[article] in Development and Psychopathology > 24-4 (November 2012) . - p.1427-1442 | Titre : | Age-related changes of gene expression in the neocortex: Preliminary data on RNA-Seq of the transcriptome in three functionally distinct cortical areas | | Type de document : | texte imprimé | | Auteurs : | Oksana Yu NAUMOVA, Auteur ; Dean PALEJEV, Auteur ; Natalia V. VLASOVA, Auteur ; Maria LEE, Auteur ; Sergei Yu RYCHKOV, Auteur ; Olga N. BABICH, Auteur ; Flora M. VACCARINO, Auteur ; Elena L. GRIGORENKO, Auteur | | Année de publication : | 2012 | | Article en page(s) : | p.1427-1442 | | Langues : | Anglais (eng) | | Catégories : | CERVEAU
GENETIQUE
NEUROLOGIE
| | Index. décimale : | PER Périodiques | | Résumé : | The study of gene expression (i.e., the study of the transcriptome) in different cells and tissues allows us to understand the molecular mechanisms of their differentiation, development and functioning. In this article, we describe some studies of gene-expression profiling for the purposes of understanding developmental (age-related) changes in the brain using different technologies (e.g., DNA-Microarray) and the new and increasingly popular RNA-Seq. We focus on advancements in studies of gene expression in the human brain, which have provided data on the structure and age-related variability of the transcriptome in the brain. We present data on RNA-Seq of the transcriptome in three distinct areas of the neocortex from different ages: mature and elderly individuals. We report that most age-related transcriptional changes affect cellular signaling systems, and, as a result, the transmission of nerve impulses. In general, the results demonstrate the high potential of RNA-Seq for the study of distinctive features of gene expression among cortical areas and the changes in expression through normal and atypical development of the central nervous system. | | En ligne : | http://dx.doi.org/10.1017/S0954579412000818 | | Permalink : | http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=1824 |
[article] Age-related changes of gene expression in the neocortex: Preliminary data on RNA-Seq of the transcriptome in three functionally distinct cortical areas [texte imprimé] / Oksana Yu NAUMOVA, Auteur ; Dean PALEJEV, Auteur ; Natalia V. VLASOVA, Auteur ; Maria LEE, Auteur ; Sergei Yu RYCHKOV, Auteur ; Olga N. BABICH, Auteur ; Flora M. VACCARINO, Auteur ; Elena L. GRIGORENKO, Auteur . - 2012 . - p.1427-1442. Langues : Anglais ( eng) in Development and Psychopathology > 24-4 (November 2012) . - p.1427-1442 | Catégories : | CERVEAU
GENETIQUE
NEUROLOGIE
| | Index. décimale : | PER Périodiques | | Résumé : | The study of gene expression (i.e., the study of the transcriptome) in different cells and tissues allows us to understand the molecular mechanisms of their differentiation, development and functioning. In this article, we describe some studies of gene-expression profiling for the purposes of understanding developmental (age-related) changes in the brain using different technologies (e.g., DNA-Microarray) and the new and increasingly popular RNA-Seq. We focus on advancements in studies of gene expression in the human brain, which have provided data on the structure and age-related variability of the transcriptome in the brain. We present data on RNA-Seq of the transcriptome in three distinct areas of the neocortex from different ages: mature and elderly individuals. We report that most age-related transcriptional changes affect cellular signaling systems, and, as a result, the transmission of nerve impulses. In general, the results demonstrate the high potential of RNA-Seq for the study of distinctive features of gene expression among cortical areas and the changes in expression through normal and atypical development of the central nervous system. | | En ligne : | http://dx.doi.org/10.1017/S0954579412000818 | | Permalink : | http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=1824 |
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Age-related changes of gene expression in the neocortex: Preliminary data on RNA-Seq of the transcriptome in three functionally distinct cortical areas / Oksana Yu NAUMOVA in Development and Psychopathology, 24-4 (November 2012)
