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Allelic Variation Within the Putative Autism Spectrum Disorder Risk Gene Homeobox A1 and Cerebellar Maturation in Typically Developing Children and Adolescents / Armin RAZNAHAN in Autism Research, 5-2 (April 2012)
[article]
Titre : Allelic Variation Within the Putative Autism Spectrum Disorder Risk Gene Homeobox A1 and Cerebellar Maturation in Typically Developing Children and Adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Armin RAZNAHAN, Auteur ; Yohan LEE, Auteur ; Catherine VAITUZIS, Auteur ; Lan TRAN, Auteur ; Susan MACKIE, Auteur ; Henning TIEMEIER, Auteur ; Liv S. CLASEN, Auteur ; Francois LALONDE, Auteur ; Deanna GREENSTEIN, Auteur ; Ron PIERSON, Auteur ; Jay N. GIEDD, Auteur Année de publication : 2012 Article en page(s) : p.93-100 Langues : Anglais (eng) Mots-clés : autism HOXA1 cerebellum gene brain MRI Index. décimale : PER Périodiques Résumé : Homeobox A1 (HOXA1) has been proposed as a candidate gene for autism spectrum disorder (ASD) as it regulates embryological patterning of hind-brain structures implicated in autism neurobiology. In line with this notion, a nonsynonymous single nucleotide polymorphism within a highly conserved domain of HOXA1—A218G (rs10951154)—has been linked to both ASD risk, and cross-sectional differences in superior posterior lobar cerebellar anatomy in late adulthood. Despite evidence for early onset and developmentally dynamic cerebellar involvement in ASD, little is known of the relationship between A218G genotype and maturation of the cerebellum over early development. We addressed this issue using 296 longitudinally acquired structural magnetic resonance imaging brain scans from 116 healthy individuals between 5 and 23 years of age. Mixed models were used to compare the relationship between age and semi-automated measures of cerebellar volume in A-homozygotes (AA) and carriers of the G allele (Gcar). Total cerebellar volume increased between ages of 5 and 23 years in both groups. However, this was accelerated in the Gcar relative to the AA group (Genotype-by-age interaction term, P = 0.03), and driven by genotype-dependent differences in the rate of bilateral superior posterior lobar volume change with age (P = 0.002). Resultantly, although superior posterior lobar volume did not differ significantly between genotype groups at age 5 (P = 0.9), by age 23 it was 12% greater in Gcar than AA (P = 0.002). Our results suggest that common genetic variation within this putative ASD risk gene has the capacity to modify the development of cerebellar systems implicated in ASD neurobiology. En ligne : http://dx.doi.org/10.1002/aur.238 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155
in Autism Research > 5-2 (April 2012) . - p.93-100[article] Allelic Variation Within the Putative Autism Spectrum Disorder Risk Gene Homeobox A1 and Cerebellar Maturation in Typically Developing Children and Adolescents [Texte imprimé et/ou numérique] / Armin RAZNAHAN, Auteur ; Yohan LEE, Auteur ; Catherine VAITUZIS, Auteur ; Lan TRAN, Auteur ; Susan MACKIE, Auteur ; Henning TIEMEIER, Auteur ; Liv S. CLASEN, Auteur ; Francois LALONDE, Auteur ; Deanna GREENSTEIN, Auteur ; Ron PIERSON, Auteur ; Jay N. GIEDD, Auteur . - 2012 . - p.93-100.
Langues : Anglais (eng)
in Autism Research > 5-2 (April 2012) . - p.93-100
Mots-clés : autism HOXA1 cerebellum gene brain MRI Index. décimale : PER Périodiques Résumé : Homeobox A1 (HOXA1) has been proposed as a candidate gene for autism spectrum disorder (ASD) as it regulates embryological patterning of hind-brain structures implicated in autism neurobiology. In line with this notion, a nonsynonymous single nucleotide polymorphism within a highly conserved domain of HOXA1—A218G (rs10951154)—has been linked to both ASD risk, and cross-sectional differences in superior posterior lobar cerebellar anatomy in late adulthood. Despite evidence for early onset and developmentally dynamic cerebellar involvement in ASD, little is known of the relationship between A218G genotype and maturation of the cerebellum over early development. We addressed this issue using 296 longitudinally acquired structural magnetic resonance imaging brain scans from 116 healthy individuals between 5 and 23 years of age. Mixed models were used to compare the relationship between age and semi-automated measures of cerebellar volume in A-homozygotes (AA) and carriers of the G allele (Gcar). Total cerebellar volume increased between ages of 5 and 23 years in both groups. However, this was accelerated in the Gcar relative to the AA group (Genotype-by-age interaction term, P = 0.03), and driven by genotype-dependent differences in the rate of bilateral superior posterior lobar volume change with age (P = 0.002). Resultantly, although superior posterior lobar volume did not differ significantly between genotype groups at age 5 (P = 0.9), by age 23 it was 12% greater in Gcar than AA (P = 0.002). Our results suggest that common genetic variation within this putative ASD risk gene has the capacity to modify the development of cerebellar systems implicated in ASD neurobiology. En ligne : http://dx.doi.org/10.1002/aur.238 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155 Altered Dynamics of the fMRI Response to Faces in Individuals with Autism / Natalia M. KLEINHANS in Journal of Autism and Developmental Disorders, 46-1 (January 2016)
[article]
Titre : Altered Dynamics of the fMRI Response to Faces in Individuals with Autism Type de document : Texte imprimé et/ou numérique Auteurs : Natalia M. KLEINHANS, Auteur ; Todd RICHARDS, Auteur ; Jessica GREENSON, Auteur ; Geraldine DAWSON, Auteur ; Elizabeth H. AYLWARD, Auteur Année de publication : 2016 Article en page(s) : p.232-241 Langues : Anglais (eng) Mots-clés : Habituation Faces Houses Amygdala Fusiform Adaptation Index. décimale : PER Périodiques Résumé : Abnormal fMRI habituation in autism spectrum disorders (ASDs) has been proposed as a critical component in social impairment. This study investigated habituation to fearful faces and houses in ASD and whether fMRI measures of brain activity discriminate between ASD and typically developing (TD) controls. Two identical fMRI runs presenting masked fearful faces, houses, and scrambled images were collected. We found significantly slower fMRI responses to fearful faces but not houses in ASD. In addition, the pattern of slow to emerge amygdala activation to faces had robust discriminability [ASD vs. TD; area under the curve (AUC) = .852, p < .001]. In contrast, habituation to houses had no predictive value (AUC = .573, p = .365). Amygdala habituation to emotional faces may be useful for quantifying risk in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2565-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278
in Journal of Autism and Developmental Disorders > 46-1 (January 2016) . - p.232-241[article] Altered Dynamics of the fMRI Response to Faces in Individuals with Autism [Texte imprimé et/ou numérique] / Natalia M. KLEINHANS, Auteur ; Todd RICHARDS, Auteur ; Jessica GREENSON, Auteur ; Geraldine DAWSON, Auteur ; Elizabeth H. AYLWARD, Auteur . - 2016 . - p.232-241.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 46-1 (January 2016) . - p.232-241
Mots-clés : Habituation Faces Houses Amygdala Fusiform Adaptation Index. décimale : PER Périodiques Résumé : Abnormal fMRI habituation in autism spectrum disorders (ASDs) has been proposed as a critical component in social impairment. This study investigated habituation to fearful faces and houses in ASD and whether fMRI measures of brain activity discriminate between ASD and typically developing (TD) controls. Two identical fMRI runs presenting masked fearful faces, houses, and scrambled images were collected. We found significantly slower fMRI responses to fearful faces but not houses in ASD. In addition, the pattern of slow to emerge amygdala activation to faces had robust discriminability [ASD vs. TD; area under the curve (AUC) = .852, p < .001]. In contrast, habituation to houses had no predictive value (AUC = .573, p = .365). Amygdala habituation to emotional faces may be useful for quantifying risk in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2565-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278 Amygdale et Autisme: apport des études chez le primate non humain / David G. AMARAL
Titre : Amygdale et Autisme: apport des études chez le primate non humain Type de document : Texte imprimé et/ou numérique Auteurs : David G. AMARAL, Auteur ; Margaret L. BAUMAN, Auteur ; Cynthia MILLS-SCHUMANN, Auteur Année de publication : 2005 Importance : p.321-342 Langues : Français (fre) Mots-clés : Amygdales Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=193 Amygdale et Autisme: apport des études chez le primate non humain [Texte imprimé et/ou numérique] / David G. AMARAL, Auteur ; Margaret L. BAUMAN, Auteur ; Cynthia MILLS-SCHUMANN, Auteur . - 2005 . - p.321-342.
Langues : Français (fre)
Mots-clés : Amygdales Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=193 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire L’apport des neurosciences et l’espoir de la plasticité cérébrale / Catherine DOYEN
Titre : L’apport des neurosciences et l’espoir de la plasticité cérébrale Type de document : Texte imprimé et/ou numérique Auteurs : Catherine DOYEN, Auteur Année de publication : 2012 Importance : p.95-112 Langues : Français (fre) Mots-clés : Plasticité cérébrale Vignette clinique Index. décimale : AUT-E AUT-E - L'Autisme - Accompagnement et Qualité de Vie Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=167 L’apport des neurosciences et l’espoir de la plasticité cérébrale [Texte imprimé et/ou numérique] / Catherine DOYEN, Auteur . - 2012 . - p.95-112.
Langues : Français (fre)
Mots-clés : Plasticité cérébrale Vignette clinique Index. décimale : AUT-E AUT-E - L'Autisme - Accompagnement et Qualité de Vie Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=167 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire Approche neurologique des dyslexies de développement / Jean-François DEMONET
Titre : Approche neurologique des dyslexies de développement Type de document : Texte imprimé et/ou numérique Auteurs : Jean-François DEMONET, Auteur ; Mélanie JUCLA, Auteur Année de publication : 2010 Importance : p.47-65 Langues : Français (fre) Index. décimale : SCI-C SCI-C - Neuropsychologie Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141 Approche neurologique des dyslexies de développement [Texte imprimé et/ou numérique] / Jean-François DEMONET, Auteur ; Mélanie JUCLA, Auteur . - 2010 . - p.47-65.
Langues : Français (fre)
Index. décimale : SCI-C SCI-C - Neuropsychologie Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire Are There Reliable Biological Tests to Diagnose ASC? / Roberto TUCHMAN
PermalinkAspects biologiques de l’autisme et syndrome de Gilles de la Tourette / Aribert ROTHENBERGER
PermalinkAutism imaging and Devices / Manuel F. CASANOVA
PermalinkAutism Spectrum Disorder: Does Neuroimaging Support the DSM-5 Proposal for a Symptom Dyad? A Systematic Review of Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging Studies / Laura PINA-CAMACHO in Journal of Autism and Developmental Disorders, 42-7 (July 2012)
PermalinkAutisme de Kanner ou autisme de Scanner... IRM et autisme. A propos des recherches INSERM-CEA d’Orsay / Bernard GOLSE
PermalinkBrain imaging and the neuroanatomical correlates of autism / Michael D. SPENCER
PermalinkBrief Report: Approaches to 31P-MRS in Awake, Non-Sedated Children with and without Autism Spectrum Disorder / Laura C. ERICKSON in Journal of Autism and Developmental Disorders, 42-6 (June 2012)
PermalinkUn cerveau pour apprendre à lire / David A. SOUSA
PermalinkChanges in the Sulcal Size Associated With Autism Spectrum Disorder Revealed by Sulcal Morphometry / Mahsa SHOKOUHI in Autism Research, 5-4 (August 2012)
PermalinkLa cognition / Margaret W. MATLIN
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