variance in phenotypes. Common explanations for this “missing heritability” include massive polygenicity, rare variants, epigenetics, epistasis, and gene–environment interactions. Gene–trait (G × T) interaction is another concept useful for understanding the lack of obvious genetic main effects. Both genes and environments are distal contributors to human behavior, but the brain is the proximal driver of behavior. The effect of any single genetic variant is dependent on the configuration of the brain in which it is expressed. One method to begin studying how single genes interact with variations in the rest of the brain is to investigate G × T interactions. A psychological trait reflects a characteristic pattern of psychological function (and, therefore, of brain function), which has its origin in the cumulative effects of both the genome and the environment. A trait therefore describes variation in the broad organismic context in which any single gene operates. We describe the nature and significance of G × T interactions for understanding psychopathology and normal trait variation, which are illustrated with empirical examples. En ligne : http://dx.doi.org/10.1017/S0954579412000727 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182
in Development and Psychopathology > 24-4 (November 2012) . - p.1307-1318[article] The gene in its natural habitat: The importance of gene–trait interactions [Texte imprimé et/ou numérique] / Colin G. DEYOUNG, Auteur ; Rachel CLARK, Auteur . - 2012 . - p.1307-1318.
Langues : Anglais (eng)
in Development and Psychopathology > 24-4 (November 2012) . - p.1307-1318
Index. décimale : PER Périodiques Résumé : Despite the substantial heritability of nearly all psychological traits, it has been difficult to identify specific genetic variants that account for more than a tiny percentage of genetic variance in phenotypes. Common explanations for this “missing heritability” include massive polygenicity, rare variants, epigenetics, epistasis, and gene–environment interactions. Gene–trait (G × T) interaction is another concept useful for understanding the lack of obvious genetic main effects. Both genes and environments are distal contributors to human behavior, but the brain is the proximal driver of behavior. The effect of any single genetic variant is dependent on the configuration of the brain in which it is expressed. One method to begin studying how single genes interact with variations in the rest of the brain is to investigate G × T interactions. A psychological trait reflects a characteristic pattern of psychological function (and, therefore, of brain function), which has its origin in the cumulative effects of both the genome and the environment. A trait therefore describes variation in the broad organismic context in which any single gene operates. We describe the nature and significance of G × T interactions for understanding psychopathology and normal trait variation, which are illustrated with empirical examples. En ligne : http://dx.doi.org/10.1017/S0954579412000727 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182 The Genetics of Neurodevelopmental Disorders / Kevin J. MITCHELL
Titre : The Genetics of Neurodevelopmental Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Kevin J. MITCHELL, Directeur de publication Editeur : Hoboken [Etats-Unis] : Wiley Année de publication : 2015 Importance : 356 p. Présentation : ill. Format : 18,5cm x 26cm x 2,3cm ISBN/ISSN/EAN : 978-1-118-52488-6 Note générale : Bibliogr.; Index Langues : Anglais (eng) Mots-clés : Troubles du neurodéveloppement Index. décimale : SCI-B SCI-B - Génétique Résumé : Neurodevelopmental disorders arise from disturbances to various processes of brain development, which can manifest in diverse ways. They encompass many rare genetic syndromes as well as common, heritable conditions such as intellectual disability, autism, ADHD, schizophrenia and many types of epilepsy. The Genetics of Neurodevelopmental Disorders examines recent revolutionary advances in our understanding of the genetics of these disorders, exploring both basic discoveries and the translation of new findings into the clinical setting.
The book begins by examining the genetic architecture and etiology of neurodevelopmental disorders. It describes the striking recent progress in identifying pathogenic mutations, which are grouped here based on the neurodevelopmental processes impacted. Subsequent chapters consider the use of cellular and animal models to elucidate the cascading consequences of such mutations, from molecular and cellular levels to emergent effects on neural circuits, brain systems and subsequent psychological development. The text concludes by examining the important clinical implications of the recent advances in the field, from recognition of the genetic causes in individual patients to development of new treatments and interventions.
A timely synthesis, The Genetics of Neurodevelopmental Disorders is a unique and essential resource for neuroscientists, geneticists, neurologists and psychiatrists and an accessible and up-to-date overview for medical and science students. [Résumé d'Auteur/Editeur]Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=399 The Genetics of Neurodevelopmental Disorders [Texte imprimé et/ou numérique] / Kevin J. MITCHELL, Directeur de publication . - Hoboken [Etats-Unis] : Wiley, 2015 . - 356 p. : ill. ; 18,5cm x 26cm x 2,3cm.
ISBN : 978-1-118-52488-6
Bibliogr.; Index
Langues : Anglais (eng)
Mots-clés : Troubles du neurodéveloppement Index. décimale : SCI-B SCI-B - Génétique Résumé : Neurodevelopmental disorders arise from disturbances to various processes of brain development, which can manifest in diverse ways. They encompass many rare genetic syndromes as well as common, heritable conditions such as intellectual disability, autism, ADHD, schizophrenia and many types of epilepsy. The Genetics of Neurodevelopmental Disorders examines recent revolutionary advances in our understanding of the genetics of these disorders, exploring both basic discoveries and the translation of new findings into the clinical setting.
The book begins by examining the genetic architecture and etiology of neurodevelopmental disorders. It describes the striking recent progress in identifying pathogenic mutations, which are grouped here based on the neurodevelopmental processes impacted. Subsequent chapters consider the use of cellular and animal models to elucidate the cascading consequences of such mutations, from molecular and cellular levels to emergent effects on neural circuits, brain systems and subsequent psychological development. The text concludes by examining the important clinical implications of the recent advances in the field, from recognition of the genetic causes in individual patients to development of new treatments and interventions.
A timely synthesis, The Genetics of Neurodevelopmental Disorders is a unique and essential resource for neuroscientists, geneticists, neurologists and psychiatrists and an accessible and up-to-date overview for medical and science students. [Résumé d'Auteur/Editeur]Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=399 Contenu
- The Mutational Spectrum of Neurodevelopmental Disorders / Nancy D. MERNER
- The Genetic Architecture of Neurodevelopmental Disorders / Kevin J. MITCHELL
- Overlapping Etiology of Neurodevelopmental Disorders / Eric KELLEHER
- The Role of Genetic Interactions in Neurodevelopmental Disorders / Jason H. MOORE
- Developmental Instability, Mutation Load, and Neurodevelopmental Disorders / Ronald A. YEO
- Environmental Factors and Gene-Environment Interactions / John MCGRATH
- The Genetics of Brain Malformations / M. Chiara MANZINI
- Animal Models for Neurodevelopmental Disorders / Hala HARONY-NICOLAS
- Cascading Genetic and Environmental Effects on Development: Implications for Intervention / Esha MASSAND
- Disorders of Axon Guidance / Heike BLOCKUS
- Synaptic Disorders / Catalina BETANCUR
- Human Stem Cell Models of Neurodevelopmental Disorders / Peter KIRWAN
- Human Genetics and Clinical Aspects of Neurodevelopmental Disorders / Gholson J. LYON
- Progress Toward Therapies and Interventions for Neurodevelopmental Disorders / Ayokunmi AJETUNMOBI
Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité DOC0005031 SCI-B MIT Livre Centre d'Information et de Documentation du CRA Rhône-Alpes SCI - Disciplines Scientifiques Disponible Les abonnés qui ont emprunté ce document ont également emprunté :
Traité de neuropsychologie de l'enfant MAJERUS, Steve Neuropsychologie de l'enfant ROY, Arnaud Neuro-imagerie de l'enfant LOURYAN, Stéphane Le cerveau et les maux de la parole GIRAUD, Anne-Lise L'effet domino "dys" GUILLOUX, Roselyne Les troubles dys - En finir avec les idées reçues MORET, Alain The immune system / Andrew W. ZIMMERMAN
Titre : The immune system Type de document : Texte imprimé et/ou numérique Auteurs : Andrew W. ZIMMERMAN, Auteur Année de publication : 2006 Importance : p.371-386 Langues : Anglais (eng) Mots-clés : Système immunitaire Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=793 The immune system [Texte imprimé et/ou numérique] / Andrew W. ZIMMERMAN, Auteur . - 2006 . - p.371-386.
Langues : Anglais (eng)
Mots-clés : Système immunitaire Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=793 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire The implications of genotype–environment correlation for establishing causal processes in psychopathology / Sara R. JAFFEE in Development and Psychopathology, 24-4 (November 2012)
[article]
Titre : The implications of genotype–environment correlation for establishing causal processes in psychopathology Type de document : Texte imprimé et/ou numérique Auteurs : Sara R. JAFFEE, Auteur Année de publication : 2012 Article en page(s) : p.1253-1264 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The significance of genotype–environment interplay is its focus on how causal factors, whether environmental or genetic, have their effects. It is difficult to establish causality in observational research because of the potential for reverse causation and confounding. Most environmental measures are heritable, which means that their effects on the risk for psychopathology are potentially confounded by genotype. In contrast, genetic influences on psychopathology may be mediated by their effect on environmental exposures. The existence of genetic influences on putative environmental risk factors offers both possibilities and pitfalls for research into environmental epidemiology. We use the example of parenting and its influence on childhood externalizing problems to review how genotype–environment correlations can be exploited to demonstrate causal processes in pyschopathology. En ligne : http://dx.doi.org/10.1017/S0954579412000685 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182
in Development and Psychopathology > 24-4 (November 2012) . - p.1253-1264[article] The implications of genotype–environment correlation for establishing causal processes in psychopathology [Texte imprimé et/ou numérique] / Sara R. JAFFEE, Auteur . - 2012 . - p.1253-1264.
Langues : Anglais (eng)
in Development and Psychopathology > 24-4 (November 2012) . - p.1253-1264
Index. décimale : PER Périodiques Résumé : The significance of genotype–environment interplay is its focus on how causal factors, whether environmental or genetic, have their effects. It is difficult to establish causality in observational research because of the potential for reverse causation and confounding. Most environmental measures are heritable, which means that their effects on the risk for psychopathology are potentially confounded by genotype. In contrast, genetic influences on psychopathology may be mediated by their effect on environmental exposures. The existence of genetic influences on putative environmental risk factors offers both possibilities and pitfalls for research into environmental epidemiology. We use the example of parenting and its influence on childhood externalizing problems to review how genotype–environment correlations can be exploited to demonstrate causal processes in pyschopathology. En ligne : http://dx.doi.org/10.1017/S0954579412000685 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182 The Imprinted Brain / Christopher BADCOCK
Titre : The Imprinted Brain : How Genes Set the Balance Between Autism and Psychosis Type de document : Texte imprimé et/ou numérique Auteurs : Christopher BADCOCK, Auteur Année de publication : 2009 Importance : 240 p. Format : 23,4cm x 15,6cm 2cm ISBN/ISSN/EAN : 978-1-84905-023-4 Note générale : Bibliogr., Index Langues : Anglais (eng) Index. décimale : SCI-B SCI-B - Génétique Résumé : The Imprinted Brain sets out a radical new theory of the mind and mental illness based on the recent discovery of genomic imprinting. Imprinted genes are those from one parent that, in that parent's interest, are expressed in an offspring rather than the diametrically opposed genes from the other parent. For example, a higher birth weight may represent the dominance of the father's genes in leading to a healthy child, whereas a lower birth weight is beneficial to the mother's immediate wellbeing, and the imprint of the mother's genes will result in a smaller baby. According to this view, a win for the father's genes may result in autism, whereas one for the mother's may result in psychosis. A state of equilibrium - normality - is the most likely outcome, with a no-win situation of balanced expression. Imprinted genes typically produce symptoms that are opposites of each other, and the author uses psychiatric case material to show how many of the symptoms of psychosis can be shown to be the mental mirror-images of those of autism.
Combining psychiatry with insights from modern genetics and cognitive science, Christopher Badcock explains the fascinating imprinted brain theory to the reader in a thorough but accessible way. This new theory casts some intriguing new light on other topics as diverse as the nature of genius, the appeal of detective fiction, and the successes - and failures - of psychoanalysis.
This thought-provoking book is a must-read for anyone with an interest in autism, psychiatry, cognitive science or psychology in general.
"The Imprinted Brain is a true tour de force, surveying the cutting-edge research in genomics and neuroscience and providing a fresh view on what it means to be male or female, "things people" or "people people," autistic or schizophrenic. You will never look at your parents the same way again!"
- Satoshi Kanazawa, The Scientific Fundamentalist and co-author of Why Beautiful People Have More Daughters
'Deeply scholarly yet absorbing narrative, The Imprinted Brain will change the way we view the human brain and its functions, evolution, and disordering in mental illness. Badcock has drawn evolutionary biology together with genetics, psychology, psychiatry, and neuroscience to demonstrate, for the first time, how genomic conflicts play a central role in how the human brain works, and how the brain becomes dysregulated in social-brain disorders including autism and schizophrenia.'
- Professor Bernard Crespi
Christopher Badcock was educated at Maidstone Grammar School and The London School of Economics, where he graduated with a First in Sociology and Social Anthropology. Seeking to find a sound evolutionary, genetic, and neuro-scientific basis for psychoanalysis, he realized that research into autism completely discredited Freud but suggested a completely new basis for understanding the mind and mental illness. With the help of the leading Canadian bio-scientist, Bernard Crespi, he was eventually able to consolidate these insights into the imprinted brain theory outlined here and published a number of co-authored papers on the subject. Christopher Badcock is the author of a dozen books, and today teaches courses on evolutionary psychology, genetics, and sociobiology at the London School of Economics. He lives in London.Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=825 The Imprinted Brain : How Genes Set the Balance Between Autism and Psychosis [Texte imprimé et/ou numérique] / Christopher BADCOCK, Auteur . - 2009 . - 240 p. ; 23,4cm x 15,6cm 2cm.
ISBN : 978-1-84905-023-4
Bibliogr., Index
Langues : Anglais (eng)
Index. décimale : SCI-B SCI-B - Génétique Résumé : The Imprinted Brain sets out a radical new theory of the mind and mental illness based on the recent discovery of genomic imprinting. Imprinted genes are those from one parent that, in that parent's interest, are expressed in an offspring rather than the diametrically opposed genes from the other parent. For example, a higher birth weight may represent the dominance of the father's genes in leading to a healthy child, whereas a lower birth weight is beneficial to the mother's immediate wellbeing, and the imprint of the mother's genes will result in a smaller baby. According to this view, a win for the father's genes may result in autism, whereas one for the mother's may result in psychosis. A state of equilibrium - normality - is the most likely outcome, with a no-win situation of balanced expression. Imprinted genes typically produce symptoms that are opposites of each other, and the author uses psychiatric case material to show how many of the symptoms of psychosis can be shown to be the mental mirror-images of those of autism.
Combining psychiatry with insights from modern genetics and cognitive science, Christopher Badcock explains the fascinating imprinted brain theory to the reader in a thorough but accessible way. This new theory casts some intriguing new light on other topics as diverse as the nature of genius, the appeal of detective fiction, and the successes - and failures - of psychoanalysis.
This thought-provoking book is a must-read for anyone with an interest in autism, psychiatry, cognitive science or psychology in general.
"The Imprinted Brain is a true tour de force, surveying the cutting-edge research in genomics and neuroscience and providing a fresh view on what it means to be male or female, "things people" or "people people," autistic or schizophrenic. You will never look at your parents the same way again!"
- Satoshi Kanazawa, The Scientific Fundamentalist and co-author of Why Beautiful People Have More Daughters
'Deeply scholarly yet absorbing narrative, The Imprinted Brain will change the way we view the human brain and its functions, evolution, and disordering in mental illness. Badcock has drawn evolutionary biology together with genetics, psychology, psychiatry, and neuroscience to demonstrate, for the first time, how genomic conflicts play a central role in how the human brain works, and how the brain becomes dysregulated in social-brain disorders including autism and schizophrenia.'
- Professor Bernard Crespi
Christopher Badcock was educated at Maidstone Grammar School and The London School of Economics, where he graduated with a First in Sociology and Social Anthropology. Seeking to find a sound evolutionary, genetic, and neuro-scientific basis for psychoanalysis, he realized that research into autism completely discredited Freud but suggested a completely new basis for understanding the mind and mental illness. With the help of the leading Canadian bio-scientist, Bernard Crespi, he was eventually able to consolidate these insights into the imprinted brain theory outlined here and published a number of co-authored papers on the subject. Christopher Badcock is the author of a dozen books, and today teaches courses on evolutionary psychology, genetics, and sociobiology at the London School of Economics. He lives in London.Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=825 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité DOC0000916 SCI-B BAD Livre Centre d'Information et de Documentation du CRA Rhône-Alpes SCI - Disciplines Scientifiques Disponible The Link between Genetic Abnormalities in the Monogenic Disorders and the Behavioral Phenotype of Polygenic Disorders Has Yet To Be Addressed in Research / Nagwa A. MEGUID in Autism - Open Access, 2-1 (March 2012)
PermalinkThe Neurochemical Basis of Autism / Gene J. BLATT
PermalinkThe Neuroscience of Autism Spectrum Disorders / Joseph D. BUXBAUM
PermalinkThe phenotypes of specifie language impairment in child development / Anna M. CHILOSI
PermalinkThe Research Basis for Autism Intervention / Eric SCHOPLER
PermalinkThe role of limbic system irritability in linking history of childhood maltreatment and psychiatric outcomes in low-income, high-risk women: Moderation by FK506 binding protein 5 haplotype / Melissa N. DACKIS in Development and Psychopathology, 24-4 (November 2012)
PermalinkThe roles of dopamine and norepinephrine in autism : from behavior and pharmacotherapy to genetics / Jeanette J. A. HOLDEN
PermalinkThe serotonin transporter gene is a substrate for age and stress dependent epigenetic regulation in rhesus macaque brain: Potential roles in genetic selection and Gene × Environment interaction / Stephen G. LINDELL in Development and Psychopathology, 24-4 (November 2012)
PermalinkThe Study to Explore Early Development (SEED): A Multisite Epidemiologic Study of Autism by the Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) Network / Diana SCHENDEL in Journal of Autism and Developmental Disorders, 42-10 (October 2012)
PermalinkToi, moi et le trouble du déficit de l'attention avec hyperactivité / Hervé CACI
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