Dépouillements

Early adversity, stress, and neurobehavioral development / Megan R. GUNNAR in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1555-1562 Titre : Early adversity, stress, and neurobehavioral development Type de document : Texte imprimé et/ou numérique Auteurs : Megan R. GUNNAR, Auteur Article en page(s) : p.1555-1562 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/s0954579420001649 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Early adversity, stress, and neurobehavioral development [Texte imprimé et/ou numérique] / Megan R. GUNNAR, Auteur . - p.1555-1562. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1555-1562 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/s0954579420001649 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Neural meaning making, prediction, and prefrontal-subcortical development following early adverse caregiving / Nim TOTTENHAM in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1563-1578 Titre : Neural meaning making, prediction, and prefrontal-subcortical development following early adverse caregiving Type de document : Texte imprimé et/ou numérique Auteurs : Nim TOTTENHAM, Auteur Article en page(s) : p.1563-1578 Langues : Anglais (eng) Mots-clés : Adult  Cues  Humans  Learning  *Memory  *Prefrontal Cortex  *child maltreatment  *meaning making  *schema  *semantic memory Index. décimale : PER Périodiques Résumé : Early adversities that are caregiving-related (crEAs) are associated with a significantly increased risk for mental health problems. Recent neuroscientific advances have revealed alterations in medial prefrontal cortex (mPFC)-subcortical circuitry following crEAs. While this work has identified alterations in affective operations (e.g., perceiving, reacting, controlling, learning) associated with mPFC-subcortical circuitry, this circuitry has a much broader function extending beyond operations. It plays a primary role in affective meaning making, involving conceptual-level, schematized knowledge to generate predictions about the current environment. This function of mPFC-subcortical circuitry motivates asking whether mPFC-subcortical phenotypes following crEAs support semanticized knowledge content (or the concept-level knowledge) and generate predictive models. I present a hypothesis motivated by research findings across four different lines of work that converge on mPFC-subcortical neuroanatomy, including (a) the neurobiology supporting emotion regulation processes in adulthood, (b) the neurobiology that is activated by caregiving cues during development, (c) the neurobiology that is altered by crEAs, and (d) the neurobiology of semantic-based meaning making. I hypothesize that the affective behaviors following crEAs result in part from affective semantic memory processes supported by mPFC-subcortical circuitry that over the course of development, construct affective schemas that generate meaning making and guide predictions. I use this opportunity to review some of the literature on mPFC-subcortical circuit development following crEAs to illustrate the motivation behind this hypothesis. Long recognized by clinical science and cognitive neuroscience, studying schema-based processes may be particularly helpful for understanding how affective meaning making arises from developmental trajectories of mPFC-subcortical circuitry. En ligne : http://dx.doi.org/10.1017/s0954579420001169 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Neural meaning making, prediction, and prefrontal-subcortical development following early adverse caregiving [Texte imprimé et/ou numérique] / Nim TOTTENHAM, Auteur . - p.1563-1578. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1563-1578 Mots-clés : Adult  Cues  Humans  Learning  *Memory  *Prefrontal Cortex  *child maltreatment  *meaning making  *schema  *semantic memory Index. décimale : PER Périodiques Résumé : Early adversities that are caregiving-related (crEAs) are associated with a significantly increased risk for mental health problems. Recent neuroscientific advances have revealed alterations in medial prefrontal cortex (mPFC)-subcortical circuitry following crEAs. While this work has identified alterations in affective operations (e.g., perceiving, reacting, controlling, learning) associated with mPFC-subcortical circuitry, this circuitry has a much broader function extending beyond operations. It plays a primary role in affective meaning making, involving conceptual-level, schematized knowledge to generate predictions about the current environment. This function of mPFC-subcortical circuitry motivates asking whether mPFC-subcortical phenotypes following crEAs support semanticized knowledge content (or the concept-level knowledge) and generate predictive models. I present a hypothesis motivated by research findings across four different lines of work that converge on mPFC-subcortical neuroanatomy, including (a) the neurobiology supporting emotion regulation processes in adulthood, (b) the neurobiology that is activated by caregiving cues during development, (c) the neurobiology that is altered by crEAs, and (d) the neurobiology of semantic-based meaning making. I hypothesize that the affective behaviors following crEAs result in part from affective semantic memory processes supported by mPFC-subcortical circuitry that over the course of development, construct affective schemas that generate meaning making and guide predictions. I use this opportunity to review some of the literature on mPFC-subcortical circuit development following crEAs to illustrate the motivation behind this hypothesis. Long recognized by clinical science and cognitive neuroscience, studying schema-based processes may be particularly helpful for understanding how affective meaning making arises from developmental trajectories of mPFC-subcortical circuitry. En ligne : http://dx.doi.org/10.1017/s0954579420001169 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Developmental outcomes of early adverse care on amygdala functional connectivity in nonhuman primates / Elyse L. MORIN in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1579-1596 Titre : Developmental outcomes of early adverse care on amygdala functional connectivity in nonhuman primates Type de document : Texte imprimé et/ou numérique Auteurs : Elyse L. MORIN, Auteur ; Brittany R. HOWELL, Auteur ; Eric FECZKO, Auteur ; Eric EARL, Auteur ; Melanie PINCUS, Auteur ; Katherine REDING, Auteur ; Zsofia A. KOVACS-BALINT, Auteur ; Jerrold S. MEYER, Auteur ; Martin STYNER, Auteur ; Damien A. FAIR, Auteur ; Mar M. SANCHEZ, Auteur Article en page(s) : p.1579-1596 Langues : Anglais (eng) Mots-clés : Adolescent  *Amygdala/diagnostic imaging  Animals  Brain  Child  Female  Humans  Magnetic Resonance Imaging  Neural Pathways/diagnostic imaging  *Prefrontal Cortex/diagnostic imaging  Pregnancy  Primates  *amygdala functional connectivity  *childhood maltreatment  *early life stress  *prefrontal cortex  *rhesus monkey Index. décimale : PER Périodiques Résumé : Despite the strong link between childhood maltreatment and psychopathology, the underlying neurodevelopmental mechanisms are poorly understood and difficult to disentangle from heritable and prenatal factors. This study used a translational macaque model of infant maltreatment in which the adverse experience occurs in the first months of life, during intense maturation of amygdala circuits important for stress and emotional regulation. Thus, we examined the developmental impact of maltreatment on amygdala functional connectivity (FC) longitudinally, from infancy through the juvenile period. Using resting state functional magnetic resonance imaging (MRI) we performed amygdala-prefrontal cortex (PFC) region-of-interest and exploratory whole-brain amygdala FC analyses. The latter showed (a) developmental increases in amygdala FC with many regions, likely supporting increased processing of socioemotional-relevant stimuli with age; and (b) maltreatment effects on amygdala coupling with arousal and stress brain regions (locus coeruleus, laterodorsal tegmental area) that emerged with age. Maltreated juveniles showed weaker FC than controls, which was negatively associated with infant hair cortisol concentrations. Findings from the region-of-interest analysis also showed weaker amygdala FC with PFC regions in maltreated animals than controls since infancy, whereas bilateral amygdala FC was stronger in maltreated animals. These effects on amygdala FC development may underlie the poor behavioral outcomes associated with this adverse experience. En ligne : http://dx.doi.org/10.1017/s0954579420001133 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Developmental outcomes of early adverse care on amygdala functional connectivity in nonhuman primates [Texte imprimé et/ou numérique] / Elyse L. MORIN, Auteur ; Brittany R. HOWELL, Auteur ; Eric FECZKO, Auteur ; Eric EARL, Auteur ; Melanie PINCUS, Auteur ; Katherine REDING, Auteur ; Zsofia A. KOVACS-BALINT, Auteur ; Jerrold S. MEYER, Auteur ; Martin STYNER, Auteur ; Damien A. FAIR, Auteur ; Mar M. SANCHEZ, Auteur . - p.1579-1596. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1579-1596 Mots-clés : Adolescent  *Amygdala/diagnostic imaging  Animals  Brain  Child  Female  Humans  Magnetic Resonance Imaging  Neural Pathways/diagnostic imaging  *Prefrontal Cortex/diagnostic imaging  Pregnancy  Primates  *amygdala functional connectivity  *childhood maltreatment  *early life stress  *prefrontal cortex  *rhesus monkey Index. décimale : PER Périodiques Résumé : Despite the strong link between childhood maltreatment and psychopathology, the underlying neurodevelopmental mechanisms are poorly understood and difficult to disentangle from heritable and prenatal factors. This study used a translational macaque model of infant maltreatment in which the adverse experience occurs in the first months of life, during intense maturation of amygdala circuits important for stress and emotional regulation. Thus, we examined the developmental impact of maltreatment on amygdala functional connectivity (FC) longitudinally, from infancy through the juvenile period. Using resting state functional magnetic resonance imaging (MRI) we performed amygdala-prefrontal cortex (PFC) region-of-interest and exploratory whole-brain amygdala FC analyses. The latter showed (a) developmental increases in amygdala FC with many regions, likely supporting increased processing of socioemotional-relevant stimuli with age; and (b) maltreatment effects on amygdala coupling with arousal and stress brain regions (locus coeruleus, laterodorsal tegmental area) that emerged with age. Maltreated juveniles showed weaker FC than controls, which was negatively associated with infant hair cortisol concentrations. Findings from the region-of-interest analysis also showed weaker amygdala FC with PFC regions in maltreated animals than controls since infancy, whereas bilateral amygdala FC was stronger in maltreated animals. These effects on amygdala FC development may underlie the poor behavioral outcomes associated with this adverse experience. En ligne : http://dx.doi.org/10.1017/s0954579420001133 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Challenges in researching the immune pathways between early life adversity and psychopathology / Brie REID in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1597-1624 Titre : Challenges in researching the immune pathways between early life adversity and psychopathology Type de document : Texte imprimé et/ou numérique Auteurs : Brie REID, Auteur ; Andrea DANESE, Auteur Article en page(s) : p.1597-1624 Langues : Anglais (eng) Mots-clés : Biomarkers  Child  Humans  Inflammation  *Psychopathology  Risk Factors  *Stress, Psychological  *childhood adversity  *immunity  *inflammation  *maltreatment  *psychiatric disorders Index. décimale : PER Périodiques Résumé : Exposure to childhood adversity is a critical risk factor for the development of psychopathology. A growing field of research examines how exposure to childhood adversity is translated into biological risk for psychopathology through alterations in immune system functioning, most notably heightened levels of inflammation biomarkers. Though our knowledge about how childhood adversity can instantiate biological risk for psychopathology is growing, there remain many challenges and gaps in the field to understand how inflammation from childhood adversity contributes to psychopathology. This paper reviews research on the inflammatory outcomes arising from childhood adversity and presents four major challenges that future research must address: (a) the measurement of childhood adversity, (b) the measurement of inflammation, (c) the identification of mediators between childhood adversity and inflammation, and (d) the identification of moderators of inflammatory outcomes following childhood adversity. We discuss synergies and inconsistencies in the literature to summarize the current understanding of the association between childhood adversity, a proinflammatory phenotype, and the biological risk for psychopathology. We discuss the clinical implications of the inflammatory links between childhood adversity and psychopathology, including possibilities for intervention. Finally, this review conclude by delineates future directions for research, including issues of how best to detect, prevent, and understand these "hidden wounds" of childhood adversity. En ligne : http://dx.doi.org/10.1017/s0954579420001157 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Challenges in researching the immune pathways between early life adversity and psychopathology [Texte imprimé et/ou numérique] / Brie REID, Auteur ; Andrea DANESE, Auteur . - p.1597-1624. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1597-1624 Mots-clés : Biomarkers  Child  Humans  Inflammation  *Psychopathology  Risk Factors  *Stress, Psychological  *childhood adversity  *immunity  *inflammation  *maltreatment  *psychiatric disorders Index. décimale : PER Périodiques Résumé : Exposure to childhood adversity is a critical risk factor for the development of psychopathology. A growing field of research examines how exposure to childhood adversity is translated into biological risk for psychopathology through alterations in immune system functioning, most notably heightened levels of inflammation biomarkers. Though our knowledge about how childhood adversity can instantiate biological risk for psychopathology is growing, there remain many challenges and gaps in the field to understand how inflammation from childhood adversity contributes to psychopathology. This paper reviews research on the inflammatory outcomes arising from childhood adversity and presents four major challenges that future research must address: (a) the measurement of childhood adversity, (b) the measurement of inflammation, (c) the identification of mediators between childhood adversity and inflammation, and (d) the identification of moderators of inflammatory outcomes following childhood adversity. We discuss synergies and inconsistencies in the literature to summarize the current understanding of the association between childhood adversity, a proinflammatory phenotype, and the biological risk for psychopathology. We discuss the clinical implications of the inflammatory links between childhood adversity and psychopathology, including possibilities for intervention. Finally, this review conclude by delineates future directions for research, including issues of how best to detect, prevent, and understand these "hidden wounds" of childhood adversity. En ligne : http://dx.doi.org/10.1017/s0954579420001157 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Pregnancy as a period of risk, adaptation, and resilience for mothers and infants / Elysia Poggi DAVIS in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1625-1639 Titre : Pregnancy as a period of risk, adaptation, and resilience for mothers and infants Type de document : Texte imprimé et/ou numérique Auteurs : Elysia Poggi DAVIS, Auteur ; Angela J. NARAYAN, Auteur Article en page(s) : p.1625-1639 Langues : Anglais (eng) Mots-clés : Child  Female  Humans  Infant  *Mothers  Pregnancy  Protective Factors  *adaptation  *adversity  *intergenerational transmission  *pregnancy  *prenatal programming  *resilience  *stress Index. décimale : PER Périodiques Résumé : The pregnancy period represents a unique window of opportunity to identify risks to both the fetus and mother and to deter the intergenerational transmission of adversity and mental health problems. Although the maternal-fetal dyad is especially vulnerable to the effects of stress during pregnancy, less is known about how the dyad is also receptive to salutary, resilience-promoting influences. The present review adopts life span and intergenerational perspectives to review four key areas of research. The first part describes how pregnancy is a sensitive period for both the mother and fetus. In the second part, the focus is on antecedents of maternal prenatal risks pertaining to prenatal stress response systems and mental health. The third part then turns to elucidating how these alterations in prenatal stress physiology and mental health problems may affect infant and child outcomes. The fourth part underscores how pregnancy is also a time of heightened fetal receptivity to maternal and environmental signals, with profound implications for adaptation. This section also reviews empirical evidence of promotive and protective factors that buffer the mother and fetus from developmental and adaptational problems and covers a sample of rigorous evidence-based prenatal interventions that prevent maladaptation in the maternal-fetal dyad before babies are born. Finally, recommendations elaborate on how to further strengthen understanding of pregnancy as a period of multilevel risk and resilience, enhance comprehensive prenatal screening, and expand on prenatal interventions to promote maternal-fetal adaptation before birth. En ligne : http://dx.doi.org/10.1017/s0954579420001121 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Pregnancy as a period of risk, adaptation, and resilience for mothers and infants [Texte imprimé et/ou numérique] / Elysia Poggi DAVIS, Auteur ; Angela J. NARAYAN, Auteur . - p.1625-1639. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1625-1639 Mots-clés : Child  Female  Humans  Infant  *Mothers  Pregnancy  Protective Factors  *adaptation  *adversity  *intergenerational transmission  *pregnancy  *prenatal programming  *resilience  *stress Index. décimale : PER Périodiques Résumé : The pregnancy period represents a unique window of opportunity to identify risks to both the fetus and mother and to deter the intergenerational transmission of adversity and mental health problems. Although the maternal-fetal dyad is especially vulnerable to the effects of stress during pregnancy, less is known about how the dyad is also receptive to salutary, resilience-promoting influences. The present review adopts life span and intergenerational perspectives to review four key areas of research. The first part describes how pregnancy is a sensitive period for both the mother and fetus. In the second part, the focus is on antecedents of maternal prenatal risks pertaining to prenatal stress response systems and mental health. The third part then turns to elucidating how these alterations in prenatal stress physiology and mental health problems may affect infant and child outcomes. The fourth part underscores how pregnancy is also a time of heightened fetal receptivity to maternal and environmental signals, with profound implications for adaptation. This section also reviews empirical evidence of promotive and protective factors that buffer the mother and fetus from developmental and adaptational problems and covers a sample of rigorous evidence-based prenatal interventions that prevent maladaptation in the maternal-fetal dyad before babies are born. Finally, recommendations elaborate on how to further strengthen understanding of pregnancy as a period of multilevel risk and resilience, enhance comprehensive prenatal screening, and expand on prenatal interventions to promote maternal-fetal adaptation before birth. En ligne : http://dx.doi.org/10.1017/s0954579420001121 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

How developmental neuroscience can help address the problem of child poverty / Seth D. POLLAK in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1640-1656 Titre : How developmental neuroscience can help address the problem of child poverty Type de document : Texte imprimé et/ou numérique Auteurs : Seth D. POLLAK, Auteur ; Barbara L. WOLFE, Auteur Article en page(s) : p.1640-1656 Langues : Anglais (eng) Mots-clés : Child  *Family  Family Characteristics  Humans  Income  Infant  *Poverty  Socioeconomic Factors  United States  *brain  *child poverty  *development  *socioeconomic status Index. décimale : PER Périodiques Résumé : Nearly 1 in 5 children in the United States lives in a household whose income is below the official federal poverty line, and more than 40% of children live in poor or near-poor households. Research on the effects of poverty on children's development has been a focus of study for many decades and is now increasing as we accumulate more evidence about the implications of poverty. The American Academy of Pediatrics recently added "Poverty and Child Health" to its Agenda for Children to recognize what has now been established as broad and enduring effects of poverty on child development. A recent addition to the field has been the application of neuroscience-based methods. Various techniques including neuroimaging, neuroendocrinology, cognitive psychophysiology, and epigenetics are beginning to document ways in which early experiences of living in poverty affect infant brain development. We discuss whether there are truly worthwhile reasons for adding neuroscience and related biological methods to study child poverty, and how might these perspectives help guide developmentally based and targeted interventions and policies for these children and their families. En ligne : http://dx.doi.org/10.1017/s0954579420001145 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] How developmental neuroscience can help address the problem of child poverty [Texte imprimé et/ou numérique] / Seth D. POLLAK, Auteur ; Barbara L. WOLFE, Auteur . - p.1640-1656. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1640-1656 Mots-clés : Child  *Family  Family Characteristics  Humans  Income  Infant  *Poverty  Socioeconomic Factors  United States  *brain  *child poverty  *development  *socioeconomic status Index. décimale : PER Périodiques Résumé : Nearly 1 in 5 children in the United States lives in a household whose income is below the official federal poverty line, and more than 40% of children live in poor or near-poor households. Research on the effects of poverty on children's development has been a focus of study for many decades and is now increasing as we accumulate more evidence about the implications of poverty. The American Academy of Pediatrics recently added "Poverty and Child Health" to its Agenda for Children to recognize what has now been established as broad and enduring effects of poverty on child development. A recent addition to the field has been the application of neuroscience-based methods. Various techniques including neuroimaging, neuroendocrinology, cognitive psychophysiology, and epigenetics are beginning to document ways in which early experiences of living in poverty affect infant brain development. We discuss whether there are truly worthwhile reasons for adding neuroscience and related biological methods to study child poverty, and how might these perspectives help guide developmentally based and targeted interventions and policies for these children and their families. En ligne : http://dx.doi.org/10.1017/s0954579420001145 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Enhancing diurnal cortisol regulation among young children adopted internationally: A randomized controlled trial of a parenting-based intervention / K. Lee RABY in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1657-1668 Titre : Enhancing diurnal cortisol regulation among young children adopted internationally: A randomized controlled trial of a parenting-based intervention Type de document : Texte imprimé et/ou numérique Auteurs : K. Lee RABY, Auteur ; Kristin BERNARD, Auteur ; M. Kathleen GORDON, Auteur ; Mary DOZIER, Auteur Article en page(s) : p.1657-1668 Langues : Anglais (eng) Mots-clés : Child  *Child, Adopted  Child, Preschool  Humans  *Hydrocortisone  Hypothalamo-Hypophyseal System  Infant  Parenting  Pituitary-Adrenal System  *cortisol  *early adversity  *international adoption  *intervention  *parental sensitivity Index. décimale : PER Périodiques Résumé : Children who have been adopted internationally commonly experience institutional care and other forms of adversity prior to adoption that can alter the functioning of the hypothalamic-pituitary-adrenal (HPA) axis. In particular, internationally adopted children tend to have blunted diurnal declines compared to children raised in their birth families. The Attachment and Biobehavioral Catch-Up (ABC) intervention was developed to enhance young children's biological and behavioral regulation by promoting sensitive parenting. The current study used a randomized controlled trial to assess whether ABC improved the diurnal functioning of the HPA axis among 85 children who had been adopted internationally when they were between the ages of 4 and 33 months (M = 16.12). Prior to the intervention, there were no significant differences in diurnal cortisol production between children whose parents were randomly assigned to receive ABC and children whose parents were randomly assigned to receive a control intervention. After the intervention, children whose parents had received the ABC intervention exhibited steeper declines in cortisol levels throughout the day than children whose parents had received the control intervention. These results indicate that the ABC intervention is effective in enhancing a healthy pattern of diurnal HPA axis regulation for young children who have been adopted internationally. En ligne : http://dx.doi.org/10.1017/s0954579420001303 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Enhancing diurnal cortisol regulation among young children adopted internationally: A randomized controlled trial of a parenting-based intervention [Texte imprimé et/ou numérique] / K. Lee RABY, Auteur ; Kristin BERNARD, Auteur ; M. Kathleen GORDON, Auteur ; Mary DOZIER, Auteur . - p.1657-1668. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1657-1668 Mots-clés : Child  *Child, Adopted  Child, Preschool  Humans  *Hydrocortisone  Hypothalamo-Hypophyseal System  Infant  Parenting  Pituitary-Adrenal System  *cortisol  *early adversity  *international adoption  *intervention  *parental sensitivity Index. décimale : PER Périodiques Résumé : Children who have been adopted internationally commonly experience institutional care and other forms of adversity prior to adoption that can alter the functioning of the hypothalamic-pituitary-adrenal (HPA) axis. In particular, internationally adopted children tend to have blunted diurnal declines compared to children raised in their birth families. The Attachment and Biobehavioral Catch-Up (ABC) intervention was developed to enhance young children's biological and behavioral regulation by promoting sensitive parenting. The current study used a randomized controlled trial to assess whether ABC improved the diurnal functioning of the HPA axis among 85 children who had been adopted internationally when they were between the ages of 4 and 33 months (M = 16.12). Prior to the intervention, there were no significant differences in diurnal cortisol production between children whose parents were randomly assigned to receive ABC and children whose parents were randomly assigned to receive a control intervention. After the intervention, children whose parents had received the ABC intervention exhibited steeper declines in cortisol levels throughout the day than children whose parents had received the control intervention. These results indicate that the ABC intervention is effective in enhancing a healthy pattern of diurnal HPA axis regulation for young children who have been adopted internationally. En ligne : http://dx.doi.org/10.1017/s0954579420001303 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Racial discrimination and ethnic racial identity in adolescence as modulators of HPA axis activity / Emma K. ADAM in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1669-1684 Titre : Racial discrimination and ethnic racial identity in adolescence as modulators of HPA axis activity Type de document : Texte imprimé et/ou numérique Auteurs : Emma K. ADAM, Auteur ; Emily F. HITTNER, Auteur ; Sara E. THOMAS, Auteur ; Sarah Collier VILLAUME, Auteur ; Ednah E. NWAFOR, Auteur Article en page(s) : p.1669-1684 Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Child  Ethnic Groups  Humans  Hydrocortisone  *Hypothalamo-Hypophyseal System  Pituitary-Adrenal System  *Racism  Stress, Psychological  *HPA axis  *adolescence  *adversity  *cortisol  *early adulthood  *ethnic racial identity  *racial discrimination Index. décimale : PER Périodiques Résumé : We review evidence of racial discrimination as a critical and understudied form of adversity that has the potential to impact stress biology, particularly hypothalamic-pituitary-adrenal (HPA) axis activity. We highlight ethnic racial identity (ERI) as a positive regulatory influence on HPA axis activity, as indexed by levels of salivary cortisol. In past research by our group, Black individuals with high adolescent discrimination had low adult cortisol levels (hypocortisolism). Here, we present new analyses showing that ERI, measured prospectively from ages 12 through 32 in 112 Black and white individuals, is related to better-regulated cortisol levels in adulthood, particularly for Black participants. We also describe ongoing research that explores whether the promotion of ERI during adolescence can reduce ethnic-racial disparities in stress biology and in emotional health and academic outcomes. En ligne : http://dx.doi.org/10.1017/s095457942000111x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Racial discrimination and ethnic racial identity in adolescence as modulators of HPA axis activity [Texte imprimé et/ou numérique] / Emma K. ADAM, Auteur ; Emily F. HITTNER, Auteur ; Sara E. THOMAS, Auteur ; Sarah Collier VILLAUME, Auteur ; Ednah E. NWAFOR, Auteur . - p.1669-1684. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1669-1684 Mots-clés : Adolescent  Adult  Child  Ethnic Groups  Humans  Hydrocortisone  *Hypothalamo-Hypophyseal System  Pituitary-Adrenal System  *Racism  Stress, Psychological  *HPA axis  *adolescence  *adversity  *cortisol  *early adulthood  *ethnic racial identity  *racial discrimination Index. décimale : PER Périodiques Résumé : We review evidence of racial discrimination as a critical and understudied form of adversity that has the potential to impact stress biology, particularly hypothalamic-pituitary-adrenal (HPA) axis activity. We highlight ethnic racial identity (ERI) as a positive regulatory influence on HPA axis activity, as indexed by levels of salivary cortisol. In past research by our group, Black individuals with high adolescent discrimination had low adult cortisol levels (hypocortisolism). Here, we present new analyses showing that ERI, measured prospectively from ages 12 through 32 in 112 Black and white individuals, is related to better-regulated cortisol levels in adulthood, particularly for Black participants. We also describe ongoing research that explores whether the promotion of ERI during adolescence can reduce ethnic-racial disparities in stress biology and in emotional health and academic outcomes. En ligne : http://dx.doi.org/10.1017/s095457942000111x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Prenatal maternal psychological distress and fetal developmental trajectories: associations with infant temperament / Mariann A. HOWLAND in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1685-1695 Titre : Prenatal maternal psychological distress and fetal developmental trajectories: associations with infant temperament Type de document : Texte imprimé et/ou numérique Auteurs : Mariann A. HOWLAND, Auteur ; Curt A. SANDMAN, Auteur ; Elysia Poggi DAVIS, Auteur ; Laura M. GLYNN, Auteur Article en page(s) : p.1685-1695 Langues : Anglais (eng) Mots-clés : Female  Fetal Development  Humans  Infant  Longitudinal Studies  Male  Pregnancy  *Prenatal Exposure Delayed Effects  Prospective Studies  Psychological Distress  Stress, Psychological  *Temperament  *fetal  *heart rate  *prenatal  *stress Index. décimale : PER Périodiques Résumé : Associations between prenatal maternal psychological distress and offspring developmental outcomes are well documented, yet relatively little research has examined links between maternal distress and development in utero, prior to postpartum influences. Fetal heart rate (FHR) parameters are established indices of central and autonomic nervous system maturation and function which demonstrate continuity with postnatal outcomes. This prospective, longitudinal study of 149 maternal-fetal pairs evaluated associations between prenatal maternal distress, FHR parameters, and dimensions of infant temperament. Women reported their symptoms of psychological distress at five prenatal visits, and FHR monitoring was conducted at the last three visits. Maternal report of infant temperament was collected at 3 and 6 months of age. Exposure to elevated prenatal maternal psychological distress was associated with higher late-gestation resting mean FHR (FHRM) among female but not male fetuses. Higher late-gestation FHRM was associated with lower infant orienting/regulation and with higher infant negative affectivity, and these associations did not differ by infant sex. A path analysis identified higher FHRM as one pathway by which elevated prenatal maternal distress was associated with lower orienting/regulation among female infants. Findings suggest that, for females, elevated maternal distress alters fetal development, with implications for postnatal function. Results also support the notion that, for both sexes, individual differences in regulation emerge prenatally and are maintained into infancy. Collectively, these findings underscore the utility of direct assessment of development in utero when examining if prenatal experiences are carried forward into postnatal life. En ligne : http://dx.doi.org/10.1017/s095457942000142x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Prenatal maternal psychological distress and fetal developmental trajectories: associations with infant temperament [Texte imprimé et/ou numérique] / Mariann A. HOWLAND, Auteur ; Curt A. SANDMAN, Auteur ; Elysia Poggi DAVIS, Auteur ; Laura M. GLYNN, Auteur . - p.1685-1695. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1685-1695 Mots-clés : Female  Fetal Development  Humans  Infant  Longitudinal Studies  Male  Pregnancy  *Prenatal Exposure Delayed Effects  Prospective Studies  Psychological Distress  Stress, Psychological  *Temperament  *fetal  *heart rate  *prenatal  *stress Index. décimale : PER Périodiques Résumé : Associations between prenatal maternal psychological distress and offspring developmental outcomes are well documented, yet relatively little research has examined links between maternal distress and development in utero, prior to postpartum influences. Fetal heart rate (FHR) parameters are established indices of central and autonomic nervous system maturation and function which demonstrate continuity with postnatal outcomes. This prospective, longitudinal study of 149 maternal-fetal pairs evaluated associations between prenatal maternal distress, FHR parameters, and dimensions of infant temperament. Women reported their symptoms of psychological distress at five prenatal visits, and FHR monitoring was conducted at the last three visits. Maternal report of infant temperament was collected at 3 and 6 months of age. Exposure to elevated prenatal maternal psychological distress was associated with higher late-gestation resting mean FHR (FHRM) among female but not male fetuses. Higher late-gestation FHRM was associated with lower infant orienting/regulation and with higher infant negative affectivity, and these associations did not differ by infant sex. A path analysis identified higher FHRM as one pathway by which elevated prenatal maternal distress was associated with lower orienting/regulation among female infants. Findings suggest that, for females, elevated maternal distress alters fetal development, with implications for postnatal function. Results also support the notion that, for both sexes, individual differences in regulation emerge prenatally and are maintained into infancy. Collectively, these findings underscore the utility of direct assessment of development in utero when examining if prenatal experiences are carried forward into postnatal life. En ligne : http://dx.doi.org/10.1017/s095457942000142x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Elevated infant cortisol is necessary but not sufficient for transmission of environmental risk to infant social development: Cross-species evidence of mother-infant physiological social transmission / Rosemarie E. PERRY in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1696-1714 Titre : Elevated infant cortisol is necessary but not sufficient for transmission of environmental risk to infant social development: Cross-species evidence of mother-infant physiological social transmission Type de document : Texte imprimé et/ou numérique Auteurs : Rosemarie E. PERRY, Auteur ; Stephen H. BRAREN, Auteur ; Maya OPENDAK, Auteur ; Annie BRANDES-AITKEN, Auteur ; Divija CHOPRA, Auteur ; Joyce WOO, Auteur ; Regina SULLIVAN, Auteur ; Clancy BLAIR, Auteur Article en page(s) : p.1696-1714 Langues : Anglais (eng) Mots-clés : Corticosterone  Female  Humans  *Hydrocortisone  Infant  Mother-Child Relations  *Mothers  Parenting  Stress, Psychological  *corticosterone  *cortisol  *early-life adversity  *early-life stress  *mother–infant  *social transmission Index. décimale : PER Périodiques Résumé : Environmental adversity increases child susceptibility to disrupted developmental outcomes, but the mechanisms by which adversity can shape development remain unclear. A translational cross-species approach was used to examine stress-mediated pathways by which poverty-related adversity can influence infant social development. Findings from a longitudinal sample of low-income mother-infant dyads indicated that infant cortisol (CORT) on its own did not mediate relations between early-life scarcity-adversity exposure and later infant behavior in a mother-child interaction task. However, maternal CORT through infant CORT served as a mediating pathway, even when controlling for parenting behavior. Findings using a rodent "scarcity-adversity" model indicated that pharmacologically blocking pup corticosterone (CORT, rodent equivalent to cortisol) in the presence of a stressed mother causally prevented social transmission of scarcity-adversity effects on pup social behavior. Furthermore, pharmacologically increasing pup CORT without the mother present was not sufficient to disrupt pup social behavior. Integration of our cross-species results suggests that elevated infant CORT may be necessary, but without elevated caregiver CORT, may not be sufficient in mediating the effects of environmental adversity on development. These findings underscore the importance of considering infant stress physiology in relation to the broader social context, including caregiver stress physiology, in research and interventional efforts. En ligne : http://dx.doi.org/10.1017/s0954579420001455 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Elevated infant cortisol is necessary but not sufficient for transmission of environmental risk to infant social development: Cross-species evidence of mother-infant physiological social transmission [Texte imprimé et/ou numérique] / Rosemarie E. PERRY, Auteur ; Stephen H. BRAREN, Auteur ; Maya OPENDAK, Auteur ; Annie BRANDES-AITKEN, Auteur ; Divija CHOPRA, Auteur ; Joyce WOO, Auteur ; Regina SULLIVAN, Auteur ; Clancy BLAIR, Auteur . - p.1696-1714. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1696-1714 Mots-clés : Corticosterone  Female  Humans  *Hydrocortisone  Infant  Mother-Child Relations  *Mothers  Parenting  Stress, Psychological  *corticosterone  *cortisol  *early-life adversity  *early-life stress  *mother–infant  *social transmission Index. décimale : PER Périodiques Résumé : Environmental adversity increases child susceptibility to disrupted developmental outcomes, but the mechanisms by which adversity can shape development remain unclear. A translational cross-species approach was used to examine stress-mediated pathways by which poverty-related adversity can influence infant social development. Findings from a longitudinal sample of low-income mother-infant dyads indicated that infant cortisol (CORT) on its own did not mediate relations between early-life scarcity-adversity exposure and later infant behavior in a mother-child interaction task. However, maternal CORT through infant CORT served as a mediating pathway, even when controlling for parenting behavior. Findings using a rodent "scarcity-adversity" model indicated that pharmacologically blocking pup corticosterone (CORT, rodent equivalent to cortisol) in the presence of a stressed mother causally prevented social transmission of scarcity-adversity effects on pup social behavior. Furthermore, pharmacologically increasing pup CORT without the mother present was not sufficient to disrupt pup social behavior. Integration of our cross-species results suggests that elevated infant CORT may be necessary, but without elevated caregiver CORT, may not be sufficient in mediating the effects of environmental adversity on development. These findings underscore the importance of considering infant stress physiology in relation to the broader social context, including caregiver stress physiology, in research and interventional efforts. En ligne : http://dx.doi.org/10.1017/s0954579420001455 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

The prospective association between stressful life events and inflammation among adolescents with a history of early institutional rearing / Alva TANG in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1715-1724 Titre : The prospective association between stressful life events and inflammation among adolescents with a history of early institutional rearing Type de document : Texte imprimé et/ou numérique Auteurs : Alva TANG, Auteur ; Mark WADE, Auteur ; Nathan A. FOX, Auteur ; Charles A. NELSON, Auteur ; Charles H. ZEANAH, Auteur ; Natalie SLOPEN, Auteur Article en page(s) : p.1715-1724 Langues : Anglais (eng) Mots-clés : Adolescent  Child  *Child, Institutionalized  Child, Preschool  *Foster Home Care  Humans  Infant  Inflammation  Prospective Studies  Romania  *adolescence  *inflammation  *neglect  *stress sensitization  *stressful life events Index. décimale : PER Périodiques Résumé : Early adversity has been shown to sensitize individuals to the effects of later stress and enhance risk of psychopathology. Using a longitudinal randomized trial of foster care as an alternative to institutional care, we extend the stress sensitization hypothesis to examine whether early institutional rearing sensitizes individuals to stressful events in adolescence engendering chronic low-grade inflammation. At baseline, institutionalized children in Romania (ages 6-31 months) were randomly assigned to foster care or to remain in usual care within institutions. A group of never-institutionalized children was recruited as an in-country comparison sample. At ages 12 and 16, participants reported stressful events. At age 16, Interleukin-6 (IL-6) and C-reactive protein (CRP) were derived from blood spots. Among children assigned to care as usual, more stressful events at age 12, but not age 16, were associated with higher IL-6. In the same group, stressful events at age 16 were associated with higher CRP, though these effects attenuated after adjusting for covariates. These associations were not observed in the foster care or never-institutionalized groups. The findings suggest that heightened inflammation following stress exposure is one pathway through which early neglect could compromise physical health. In contrast, early family care might buffer against these risks. En ligne : http://dx.doi.org/10.1017/s0954579420001479 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] The prospective association between stressful life events and inflammation among adolescents with a history of early institutional rearing [Texte imprimé et/ou numérique] / Alva TANG, Auteur ; Mark WADE, Auteur ; Nathan A. FOX, Auteur ; Charles A. NELSON, Auteur ; Charles H. ZEANAH, Auteur ; Natalie SLOPEN, Auteur . - p.1715-1724. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1715-1724 Mots-clés : Adolescent  Child  *Child, Institutionalized  Child, Preschool  *Foster Home Care  Humans  Infant  Inflammation  Prospective Studies  Romania  *adolescence  *inflammation  *neglect  *stress sensitization  *stressful life events Index. décimale : PER Périodiques Résumé : Early adversity has been shown to sensitize individuals to the effects of later stress and enhance risk of psychopathology. Using a longitudinal randomized trial of foster care as an alternative to institutional care, we extend the stress sensitization hypothesis to examine whether early institutional rearing sensitizes individuals to stressful events in adolescence engendering chronic low-grade inflammation. At baseline, institutionalized children in Romania (ages 6-31 months) were randomly assigned to foster care or to remain in usual care within institutions. A group of never-institutionalized children was recruited as an in-country comparison sample. At ages 12 and 16, participants reported stressful events. At age 16, Interleukin-6 (IL-6) and C-reactive protein (CRP) were derived from blood spots. Among children assigned to care as usual, more stressful events at age 12, but not age 16, were associated with higher IL-6. In the same group, stressful events at age 16 were associated with higher CRP, though these effects attenuated after adjusting for covariates. These associations were not observed in the foster care or never-institutionalized groups. The findings suggest that heightened inflammation following stress exposure is one pathway through which early neglect could compromise physical health. In contrast, early family care might buffer against these risks. En ligne : http://dx.doi.org/10.1017/s0954579420001479 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Immediate and longitudinal effects of maltreatment on systemic inflammation in young children / Sonja ENTRINGER in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1725-1731 Titre : Immediate and longitudinal effects of maltreatment on systemic inflammation in young children Type de document : Texte imprimé et/ou numérique Auteurs : Sonja ENTRINGER, Auteur ; Karin DE PUNDER, Auteur ; Judith OVERFELD, Auteur ; Gergana KARABOYCHEVA, Auteur ; Katja DITTRICH, Auteur ; Claudia BUSS, Auteur ; Sibylle Maria WINTER, Auteur ; Elisabeth B. BINDER, Auteur ; Christine HEIM, Auteur Article en page(s) : p.1725-1731 Langues : Anglais (eng) Mots-clés : C-Reactive Protein  Child  *Child Abuse  Child, Preschool  Cross-Sectional Studies  Female  Humans  Infant  Inflammation  Male  Retrospective Studies  *crp  *early life stress  *inflammation  *maltreatment  *sex differences Index. décimale : PER Périodiques Résumé : Exposure to child maltreatment increases the risk for psychiatric and physical diseases. Inflammation has been proposed as a mechanism through which early adverse experiences become biologically embedded. However, most studies providing evidence for the link between early adverse exposures and inflammation have been retrospective or cross-sectional in design, or did not assess inflammation immediately after maltreatment in young children. In the present study we investigated the association between childhood maltreatment and salivary C-reactive protein (CRP) concentrations in a population of N = 173 children, 3-5 years of age, who were recruited in the immediate aftermath of maltreatment and followed-up longitudinally every 6 months over a period of 2 years. We found that the association between maltreatment and CRP concentrations was significantly moderated by child sex, such that in girls, CRP concentrations were higher in the maltreated compared to the control group, and this difference was stable across the 2-year follow-up-period, while in boys, there was no association between maltreatment and CRP. Our findings suggest that the effect of maltreatment on inflammation may already emerge right after exposure at a very young age in girls and manifest over time. Our study provides important evidence for the development of personalized, early interventions strategies targeting the early-life period. En ligne : http://dx.doi.org/10.1017/s0954579420001686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Immediate and longitudinal effects of maltreatment on systemic inflammation in young children [Texte imprimé et/ou numérique] / Sonja ENTRINGER, Auteur ; Karin DE PUNDER, Auteur ; Judith OVERFELD, Auteur ; Gergana KARABOYCHEVA, Auteur ; Katja DITTRICH, Auteur ; Claudia BUSS, Auteur ; Sibylle Maria WINTER, Auteur ; Elisabeth B. BINDER, Auteur ; Christine HEIM, Auteur . - p.1725-1731. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1725-1731 Mots-clés : C-Reactive Protein  Child  *Child Abuse  Child, Preschool  Cross-Sectional Studies  Female  Humans  Infant  Inflammation  Male  Retrospective Studies  *crp  *early life stress  *inflammation  *maltreatment  *sex differences Index. décimale : PER Périodiques Résumé : Exposure to child maltreatment increases the risk for psychiatric and physical diseases. Inflammation has been proposed as a mechanism through which early adverse experiences become biologically embedded. However, most studies providing evidence for the link between early adverse exposures and inflammation have been retrospective or cross-sectional in design, or did not assess inflammation immediately after maltreatment in young children. In the present study we investigated the association between childhood maltreatment and salivary C-reactive protein (CRP) concentrations in a population of N = 173 children, 3-5 years of age, who were recruited in the immediate aftermath of maltreatment and followed-up longitudinally every 6 months over a period of 2 years. We found that the association between maltreatment and CRP concentrations was significantly moderated by child sex, such that in girls, CRP concentrations were higher in the maltreated compared to the control group, and this difference was stable across the 2-year follow-up-period, while in boys, there was no association between maltreatment and CRP. Our findings suggest that the effect of maltreatment on inflammation may already emerge right after exposure at a very young age in girls and manifest over time. Our study provides important evidence for the development of personalized, early interventions strategies targeting the early-life period. En ligne : http://dx.doi.org/10.1017/s0954579420001686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Environmental determinants of physiological reactivity to stress: The interacting effects of early life deprivation, caregiving quality, and stressful life events / Mark WADE in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1732-1742 Titre : Environmental determinants of physiological reactivity to stress: The interacting effects of early life deprivation, caregiving quality, and stressful life events Type de document : Texte imprimé et/ou numérique Auteurs : Mark WADE, Auteur ; Margaret A. SHERIDAN, Auteur ; Charles H. ZEANAH, Auteur ; Nathan A. FOX, Auteur ; Charles A. NELSON, Auteur ; Katie A. MCLAUGHLIN, Auteur Article en page(s) : p.1732-1742 Langues : Anglais (eng) Mots-clés : Adolescent  Child  *Child, Institutionalized  Foster Home Care  Humans  Hydrocortisone  Hypothalamo-Hypophyseal System  *Pituitary-Adrenal System  Psychosocial Deprivation  Stress, Psychological  *HPA-axis  *developmental psychobiology  *institutional rearing  *neglect  *stress reactivity  *sympathetic nervous system Index. décimale : PER Périodiques Résumé : Children who spend their early lives in institutions experience profound psychosocial deprivation that is associated with altered stress response system development. Here, we used data from a longitudinal randomized controlled trial of foster care for institutionally reared children to examine whether caregiving quality and stressful life events (SLEs) in early adolescence (age 12) influence patterns of hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) reactivity. Controlling for the effect of institutional care, higher caregiving quality at age 12 was associated with heightened cortisol and SNS reactivity. However, moderation analysis revealed that the latter effect was only observed among never-institutionalized children, whereas ever-institutionalized children demonstrated a persistently blunted SNS response regardless of recent caregiving quality. Among institutionally reared children, SLEs interacted with prior random assignment to foster care, such that those placed in foster care early in development had a SNS response that approximated never-institutionalized children when SLEs at age 12 were low. In contrast, SNS reactivity was persistently blunted among those with prolonged deprivation, regardless of recent SLEs. Early-life deprivation is associated with persistent blunting of stress response systems, but normalization may be achievable if SLEs are limited following placement into enriched family-based care. En ligne : http://dx.doi.org/10.1017/s0954579420001327 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Environmental determinants of physiological reactivity to stress: The interacting effects of early life deprivation, caregiving quality, and stressful life events [Texte imprimé et/ou numérique] / Mark WADE, Auteur ; Margaret A. SHERIDAN, Auteur ; Charles H. ZEANAH, Auteur ; Nathan A. FOX, Auteur ; Charles A. NELSON, Auteur ; Katie A. MCLAUGHLIN, Auteur . - p.1732-1742. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1732-1742 Mots-clés : Adolescent  Child  *Child, Institutionalized  Foster Home Care  Humans  Hydrocortisone  Hypothalamo-Hypophyseal System  *Pituitary-Adrenal System  Psychosocial Deprivation  Stress, Psychological  *HPA-axis  *developmental psychobiology  *institutional rearing  *neglect  *stress reactivity  *sympathetic nervous system Index. décimale : PER Périodiques Résumé : Children who spend their early lives in institutions experience profound psychosocial deprivation that is associated with altered stress response system development. Here, we used data from a longitudinal randomized controlled trial of foster care for institutionally reared children to examine whether caregiving quality and stressful life events (SLEs) in early adolescence (age 12) influence patterns of hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) reactivity. Controlling for the effect of institutional care, higher caregiving quality at age 12 was associated with heightened cortisol and SNS reactivity. However, moderation analysis revealed that the latter effect was only observed among never-institutionalized children, whereas ever-institutionalized children demonstrated a persistently blunted SNS response regardless of recent caregiving quality. Among institutionally reared children, SLEs interacted with prior random assignment to foster care, such that those placed in foster care early in development had a SNS response that approximated never-institutionalized children when SLEs at age 12 were low. In contrast, SNS reactivity was persistently blunted among those with prolonged deprivation, regardless of recent SLEs. Early-life deprivation is associated with persistent blunting of stress response systems, but normalization may be achievable if SLEs are limited following placement into enriched family-based care. En ligne : http://dx.doi.org/10.1017/s0954579420001327 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Alpha electroencephalogram (EEG) asymmetry among toddlers in foster care / Kellyn N. BLAISDELL in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1743-1753 Titre : Alpha electroencephalogram (EEG) asymmetry among toddlers in foster care Type de document : Texte imprimé et/ou numérique Auteurs : Kellyn N. BLAISDELL, Auteur ; Tyson V. BARKER, Auteur ; Ryan J. GIULIANO, Auteur ; Philip A. FISHER, Auteur Article en page(s) : p.1743-1753 Langues : Anglais (eng) Mots-clés : Child  Child, Preschool  *Electroencephalography  *Foster Home Care  Frontal Lobe  Humans  *alpha asymmetry  *child maltreatment  *early adversity  *foster care Index. décimale : PER Périodiques Résumé : The majority of children living in foster care in the United States have a history of maltreatment and/or disrupted caregiving. Maltreatment in early childhood adversely affects development at many levels, including neurobiology and behavior. One neurobiological measure associated with maltreatment is alpha electroencephalogram (EEG) asymmetry. Prior research has found greater right frontal asymmetry among children with a history of maltreatment. However, little research has been extended developmentally downward to examine alpha asymmetry and its behavioral correlates among toddlers in foster care; this was the purpose of the present study. Differences in EEG asymmetry were examined between a sample of foster toddlers (mean age = 3.21 years, n = 38) and a community comparison, low-income sample without a history of foster care (mean age = 3.04 years, n = 16). The toddlers in the foster care group exhibited greater right alpha asymmetry, primarily driven by differences in parietal asymmetry. Neither frontal nor parietal asymmetry were clearly related to internalizing or externalizing behaviors, measured concurrently or at previous time points. These findings reveal differences in alpha EEG asymmetry among toddlers in foster care, and highlight the need to better understand associations between neurobiological and behavioral functioning following early adversity. En ligne : http://dx.doi.org/10.1017/s0954579420001212 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Alpha electroencephalogram (EEG) asymmetry among toddlers in foster care [Texte imprimé et/ou numérique] / Kellyn N. BLAISDELL, Auteur ; Tyson V. BARKER, Auteur ; Ryan J. GIULIANO, Auteur ; Philip A. FISHER, Auteur . - p.1743-1753. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1743-1753 Mots-clés : Child  Child, Preschool  *Electroencephalography  *Foster Home Care  Frontal Lobe  Humans  *alpha asymmetry  *child maltreatment  *early adversity  *foster care Index. décimale : PER Périodiques Résumé : The majority of children living in foster care in the United States have a history of maltreatment and/or disrupted caregiving. Maltreatment in early childhood adversely affects development at many levels, including neurobiology and behavior. One neurobiological measure associated with maltreatment is alpha electroencephalogram (EEG) asymmetry. Prior research has found greater right frontal asymmetry among children with a history of maltreatment. However, little research has been extended developmentally downward to examine alpha asymmetry and its behavioral correlates among toddlers in foster care; this was the purpose of the present study. Differences in EEG asymmetry were examined between a sample of foster toddlers (mean age = 3.21 years, n = 38) and a community comparison, low-income sample without a history of foster care (mean age = 3.04 years, n = 16). The toddlers in the foster care group exhibited greater right alpha asymmetry, primarily driven by differences in parietal asymmetry. Neither frontal nor parietal asymmetry were clearly related to internalizing or externalizing behaviors, measured concurrently or at previous time points. These findings reveal differences in alpha EEG asymmetry among toddlers in foster care, and highlight the need to better understand associations between neurobiological and behavioral functioning following early adversity. En ligne : http://dx.doi.org/10.1017/s0954579420001212 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

A systematic review of caregiver-child physiological synchrony across systems: Associations with behavior and child functioning / Carrie E. DEPASQUALE in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1754-1777 Titre : A systematic review of caregiver-child physiological synchrony across systems: Associations with behavior and child functioning Type de document : Texte imprimé et/ou numérique Auteurs : Carrie E. DEPASQUALE, Auteur Article en page(s) : p.1754-1777 Langues : Anglais (eng) Mots-clés : Autonomic Nervous System  *Caregivers  Child  Humans  *Mother-Child Relations  Parent-Child Relations  Parents  *behavior  *caregiver  *development  *physiology  *synchrony Index. décimale : PER Périodiques Résumé : Extensive research has established a positive association between caregiver-child behavioral synchrony and child developmental functioning. Burgeoning research examining physiological synchrony has yet to elucidate its impact for children's developing self-regulation. The objectives of this systematic review were to: 1) determine whether there is evidence that caregiver-child physiological synchrony promotes positive child development, 2) examine developmental differences in physiological synchrony and its correlates, and 3) explore whether context, risk, and/or stress influence patterns of synchrony. Sixty-nine studies met the following criteria on PubMed and PsycINFO: 1) peer-reviewed empirical articles in English that 2) examine autonomic, hypothalamic-pituitary-adrenocortical, and/or central nervous system activity 3) for caregivers and children 4) in response to a task and 5) directly examine the association between caregiver and child physiology. Findings varied based on developmental period and current behavioral context. Functional differences may exist across physiological systems and contexts. Synchrony may have different developmental consequences for dyads with and without certain risk factors. Few studies examine physiological synchrony across multiple systems or contexts, nor do they measure child characteristics associated with synchrony. Statistical and methodological challenges impede interpretation. Findings generally support the idea that physiological synchrony may support children's developing self-regulation. Longitudinal research is needed to examine child developmental outcomes over time. En ligne : http://dx.doi.org/10.1017/s0954579420001236 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] A systematic review of caregiver-child physiological synchrony across systems: Associations with behavior and child functioning [Texte imprimé et/ou numérique] / Carrie E. DEPASQUALE, Auteur . - p.1754-1777. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1754-1777 Mots-clés : Autonomic Nervous System  *Caregivers  Child  Humans  *Mother-Child Relations  Parent-Child Relations  Parents  *behavior  *caregiver  *development  *physiology  *synchrony Index. décimale : PER Périodiques Résumé : Extensive research has established a positive association between caregiver-child behavioral synchrony and child developmental functioning. Burgeoning research examining physiological synchrony has yet to elucidate its impact for children's developing self-regulation. The objectives of this systematic review were to: 1) determine whether there is evidence that caregiver-child physiological synchrony promotes positive child development, 2) examine developmental differences in physiological synchrony and its correlates, and 3) explore whether context, risk, and/or stress influence patterns of synchrony. Sixty-nine studies met the following criteria on PubMed and PsycINFO: 1) peer-reviewed empirical articles in English that 2) examine autonomic, hypothalamic-pituitary-adrenocortical, and/or central nervous system activity 3) for caregivers and children 4) in response to a task and 5) directly examine the association between caregiver and child physiology. Findings varied based on developmental period and current behavioral context. Functional differences may exist across physiological systems and contexts. Synchrony may have different developmental consequences for dyads with and without certain risk factors. Few studies examine physiological synchrony across multiple systems or contexts, nor do they measure child characteristics associated with synchrony. Statistical and methodological challenges impede interpretation. Findings generally support the idea that physiological synchrony may support children's developing self-regulation. Longitudinal research is needed to examine child developmental outcomes over time. En ligne : http://dx.doi.org/10.1017/s0954579420001236 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Parental buffering in the context of poverty: positive parenting behaviors differentiate young children's stress reactivity profiles / Samantha M. BROWN in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1778-1787 Titre : Parental buffering in the context of poverty: positive parenting behaviors differentiate young children's stress reactivity profiles Type de document : Texte imprimé et/ou numérique Auteurs : Samantha M. BROWN, Auteur ; Lisa J. SCHLUETER, Auteur ; Eliana HURWICH-REISS, Auteur ; Julia DMITRIEVA, Auteur ; Elly MILES, Auteur ; Sarah E. WATAMURA, Auteur Article en page(s) : p.1778-1787 Langues : Anglais (eng) Mots-clés : Child  Child, Preschool  Humans  Hydrocortisone  *Hypothalamo-Hypophyseal System  *Parenting  Parents  Pituitary-Adrenal System  Poverty  Saliva  Stress, Psychological  *HPA axis  *early childhood  *poverty  *stress Index. décimale : PER Périodiques Résumé : Experiencing poverty increases vulnerability for dysregulated hypothalamic-pituitary-adrenal (HPA) axis functioning and compromises long-term health. Positive parenting buffers children from HPA axis reactivity, yet this has primarily been documented among families not experiencing poverty. We tested the theorized power of positive parenting in 124 parent-child dyads recruited from Early Head Start (Mage = 25.21 months) by examining child cortisol trajectories using five samples collected across a standardized stress paradigm. Piecewise latent growth models revealed that positive parenting buffered children's stress responses when controlling for time of day, last stress task completed, and demographics. Positive parenting also interacted with income such that positive parenting was especially protective for cortisol reactivity in families experiencing greater poverty. Findings suggest that positive parenting behaviors are important for protecting children in families experiencing low income from heightened or prolonged physiologic stress reactivity to an acute stressor. En ligne : http://dx.doi.org/10.1017/s0954579420001224 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Parental buffering in the context of poverty: positive parenting behaviors differentiate young children's stress reactivity profiles [Texte imprimé et/ou numérique] / Samantha M. BROWN, Auteur ; Lisa J. SCHLUETER, Auteur ; Eliana HURWICH-REISS, Auteur ; Julia DMITRIEVA, Auteur ; Elly MILES, Auteur ; Sarah E. WATAMURA, Auteur . - p.1778-1787. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1778-1787 Mots-clés : Child  Child, Preschool  Humans  Hydrocortisone  *Hypothalamo-Hypophyseal System  *Parenting  Parents  Pituitary-Adrenal System  Poverty  Saliva  Stress, Psychological  *HPA axis  *early childhood  *poverty  *stress Index. décimale : PER Périodiques Résumé : Experiencing poverty increases vulnerability for dysregulated hypothalamic-pituitary-adrenal (HPA) axis functioning and compromises long-term health. Positive parenting buffers children from HPA axis reactivity, yet this has primarily been documented among families not experiencing poverty. We tested the theorized power of positive parenting in 124 parent-child dyads recruited from Early Head Start (Mage = 25.21 months) by examining child cortisol trajectories using five samples collected across a standardized stress paradigm. Piecewise latent growth models revealed that positive parenting buffered children's stress responses when controlling for time of day, last stress task completed, and demographics. Positive parenting also interacted with income such that positive parenting was especially protective for cortisol reactivity in families experiencing greater poverty. Findings suggest that positive parenting behaviors are important for protecting children in families experiencing low income from heightened or prolonged physiologic stress reactivity to an acute stressor. En ligne : http://dx.doi.org/10.1017/s0954579420001224 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Early adversity and children's emotion regulation: Differential roles of parent emotion regulation and adversity exposure / Helen M. MILOJEVICH in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1788-1798 Titre : Early adversity and children's emotion regulation: Differential roles of parent emotion regulation and adversity exposure Type de document : Texte imprimé et/ou numérique Auteurs : Helen M. MILOJEVICH, Auteur ; Laura MACHLIN, Auteur ; Margaret A. SHERIDAN, Auteur Article en page(s) : p.1788-1798 Langues : Anglais (eng) Mots-clés : Child  Child, Preschool  *Emotional Regulation  Emotions  Family  Humans  Parents  *Socialization  *dmap  *abuse  *early adversity  *emotion regulation  *neglect Index. décimale : PER Périodiques Résumé : Exposure to early life adversity (ELA) is associated with increased rates of psychopathology and poor physical health. The present study builds on foundational work by Megan Gunnar identifying how ELA results in poor long-term outcomes through alterations in the stress response system, leading to major disruptions in emotional and behavioral regulation. Specifically, the present study tested the direct effects of ELA against the role of parent socialization to shed light on the mechanisms by which ELA leads to emotion regulation deficits. Children ages 4-7 years (N = 64) completed interviews about their experiences of deprivation and threat, a fear conditioning and extinction paradigm, and an IQ test. Parents of the children completed questionnaires regarding their own emotion regulation difficulties and psychopathology, their children's emotion regulation, and child exposure to adversity. At the bivariate level, greater exposure to threat and parental difficulties with emotion regulation were associated with poorer emotion regulation in children, assessed both via parental report and physiologically. In models where parental difficulties with emotion regulation, threat, and deprivation were introduced simultaneously, regression results indicated that parental difficulties with emotion regulation, but not deprivation or threat, continued to predict children's emotion regulation abilities. These results suggest that parental socialization of emotion is a robust predictor of emotion regulation tendencies in children exposed to early adversity. En ligne : http://dx.doi.org/10.1017/s0954579420001273 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Early adversity and children's emotion regulation: Differential roles of parent emotion regulation and adversity exposure [Texte imprimé et/ou numérique] / Helen M. MILOJEVICH, Auteur ; Laura MACHLIN, Auteur ; Margaret A. SHERIDAN, Auteur . - p.1788-1798. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1788-1798 Mots-clés : Child  Child, Preschool  *Emotional Regulation  Emotions  Family  Humans  Parents  *Socialization  *dmap  *abuse  *early adversity  *emotion regulation  *neglect Index. décimale : PER Périodiques Résumé : Exposure to early life adversity (ELA) is associated with increased rates of psychopathology and poor physical health. The present study builds on foundational work by Megan Gunnar identifying how ELA results in poor long-term outcomes through alterations in the stress response system, leading to major disruptions in emotional and behavioral regulation. Specifically, the present study tested the direct effects of ELA against the role of parent socialization to shed light on the mechanisms by which ELA leads to emotion regulation deficits. Children ages 4-7 years (N = 64) completed interviews about their experiences of deprivation and threat, a fear conditioning and extinction paradigm, and an IQ test. Parents of the children completed questionnaires regarding their own emotion regulation difficulties and psychopathology, their children's emotion regulation, and child exposure to adversity. At the bivariate level, greater exposure to threat and parental difficulties with emotion regulation were associated with poorer emotion regulation in children, assessed both via parental report and physiologically. In models where parental difficulties with emotion regulation, threat, and deprivation were introduced simultaneously, regression results indicated that parental difficulties with emotion regulation, but not deprivation or threat, continued to predict children's emotion regulation abilities. These results suggest that parental socialization of emotion is a robust predictor of emotion regulation tendencies in children exposed to early adversity. En ligne : http://dx.doi.org/10.1017/s0954579420001273 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Parenting matters: Parents can reduce or amplify children's anxiety and cortisol responses to acute stress / Anna M. PARENTEAU in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1799-1809 Titre : Parenting matters: Parents can reduce or amplify children's anxiety and cortisol responses to acute stress Type de document : Texte imprimé et/ou numérique Auteurs : Anna M. PARENTEAU, Auteur ; Nicholas V. ALEN, Auteur ; LillyBelle K. DEER, Auteur ; Adam T. NISSEN, Auteur ; Alison T. LUCK, Auteur ; Camelia E. HOSTINAR, Auteur Article en page(s) : p.1799-1809 Langues : Anglais (eng) Mots-clés : Anxiety  Child  Humans  *Hydrocortisone  *Parenting  Parents  Stress, Psychological  *HPA axis  *anxiety  *cortisol reactivity  *social buffering Index. décimale : PER Périodiques Résumé : Parents serve important functions in regulating children's responses to stress and challenge. However, the parental characteristics that modulate the effectiveness of parents as stress buffers remain to be fully characterized. To address this gap, this study examined parental characteristics and behaviors that may explain variation in parents' ability to buffer cortisol responses to acute stress of 180 children (ages 9-11 years old, M = 9.9 years, SD = .58). Children were randomly assigned to either participate in a public speaking task, the Trier Social Stress Test - modified for children (TSST-M) or a control condition. Children in the TSST-M condition were randomly assigned to prepare for the public speaking task either with their parent (N = 59) or alone (N = 60), whereas 61 children were assigned to the control condition (no TSST-M). We found that parental education moderated the effect of condition on children's responses to acute stress. Children whose parents had lower levels of education exhibited reduced cortisol responses in the parent condition compared to the alone condition, showing a buffered pattern of reactivity. In contrast, children of parents with high levels of education displayed higher cortisol reactivity in the parent condition compared to the alone and control conditions. Parental education was also positively associated with higher levels of state anxiety within the parent condition. These results suggest that highly educated parents may emphasize performance over comfort, amplifying their children's state anxiety and cortisol responses to a public performance. En ligne : http://dx.doi.org/10.1017/s0954579420001285 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Parenting matters: Parents can reduce or amplify children's anxiety and cortisol responses to acute stress [Texte imprimé et/ou numérique] / Anna M. PARENTEAU, Auteur ; Nicholas V. ALEN, Auteur ; LillyBelle K. DEER, Auteur ; Adam T. NISSEN, Auteur ; Alison T. LUCK, Auteur ; Camelia E. HOSTINAR, Auteur . - p.1799-1809. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1799-1809 Mots-clés : Anxiety  Child  Humans  *Hydrocortisone  *Parenting  Parents  Stress, Psychological  *HPA axis  *anxiety  *cortisol reactivity  *social buffering Index. décimale : PER Périodiques Résumé : Parents serve important functions in regulating children's responses to stress and challenge. However, the parental characteristics that modulate the effectiveness of parents as stress buffers remain to be fully characterized. To address this gap, this study examined parental characteristics and behaviors that may explain variation in parents' ability to buffer cortisol responses to acute stress of 180 children (ages 9-11 years old, M = 9.9 years, SD = .58). Children were randomly assigned to either participate in a public speaking task, the Trier Social Stress Test - modified for children (TSST-M) or a control condition. Children in the TSST-M condition were randomly assigned to prepare for the public speaking task either with their parent (N = 59) or alone (N = 60), whereas 61 children were assigned to the control condition (no TSST-M). We found that parental education moderated the effect of condition on children's responses to acute stress. Children whose parents had lower levels of education exhibited reduced cortisol responses in the parent condition compared to the alone condition, showing a buffered pattern of reactivity. In contrast, children of parents with high levels of education displayed higher cortisol reactivity in the parent condition compared to the alone and control conditions. Parental education was also positively associated with higher levels of state anxiety within the parent condition. These results suggest that highly educated parents may emphasize performance over comfort, amplifying their children's state anxiety and cortisol responses to a public performance. En ligne : http://dx.doi.org/10.1017/s0954579420001285 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Maternal antenatal depression and child mental health: Moderation by genomic risk for attention-deficit/hyperactivity disorder / Lawrence M. CHEN in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1810-1821 Titre : Maternal antenatal depression and child mental health: Moderation by genomic risk for attention-deficit/hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Lawrence M. CHEN, Auteur ; Marieke S. TOLLENAAR, Auteur ; Shantala A. HARI DASS, Auteur ; Andrée-Anne BOUVETTE-TURCOT, Auteur ; Irina POKHVISNEVA, Auteur ; Helene GAUDREAU, Auteur ; Carine PARENT, Auteur ; Josie DIORIO, Auteur ; Lisa M. MCEWEN, Auteur ; Julia L. MACISAAC, Auteur ; Michael S. KOBOR, Auteur ; Roseriet BEIJERS, Auteur ; Carolina DE WEERTH, Auteur ; Patricia P. SILVEIRA, Auteur ; Sherif KARAMA, Auteur ; Michael J. MEANEY, Auteur ; Kieran J. O'DONNELL, Auteur Article en page(s) : p.1810-1821 Langues : Anglais (eng) Mots-clés : *Attention Deficit Disorder with Hyperactivity/genetics  Child  Depression/genetics  Female  Genomics  Humans  Mental Health  Mothers  Pregnancy  *adhd  *child development  *gene by environment (GxE)  *perinatal mental health  *polygenic risk score Index. décimale : PER Périodiques Résumé : Maternal antenatal depression strongly influences child mental health but with considerable inter-individual variation that is, in part, linked to genotype. The challenge is to effectively capture the genotypic influence. We outline a novel approach to describe genomic susceptibility to maternal antenatal depression focusing on child emotional/behavioral difficulties. Two cohorts provided measures of maternal depression, child genetic variation, and child mental health symptoms. We constructed a conventional polygenic risk score (PRS) for attention-deficit/hyperactivity disorder (ADHD) (PRSADHD) that significantly moderated the association between maternal antenatal depression and internalizing problems at 60 months (p = 2.94 × 10-4, R2 = .18). We then constructed an interaction PRS (xPRS) based on a subset of those single nucleotide polymorphisms from the PRSADHD that most accounted for the moderation of the association between maternal antenatal depression and child outcome. The interaction between maternal antenatal depression and this xPRS accounted for a larger proportion of the variance in child emotional/behavioral problems than models based on any PRSADHD (p = 5.50 × 10-9, R2 = .27), with similar findings in the replication cohort. The xPRS was significantly enriched for genes involved in neuronal development and synaptic function. Our study illustrates a novel approach to the study of genotypic moderation on the impact of maternal antenatal depression on child mental health and highlights the utility of the xPRS approach. These findings advance our understanding of individual differences in the developmental origins of mental health. En ligne : http://dx.doi.org/10.1017/s0954579420001418 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Maternal antenatal depression and child mental health: Moderation by genomic risk for attention-deficit/hyperactivity disorder [Texte imprimé et/ou numérique] / Lawrence M. CHEN, Auteur ; Marieke S. TOLLENAAR, Auteur ; Shantala A. HARI DASS, Auteur ; Andrée-Anne BOUVETTE-TURCOT, Auteur ; Irina POKHVISNEVA, Auteur ; Helene GAUDREAU, Auteur ; Carine PARENT, Auteur ; Josie DIORIO, Auteur ; Lisa M. MCEWEN, Auteur ; Julia L. MACISAAC, Auteur ; Michael S. KOBOR, Auteur ; Roseriet BEIJERS, Auteur ; Carolina DE WEERTH, Auteur ; Patricia P. SILVEIRA, Auteur ; Sherif KARAMA, Auteur ; Michael J. MEANEY, Auteur ; Kieran J. O'DONNELL, Auteur . - p.1810-1821. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1810-1821 Mots-clés : *Attention Deficit Disorder with Hyperactivity/genetics  Child  Depression/genetics  Female  Genomics  Humans  Mental Health  Mothers  Pregnancy  *adhd  *child development  *gene by environment (GxE)  *perinatal mental health  *polygenic risk score Index. décimale : PER Périodiques Résumé : Maternal antenatal depression strongly influences child mental health but with considerable inter-individual variation that is, in part, linked to genotype. The challenge is to effectively capture the genotypic influence. We outline a novel approach to describe genomic susceptibility to maternal antenatal depression focusing on child emotional/behavioral difficulties. Two cohorts provided measures of maternal depression, child genetic variation, and child mental health symptoms. We constructed a conventional polygenic risk score (PRS) for attention-deficit/hyperactivity disorder (ADHD) (PRSADHD) that significantly moderated the association between maternal antenatal depression and internalizing problems at 60 months (p = 2.94 × 10-4, R2 = .18). We then constructed an interaction PRS (xPRS) based on a subset of those single nucleotide polymorphisms from the PRSADHD that most accounted for the moderation of the association between maternal antenatal depression and child outcome. The interaction between maternal antenatal depression and this xPRS accounted for a larger proportion of the variance in child emotional/behavioral problems than models based on any PRSADHD (p = 5.50 × 10-9, R2 = .27), with similar findings in the replication cohort. The xPRS was significantly enriched for genes involved in neuronal development and synaptic function. Our study illustrates a novel approach to the study of genotypic moderation on the impact of maternal antenatal depression on child mental health and highlights the utility of the xPRS approach. These findings advance our understanding of individual differences in the developmental origins of mental health. En ligne : http://dx.doi.org/10.1017/s0954579420001418 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Stigma associated with parental depression or cancer: Impact on spouse and offspring's cortisol levels and socioemotional functioning / Sonia J. LUPIEN in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1822-1837 Titre : Stigma associated with parental depression or cancer: Impact on spouse and offspring's cortisol levels and socioemotional functioning Type de document : Texte imprimé et/ou numérique Auteurs : Sonia J. LUPIEN, Auteur ; Denis-Claude ROY, Auteur ; Catherine RAYMOND, Auteur ; Sarah LECLAIRE, Auteur ; Nathalie WAN, Auteur ; Réal LABELLE, Auteur ; Charles-Édouard GIGUERE, Auteur ; Isabelle OUELLET-MORIN, Auteur Article en page(s) : p.1822-1837 Langues : Anglais (eng) Mots-clés : Bayes Theorem  Caregivers  Child  Depression  *Depressive Disorder, Major  Humans  Hydrocortisone  *Neoplasms  Parents  Spouses  Stress, Psychological  *cancer  *caregiver  *cortisol  *depression  *offspring  *stigma  *stress Index. décimale : PER Périodiques Résumé : Stress associated with caring for a mentally ill spouse can adversely affect the health status of caregivers and their children. Adding to the stress of caregiving is the stigma often placed against spouses and children of people with mental illness. Contrary to mental illness, many physical disorders such as cancer may be less stigmatized (expect pulmonary cancer). In this study, we measured externalized and internalized stigma, as well as psychological (depressive symptoms and stressful life events) and physiological (basal salivary cortisol levels) markers of stress in 115 spouses and 154 children of parents suffering from major depressive disorder, cancer, or no illness (control group). The results show that spouses and children from families with parental depression present significantly more externalized stigma than spouses and children from families with parental cancer or no illness, although we find no group differences on internalized stigma. The analysis did not show a significant group difference either for spouses or their children on depressive symptomatology, although spouses from the parental depression group reported greater work/family stress. Finally, we found that although for both spouses children the awakening cortisol response was greater on weekdays than on weekend days, salivary cortisol levels did not differ between groups. Bayes factor calculated on the null result for cortisol levels was greater than 100, providing strong evidence for the null hypothesis H0. Altogether, these results suggest an impact of stigma toward mental health disorder on psychological markers of stress but no impact of stigma on physiological markers of stress. We suggest that these results may be due to the characteristics of the families who participated in the present study. En ligne : http://dx.doi.org/10.1017/s0954579420001431 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Stigma associated with parental depression or cancer: Impact on spouse and offspring's cortisol levels and socioemotional functioning [Texte imprimé et/ou numérique] / Sonia J. LUPIEN, Auteur ; Denis-Claude ROY, Auteur ; Catherine RAYMOND, Auteur ; Sarah LECLAIRE, Auteur ; Nathalie WAN, Auteur ; Réal LABELLE, Auteur ; Charles-Édouard GIGUERE, Auteur ; Isabelle OUELLET-MORIN, Auteur . - p.1822-1837. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1822-1837 Mots-clés : Bayes Theorem  Caregivers  Child  Depression  *Depressive Disorder, Major  Humans  Hydrocortisone  *Neoplasms  Parents  Spouses  Stress, Psychological  *cancer  *caregiver  *cortisol  *depression  *offspring  *stigma  *stress Index. décimale : PER Périodiques Résumé : Stress associated with caring for a mentally ill spouse can adversely affect the health status of caregivers and their children. Adding to the stress of caregiving is the stigma often placed against spouses and children of people with mental illness. Contrary to mental illness, many physical disorders such as cancer may be less stigmatized (expect pulmonary cancer). In this study, we measured externalized and internalized stigma, as well as psychological (depressive symptoms and stressful life events) and physiological (basal salivary cortisol levels) markers of stress in 115 spouses and 154 children of parents suffering from major depressive disorder, cancer, or no illness (control group). The results show that spouses and children from families with parental depression present significantly more externalized stigma than spouses and children from families with parental cancer or no illness, although we find no group differences on internalized stigma. The analysis did not show a significant group difference either for spouses or their children on depressive symptomatology, although spouses from the parental depression group reported greater work/family stress. Finally, we found that although for both spouses children the awakening cortisol response was greater on weekdays than on weekend days, salivary cortisol levels did not differ between groups. Bayes factor calculated on the null result for cortisol levels was greater than 100, providing strong evidence for the null hypothesis H0. Altogether, these results suggest an impact of stigma toward mental health disorder on psychological markers of stress but no impact of stigma on physiological markers of stress. We suggest that these results may be due to the characteristics of the families who participated in the present study. En ligne : http://dx.doi.org/10.1017/s0954579420001431 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Maltreatment timing, HPA axis functioning, multigenic risk, and depressive symptoms in African American youth: Differential associations without moderated mediation / Adrienne A. VANZOMEREN in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1838-1853 Titre : Maltreatment timing, HPA axis functioning, multigenic risk, and depressive symptoms in African American youth: Differential associations without moderated mediation Type de document : Texte imprimé et/ou numérique Auteurs : Adrienne A. VANZOMEREN, Auteur ; Jingchen ZHANG, Auteur ; Sun-Kyung LEE, Auteur ; Meredith GUNLICKS-STOESSEL, Auteur ; Timothy PIEHLER, Auteur ; Dante CICCHETTI, Auteur Article en page(s) : p.1838-1853 Langues : Anglais (eng) Mots-clés : Adolescent  African Americans  Child  *Depression  Humans  Hydrocortisone  *Hypothalamo-Hypophyseal System  Pituitary-Adrenal System  Saliva  *African American youth  *HPA axis  *maltreatment  *multigenic risk Index. décimale : PER Périodiques Résumé : Utilizing a large (N = 739), ancestrally homogenous sample, the current study aimed to better understand biological risk processes involved in the development of depressive symptoms in maltreated, African American children age 8-12 years. Maltreatment was independently coded from Child Protective Services records and maternal report. Self-reported depressive symptoms were attained in the context of a week-long, summer research camp. DNA was acquired from buccal cell or saliva samples and genotyped for nine polymorphisms in four hypothalamic-pituitary-adrenal (HPA)-axis-related genes: FKBP5, NR3C1, NR3C2, and CRHR1. Salivary cortisol samples were collected each morning (9 a.m.) and late afternoon (4 p.m.) throughout the week to assess HPA functioning. Results revealed that experiences of maltreatment beginning prior to age 5 were most predictive of depressive symptoms, whereas maltreatment onset after age 5 was most predictive of HPA axis dysregulation (blunted daytime cortisol patterns). Multigenic risk did not relate to HPA functioning, nor did it moderate the relationship between maltreatment and HPA activity. There was no mediation of the relationship between maltreatment and depressive symptoms by HPA dysfunction. Results are interpreted through a developmental psychopathology lens, emphasizing the principle of equifinality while carefully appraising racial differences. Implications for future research, particularly the need for longitudinal studies, and important methodological considerations are discussed. En ligne : http://dx.doi.org/10.1017/s0954579420000589 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Maltreatment timing, HPA axis functioning, multigenic risk, and depressive symptoms in African American youth: Differential associations without moderated mediation [Texte imprimé et/ou numérique] / Adrienne A. VANZOMEREN, Auteur ; Jingchen ZHANG, Auteur ; Sun-Kyung LEE, Auteur ; Meredith GUNLICKS-STOESSEL, Auteur ; Timothy PIEHLER, Auteur ; Dante CICCHETTI, Auteur . - p.1838-1853. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1838-1853 Mots-clés : Adolescent  African Americans  Child  *Depression  Humans  Hydrocortisone  *Hypothalamo-Hypophyseal System  Pituitary-Adrenal System  Saliva  *African American youth  *HPA axis  *maltreatment  *multigenic risk Index. décimale : PER Périodiques Résumé : Utilizing a large (N = 739), ancestrally homogenous sample, the current study aimed to better understand biological risk processes involved in the development of depressive symptoms in maltreated, African American children age 8-12 years. Maltreatment was independently coded from Child Protective Services records and maternal report. Self-reported depressive symptoms were attained in the context of a week-long, summer research camp. DNA was acquired from buccal cell or saliva samples and genotyped for nine polymorphisms in four hypothalamic-pituitary-adrenal (HPA)-axis-related genes: FKBP5, NR3C1, NR3C2, and CRHR1. Salivary cortisol samples were collected each morning (9 a.m.) and late afternoon (4 p.m.) throughout the week to assess HPA functioning. Results revealed that experiences of maltreatment beginning prior to age 5 were most predictive of depressive symptoms, whereas maltreatment onset after age 5 was most predictive of HPA axis dysregulation (blunted daytime cortisol patterns). Multigenic risk did not relate to HPA functioning, nor did it moderate the relationship between maltreatment and HPA activity. There was no mediation of the relationship between maltreatment and depressive symptoms by HPA dysfunction. Results are interpreted through a developmental psychopathology lens, emphasizing the principle of equifinality while carefully appraising racial differences. Implications for future research, particularly the need for longitudinal studies, and important methodological considerations are discussed. En ligne : http://dx.doi.org/10.1017/s0954579420000589 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Associations between stress reactivity and behavior problems for previously institutionalized youth across puberty / Nicole B. PERRY in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1854-1863 Titre : Associations between stress reactivity and behavior problems for previously institutionalized youth across puberty Type de document : Texte imprimé et/ou numérique Auteurs : Nicole B. PERRY, Auteur ; Carrie E. DEPASQUALE, Auteur ; Bonny DONZELLA, Auteur ; Megan R. GUNNAR, Auteur Article en page(s) : p.1854-1863 Langues : Anglais (eng) Mots-clés : Adolescent  Humans  Hydrocortisone  Parents  *Problem Behavior  Puberty  Saliva  *Stress, Psychological  *cortisol  *externalizing  *institutions  *internalizing  *puberty  *stress Index. décimale : PER Périodiques Résumé : Megan Gunnar's pubertal stress recalibration hypothesis was supported in a recent study of previously institutionalized (PI) youth such that increases in pubertal stage were associated with increases in cortisol stress reactivity. This work provides evidence that puberty may open up a window of recalibration for PI youth, resulting in a shift from a blunted to a more typical cortisol stress response. Using the same sample (N = 132), the current study aimed to elucidate whether increases in cortisol are associated with increases in adaptive functioning or whether they further underlie potential links to developmental psychopathology. Specifically, we examined the bidirectional associations between cortisol stress reactivity and both internalizing and externalizing symptoms across three timepoints during the pubertal period. Youth reported on their own internalizing symptoms and parents reported on youths' externalizing symptoms. Cortisol reactivity was assessed during the Trier social stress test. Analyses revealed no associations between cortisol reactivity and externalizing symptoms across puberty for PI youth. However, longitudinal bidirectional associations did emerge for internalizing symptoms such that increases in cortisol reactivity predicted increases in internalizing symptoms and increases in internalizing symptoms predicted increases in cortisol reactivity. Findings suggest that recalibrating to more normative levels of cortisol reactivity may not always be associated with adaptive outcomes for PI youth. En ligne : http://dx.doi.org/10.1017/s0954579420001297 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Associations between stress reactivity and behavior problems for previously institutionalized youth across puberty [Texte imprimé et/ou numérique] / Nicole B. PERRY, Auteur ; Carrie E. DEPASQUALE, Auteur ; Bonny DONZELLA, Auteur ; Megan R. GUNNAR, Auteur . - p.1854-1863. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1854-1863 Mots-clés : Adolescent  Humans  Hydrocortisone  Parents  *Problem Behavior  Puberty  Saliva  *Stress, Psychological  *cortisol  *externalizing  *institutions  *internalizing  *puberty  *stress Index. décimale : PER Périodiques Résumé : Megan Gunnar's pubertal stress recalibration hypothesis was supported in a recent study of previously institutionalized (PI) youth such that increases in pubertal stage were associated with increases in cortisol stress reactivity. This work provides evidence that puberty may open up a window of recalibration for PI youth, resulting in a shift from a blunted to a more typical cortisol stress response. Using the same sample (N = 132), the current study aimed to elucidate whether increases in cortisol are associated with increases in adaptive functioning or whether they further underlie potential links to developmental psychopathology. Specifically, we examined the bidirectional associations between cortisol stress reactivity and both internalizing and externalizing symptoms across three timepoints during the pubertal period. Youth reported on their own internalizing symptoms and parents reported on youths' externalizing symptoms. Cortisol reactivity was assessed during the Trier social stress test. Analyses revealed no associations between cortisol reactivity and externalizing symptoms across puberty for PI youth. However, longitudinal bidirectional associations did emerge for internalizing symptoms such that increases in cortisol reactivity predicted increases in internalizing symptoms and increases in internalizing symptoms predicted increases in cortisol reactivity. Findings suggest that recalibrating to more normative levels of cortisol reactivity may not always be associated with adaptive outcomes for PI youth. En ligne : http://dx.doi.org/10.1017/s0954579420001297 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Sensitive periods for psychosocial risk in childhood and adolescence and cardiometabolic outcomes in young adulthood / Jenalee R. DOOM in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1864-1875 Titre : Sensitive periods for psychosocial risk in childhood and adolescence and cardiometabolic outcomes in young adulthood Type de document : Texte imprimé et/ou numérique Auteurs : Jenalee R. DOOM, Auteur ; Kenia M. RIVERA, Auteur ; Estela BLANCO, Auteur ; Raquel BURROWS, Auteur ; Paulina CORREA-BURROWS, Auteur ; Patricia L. EAST, Auteur ; Betsy LOZOFF, Auteur ; Sheila GAHAGAN, Auteur Article en page(s) : p.1864-1875 Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Body Mass Index  *Cardiovascular Diseases  Child  Chile  Female  Humans  Infant  Longitudinal Studies  Male  Risk Factors  Young Adult  *cardiometabolic risk  *infancy  *metabolic syndrome  *psychosocial risk  *young adulthood Index. décimale : PER Périodiques Résumé : Greater psychosocial risk in childhood and adolescence predicts poorer cardiometabolic outcomes in adulthood. We assessed whether the timing of psychosocial risk from infancy through adolescence predicts cardiometabolic outcomes in young adulthood. Young adults and their mothers participated in a longitudinal study beginning in infancy in Santiago, Chile (N = 1040). At infancy, 5 years, 10 years, and adolescence, mothers reported on depressive symptoms, stressful experiences, support for child development in the home, father absence, parental education, and socioeconomic status (SES) to create a psychosocial risk composite at each time point. Young adults (52.1% female; 21-27 years) provided fasting serum samples and participated in anthropometric and blood pressure (BP) assessments, including a dual-energy X-ray absorptiometry (DXA) scan for measuring body fat. Greater infant psychosocial risk was associated with a greater young adult metabolic syndrome score (? = 0.07, 95% confidence intervals (CI): 0.01 to 0.13, p = 0.02), a higher body mass index and waist circumference composite (? = 0.08, 95% CI: 0.03 to 0.13, p = 0.002), and a higher body fat (DXA) composite (? = 0.07, 95% CI: 0.01 to 0.12, p = 0.02). No psychosocial risk measure from any time point was associated with BP. Infant psychosocial risk predicted cardiometabolic outcomes in young adulthood better than psychosocial risk at 5 years, 10 years, or adolescence, mean of psychosocial risk from infancy through adolescence, and maximum of psychosocial risk at any one time. Consistent with the Developmental Origins of Health and Disease model, findings suggest that infancy is a sensitive period for psychosocial risk leading to poorer cardiometabolic outcomes in young adulthood. En ligne : http://dx.doi.org/10.1017/s0954579420001248 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Sensitive periods for psychosocial risk in childhood and adolescence and cardiometabolic outcomes in young adulthood [Texte imprimé et/ou numérique] / Jenalee R. DOOM, Auteur ; Kenia M. RIVERA, Auteur ; Estela BLANCO, Auteur ; Raquel BURROWS, Auteur ; Paulina CORREA-BURROWS, Auteur ; Patricia L. EAST, Auteur ; Betsy LOZOFF, Auteur ; Sheila GAHAGAN, Auteur . - p.1864-1875. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1864-1875 Mots-clés : Adolescent  Adult  Body Mass Index  *Cardiovascular Diseases  Child  Chile  Female  Humans  Infant  Longitudinal Studies  Male  Risk Factors  Young Adult  *cardiometabolic risk  *infancy  *metabolic syndrome  *psychosocial risk  *young adulthood Index. décimale : PER Périodiques Résumé : Greater psychosocial risk in childhood and adolescence predicts poorer cardiometabolic outcomes in adulthood. We assessed whether the timing of psychosocial risk from infancy through adolescence predicts cardiometabolic outcomes in young adulthood. Young adults and their mothers participated in a longitudinal study beginning in infancy in Santiago, Chile (N = 1040). At infancy, 5 years, 10 years, and adolescence, mothers reported on depressive symptoms, stressful experiences, support for child development in the home, father absence, parental education, and socioeconomic status (SES) to create a psychosocial risk composite at each time point. Young adults (52.1% female; 21-27 years) provided fasting serum samples and participated in anthropometric and blood pressure (BP) assessments, including a dual-energy X-ray absorptiometry (DXA) scan for measuring body fat. Greater infant psychosocial risk was associated with a greater young adult metabolic syndrome score (? = 0.07, 95% confidence intervals (CI): 0.01 to 0.13, p = 0.02), a higher body mass index and waist circumference composite (? = 0.08, 95% CI: 0.03 to 0.13, p = 0.002), and a higher body fat (DXA) composite (? = 0.07, 95% CI: 0.01 to 0.12, p = 0.02). No psychosocial risk measure from any time point was associated with BP. Infant psychosocial risk predicted cardiometabolic outcomes in young adulthood better than psychosocial risk at 5 years, 10 years, or adolescence, mean of psychosocial risk from infancy through adolescence, and maximum of psychosocial risk at any one time. Consistent with the Developmental Origins of Health and Disease model, findings suggest that infancy is a sensitive period for psychosocial risk leading to poorer cardiometabolic outcomes in young adulthood. En ligne : http://dx.doi.org/10.1017/s0954579420001248 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Cortisol and socioeconomic status in early childhood: A multidimensional assessment / Amanda R. TARULLO in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1876-1887 Titre : Cortisol and socioeconomic status in early childhood: A multidimensional assessment Type de document : Texte imprimé et/ou numérique Auteurs : Amanda R. TARULLO, Auteur ; Charu T. TULADHAR, Auteur ; Katie KAO, Auteur ; Eleanor B. DRURY, Auteur ; Jerrold MEYER, Auteur Article en page(s) : p.1876-1887 Langues : Anglais (eng) Mots-clés : Child  Child, Preschool  Humans  *Hydrocortisone  Hypothalamo-Hypophyseal System  Infant  Pituitary-Adrenal System  *Saliva  Social Class  Stress, Psychological  *food insecurity  *hair cortisol  *salivary cortisol  *socioeconomic status  *stress Index. décimale : PER Périodiques Résumé : The hypothalamic-pituitary-adrenal (HPA) axis is sensitive to early life stress, with enduring consequences for biological stress vulnerability and health (Gunnar & Talge, 2008). Low socioeconomic status (SES) is associated with dysregulation of the stress hormone cortisol in early childhood. However, a mechanistic understanding of this association is lacking. Multidimensional assessment of both SES and cortisol is needed to characterize the intricate relations between SES and cortisol function in early childhood. We assessed parent-reported family income, parent education, occupational prestige, neighborhood risk, food insecurity, and household chaos for 12-month-old infants (N = 90) and 3.5-year-old children (N = 91). Hair cortisol concentration (HCC) was obtained from parent and child, indexing chronic biological stress, and diurnal salivary cortisol was measured in the children. Controlling for parent HCC, parent education uniquely predicted infant and child HCC and, in addition, neighborhood risk uniquely predicted infant HCC. Household chaos predicted bedtime salivary cortisol concentration (SCC) for both infants and children, and infant daily cortisol output. Food insecurity was associated with flattened cortisol slope in 3.5-year-old children. Parental sensitivity did not mediate relations between SES and cortisol. Results highlight the utility of SES measures that index unpredictable and unsafe contexts, such as neighborhood risk, food insecurity, and household chaos. En ligne : http://dx.doi.org/10.1017/s0954579420001315 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Cortisol and socioeconomic status in early childhood: A multidimensional assessment [Texte imprimé et/ou numérique] / Amanda R. TARULLO, Auteur ; Charu T. TULADHAR, Auteur ; Katie KAO, Auteur ; Eleanor B. DRURY, Auteur ; Jerrold MEYER, Auteur . - p.1876-1887. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1876-1887 Mots-clés : Child  Child, Preschool  Humans  *Hydrocortisone  Hypothalamo-Hypophyseal System  Infant  Pituitary-Adrenal System  *Saliva  Social Class  Stress, Psychological  *food insecurity  *hair cortisol  *salivary cortisol  *socioeconomic status  *stress Index. décimale : PER Périodiques Résumé : The hypothalamic-pituitary-adrenal (HPA) axis is sensitive to early life stress, with enduring consequences for biological stress vulnerability and health (Gunnar & Talge, 2008). Low socioeconomic status (SES) is associated with dysregulation of the stress hormone cortisol in early childhood. However, a mechanistic understanding of this association is lacking. Multidimensional assessment of both SES and cortisol is needed to characterize the intricate relations between SES and cortisol function in early childhood. We assessed parent-reported family income, parent education, occupational prestige, neighborhood risk, food insecurity, and household chaos for 12-month-old infants (N = 90) and 3.5-year-old children (N = 91). Hair cortisol concentration (HCC) was obtained from parent and child, indexing chronic biological stress, and diurnal salivary cortisol was measured in the children. Controlling for parent HCC, parent education uniquely predicted infant and child HCC and, in addition, neighborhood risk uniquely predicted infant HCC. Household chaos predicted bedtime salivary cortisol concentration (SCC) for both infants and children, and infant daily cortisol output. Food insecurity was associated with flattened cortisol slope in 3.5-year-old children. Parental sensitivity did not mediate relations between SES and cortisol. Results highlight the utility of SES measures that index unpredictable and unsafe contexts, such as neighborhood risk, food insecurity, and household chaos. En ligne : http://dx.doi.org/10.1017/s0954579420001315 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Associations between multisystem stress reactivity and peer nominated aggression in early childhood vary by sex / Melissa J. HAGAN in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1888-1898 Titre : Associations between multisystem stress reactivity and peer nominated aggression in early childhood vary by sex Type de document : Texte imprimé et/ou numérique Auteurs : Melissa J. HAGAN, Auteur ; Danielle S. ROUBINOV, Auteur ; W. Thomas BOYCE, Auteur ; Nicole R. BUSH, Auteur Article en page(s) : p.1888-1898 Langues : Anglais (eng) Mots-clés : *Aggression  Child  Child, Preschool  Female  Humans  Hydrocortisone  Hypothalamo-Hypophyseal System  Male  Pituitary-Adrenal System  *Saliva  Stress, Psychological  *cortisol reactivity  *early childhood  *peer-directed aggression  *sympathetic reactivity Index. décimale : PER Périodiques Résumé : There is emerging evidence that the development of problematic aggression in childhood may be associated with specific physiological stress response patterns, with both biological overactivation and underactivation implicated. This study tested associations between sex-specific patterns of stress responses across the sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenal (HPA) axis and peer nominations of aggression among 271 kindergarten children (Mean age = 5.32 years; 52% Female; 44% White). Upon entry to kindergarten, children participated in a multidomain standardized stress paradigm. Changes in pre-ejection period (PEP) and salivary cortisol were assessed. On a separate day, children provided peer ratings of physical and relational aggression in a standardized interview. As expected, there was a significant three-way interaction between PEP, cortisol reactivity, and sex, but only for physical aggression. Among boys, cortisol reactivity was positively associated with physical aggression only for those with higher SNS reactivity. Findings suggest that for boys, asymmetrical and symmetrical HPA/SNS reactivity may be associated with lower and higher risk for peer-directed physical aggression, respectively. Understanding the complex associations between multisystem physiology, child sex and peer-directed aggression in early childhood may offer insight into individual differences underlying the emergence of behavioral dysregulation in early peer contexts. En ligne : http://dx.doi.org/10.1017/s0954579420001406 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Associations between multisystem stress reactivity and peer nominated aggression in early childhood vary by sex [Texte imprimé et/ou numérique] / Melissa J. HAGAN, Auteur ; Danielle S. ROUBINOV, Auteur ; W. Thomas BOYCE, Auteur ; Nicole R. BUSH, Auteur . - p.1888-1898. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1888-1898 Mots-clés : *Aggression  Child  Child, Preschool  Female  Humans  Hydrocortisone  Hypothalamo-Hypophyseal System  Male  Pituitary-Adrenal System  *Saliva  Stress, Psychological  *cortisol reactivity  *early childhood  *peer-directed aggression  *sympathetic reactivity Index. décimale : PER Périodiques Résumé : There is emerging evidence that the development of problematic aggression in childhood may be associated with specific physiological stress response patterns, with both biological overactivation and underactivation implicated. This study tested associations between sex-specific patterns of stress responses across the sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenal (HPA) axis and peer nominations of aggression among 271 kindergarten children (Mean age = 5.32 years; 52% Female; 44% White). Upon entry to kindergarten, children participated in a multidomain standardized stress paradigm. Changes in pre-ejection period (PEP) and salivary cortisol were assessed. On a separate day, children provided peer ratings of physical and relational aggression in a standardized interview. As expected, there was a significant three-way interaction between PEP, cortisol reactivity, and sex, but only for physical aggression. Among boys, cortisol reactivity was positively associated with physical aggression only for those with higher SNS reactivity. Findings suggest that for boys, asymmetrical and symmetrical HPA/SNS reactivity may be associated with lower and higher risk for peer-directed physical aggression, respectively. Understanding the complex associations between multisystem physiology, child sex and peer-directed aggression in early childhood may offer insight into individual differences underlying the emergence of behavioral dysregulation in early peer contexts. En ligne : http://dx.doi.org/10.1017/s0954579420001406 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Addressing educational inequalities and promoting learning through studies of stress physiology in elementary school students / Jelena OBRADOVIC in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1899-1913 Titre : Addressing educational inequalities and promoting learning through studies of stress physiology in elementary school students Type de document : Texte imprimé et/ou numérique Auteurs : Jelena OBRADOVIC, Auteur ; Emma ARMSTRONG-CARTER, Auteur Article en page(s) : p.1899-1913 Langues : Anglais (eng) Mots-clés : Achievement  Child  Educational Status  Humans  *Learning  Schools  *Students  *classroom context  *elementary school students  *inequality  *stress physiology Index. décimale : PER Périodiques Résumé : To be ready to learn, children need to be focused, engaged, and able to bounce back from setbacks. However, many children come to school with heightened or diminished physiological arousal due to exposure to poverty-related risks. While stress physiology plays a role in explaining how adversity relates to processes that support students' cognitive development, there is a lack of studies of physiological stress response in educational settings. This review integrates relevant studies and offers future directions for research on the role of stress physiology in the school adaptation of elementary school students, focusing on these important questions: (a) What are the links between physiological stress response and learning-related skills and behaviors, and do they vary as a function of proximal and distal experiences outside of school? (b) How are school experiences associated with students' physiological stress response and related cognitive and behavioral adaptations? (c) How can we leverage measures of students' physiological stress response in evaluations of school-based interventions to better support the school success of every student? We hope to stimulate a new wave of research that will advance the science of developmental stress physiology, as well as improve the application of these findings in educational policy and practice. En ligne : http://dx.doi.org/10.1017/s0954579420001443 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Addressing educational inequalities and promoting learning through studies of stress physiology in elementary school students [Texte imprimé et/ou numérique] / Jelena OBRADOVIC, Auteur ; Emma ARMSTRONG-CARTER, Auteur . - p.1899-1913. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1899-1913 Mots-clés : Achievement  Child  Educational Status  Humans  *Learning  Schools  *Students  *classroom context  *elementary school students  *inequality  *stress physiology Index. décimale : PER Périodiques Résumé : To be ready to learn, children need to be focused, engaged, and able to bounce back from setbacks. However, many children come to school with heightened or diminished physiological arousal due to exposure to poverty-related risks. While stress physiology plays a role in explaining how adversity relates to processes that support students' cognitive development, there is a lack of studies of physiological stress response in educational settings. This review integrates relevant studies and offers future directions for research on the role of stress physiology in the school adaptation of elementary school students, focusing on these important questions: (a) What are the links between physiological stress response and learning-related skills and behaviors, and do they vary as a function of proximal and distal experiences outside of school? (b) How are school experiences associated with students' physiological stress response and related cognitive and behavioral adaptations? (c) How can we leverage measures of students' physiological stress response in evaluations of school-based interventions to better support the school success of every student? We hope to stimulate a new wave of research that will advance the science of developmental stress physiology, as well as improve the application of these findings in educational policy and practice. En ligne : http://dx.doi.org/10.1017/s0954579420001443 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Sympathetic nervous system dominance during stress recovery mediates associations between stress sensitivity and social anxiety symptoms in female adolescents / Tiffany C. HO in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1914-1925 Titre : Sympathetic nervous system dominance during stress recovery mediates associations between stress sensitivity and social anxiety symptoms in female adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Tiffany C. HO, Auteur ; Holly T. PHAM, Auteur ; Jonas G. MILLER, Auteur ; Katharina KIRCANSKI, Auteur ; Ian H. GOTLIB, Auteur Article en page(s) : p.1914-1925 Langues : Anglais (eng) Mots-clés : Adolescent  Anxiety  Autonomic Nervous System  Female  Heart Rate  Humans  Male  *Respiratory Sinus Arrhythmia  Stress, Psychological  Sympathetic Nervous System  *adolescence  *skin conductance level stress  *social anxiety disorder Index. décimale : PER Périodiques Résumé : Social anxiety disorder (SAD) is commonly diagnosed during adolescence and is associated with psychological stress reactivity and heightened physiological arousal. No study, however, has systematically examined which aspects of autonomic nervous system function mediate likely links between stress sensitivity and social anxiety symptoms in adolescents. Here, we assessed 163 adolescents (90 females; 12.29 ± 1.39 years) with respect to life stress and social anxiety symptoms, and measured respiratory sinus arrhythmia (RSA) and skin conductance levels (SCL) during a psychosocial stress paradigm. We operationalized stress sensitivity as the residual variance in subjective stress severity after accounting for objective severity and changes in autonomic regulation using standardized change scores in RSA and SCL. In females only, stress sensitivity and social anxiety symptoms were significantly correlated with each other (p < .001) and with autonomic regulation during both reactivity and recovery (all ps < 0.04). Further, sympathetic nervous system dominance during recovery specifically mediated associations between stress sensitivity and social anxiety symptoms (B = 1.06, 95% CI: 0.02-2.64). In contrast, in males, stress sensitivity, autonomic regulation during reactivity or recovery, and social anxiety symptoms were not significantly associated (all ps > 0.1). We interpret these results in the context of psychobiological models of SAD and discuss implications for interventions targeting autonomic processes. En ligne : http://dx.doi.org/10.1017/s0954579420001261 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Sympathetic nervous system dominance during stress recovery mediates associations between stress sensitivity and social anxiety symptoms in female adolescents [Texte imprimé et/ou numérique] / Tiffany C. HO, Auteur ; Holly T. PHAM, Auteur ; Jonas G. MILLER, Auteur ; Katharina KIRCANSKI, Auteur ; Ian H. GOTLIB, Auteur . - p.1914-1925. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1914-1925 Mots-clés : Adolescent  Anxiety  Autonomic Nervous System  Female  Heart Rate  Humans  Male  *Respiratory Sinus Arrhythmia  Stress, Psychological  Sympathetic Nervous System  *adolescence  *skin conductance level stress  *social anxiety disorder Index. décimale : PER Périodiques Résumé : Social anxiety disorder (SAD) is commonly diagnosed during adolescence and is associated with psychological stress reactivity and heightened physiological arousal. No study, however, has systematically examined which aspects of autonomic nervous system function mediate likely links between stress sensitivity and social anxiety symptoms in adolescents. Here, we assessed 163 adolescents (90 females; 12.29 ± 1.39 years) with respect to life stress and social anxiety symptoms, and measured respiratory sinus arrhythmia (RSA) and skin conductance levels (SCL) during a psychosocial stress paradigm. We operationalized stress sensitivity as the residual variance in subjective stress severity after accounting for objective severity and changes in autonomic regulation using standardized change scores in RSA and SCL. In females only, stress sensitivity and social anxiety symptoms were significantly correlated with each other (p < .001) and with autonomic regulation during both reactivity and recovery (all ps < 0.04). Further, sympathetic nervous system dominance during recovery specifically mediated associations between stress sensitivity and social anxiety symptoms (B = 1.06, 95% CI: 0.02-2.64). In contrast, in males, stress sensitivity, autonomic regulation during reactivity or recovery, and social anxiety symptoms were not significantly associated (all ps > 0.1). We interpret these results in the context of psychobiological models of SAD and discuss implications for interventions targeting autonomic processes. En ligne : http://dx.doi.org/10.1017/s0954579420001261 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Differential brain activity as a function of social evaluative stress in early adolescence: Brain function and salivary cortisol / Max P. HERZBERG in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1926-1936 Titre : Differential brain activity as a function of social evaluative stress in early adolescence: Brain function and salivary cortisol Type de document : Texte imprimé et/ou numérique Auteurs : Max P. HERZBERG, Auteur ; Ruskin H. HUNT, Auteur ; Kathleen M. THOMAS, Auteur ; Megan R. GUNNAR, Auteur Article en page(s) : p.1926-1936 Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Brain/diagnostic imaging  Child  Humans  *Hydrocortisone  Magnetic Resonance Imaging  Minnesota  *Saliva  Stress, Psychological/diagnostic imaging  *adolescence  *brain function  *cortisol  *socially evaluative stress Index. décimale : PER Périodiques Résumé : Understanding individual differences in neural responses to stressful environments is an important avenue of research throughout development. These differences may be especially critical during adolescence, which is characterized by opportunities for healthy development and increased susceptibility to the development of psychopathology. While the neural correlates of the psychosocial stress response have been investigated in adults, these links have not been explored during development. Using a new task, the Minnesota Imaging Stress Test in Children (MISTiC), differences in activation are found in fusiform gyrus, superior frontal gyrus, insula, and anterior cingulate cortex when comparing a stressful math task to a nonstressful math task. The MISTiC task successfully elicits cortisol responses in a similar proportion of adolescents as in behavioral studies while collecting brain imaging data. Cortisol responders and nonresponders did not differ in their perceived stress level or behavioral performance during the task despite differences in neuroendocrine function. Future research will be able to leverage the MISTiC task for many purposes, including probing associations between individual differences in stress responses with environmental conditions, personality differences, and the development of psychopathology. En ligne : http://dx.doi.org/10.1017/s095457942000125x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Differential brain activity as a function of social evaluative stress in early adolescence: Brain function and salivary cortisol [Texte imprimé et/ou numérique] / Max P. HERZBERG, Auteur ; Ruskin H. HUNT, Auteur ; Kathleen M. THOMAS, Auteur ; Megan R. GUNNAR, Auteur . - p.1926-1936. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1926-1936 Mots-clés : Adolescent  Adult  Brain/diagnostic imaging  Child  Humans  *Hydrocortisone  Magnetic Resonance Imaging  Minnesota  *Saliva  Stress, Psychological/diagnostic imaging  *adolescence  *brain function  *cortisol  *socially evaluative stress Index. décimale : PER Périodiques Résumé : Understanding individual differences in neural responses to stressful environments is an important avenue of research throughout development. These differences may be especially critical during adolescence, which is characterized by opportunities for healthy development and increased susceptibility to the development of psychopathology. While the neural correlates of the psychosocial stress response have been investigated in adults, these links have not been explored during development. Using a new task, the Minnesota Imaging Stress Test in Children (MISTiC), differences in activation are found in fusiform gyrus, superior frontal gyrus, insula, and anterior cingulate cortex when comparing a stressful math task to a nonstressful math task. The MISTiC task successfully elicits cortisol responses in a similar proportion of adolescents as in behavioral studies while collecting brain imaging data. Cortisol responders and nonresponders did not differ in their perceived stress level or behavioral performance during the task despite differences in neuroendocrine function. Future research will be able to leverage the MISTiC task for many purposes, including probing associations between individual differences in stress responses with environmental conditions, personality differences, and the development of psychopathology. En ligne : http://dx.doi.org/10.1017/s095457942000125x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Characterizing competence among a high-risk sample of emerging adults: Prospective predictions and biological considerations / Justin RUSSOTTI in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1937-1953 Titre : Characterizing competence among a high-risk sample of emerging adults: Prospective predictions and biological considerations Type de document : Texte imprimé et/ou numérique Auteurs : Justin RUSSOTTI, Auteur ; Jennifer M. WARMINGHAM, Auteur ; Elizabeth D. HANDLEY, Auteur ; Fred A. ROGOSCH, Auteur ; Dante CICCHETTI, Auteur Article en page(s) : p.1937-1953 Langues : Anglais (eng) Mots-clés : Adult  African Americans  C-Reactive Protein  Child  *Child Abuse  Humans  Male  Poverty  Prospective Studies  *crp  *adversity  *child maltreatment  *developmental competence  *stress Index. décimale : PER Périodiques Résumé : Few conditions epitomize severe and chronic stress to a greater extent than child maltreatment, which can derail development across multiple domains of functioning and throughout the life course. Furthermore, child maltreatment tends to co-occur with other adversities, such as poverty. Many individuals grow up under the stressful conditions of these adversities and exhibit developmental competence. The current study prospectively charted the developmental progression of economically disadvantaged maltreated and nonmaltreated children from childhood to emerging adulthood, and examined patterns of competence across multiple developmental domains of functioning central to the period of emerging adulthood. The study investigated childhood precursors to these patterns of adaptation and maladaptation, as well as the physiological cost of these patterns of adaptation (i.e., C-reactive protein; CRP). Latent class analysis revealed four distinct classes of functioning: multifaceted competence across domains (Multifaceted Competence); (multifaceted maladaptation across domains (Multi-Problem); (c) and two classes with mixed patterns of competence and maladaptation (Externalizing Problems and Work/School Impairment). Maltreated individuals were less likely than nonmaltreated individuals to demonstrate patterns of multifaceted competence and more likely to demonstrate aggregate maladaptation across domains. Additionally, Black men who demonstrated a pattern of multifaceted psychosocial competence also evidenced higher levels of low-grade inflammation (indexed by CRP), suggesting physiological distress was associated with adaptation in the context of stress among these individuals. Findings demonstrate the heterogenous patterns of functioning and diverse developmental outcomes that follow early adversity. En ligne : http://dx.doi.org/10.1017/s0954579420001467 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Characterizing competence among a high-risk sample of emerging adults: Prospective predictions and biological considerations [Texte imprimé et/ou numérique] / Justin RUSSOTTI, Auteur ; Jennifer M. WARMINGHAM, Auteur ; Elizabeth D. HANDLEY, Auteur ; Fred A. ROGOSCH, Auteur ; Dante CICCHETTI, Auteur . - p.1937-1953. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1937-1953 Mots-clés : Adult  African Americans  C-Reactive Protein  Child  *Child Abuse  Humans  Male  Poverty  Prospective Studies  *crp  *adversity  *child maltreatment  *developmental competence  *stress Index. décimale : PER Périodiques Résumé : Few conditions epitomize severe and chronic stress to a greater extent than child maltreatment, which can derail development across multiple domains of functioning and throughout the life course. Furthermore, child maltreatment tends to co-occur with other adversities, such as poverty. Many individuals grow up under the stressful conditions of these adversities and exhibit developmental competence. The current study prospectively charted the developmental progression of economically disadvantaged maltreated and nonmaltreated children from childhood to emerging adulthood, and examined patterns of competence across multiple developmental domains of functioning central to the period of emerging adulthood. The study investigated childhood precursors to these patterns of adaptation and maladaptation, as well as the physiological cost of these patterns of adaptation (i.e., C-reactive protein; CRP). Latent class analysis revealed four distinct classes of functioning: multifaceted competence across domains (Multifaceted Competence); (multifaceted maladaptation across domains (Multi-Problem); (c) and two classes with mixed patterns of competence and maladaptation (Externalizing Problems and Work/School Impairment). Maltreated individuals were less likely than nonmaltreated individuals to demonstrate patterns of multifaceted competence and more likely to demonstrate aggregate maladaptation across domains. Additionally, Black men who demonstrated a pattern of multifaceted psychosocial competence also evidenced higher levels of low-grade inflammation (indexed by CRP), suggesting physiological distress was associated with adaptation in the context of stress among these individuals. Findings demonstrate the heterogenous patterns of functioning and diverse developmental outcomes that follow early adversity. En ligne : http://dx.doi.org/10.1017/s0954579420001467 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437