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Trajectories of Change in the Behavioral and Health Phenotype of Adolescents and Adults with Fragile X Syndrome and Intellectual Disability: Longitudinal Trends Over a Decade / Lauren V. USHER in Journal of Autism and Developmental Disorders, 50-8 (August 2020)
[article]
Titre : Trajectories of Change in the Behavioral and Health Phenotype of Adolescents and Adults with Fragile X Syndrome and Intellectual Disability: Longitudinal Trends Over a Decade Type de document : Texte imprimé et/ou numérique Auteurs : Lauren V. USHER, Auteur ; Leann S. DAWALT, Auteur ; Jinkuk HONG, Auteur ; Jan S GREENBERG, Auteur ; Marsha R. MAILICK, Auteur Article en page(s) : p.2779-2792 Langues : Anglais (eng) Mots-clés : Adolescents Adults Behavioral phenotype Fragile X syndrome Health phenotype Index. décimale : PER Périodiques Résumé : This study examined trajectories of daily living skills, behavior problems, body mass index (BMI), and health conditions spanning nearly a decade in adolescents and adults with fragile X syndrome (N?=?134; age range at study end?=?19-49 years), examining influences of sex and autism spectrum disorder (ASD) symptoms. Hierarchical linear modeling revealed early increases in daily living skills, with decreases at older ages. Behavior problems became less severe over time, with some increases at older ages. Individuals gained weight and had increasing health problems over time. Fewer ASD symptoms were associated with greater daily living skills and fewer behavior problems at study start. This study offers some of the first prospective quantitative analyses of behavioral and health life course trajectories in FXS. En ligne : http://dx.doi.org/10.1007/s10803-020-04367-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=428
in Journal of Autism and Developmental Disorders > 50-8 (August 2020) . - p.2779-2792[article] Trajectories of Change in the Behavioral and Health Phenotype of Adolescents and Adults with Fragile X Syndrome and Intellectual Disability: Longitudinal Trends Over a Decade [Texte imprimé et/ou numérique] / Lauren V. USHER, Auteur ; Leann S. DAWALT, Auteur ; Jinkuk HONG, Auteur ; Jan S GREENBERG, Auteur ; Marsha R. MAILICK, Auteur . - p.2779-2792.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 50-8 (August 2020) . - p.2779-2792
Mots-clés : Adolescents Adults Behavioral phenotype Fragile X syndrome Health phenotype Index. décimale : PER Périodiques Résumé : This study examined trajectories of daily living skills, behavior problems, body mass index (BMI), and health conditions spanning nearly a decade in adolescents and adults with fragile X syndrome (N?=?134; age range at study end?=?19-49 years), examining influences of sex and autism spectrum disorder (ASD) symptoms. Hierarchical linear modeling revealed early increases in daily living skills, with decreases at older ages. Behavior problems became less severe over time, with some increases at older ages. Individuals gained weight and had increasing health problems over time. Fewer ASD symptoms were associated with greater daily living skills and fewer behavior problems at study start. This study offers some of the first prospective quantitative analyses of behavioral and health life course trajectories in FXS. En ligne : http://dx.doi.org/10.1007/s10803-020-04367-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=428 Delineation of Behavioral Phenotypes in Genetic Syndromes: Characteristics of Autism Spectrum Disorder, Affect and Hyperactivity / Chris OLIVER in Journal of Autism and Developmental Disorders, 41-8 (August 2011)
[article]
Titre : Delineation of Behavioral Phenotypes in Genetic Syndromes: Characteristics of Autism Spectrum Disorder, Affect and Hyperactivity Type de document : Texte imprimé et/ou numérique Auteurs : Chris OLIVER, Auteur ; Katy BERG, Auteur ; Jo MOSS, Auteur ; Kate ARRON, Auteur ; Cheryl BURBIDGE, Auteur Année de publication : 2011 Article en page(s) : p.1019-1032 Langues : Anglais (eng) Mots-clés : Behavioral phenotype Autism spectrum disorder Hyperactivity Impulsivity Affect Genetic syndromes Index. décimale : PER Périodiques Résumé : We investigated autism spectrum disorder (ASD) symptomatology, hyperactivity and affect in seven genetic syndromes; Angelman (AS; n = 104), Cri du Chat (CdCS; 58), Cornelia de Lange (CdLS; 101), Fragile X (FXS; 191), Prader-Willi (PWS; 189), Smith-Magenis (SMS; 42) and Lowe (LS; 56) syndromes (age range 4–51). ASD symptomatology was heightened in CdLS and FXS. High levels of impulsivity were seen in SMS, AS, CdCS, FXS and adults with CdLS. Negative affect was prominent in adults with CdLS, while positive affect was prominent in adults with AS and FXS. Heightened levels of overactivity and impulsivity were identified in FXS, AS and SMS while low levels were identified in PWS. These findings confirm and extend previously reported behavioral phenotypes. En ligne : http://dx.doi.org/10.1007/s10803-010-1125-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132
in Journal of Autism and Developmental Disorders > 41-8 (August 2011) . - p.1019-1032[article] Delineation of Behavioral Phenotypes in Genetic Syndromes: Characteristics of Autism Spectrum Disorder, Affect and Hyperactivity [Texte imprimé et/ou numérique] / Chris OLIVER, Auteur ; Katy BERG, Auteur ; Jo MOSS, Auteur ; Kate ARRON, Auteur ; Cheryl BURBIDGE, Auteur . - 2011 . - p.1019-1032.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 41-8 (August 2011) . - p.1019-1032
Mots-clés : Behavioral phenotype Autism spectrum disorder Hyperactivity Impulsivity Affect Genetic syndromes Index. décimale : PER Périodiques Résumé : We investigated autism spectrum disorder (ASD) symptomatology, hyperactivity and affect in seven genetic syndromes; Angelman (AS; n = 104), Cri du Chat (CdCS; 58), Cornelia de Lange (CdLS; 101), Fragile X (FXS; 191), Prader-Willi (PWS; 189), Smith-Magenis (SMS; 42) and Lowe (LS; 56) syndromes (age range 4–51). ASD symptomatology was heightened in CdLS and FXS. High levels of impulsivity were seen in SMS, AS, CdCS, FXS and adults with CdLS. Negative affect was prominent in adults with CdLS, while positive affect was prominent in adults with AS and FXS. Heightened levels of overactivity and impulsivity were identified in FXS, AS and SMS while low levels were identified in PWS. These findings confirm and extend previously reported behavioral phenotypes. En ligne : http://dx.doi.org/10.1007/s10803-010-1125-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132 Brief Report: A Longitudinal Study of Excessive Smiling and Laughing in Children with Angelman Syndrome / Dawn ADAMS in Journal of Autism and Developmental Disorders, 45-8 (August 2015)
[article]
Titre : Brief Report: A Longitudinal Study of Excessive Smiling and Laughing in Children with Angelman Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Dawn ADAMS, Auteur ; Kate HORSLER, Auteur ; Rebecca MOUNT, Auteur ; Chris OLIVER, Auteur Année de publication : 2015 Article en page(s) : p.2624-2627 Langues : Anglais (eng) Mots-clés : Angelman syndrome Behavioral phenotype Intellectual disability Aging Behavior Index. décimale : PER Périodiques Résumé : Elevated laughing and smiling is a key characteristic of the Angelman syndrome behavioral phenotype, with cross-sectional studies reporting changes with environment and age. This study compares levels of laughing and smiling in 12 participants across three experimental conditions [full social interaction (with eye contact), social interaction with no eye contact, proximity only] at two data points. No differences were noted in frequency of laughing and smiling over time in any condition. However, with age as a covariate, the frequency of laughing and smiling decreased over time in the full social interaction (with eye contact) condition only. As this is the first longitudinal study to explore these behaviors in Angelman syndrome, the results suggest a gene–environment–time interaction within the behavioral phenotype. En ligne : http://dx.doi.org/10.1007/s10803-015-2404-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263
in Journal of Autism and Developmental Disorders > 45-8 (August 2015) . - p.2624-2627[article] Brief Report: A Longitudinal Study of Excessive Smiling and Laughing in Children with Angelman Syndrome [Texte imprimé et/ou numérique] / Dawn ADAMS, Auteur ; Kate HORSLER, Auteur ; Rebecca MOUNT, Auteur ; Chris OLIVER, Auteur . - 2015 . - p.2624-2627.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-8 (August 2015) . - p.2624-2627
Mots-clés : Angelman syndrome Behavioral phenotype Intellectual disability Aging Behavior Index. décimale : PER Périodiques Résumé : Elevated laughing and smiling is a key characteristic of the Angelman syndrome behavioral phenotype, with cross-sectional studies reporting changes with environment and age. This study compares levels of laughing and smiling in 12 participants across three experimental conditions [full social interaction (with eye contact), social interaction with no eye contact, proximity only] at two data points. No differences were noted in frequency of laughing and smiling over time in any condition. However, with age as a covariate, the frequency of laughing and smiling decreased over time in the full social interaction (with eye contact) condition only. As this is the first longitudinal study to explore these behaviors in Angelman syndrome, the results suggest a gene–environment–time interaction within the behavioral phenotype. En ligne : http://dx.doi.org/10.1007/s10803-015-2404-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263 Autism Symptomatology in Boys with Fragile X Syndrome: A Cross Sectional Developmental Trajectories Comparison with Nonsyndromic Autism Spectrum Disorder / Angela John THURMAN in Journal of Autism and Developmental Disorders, 45-9 (September 2015)
[article]
Titre : Autism Symptomatology in Boys with Fragile X Syndrome: A Cross Sectional Developmental Trajectories Comparison with Nonsyndromic Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Angela John THURMAN, Auteur ; Andrea MCDUFFIE, Auteur ; Sara T. KOVER, Auteur ; Randi J. HAGERMAN, Auteur ; Leonard ABBEDUTO, Auteur Article en page(s) : p.2816-2832 Langues : Anglais (eng) Mots-clés : Fragile X syndrome Autism spectrum disorder Behavioral phenotype Nonverbal cognition Expressive vocabulary Developmental trajectory Index. décimale : PER Périodiques Résumé : Although males with fragile X syndrome (FXS) are frequently described as demonstrating autism symptomatology, there is much debate regarding whether the behavioral symptoms representing the core domains of autism are the result of the same or different underlying neurological/psychological mechanisms. The present study used a cross-sectional developmental trajectories approach to compare the profiles of autism symptomatology relative to chronological age (CA), nonverbal IQ, and expressive vocabulary ability between individuals with FXS and individuals with nonsyndromic ASD. Results suggest that the onset of autism symptoms and their developmental trajectories in males with FXS differ in important ways as a function of CA, nonverbal cognitive ability, and expressive vocabulary relative to males with nonsyndromic ASD. Theoretical and clinical implications are discussed. En ligne : http://dx.doi.org/10.1007/s10803-015-2443-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267
in Journal of Autism and Developmental Disorders > 45-9 (September 2015) . - p.2816-2832[article] Autism Symptomatology in Boys with Fragile X Syndrome: A Cross Sectional Developmental Trajectories Comparison with Nonsyndromic Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Angela John THURMAN, Auteur ; Andrea MCDUFFIE, Auteur ; Sara T. KOVER, Auteur ; Randi J. HAGERMAN, Auteur ; Leonard ABBEDUTO, Auteur . - p.2816-2832.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-9 (September 2015) . - p.2816-2832
Mots-clés : Fragile X syndrome Autism spectrum disorder Behavioral phenotype Nonverbal cognition Expressive vocabulary Developmental trajectory Index. décimale : PER Périodiques Résumé : Although males with fragile X syndrome (FXS) are frequently described as demonstrating autism symptomatology, there is much debate regarding whether the behavioral symptoms representing the core domains of autism are the result of the same or different underlying neurological/psychological mechanisms. The present study used a cross-sectional developmental trajectories approach to compare the profiles of autism symptomatology relative to chronological age (CA), nonverbal IQ, and expressive vocabulary ability between individuals with FXS and individuals with nonsyndromic ASD. Results suggest that the onset of autism symptoms and their developmental trajectories in males with FXS differ in important ways as a function of CA, nonverbal cognitive ability, and expressive vocabulary relative to males with nonsyndromic ASD. Theoretical and clinical implications are discussed. En ligne : http://dx.doi.org/10.1007/s10803-015-2443-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267 Ed Zigler's developmental approach to intellectual disabilities: Past, present, and future contributions / Robert M. HODAPP in Development and Psychopathology, 33-2 (May 2021)
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Titre : Ed Zigler's developmental approach to intellectual disabilities: Past, present, and future contributions Type de document : Texte imprimé et/ou numérique Auteurs : Robert M. HODAPP, Auteur Année de publication : 2021 Article en page(s) : p.453-465 Langues : Anglais (eng) Mots-clés : Down syndrome Williams syndrome behavioral phenotype cultural–familial ID developmental approach to intellectual disabilities personality–motivational factors two-group approach Index. décimale : PER Périodiques Résumé : Comprising two parts, Ed Zigler's developmental approach has greatly influenced how one conceptualizes children with intellectual disabilities (ID). In part one, Zigler championed a "two-group approach" concerning the cause of children's ID. He distinguished persons with a clear, organic cause of their ID from those displaying no clear cause. Members of this "organic" group often displayed IQs below 50 and co-occurring physical-medical conditions. The second, "cultural-familial" group, mostly showed IQs of 50-70, did not possess co-occurring physical or health problems, and often came from families of lower IQs and lower socioeconomic status. While the presence of these two groups has been supported, recent advances have also further differentiated the organic group, mostly in relation to behavioral phenotypes of persons with several genetic etiologies. In part two, Zigler championed the child with ID as a "whole person." Originally focused on the child's reactions to social deprivation and failure, recent studies directly examine parent-child, within-family, and wider system interactions throughout the life span. For decades a force within the ID field, Zigler's developmental approach to children with ID continues to influence researchers, interventionists, and policymakers. En ligne : http://dx.doi.org/10.1017/s0954579420002084 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=444
in Development and Psychopathology > 33-2 (May 2021) . - p.453-465[article] Ed Zigler's developmental approach to intellectual disabilities: Past, present, and future contributions [Texte imprimé et/ou numérique] / Robert M. HODAPP, Auteur . - 2021 . - p.453-465.
Langues : Anglais (eng)
in Development and Psychopathology > 33-2 (May 2021) . - p.453-465
Mots-clés : Down syndrome Williams syndrome behavioral phenotype cultural–familial ID developmental approach to intellectual disabilities personality–motivational factors two-group approach Index. décimale : PER Périodiques Résumé : Comprising two parts, Ed Zigler's developmental approach has greatly influenced how one conceptualizes children with intellectual disabilities (ID). In part one, Zigler championed a "two-group approach" concerning the cause of children's ID. He distinguished persons with a clear, organic cause of their ID from those displaying no clear cause. Members of this "organic" group often displayed IQs below 50 and co-occurring physical-medical conditions. The second, "cultural-familial" group, mostly showed IQs of 50-70, did not possess co-occurring physical or health problems, and often came from families of lower IQs and lower socioeconomic status. While the presence of these two groups has been supported, recent advances have also further differentiated the organic group, mostly in relation to behavioral phenotypes of persons with several genetic etiologies. In part two, Zigler championed the child with ID as a "whole person." Originally focused on the child's reactions to social deprivation and failure, recent studies directly examine parent-child, within-family, and wider system interactions throughout the life span. For decades a force within the ID field, Zigler's developmental approach to children with ID continues to influence researchers, interventionists, and policymakers. En ligne : http://dx.doi.org/10.1017/s0954579420002084 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=444 “Frank” presentations as a novel research construct and element of diagnostic decision-making in autism spectrum disorder / Ashley DE MARCHENA in Autism Research, 10-4 (April 2017)
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