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Factors associated with enrollment into a clinical trial of caregiver-implemented intervention for infants at risk for autism spectrum disorder / Jessica BRADSHAW in Autism, 24-7 (October 2020)
[article]
Titre : Factors associated with enrollment into a clinical trial of caregiver-implemented intervention for infants at risk for autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Jessica BRADSHAW, Auteur ; Ashley TRUMBULL, Auteur ; Jennifer STAPEL-WAX, Auteur ; Scott GILLESPIE, Auteur ; Nisha GEORGE, Auteur ; Celine A. SAULNIER, Auteur ; Cheryl KLAIMAN, Auteur ; Juliann WOODS, Auteur ; Nathan A. CALL, Auteur ; Ami KLIN, Auteur ; Amy M. WETHERBY, Auteur Article en page(s) : p.1874-1884 Langues : Anglais (eng) Mots-clés : *autism spectrum disorders *clinical trial *communication and language *infant *interventions—psychosocial/behavioral Index. décimale : PER Périodiques Résumé : Early intervention helps to address developmental delays in young children with autism spectrum disorder. Yet, research suggests there are barriers to enrollment into research studies that test the effectiveness of these interventions for infants at risk. This study identifies family characteristics that were associated with agreement to enroll in a clinical trial of early intervention for 12-month-old infants at risk for autism spectrum disorder. As part of a large longitudinal study, infants were evaluated for early signs of autism spectrum disorder at 1?year of age. Of the fifty-seven infants who were showing signs of autism and deemed eligible for the early intervention trial, 44% declined enrollment. Results suggest that families were more likely to decline enrolling into the intervention study if the mother was working full time, the total household income was between US$60,000 and US$100,000, and they lived further from the clinic. In contrast, infant autism symptoms and parental concern at 12?months were not significantly associated with enrollment. These findings highlight the need for intervention studies that are more accessible to parents, for example, intervention that takes place in the home, in addition to more research on how parental understanding of, and willingness to act on, early social-communication delays impact intervention study enrollment. Future research can then examine how to address these barriers to enrollment in early intervention studies. Such findings will shed light on best practices for dissemination of early identification and intervention strategies. En ligne : http://dx.doi.org/10.1177/1362361320928829 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431
in Autism > 24-7 (October 2020) . - p.1874-1884[article] Factors associated with enrollment into a clinical trial of caregiver-implemented intervention for infants at risk for autism spectrum disorder [Texte imprimé et/ou numérique] / Jessica BRADSHAW, Auteur ; Ashley TRUMBULL, Auteur ; Jennifer STAPEL-WAX, Auteur ; Scott GILLESPIE, Auteur ; Nisha GEORGE, Auteur ; Celine A. SAULNIER, Auteur ; Cheryl KLAIMAN, Auteur ; Juliann WOODS, Auteur ; Nathan A. CALL, Auteur ; Ami KLIN, Auteur ; Amy M. WETHERBY, Auteur . - p.1874-1884.
Langues : Anglais (eng)
in Autism > 24-7 (October 2020) . - p.1874-1884
Mots-clés : *autism spectrum disorders *clinical trial *communication and language *infant *interventions—psychosocial/behavioral Index. décimale : PER Périodiques Résumé : Early intervention helps to address developmental delays in young children with autism spectrum disorder. Yet, research suggests there are barriers to enrollment into research studies that test the effectiveness of these interventions for infants at risk. This study identifies family characteristics that were associated with agreement to enroll in a clinical trial of early intervention for 12-month-old infants at risk for autism spectrum disorder. As part of a large longitudinal study, infants were evaluated for early signs of autism spectrum disorder at 1?year of age. Of the fifty-seven infants who were showing signs of autism and deemed eligible for the early intervention trial, 44% declined enrollment. Results suggest that families were more likely to decline enrolling into the intervention study if the mother was working full time, the total household income was between US$60,000 and US$100,000, and they lived further from the clinic. In contrast, infant autism symptoms and parental concern at 12?months were not significantly associated with enrollment. These findings highlight the need for intervention studies that are more accessible to parents, for example, intervention that takes place in the home, in addition to more research on how parental understanding of, and willingness to act on, early social-communication delays impact intervention study enrollment. Future research can then examine how to address these barriers to enrollment in early intervention studies. Such findings will shed light on best practices for dissemination of early identification and intervention strategies. En ligne : http://dx.doi.org/10.1177/1362361320928829 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431 Neural circuitry at age 6 months associated with later repetitive behavior and sensory responsiveness in autism / J. J. WOLFF in Molecular Autism, 8 (2017)
[article]
Titre : Neural circuitry at age 6 months associated with later repetitive behavior and sensory responsiveness in autism Type de document : Texte imprimé et/ou numérique Auteurs : J. J. WOLFF, Auteur ; M. R. SWANSON, Auteur ; J. T. ELISON, Auteur ; G. GERIG, Auteur ; J. R. PRUETT, Auteur ; M. A. STYNER, Auteur ; C. VACHET, Auteur ; Kelly N. BOTTERON, Auteur ; Stephen R. DAGER, Auteur ; A. M. ESTES, Auteur ; Heather C. HAZLETT, Auteur ; Robert T. SCHULTZ, Auteur ; M. D. SHEN, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; J. PIVEN, Auteur Article en page(s) : 8p. Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnostic imaging/*psychology Brain/diagnostic imaging/*physiology Brain Mapping/*methods Child, Preschool Diffusion Tensor Imaging/*methods Female Humans Infant Longitudinal Studies Male Stereotyped Behavior/*physiology *Autism *Diffusion tensor imaging *Infant *Longitudinal *Repetitive behavior *White matter Index. décimale : PER Périodiques Résumé : BACKGROUND: Restricted and repetitive behaviors are defining features of autism spectrum disorder (ASD). Under revised diagnostic criteria for ASD, this behavioral domain now includes atypical responses to sensory stimuli. To date, little is known about the neural circuitry underlying these features of ASD early in life. METHODS: Longitudinal diffusion tensor imaging data were collected from 217 infants at high familial risk for ASD. Forty-four of these infants were diagnosed with ASD at age 2. Targeted cortical, cerebellar, and striatal white matter pathways were defined and measured at ages 6, 12, and 24 months. Dependent variables included the Repetitive Behavior Scale-Revised and the Sensory Experiences Questionnaire. RESULTS: Among children diagnosed with ASD, repetitive behaviors and sensory response patterns were strongly correlated, even when accounting for developmental level or social impairment. Longitudinal analyses indicated that the genu and cerebellar pathways were significantly associated with both repetitive behaviors and sensory responsiveness but not social deficits. At age 6 months, fractional anisotropy in the genu significantly predicted repetitive behaviors and sensory responsiveness at age 2. Cerebellar pathways significantly predicted later sensory responsiveness. Exploratory analyses suggested a possible disordinal interaction based on diagnostic status for the association between fractional anisotropy and repetitive behavior. CONCLUSIONS: Our findings suggest that restricted and repetitive behaviors contributing to a diagnosis of ASD at age 2 years are associated with structural properties of callosal and cerebellar white matter pathways measured during infancy and toddlerhood. We further identified that repetitive behaviors and unusual sensory response patterns co-occur and share common brain-behavior relationships. These results were strikingly specific given the absence of association between targeted pathways and social deficits. En ligne : http://dx.doi.org/10.1186/s13229-017-0126-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331
in Molecular Autism > 8 (2017) . - 8p.[article] Neural circuitry at age 6 months associated with later repetitive behavior and sensory responsiveness in autism [Texte imprimé et/ou numérique] / J. J. WOLFF, Auteur ; M. R. SWANSON, Auteur ; J. T. ELISON, Auteur ; G. GERIG, Auteur ; J. R. PRUETT, Auteur ; M. A. STYNER, Auteur ; C. VACHET, Auteur ; Kelly N. BOTTERON, Auteur ; Stephen R. DAGER, Auteur ; A. M. ESTES, Auteur ; Heather C. HAZLETT, Auteur ; Robert T. SCHULTZ, Auteur ; M. D. SHEN, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; J. PIVEN, Auteur . - 8p.
Langues : Anglais (eng)
in Molecular Autism > 8 (2017) . - 8p.
Mots-clés : Autism Spectrum Disorder/diagnostic imaging/*psychology Brain/diagnostic imaging/*physiology Brain Mapping/*methods Child, Preschool Diffusion Tensor Imaging/*methods Female Humans Infant Longitudinal Studies Male Stereotyped Behavior/*physiology *Autism *Diffusion tensor imaging *Infant *Longitudinal *Repetitive behavior *White matter Index. décimale : PER Périodiques Résumé : BACKGROUND: Restricted and repetitive behaviors are defining features of autism spectrum disorder (ASD). Under revised diagnostic criteria for ASD, this behavioral domain now includes atypical responses to sensory stimuli. To date, little is known about the neural circuitry underlying these features of ASD early in life. METHODS: Longitudinal diffusion tensor imaging data were collected from 217 infants at high familial risk for ASD. Forty-four of these infants were diagnosed with ASD at age 2. Targeted cortical, cerebellar, and striatal white matter pathways were defined and measured at ages 6, 12, and 24 months. Dependent variables included the Repetitive Behavior Scale-Revised and the Sensory Experiences Questionnaire. RESULTS: Among children diagnosed with ASD, repetitive behaviors and sensory response patterns were strongly correlated, even when accounting for developmental level or social impairment. Longitudinal analyses indicated that the genu and cerebellar pathways were significantly associated with both repetitive behaviors and sensory responsiveness but not social deficits. At age 6 months, fractional anisotropy in the genu significantly predicted repetitive behaviors and sensory responsiveness at age 2. Cerebellar pathways significantly predicted later sensory responsiveness. Exploratory analyses suggested a possible disordinal interaction based on diagnostic status for the association between fractional anisotropy and repetitive behavior. CONCLUSIONS: Our findings suggest that restricted and repetitive behaviors contributing to a diagnosis of ASD at age 2 years are associated with structural properties of callosal and cerebellar white matter pathways measured during infancy and toddlerhood. We further identified that repetitive behaviors and unusual sensory response patterns co-occur and share common brain-behavior relationships. These results were strikingly specific given the absence of association between targeted pathways and social deficits. En ligne : http://dx.doi.org/10.1186/s13229-017-0126-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331