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Neural meaning making, prediction, and prefrontal-subcortical development following early adverse caregiving / Nim TOTTENHAM in Development and Psychopathology, 32-5 (December 2020)
[article]
Titre : Neural meaning making, prediction, and prefrontal-subcortical development following early adverse caregiving Type de document : Texte imprimé et/ou numérique Auteurs : Nim TOTTENHAM, Auteur Article en page(s) : p.1563-1578 Langues : Anglais (eng) Mots-clés : Adult Cues Humans Learning *Memory *Prefrontal Cortex *child maltreatment *meaning making *schema *semantic memory Index. décimale : PER Périodiques Résumé : Early adversities that are caregiving-related (crEAs) are associated with a significantly increased risk for mental health problems. Recent neuroscientific advances have revealed alterations in medial prefrontal cortex (mPFC)-subcortical circuitry following crEAs. While this work has identified alterations in affective operations (e.g., perceiving, reacting, controlling, learning) associated with mPFC-subcortical circuitry, this circuitry has a much broader function extending beyond operations. It plays a primary role in affective meaning making, involving conceptual-level, schematized knowledge to generate predictions about the current environment. This function of mPFC-subcortical circuitry motivates asking whether mPFC-subcortical phenotypes following crEAs support semanticized knowledge content (or the concept-level knowledge) and generate predictive models. I present a hypothesis motivated by research findings across four different lines of work that converge on mPFC-subcortical neuroanatomy, including (a) the neurobiology supporting emotion regulation processes in adulthood, (b) the neurobiology that is activated by caregiving cues during development, (c) the neurobiology that is altered by crEAs, and (d) the neurobiology of semantic-based meaning making. I hypothesize that the affective behaviors following crEAs result in part from affective semantic memory processes supported by mPFC-subcortical circuitry that over the course of development, construct affective schemas that generate meaning making and guide predictions. I use this opportunity to review some of the literature on mPFC-subcortical circuit development following crEAs to illustrate the motivation behind this hypothesis. Long recognized by clinical science and cognitive neuroscience, studying schema-based processes may be particularly helpful for understanding how affective meaning making arises from developmental trajectories of mPFC-subcortical circuitry. En ligne : http://dx.doi.org/10.1017/s0954579420001169 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437
in Development and Psychopathology > 32-5 (December 2020) . - p.1563-1578[article] Neural meaning making, prediction, and prefrontal-subcortical development following early adverse caregiving [Texte imprimé et/ou numérique] / Nim TOTTENHAM, Auteur . - p.1563-1578.
Langues : Anglais (eng)
in Development and Psychopathology > 32-5 (December 2020) . - p.1563-1578
Mots-clés : Adult Cues Humans Learning *Memory *Prefrontal Cortex *child maltreatment *meaning making *schema *semantic memory Index. décimale : PER Périodiques Résumé : Early adversities that are caregiving-related (crEAs) are associated with a significantly increased risk for mental health problems. Recent neuroscientific advances have revealed alterations in medial prefrontal cortex (mPFC)-subcortical circuitry following crEAs. While this work has identified alterations in affective operations (e.g., perceiving, reacting, controlling, learning) associated with mPFC-subcortical circuitry, this circuitry has a much broader function extending beyond operations. It plays a primary role in affective meaning making, involving conceptual-level, schematized knowledge to generate predictions about the current environment. This function of mPFC-subcortical circuitry motivates asking whether mPFC-subcortical phenotypes following crEAs support semanticized knowledge content (or the concept-level knowledge) and generate predictive models. I present a hypothesis motivated by research findings across four different lines of work that converge on mPFC-subcortical neuroanatomy, including (a) the neurobiology supporting emotion regulation processes in adulthood, (b) the neurobiology that is activated by caregiving cues during development, (c) the neurobiology that is altered by crEAs, and (d) the neurobiology of semantic-based meaning making. I hypothesize that the affective behaviors following crEAs result in part from affective semantic memory processes supported by mPFC-subcortical circuitry that over the course of development, construct affective schemas that generate meaning making and guide predictions. I use this opportunity to review some of the literature on mPFC-subcortical circuit development following crEAs to illustrate the motivation behind this hypothesis. Long recognized by clinical science and cognitive neuroscience, studying schema-based processes may be particularly helpful for understanding how affective meaning making arises from developmental trajectories of mPFC-subcortical circuitry. En ligne : http://dx.doi.org/10.1017/s0954579420001169 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 Developmental outcomes of early adverse care on amygdala functional connectivity in nonhuman primates / Elyse L. MORIN in Development and Psychopathology, 32-5 (December 2020)
[article]
Titre : Developmental outcomes of early adverse care on amygdala functional connectivity in nonhuman primates Type de document : Texte imprimé et/ou numérique Auteurs : Elyse L. MORIN, Auteur ; Brittany R. HOWELL, Auteur ; Eric FECZKO, Auteur ; Eric EARL, Auteur ; Melanie PINCUS, Auteur ; Katherine REDING, Auteur ; Zsofia A. KOVACS-BALINT, Auteur ; Jerrold S. MEYER, Auteur ; Martin STYNER, Auteur ; Damien A. FAIR, Auteur ; Mar M. SANCHEZ, Auteur Article en page(s) : p.1579-1596 Langues : Anglais (eng) Mots-clés : Adolescent *Amygdala/diagnostic imaging Animals Brain Child Female Humans Magnetic Resonance Imaging Neural Pathways/diagnostic imaging *Prefrontal Cortex/diagnostic imaging Pregnancy Primates *amygdala functional connectivity *childhood maltreatment *early life stress *prefrontal cortex *rhesus monkey Index. décimale : PER Périodiques Résumé : Despite the strong link between childhood maltreatment and psychopathology, the underlying neurodevelopmental mechanisms are poorly understood and difficult to disentangle from heritable and prenatal factors. This study used a translational macaque model of infant maltreatment in which the adverse experience occurs in the first months of life, during intense maturation of amygdala circuits important for stress and emotional regulation. Thus, we examined the developmental impact of maltreatment on amygdala functional connectivity (FC) longitudinally, from infancy through the juvenile period. Using resting state functional magnetic resonance imaging (MRI) we performed amygdala-prefrontal cortex (PFC) region-of-interest and exploratory whole-brain amygdala FC analyses. The latter showed (a) developmental increases in amygdala FC with many regions, likely supporting increased processing of socioemotional-relevant stimuli with age; and (b) maltreatment effects on amygdala coupling with arousal and stress brain regions (locus coeruleus, laterodorsal tegmental area) that emerged with age. Maltreated juveniles showed weaker FC than controls, which was negatively associated with infant hair cortisol concentrations. Findings from the region-of-interest analysis also showed weaker amygdala FC with PFC regions in maltreated animals than controls since infancy, whereas bilateral amygdala FC was stronger in maltreated animals. These effects on amygdala FC development may underlie the poor behavioral outcomes associated with this adverse experience. En ligne : http://dx.doi.org/10.1017/s0954579420001133 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437
in Development and Psychopathology > 32-5 (December 2020) . - p.1579-1596[article] Developmental outcomes of early adverse care on amygdala functional connectivity in nonhuman primates [Texte imprimé et/ou numérique] / Elyse L. MORIN, Auteur ; Brittany R. HOWELL, Auteur ; Eric FECZKO, Auteur ; Eric EARL, Auteur ; Melanie PINCUS, Auteur ; Katherine REDING, Auteur ; Zsofia A. KOVACS-BALINT, Auteur ; Jerrold S. MEYER, Auteur ; Martin STYNER, Auteur ; Damien A. FAIR, Auteur ; Mar M. SANCHEZ, Auteur . - p.1579-1596.
Langues : Anglais (eng)
in Development and Psychopathology > 32-5 (December 2020) . - p.1579-1596
Mots-clés : Adolescent *Amygdala/diagnostic imaging Animals Brain Child Female Humans Magnetic Resonance Imaging Neural Pathways/diagnostic imaging *Prefrontal Cortex/diagnostic imaging Pregnancy Primates *amygdala functional connectivity *childhood maltreatment *early life stress *prefrontal cortex *rhesus monkey Index. décimale : PER Périodiques Résumé : Despite the strong link between childhood maltreatment and psychopathology, the underlying neurodevelopmental mechanisms are poorly understood and difficult to disentangle from heritable and prenatal factors. This study used a translational macaque model of infant maltreatment in which the adverse experience occurs in the first months of life, during intense maturation of amygdala circuits important for stress and emotional regulation. Thus, we examined the developmental impact of maltreatment on amygdala functional connectivity (FC) longitudinally, from infancy through the juvenile period. Using resting state functional magnetic resonance imaging (MRI) we performed amygdala-prefrontal cortex (PFC) region-of-interest and exploratory whole-brain amygdala FC analyses. The latter showed (a) developmental increases in amygdala FC with many regions, likely supporting increased processing of socioemotional-relevant stimuli with age; and (b) maltreatment effects on amygdala coupling with arousal and stress brain regions (locus coeruleus, laterodorsal tegmental area) that emerged with age. Maltreated juveniles showed weaker FC than controls, which was negatively associated with infant hair cortisol concentrations. Findings from the region-of-interest analysis also showed weaker amygdala FC with PFC regions in maltreated animals than controls since infancy, whereas bilateral amygdala FC was stronger in maltreated animals. These effects on amygdala FC development may underlie the poor behavioral outcomes associated with this adverse experience. En ligne : http://dx.doi.org/10.1017/s0954579420001133 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437