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Autism Research . 5-2Paru le : 01/04/2012 |
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[n° ou bulletin]
5-2 - April 2012 [Texte imprimé et/ou numérique] . - 2012.
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Dépouillements
Ajouter le résultat dans votre panierMale Gender Bias in Autism and Pediatric Autoimmunity / Kevin G. BECKER in Autism Research, 5-2 (April 2012)
[article]
Titre : Male Gender Bias in Autism and Pediatric Autoimmunity Type de document : Texte imprimé et/ou numérique Auteurs : Kevin G. BECKER, Auteur Année de publication : 2012 Article en page(s) : p.77-83 Langues : Anglais (eng) Mots-clés : autoimmune immunology molecular genetics pediatrics developmental neurobiology Index. décimale : PER Périodiques Résumé : Male bias in both autism and pediatric autoimmune disease is thought to involve hormonal perturbations in pregnancy or early childhood in the context of genetic control. These early molecular events, at a time of rapid development, are intimately linked to concurrent development in the brain and immune system. It is suggested here that these early regulatory events may overlap between autism and autoimmunity in determining male sex bias and may provide evidence of an etiological link among autism, immune dysregulation, and autoimmune disease. En ligne : http://dx.doi.org/10.1002/aur.1227 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155
in Autism Research > 5-2 (April 2012) . - p.77-83[article] Male Gender Bias in Autism and Pediatric Autoimmunity [Texte imprimé et/ou numérique] / Kevin G. BECKER, Auteur . - 2012 . - p.77-83.
Langues : Anglais (eng)
in Autism Research > 5-2 (April 2012) . - p.77-83
Mots-clés : autoimmune immunology molecular genetics pediatrics developmental neurobiology Index. décimale : PER Périodiques Résumé : Male bias in both autism and pediatric autoimmune disease is thought to involve hormonal perturbations in pregnancy or early childhood in the context of genetic control. These early molecular events, at a time of rapid development, are intimately linked to concurrent development in the brain and immune system. It is suggested here that these early regulatory events may overlap between autism and autoimmunity in determining male sex bias and may provide evidence of an etiological link among autism, immune dysregulation, and autoimmune disease. En ligne : http://dx.doi.org/10.1002/aur.1227 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155 Disordered Porphyrin Metabolism: A Potential Biological Marker for Autism Risk Assessment / Nicholas J. HEYER in Autism Research, 5-2 (April 2012)
[article]
Titre : Disordered Porphyrin Metabolism: A Potential Biological Marker for Autism Risk Assessment Type de document : Texte imprimé et/ou numérique Auteurs : Nicholas J. HEYER, Auteur ; Diana ECHEVERRIA, Auteur ; James S WOODS, Auteur Année de publication : 2012 Article en page(s) : p.84-92 Langues : Anglais (eng) Mots-clés : autistic spectrum disorder biomarker children heme porphyrins Index. décimale : PER Périodiques Résumé : Autism (AUT) is a complex neurodevelopmental disorder that, together with Asperger's syndrome and Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS), comprises the expanded classification of autistic spectrum disorder (ASD). The heterogeneity of ASD underlies the need to identify biomarkers or clinical features that can be employed to identify meaningful subtypes of ASD, define specific etiologies, and inform intervention and treatment options. Previous studies have shown that disordered porphyrin metabolism, manifested principally as significantly elevated urinary concentrations of pentacarboxyl (penta) and coproporphyrins, is commonly observed among some children with ASD. Here, we extend these observations by specifically evaluating penta and coproporphyrins as biological indicators of ASD among 76 male children comprising 30 with validated AUT, 14 with PDD-NOS, and 32 neurotypical (NT) controls. ASD children (AUT and PDD-NOS) had higher mean urinary penta (P < 0.006) and copro (P < 0.006) concentrations compared with same-aged NT children, each characterized by a number of extreme values. Using Receiver Operating Characteristic curve analysis, we evaluated the sensitivity and specificity of penta, copro, and their combined Z-scores in ASD detection. The penta sensitivity was 30% for AUT and 36% for PDD-NOS, with 94% specificity. The copro sensitivity was 33% and 14%, respectively, with 94% specificity. The combined Z-score measure had 33% and 21% sensitivity for AUT and PDD-NOS, respectively, with 100% specificity. These findings demonstrate that porphyrin measures are strong predictors of both AUT and PDD-NOS, and support the potential clinical utility of urinary porphyrin measures for identifying a subgroup of ASD subjects in whom disordered porphyrin metabolism may be a salient characteristic. En ligne : http://dx.doi.org/10.1002/aur.236 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155
in Autism Research > 5-2 (April 2012) . - p.84-92[article] Disordered Porphyrin Metabolism: A Potential Biological Marker for Autism Risk Assessment [Texte imprimé et/ou numérique] / Nicholas J. HEYER, Auteur ; Diana ECHEVERRIA, Auteur ; James S WOODS, Auteur . - 2012 . - p.84-92.
Langues : Anglais (eng)
in Autism Research > 5-2 (April 2012) . - p.84-92
Mots-clés : autistic spectrum disorder biomarker children heme porphyrins Index. décimale : PER Périodiques Résumé : Autism (AUT) is a complex neurodevelopmental disorder that, together with Asperger's syndrome and Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS), comprises the expanded classification of autistic spectrum disorder (ASD). The heterogeneity of ASD underlies the need to identify biomarkers or clinical features that can be employed to identify meaningful subtypes of ASD, define specific etiologies, and inform intervention and treatment options. Previous studies have shown that disordered porphyrin metabolism, manifested principally as significantly elevated urinary concentrations of pentacarboxyl (penta) and coproporphyrins, is commonly observed among some children with ASD. Here, we extend these observations by specifically evaluating penta and coproporphyrins as biological indicators of ASD among 76 male children comprising 30 with validated AUT, 14 with PDD-NOS, and 32 neurotypical (NT) controls. ASD children (AUT and PDD-NOS) had higher mean urinary penta (P < 0.006) and copro (P < 0.006) concentrations compared with same-aged NT children, each characterized by a number of extreme values. Using Receiver Operating Characteristic curve analysis, we evaluated the sensitivity and specificity of penta, copro, and their combined Z-scores in ASD detection. The penta sensitivity was 30% for AUT and 36% for PDD-NOS, with 94% specificity. The copro sensitivity was 33% and 14%, respectively, with 94% specificity. The combined Z-score measure had 33% and 21% sensitivity for AUT and PDD-NOS, respectively, with 100% specificity. These findings demonstrate that porphyrin measures are strong predictors of both AUT and PDD-NOS, and support the potential clinical utility of urinary porphyrin measures for identifying a subgroup of ASD subjects in whom disordered porphyrin metabolism may be a salient characteristic. En ligne : http://dx.doi.org/10.1002/aur.236 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155 Allelic Variation Within the Putative Autism Spectrum Disorder Risk Gene Homeobox A1 and Cerebellar Maturation in Typically Developing Children and Adolescents / Armin RAZNAHAN in Autism Research, 5-2 (April 2012)
[article]
Titre : Allelic Variation Within the Putative Autism Spectrum Disorder Risk Gene Homeobox A1 and Cerebellar Maturation in Typically Developing Children and Adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Armin RAZNAHAN, Auteur ; Yohan LEE, Auteur ; Catherine VAITUZIS, Auteur ; Lan TRAN, Auteur ; Susan MACKIE, Auteur ; Henning TIEMEIER, Auteur ; Liv S. CLASEN, Auteur ; Francois LALONDE, Auteur ; Deanna GREENSTEIN, Auteur ; Ron PIERSON, Auteur ; Jay N. GIEDD, Auteur Année de publication : 2012 Article en page(s) : p.93-100 Langues : Anglais (eng) Mots-clés : autism HOXA1 cerebellum gene brain MRI Index. décimale : PER Périodiques Résumé : Homeobox A1 (HOXA1) has been proposed as a candidate gene for autism spectrum disorder (ASD) as it regulates embryological patterning of hind-brain structures implicated in autism neurobiology. In line with this notion, a nonsynonymous single nucleotide polymorphism within a highly conserved domain of HOXA1—A218G (rs10951154)—has been linked to both ASD risk, and cross-sectional differences in superior posterior lobar cerebellar anatomy in late adulthood. Despite evidence for early onset and developmentally dynamic cerebellar involvement in ASD, little is known of the relationship between A218G genotype and maturation of the cerebellum over early development. We addressed this issue using 296 longitudinally acquired structural magnetic resonance imaging brain scans from 116 healthy individuals between 5 and 23 years of age. Mixed models were used to compare the relationship between age and semi-automated measures of cerebellar volume in A-homozygotes (AA) and carriers of the G allele (Gcar). Total cerebellar volume increased between ages of 5 and 23 years in both groups. However, this was accelerated in the Gcar relative to the AA group (Genotype-by-age interaction term, P = 0.03), and driven by genotype-dependent differences in the rate of bilateral superior posterior lobar volume change with age (P = 0.002). Resultantly, although superior posterior lobar volume did not differ significantly between genotype groups at age 5 (P = 0.9), by age 23 it was 12% greater in Gcar than AA (P = 0.002). Our results suggest that common genetic variation within this putative ASD risk gene has the capacity to modify the development of cerebellar systems implicated in ASD neurobiology. En ligne : http://dx.doi.org/10.1002/aur.238 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155
in Autism Research > 5-2 (April 2012) . - p.93-100[article] Allelic Variation Within the Putative Autism Spectrum Disorder Risk Gene Homeobox A1 and Cerebellar Maturation in Typically Developing Children and Adolescents [Texte imprimé et/ou numérique] / Armin RAZNAHAN, Auteur ; Yohan LEE, Auteur ; Catherine VAITUZIS, Auteur ; Lan TRAN, Auteur ; Susan MACKIE, Auteur ; Henning TIEMEIER, Auteur ; Liv S. CLASEN, Auteur ; Francois LALONDE, Auteur ; Deanna GREENSTEIN, Auteur ; Ron PIERSON, Auteur ; Jay N. GIEDD, Auteur . - 2012 . - p.93-100.
Langues : Anglais (eng)
in Autism Research > 5-2 (April 2012) . - p.93-100
Mots-clés : autism HOXA1 cerebellum gene brain MRI Index. décimale : PER Périodiques Résumé : Homeobox A1 (HOXA1) has been proposed as a candidate gene for autism spectrum disorder (ASD) as it regulates embryological patterning of hind-brain structures implicated in autism neurobiology. In line with this notion, a nonsynonymous single nucleotide polymorphism within a highly conserved domain of HOXA1—A218G (rs10951154)—has been linked to both ASD risk, and cross-sectional differences in superior posterior lobar cerebellar anatomy in late adulthood. Despite evidence for early onset and developmentally dynamic cerebellar involvement in ASD, little is known of the relationship between A218G genotype and maturation of the cerebellum over early development. We addressed this issue using 296 longitudinally acquired structural magnetic resonance imaging brain scans from 116 healthy individuals between 5 and 23 years of age. Mixed models were used to compare the relationship between age and semi-automated measures of cerebellar volume in A-homozygotes (AA) and carriers of the G allele (Gcar). Total cerebellar volume increased between ages of 5 and 23 years in both groups. However, this was accelerated in the Gcar relative to the AA group (Genotype-by-age interaction term, P = 0.03), and driven by genotype-dependent differences in the rate of bilateral superior posterior lobar volume change with age (P = 0.002). Resultantly, although superior posterior lobar volume did not differ significantly between genotype groups at age 5 (P = 0.9), by age 23 it was 12% greater in Gcar than AA (P = 0.002). Our results suggest that common genetic variation within this putative ASD risk gene has the capacity to modify the development of cerebellar systems implicated in ASD neurobiology. En ligne : http://dx.doi.org/10.1002/aur.238 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155 Gastrointestinal Dysfunction in Autism: Parental Report, Clinical Evaluation, and Associated Factors / Phillip GORRINDO in Autism Research, 5-2 (April 2012)
[article]
Titre : Gastrointestinal Dysfunction in Autism: Parental Report, Clinical Evaluation, and Associated Factors Type de document : Texte imprimé et/ou numérique Auteurs : Phillip GORRINDO, Auteur ; Dean C. WILLIAMS, Auteur ; Evon B. LEE, Auteur ; Lynn S. WALKER, Auteur ; Susan G. MCGREW, Auteur ; Pat LEVITT, Auteur Année de publication : 2012 Article en page(s) : p.101-108 Langues : Anglais (eng) Mots-clés : autism constipation diet functional gastrointestinal disorders nonverbal communication social behavior Index. décimale : PER Périodiques Résumé : The objectives of this study were to characterize gastrointestinal dysfunction (GID) in autism spectrum disorder (ASD), to examine parental reports of GID relative to evaluations by pediatric gastroenterologists, and to explore factors associated with GID in ASD. One hundred twenty-one children were recruited into three groups: co-occurring ASD and GID, ASD without GID, and GID without ASD. A pediatric gastroenterologist evaluated both GID groups. Parents in all three groups completed questionnaires about their child's behavior and GI symptoms, and a dietary journal. Functional constipation was the most common type of GID in children with ASD (85.0%). Parental report of any GID was highly concordant with a clinical diagnosis of any GID (92.1%). Presence of GID in children with ASD was not associated with distinct dietary habits or medication status. Odds of constipation were associated with younger age, increased social impairment, and lack of expressive language (adjusted odds ratio in nonverbal children: 11.98, 95% confidence interval 2.54–56.57). This study validates parental concerns for GID in children with ASD, as parents were sensitive to the existence, although not necessarily the nature, of GID. The strong association between constipation and language impairment highlights the need for vigilance by health-care providers to detect and treat GID in children with ASD. Medications and diet, commonly thought to contribute to GID in ASD, were not associated with GID status. These findings are consistent with a hypothesis that GID in ASD represents pleiotropic expression of genetic risk factors. En ligne : http://dx.doi.org/10.1002/aur.237 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155
in Autism Research > 5-2 (April 2012) . - p.101-108[article] Gastrointestinal Dysfunction in Autism: Parental Report, Clinical Evaluation, and Associated Factors [Texte imprimé et/ou numérique] / Phillip GORRINDO, Auteur ; Dean C. WILLIAMS, Auteur ; Evon B. LEE, Auteur ; Lynn S. WALKER, Auteur ; Susan G. MCGREW, Auteur ; Pat LEVITT, Auteur . - 2012 . - p.101-108.
Langues : Anglais (eng)
in Autism Research > 5-2 (April 2012) . - p.101-108
Mots-clés : autism constipation diet functional gastrointestinal disorders nonverbal communication social behavior Index. décimale : PER Périodiques Résumé : The objectives of this study were to characterize gastrointestinal dysfunction (GID) in autism spectrum disorder (ASD), to examine parental reports of GID relative to evaluations by pediatric gastroenterologists, and to explore factors associated with GID in ASD. One hundred twenty-one children were recruited into three groups: co-occurring ASD and GID, ASD without GID, and GID without ASD. A pediatric gastroenterologist evaluated both GID groups. Parents in all three groups completed questionnaires about their child's behavior and GI symptoms, and a dietary journal. Functional constipation was the most common type of GID in children with ASD (85.0%). Parental report of any GID was highly concordant with a clinical diagnosis of any GID (92.1%). Presence of GID in children with ASD was not associated with distinct dietary habits or medication status. Odds of constipation were associated with younger age, increased social impairment, and lack of expressive language (adjusted odds ratio in nonverbal children: 11.98, 95% confidence interval 2.54–56.57). This study validates parental concerns for GID in children with ASD, as parents were sensitive to the existence, although not necessarily the nature, of GID. The strong association between constipation and language impairment highlights the need for vigilance by health-care providers to detect and treat GID in children with ASD. Medications and diet, commonly thought to contribute to GID in ASD, were not associated with GID status. These findings are consistent with a hypothesis that GID in ASD represents pleiotropic expression of genetic risk factors. En ligne : http://dx.doi.org/10.1002/aur.237 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155 Comprehension of Wh-Questions Precedes Their Production in Typical Development and Autism Spectrum Disorders / Anthony GOODWIN in Autism Research, 5-2 (April 2012)
[article]
Titre : Comprehension of Wh-Questions Precedes Their Production in Typical Development and Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Anthony GOODWIN, Auteur ; Deborah A. FEIN, Auteur ; Letitia R. NAIGLES, Auteur Année de publication : 2012 Article en page(s) : p.109-123 Langues : Anglais (eng) Mots-clés : wh-questions language grammar production comprehension Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorders (ASD) rarely produce wh-questions (e.g. “What hit the book?”) in naturalistic speech. It is unclear if this is due to social–pragmatic difficulties, or if grammatical deficits are also involved. If grammar is impaired, production of wh-questions by rote memorization might precede comprehension of similar forms. In a longitudinal study, 15 children with ASD and 18 initially language-matched typically developing (TD) toddlers were visited in their homes at 4-month intervals across a 3-year period. The wh-question task was presented via intermodal preferential looking. Silent “hitting” events (e.g. an apple hitting a flower) were followed by test trials in which the apple and flower were juxtaposed on the screen. During test trials, subject-wh- and object-wh-question audios were sequentially presented (e.g. “What hit the flower?” or ”What did the apple hit?”). Control audios were also presented (e.g. “Where's the apple/flower?”). Children's eye movements were coded off-line, frame by frame. To show reliable comprehension, children should look longer to the named item (i.e. apple or flower) during the “where” questions but less at the named item during the subject-wh and object-wh-questions. To compare comprehension to production, we coded 30-min spontaneous speech samples drawn from mother–child interactions at each visit. Results indicated that comprehension of subject- and object-wh-questions was delayed in children with ASD compared with age-matched TD children, but not when matched on overall language levels. Additionally, both groups comprehended wh-questions before producing similar forms, indicating that development occurred in a similar manner. This paper discusses the implications of our findings for language acquisition in ASD. En ligne : http://dx.doi.org/10.1002/aur.1220 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155
in Autism Research > 5-2 (April 2012) . - p.109-123[article] Comprehension of Wh-Questions Precedes Their Production in Typical Development and Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Anthony GOODWIN, Auteur ; Deborah A. FEIN, Auteur ; Letitia R. NAIGLES, Auteur . - 2012 . - p.109-123.
Langues : Anglais (eng)
in Autism Research > 5-2 (April 2012) . - p.109-123
Mots-clés : wh-questions language grammar production comprehension Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorders (ASD) rarely produce wh-questions (e.g. “What hit the book?”) in naturalistic speech. It is unclear if this is due to social–pragmatic difficulties, or if grammatical deficits are also involved. If grammar is impaired, production of wh-questions by rote memorization might precede comprehension of similar forms. In a longitudinal study, 15 children with ASD and 18 initially language-matched typically developing (TD) toddlers were visited in their homes at 4-month intervals across a 3-year period. The wh-question task was presented via intermodal preferential looking. Silent “hitting” events (e.g. an apple hitting a flower) were followed by test trials in which the apple and flower were juxtaposed on the screen. During test trials, subject-wh- and object-wh-question audios were sequentially presented (e.g. “What hit the flower?” or ”What did the apple hit?”). Control audios were also presented (e.g. “Where's the apple/flower?”). Children's eye movements were coded off-line, frame by frame. To show reliable comprehension, children should look longer to the named item (i.e. apple or flower) during the “where” questions but less at the named item during the subject-wh and object-wh-questions. To compare comprehension to production, we coded 30-min spontaneous speech samples drawn from mother–child interactions at each visit. Results indicated that comprehension of subject- and object-wh-questions was delayed in children with ASD compared with age-matched TD children, but not when matched on overall language levels. Additionally, both groups comprehended wh-questions before producing similar forms, indicating that development occurred in a similar manner. This paper discusses the implications of our findings for language acquisition in ASD. En ligne : http://dx.doi.org/10.1002/aur.1220 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155 Motor Learning Relies on Integrated Sensory Inputs in ADHD, but Over-Selectively on Proprioception in Autism Spectrum Conditions / Jun IZAWA in Autism Research, 5-2 (April 2012)
[article]
Titre : Motor Learning Relies on Integrated Sensory Inputs in ADHD, but Over-Selectively on Proprioception in Autism Spectrum Conditions Type de document : Texte imprimé et/ou numérique Auteurs : Jun IZAWA, Auteur ; Sarah E. PEKNY, Auteur ; Mollie K. MARKO, Auteur ; Courtney C. HASWELL, Auteur ; Reza SHADMEHR, Auteur ; Stewart H. MOSTOFSKY, Auteur Année de publication : 2012 Article en page(s) : p.124-136 Langues : Anglais (eng) Mots-clés : motor learning internal model generalization Index. décimale : PER Périodiques Résumé : The brain builds an association between action and sensory feedback to predict the sensory consequence of self-generated motor commands. This internal model of action is central to our ability to adapt movements and may also play a role in our ability to learn from observing others. Recently, we reported that the spatial generalization patterns that accompany adaptation of reaching movements were distinct in children with autism spectrum disorder (ASD) as compared with typically developing (TD) children. To test whether the generalization patterns are specific to ASD, here, we compared the patterns of adaptation with those in children with attention deficit hyperactivity disorder (ADHD). Consistent with our previous observations, we found that in ASD, the motor memory showed greater than normal generalization in proprioceptive coordinates compared with both TD children and children with ADHD; children with ASD also showed slower rates of adaptation compared with both control groups. Children with ADHD did not show this excessive generalization to the proprioceptive target, but they did show excessive variability in the speed of movements with an increase in the exponential distribution of responses (τ) as compared with both TD children and children with ASD. The results suggest that slower rate of adaptation and anomalous bias towards proprioceptive feedback during motor learning are characteristics of autism, whereas increased variability in execution is a characteristic of ADHD. En ligne : http://dx.doi.org/10.1002/aur.1222 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155
in Autism Research > 5-2 (April 2012) . - p.124-136[article] Motor Learning Relies on Integrated Sensory Inputs in ADHD, but Over-Selectively on Proprioception in Autism Spectrum Conditions [Texte imprimé et/ou numérique] / Jun IZAWA, Auteur ; Sarah E. PEKNY, Auteur ; Mollie K. MARKO, Auteur ; Courtney C. HASWELL, Auteur ; Reza SHADMEHR, Auteur ; Stewart H. MOSTOFSKY, Auteur . - 2012 . - p.124-136.
Langues : Anglais (eng)
in Autism Research > 5-2 (April 2012) . - p.124-136
Mots-clés : motor learning internal model generalization Index. décimale : PER Périodiques Résumé : The brain builds an association between action and sensory feedback to predict the sensory consequence of self-generated motor commands. This internal model of action is central to our ability to adapt movements and may also play a role in our ability to learn from observing others. Recently, we reported that the spatial generalization patterns that accompany adaptation of reaching movements were distinct in children with autism spectrum disorder (ASD) as compared with typically developing (TD) children. To test whether the generalization patterns are specific to ASD, here, we compared the patterns of adaptation with those in children with attention deficit hyperactivity disorder (ADHD). Consistent with our previous observations, we found that in ASD, the motor memory showed greater than normal generalization in proprioceptive coordinates compared with both TD children and children with ADHD; children with ASD also showed slower rates of adaptation compared with both control groups. Children with ADHD did not show this excessive generalization to the proprioceptive target, but they did show excessive variability in the speed of movements with an increase in the exponential distribution of responses (τ) as compared with both TD children and children with ASD. The results suggest that slower rate of adaptation and anomalous bias towards proprioceptive feedback during motor learning are characteristics of autism, whereas increased variability in execution is a characteristic of ADHD. En ligne : http://dx.doi.org/10.1002/aur.1222 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155 Cluster Analysis of Autistic Patients Based on Principal Pathogenetic Components / Roberto SACCO in Autism Research, 5-2 (April 2012)
[article]
Titre : Cluster Analysis of Autistic Patients Based on Principal Pathogenetic Components Type de document : Texte imprimé et/ou numérique Auteurs : Roberto SACCO, Auteur ; Carlo LENTI, Auteur ; Monica SACCANI, Auteur ; Paolo CURATOLO, Auteur ; Barbara MANZI, Auteur ; Carmela BRAVACCIO, Auteur ; Antonio M. PERSICO, Auteur Année de publication : 2012 Article en page(s) : p.137-147 Langues : Anglais (eng) Mots-clés : pervasive developmental disorders cluster analysis immune system neurodevelopment principal component analysis Index. décimale : PER Périodiques Résumé : We have recently described four principal pathogenetic components in autism: (I) circadian and sensory dysfunction, (II) immune abnormalities, (III) neurodevelopmental delay, and (IV) stereotypic behaviors. Using hierarchical and k-means clustering, the same 245 patients assessed in our principal component analysis can be partitioned into four clusters: (a) 43 (17.6%) have prominent immune abnormalities accompanied by some circadian and sensory issues; (b) 44 (18.0%) display major circadian and sensory dysfunction, with little or no immune symptoms; (c) stereotypies predominate in 75 (31.0%); and (d) 83 (33.9%) show a mixture of all four components, with greater disruptive behaviors and mental retardation. The “immune” component provides the largest contributions to phenotypic variance (P = 2.7 x 10–45), followed by “stereotypic behaviors.” These patient clusters may likely differ in genetic and immune underpinnings, developmental trajectories, and response to treatment. En ligne : http://dx.doi.org/10.1002/aur.1226 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155
in Autism Research > 5-2 (April 2012) . - p.137-147[article] Cluster Analysis of Autistic Patients Based on Principal Pathogenetic Components [Texte imprimé et/ou numérique] / Roberto SACCO, Auteur ; Carlo LENTI, Auteur ; Monica SACCANI, Auteur ; Paolo CURATOLO, Auteur ; Barbara MANZI, Auteur ; Carmela BRAVACCIO, Auteur ; Antonio M. PERSICO, Auteur . - 2012 . - p.137-147.
Langues : Anglais (eng)
in Autism Research > 5-2 (April 2012) . - p.137-147
Mots-clés : pervasive developmental disorders cluster analysis immune system neurodevelopment principal component analysis Index. décimale : PER Périodiques Résumé : We have recently described four principal pathogenetic components in autism: (I) circadian and sensory dysfunction, (II) immune abnormalities, (III) neurodevelopmental delay, and (IV) stereotypic behaviors. Using hierarchical and k-means clustering, the same 245 patients assessed in our principal component analysis can be partitioned into four clusters: (a) 43 (17.6%) have prominent immune abnormalities accompanied by some circadian and sensory issues; (b) 44 (18.0%) display major circadian and sensory dysfunction, with little or no immune symptoms; (c) stereotypies predominate in 75 (31.0%); and (d) 83 (33.9%) show a mixture of all four components, with greater disruptive behaviors and mental retardation. The “immune” component provides the largest contributions to phenotypic variance (P = 2.7 x 10–45), followed by “stereotypic behaviors.” These patient clusters may likely differ in genetic and immune underpinnings, developmental trajectories, and response to treatment. En ligne : http://dx.doi.org/10.1002/aur.1226 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155
[article]
Titre : Lay Abstracts Type de document : Texte imprimé et/ou numérique Année de publication : 2012 Article en page(s) : p.148-150 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1233 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155
in Autism Research > 5-2 (April 2012) . - p.148-150[article] Lay Abstracts [Texte imprimé et/ou numérique] . - 2012 . - p.148-150.
Langues : Anglais (eng)
in Autism Research > 5-2 (April 2012) . - p.148-150
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1233 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155 Erratum: Accuracy of Phenotyping Children With Autism Based on Parent Report: What Specifically Do We Gain Phenotyping “Rapidly”? / Zachary WARREN in Autism Research, 5-2 (April 2012)
[article]
Titre : Erratum: Accuracy of Phenotyping Children With Autism Based on Parent Report: What Specifically Do We Gain Phenotyping “Rapidly”? Type de document : Texte imprimé et/ou numérique Auteurs : Zachary WARREN, Auteur ; Alison VEHORN, Auteur ; Elizabeth DOHRMANN, Auteur ; Amy NICHOLSON, Auteur ; James S. SUTCLIFFE, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur Année de publication : 2012 Article en page(s) : p.151 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1228 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155
in Autism Research > 5-2 (April 2012) . - p.151[article] Erratum: Accuracy of Phenotyping Children With Autism Based on Parent Report: What Specifically Do We Gain Phenotyping “Rapidly”? [Texte imprimé et/ou numérique] / Zachary WARREN, Auteur ; Alison VEHORN, Auteur ; Elizabeth DOHRMANN, Auteur ; Amy NICHOLSON, Auteur ; James S. SUTCLIFFE, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur . - 2012 . - p.151.
Langues : Anglais (eng)
in Autism Research > 5-2 (April 2012) . - p.151
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1228 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155 International Society for Autism Research News / Helen TAGER-FLUSBERG in Autism Research, 5-2 (April 2012)
[article]
Titre : International Society for Autism Research News Type de document : Texte imprimé et/ou numérique Auteurs : Helen TAGER-FLUSBERG, Auteur Année de publication : 2012 Article en page(s) : p.152 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1234 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155
in Autism Research > 5-2 (April 2012) . - p.152[article] International Society for Autism Research News [Texte imprimé et/ou numérique] / Helen TAGER-FLUSBERG, Auteur . - 2012 . - p.152.
Langues : Anglais (eng)
in Autism Research > 5-2 (April 2012) . - p.152
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1234 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155