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Prenatal exposure to air pollution is associated with altered brain structure, function, and metabolism in childhood / Bradley S. PETERSON in Journal of Child Psychology and Psychiatry, 63-11 (November 2022)
[article]
Titre : Prenatal exposure to air pollution is associated with altered brain structure, function, and metabolism in childhood Type de document : Texte imprimé et/ou numérique Auteurs : Bradley S. PETERSON, Auteur ; Ravi BANSAL, Auteur ; Siddhant SAWARDEKAR, Auteur ; Carlo NATI, Auteur ; Eman R. ELGABALAWY, Auteur ; Lori A. HOEPNER, Auteur ; Wanda GARCIA, Auteur ; Xuejun HAO, Auteur ; Amy MARGOLIS, Auteur ; Frederica PERERA, Auteur ; Virginia RAUH, Auteur Article en page(s) : p.1316-1331 Langues : Anglais (eng) Mots-clés : Male Adolescent Pregnancy Female Humans Child Prenatal Exposure Delayed Effects/metabolism Prospective Studies Air Pollution/adverse effects Brain Particulate Matter/adverse effects/analysis/metabolism Polycyclic Aromatic Hydrocarbons Air Pollutants Air pollution arterial spin labeling diffusion tensor imaging magnetic resonance imaging magnetic resonance spectroscopy particulate matter polycyclic aromatic hydrocarbons Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal exposure to air pollution disrupts cognitive, emotional, and behavioral development. The brain disturbances associated with prenatal air pollution are largely unknown. METHODS: In this prospective cohort study, we estimated prenatal exposures to fine particulate matter (PM(2.5) ) and polycyclic aromatic hydrocarbons (PAH), and then assessed their associations with measures of brain anatomy, tissue microstructure, neurometabolites, and blood flow in 332 youth, 6-14 years old. We then assessed how those brain disturbances were associated with measures of intelligence, ADHD and anxiety symptoms, and socialization. RESULTS: Both exposures were associated with thinning of dorsal parietal cortices and thickening of postero-inferior and mesial wall cortices. They were associated with smaller white matter volumes, reduced organization in white matter of the internal capsule and frontal lobe, higher metabolite concentrations in frontal cortex, reduced cortical blood flow, and greater microstructural organization in subcortical gray matter nuclei. Associations were stronger for PM(2.5) in boys and PAH in girls. Youth with low exposure accounted for most significant associations of ADHD, anxiety, socialization, and intelligence measures with cortical thickness and white matter volumes, whereas it appears that high exposures generally disrupted these neurotypical brain-behavior associations, likely because strong exposure-related effects increased the variances of these brain measures. CONCLUSIONS: The commonality of effects across exposures suggests PM(2.5) and PAH disrupt brain development through one or more common molecular pathways, such as inflammation or oxidative stress. Progressively higher exposures were associated with greater disruptions in local volumes, tissue organization, metabolite concentrations, and blood flow throughout cortical and subcortical brain regions and the white matter pathways interconnecting them. Together these affected regions comprise cortico-striato-thalamo-cortical circuits, which support the regulation of thought, emotion, and behavior. En ligne : http://dx.doi.org/10.1111/jcpp.13578 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490
in Journal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1316-1331[article] Prenatal exposure to air pollution is associated with altered brain structure, function, and metabolism in childhood [Texte imprimé et/ou numérique] / Bradley S. PETERSON, Auteur ; Ravi BANSAL, Auteur ; Siddhant SAWARDEKAR, Auteur ; Carlo NATI, Auteur ; Eman R. ELGABALAWY, Auteur ; Lori A. HOEPNER, Auteur ; Wanda GARCIA, Auteur ; Xuejun HAO, Auteur ; Amy MARGOLIS, Auteur ; Frederica PERERA, Auteur ; Virginia RAUH, Auteur . - p.1316-1331.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1316-1331
Mots-clés : Male Adolescent Pregnancy Female Humans Child Prenatal Exposure Delayed Effects/metabolism Prospective Studies Air Pollution/adverse effects Brain Particulate Matter/adverse effects/analysis/metabolism Polycyclic Aromatic Hydrocarbons Air Pollutants Air pollution arterial spin labeling diffusion tensor imaging magnetic resonance imaging magnetic resonance spectroscopy particulate matter polycyclic aromatic hydrocarbons Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal exposure to air pollution disrupts cognitive, emotional, and behavioral development. The brain disturbances associated with prenatal air pollution are largely unknown. METHODS: In this prospective cohort study, we estimated prenatal exposures to fine particulate matter (PM(2.5) ) and polycyclic aromatic hydrocarbons (PAH), and then assessed their associations with measures of brain anatomy, tissue microstructure, neurometabolites, and blood flow in 332 youth, 6-14 years old. We then assessed how those brain disturbances were associated with measures of intelligence, ADHD and anxiety symptoms, and socialization. RESULTS: Both exposures were associated with thinning of dorsal parietal cortices and thickening of postero-inferior and mesial wall cortices. They were associated with smaller white matter volumes, reduced organization in white matter of the internal capsule and frontal lobe, higher metabolite concentrations in frontal cortex, reduced cortical blood flow, and greater microstructural organization in subcortical gray matter nuclei. Associations were stronger for PM(2.5) in boys and PAH in girls. Youth with low exposure accounted for most significant associations of ADHD, anxiety, socialization, and intelligence measures with cortical thickness and white matter volumes, whereas it appears that high exposures generally disrupted these neurotypical brain-behavior associations, likely because strong exposure-related effects increased the variances of these brain measures. CONCLUSIONS: The commonality of effects across exposures suggests PM(2.5) and PAH disrupt brain development through one or more common molecular pathways, such as inflammation or oxidative stress. Progressively higher exposures were associated with greater disruptions in local volumes, tissue organization, metabolite concentrations, and blood flow throughout cortical and subcortical brain regions and the white matter pathways interconnecting them. Together these affected regions comprise cortico-striato-thalamo-cortical circuits, which support the regulation of thought, emotion, and behavior. En ligne : http://dx.doi.org/10.1111/jcpp.13578 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 Association Between Air Pollution Exposure, Cognitive and Adaptive Function, and ASD Severity Among Children with Autism Spectrum Disorder / T. KERIN in Journal of Autism and Developmental Disorders, 48-1 (January 2018)
[article]
Titre : Association Between Air Pollution Exposure, Cognitive and Adaptive Function, and ASD Severity Among Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : T. KERIN, Auteur ; Heather E. VOLK, Auteur ; W. LI, Auteur ; F. LURMANN, Auteur ; S. ECKEL, Auteur ; R. MCCONNELL, Auteur ; I. HERTZ-PICCIOTTO, Auteur Article en page(s) : p.137-150 Langues : Anglais (eng) Mots-clés : Air pollution Autism spectrum disorder Cognitive impairments Mullen scales of early learning Vineland adaptive behavioral scale Index. décimale : PER Périodiques Résumé : Prenatal exposure to air pollution has been associated with autism spectrum disorder (ASD) risk but no study has examined associations with ASD severity or functioning. Cognitive ability, adaptive functioning, and ASD severity were assessed in 327 children with ASD from the Childhood Autism Risks from Genetics and the Environment study using the Mullen Scales of Early Learning (MSEL), the Vineland Adaptive Behavior Scales (VABS), and the Autism Diagnostic Observation Schedule calibrated severity score. Estimates of nitrogen dioxide (NO2), particulate matter (PM2.5 and PM10), ozone, and near-roadway air pollution were assigned to each trimester of pregnancy and first year of life. Increasing prenatal and first year NO2 exposures were associated with decreased MSEL and VABS scores. Increasing PM10 exposure in the third trimester was paradoxically associated with improved performance on the VABS. ASD severity was not associated with air pollution exposure. En ligne : https://doi.org/10.1007/s10803-017-3304-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336
in Journal of Autism and Developmental Disorders > 48-1 (January 2018) . - p.137-150[article] Association Between Air Pollution Exposure, Cognitive and Adaptive Function, and ASD Severity Among Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / T. KERIN, Auteur ; Heather E. VOLK, Auteur ; W. LI, Auteur ; F. LURMANN, Auteur ; S. ECKEL, Auteur ; R. MCCONNELL, Auteur ; I. HERTZ-PICCIOTTO, Auteur . - p.137-150.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 48-1 (January 2018) . - p.137-150
Mots-clés : Air pollution Autism spectrum disorder Cognitive impairments Mullen scales of early learning Vineland adaptive behavioral scale Index. décimale : PER Périodiques Résumé : Prenatal exposure to air pollution has been associated with autism spectrum disorder (ASD) risk but no study has examined associations with ASD severity or functioning. Cognitive ability, adaptive functioning, and ASD severity were assessed in 327 children with ASD from the Childhood Autism Risks from Genetics and the Environment study using the Mullen Scales of Early Learning (MSEL), the Vineland Adaptive Behavior Scales (VABS), and the Autism Diagnostic Observation Schedule calibrated severity score. Estimates of nitrogen dioxide (NO2), particulate matter (PM2.5 and PM10), ozone, and near-roadway air pollution were assigned to each trimester of pregnancy and first year of life. Increasing prenatal and first year NO2 exposures were associated with decreased MSEL and VABS scores. Increasing PM10 exposure in the third trimester was paradoxically associated with improved performance on the VABS. ASD severity was not associated with air pollution exposure. En ligne : https://doi.org/10.1007/s10803-017-3304-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336 Prenatal exposure to air pollution and childhood internalizing problems: roles of shyness and anterior cingulate cortex activity / Ran LIU in Journal of Child Psychology and Psychiatry, 64-7 (July 2023)
[article]
Titre : Prenatal exposure to air pollution and childhood internalizing problems: roles of shyness and anterior cingulate cortex activity Type de document : Texte imprimé et/ou numérique Auteurs : Ran LIU, Auteur ; David PAGLIACCIO, Auteur ; Julie B. HERBSTMAN, Auteur ; Nathan A. FOX, Auteur ; Amy E. MARGOLIS, Auteur Article en page(s) : p.1037-1044 Langues : Anglais (eng) Mots-clés : Air pollution polycyclic aromatic hydrocarbons prenatal internalizing problems shyness anterior cingulate cortex Index. décimale : PER Périodiques Résumé : Background Prenatal exposure to air pollution increases the risk for psychiatric disorders characterized by internalizing problems. In this study, we examined the roles of shyness and anterior cingulate cortex (ACC) activity in the association between prenatal exposure to polycyclic aromatic hydrocarbons (PAH) and children's internalizing problems at 79years old. Methods Participants include 53 children (31 girls, 22 boys). Personal air monitoring was conducted over 48 continuous hours during the third trimester of pregnancy to measure 8 PAHs. Mothers reported children's shyness (Emotionality Activity Sociability Temperament Survey) at age 5 and internalizing problems (Child Behavior Checklist) at ages 79. ACC activity was measured by fMRI during the Simon Spatial Incompatibility task at ages 79. Results Shyness mediated the association between prenatal PAH exposure and internalizing problems. Higher prenatal PAH exposure predicted increased shyness, which in turn predicted greater internalizing problems. Moreover, left ACC activity during the Simon task moderated the association between prenatal PAH exposure and internalizing problems. Prenatal PAH exposure predicted increased risk for internalizing problems only when children showed heightened left ACC activity during the resolution of cognitive conflict. Conclusions Our study innovatively synthesizes the fields of developmental psychology and environmental health science to offer new insights into the risk factors for anxiety disorders. Facilitating the development of healthy reactive and regulatory processes may improve the developmental outcomes for children highly exposed to air pollution. En ligne : https://doi.org/10.1111/jcpp.13768 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508
in Journal of Child Psychology and Psychiatry > 64-7 (July 2023) . - p.1037-1044[article] Prenatal exposure to air pollution and childhood internalizing problems: roles of shyness and anterior cingulate cortex activity [Texte imprimé et/ou numérique] / Ran LIU, Auteur ; David PAGLIACCIO, Auteur ; Julie B. HERBSTMAN, Auteur ; Nathan A. FOX, Auteur ; Amy E. MARGOLIS, Auteur . - p.1037-1044.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 64-7 (July 2023) . - p.1037-1044
Mots-clés : Air pollution polycyclic aromatic hydrocarbons prenatal internalizing problems shyness anterior cingulate cortex Index. décimale : PER Périodiques Résumé : Background Prenatal exposure to air pollution increases the risk for psychiatric disorders characterized by internalizing problems. In this study, we examined the roles of shyness and anterior cingulate cortex (ACC) activity in the association between prenatal exposure to polycyclic aromatic hydrocarbons (PAH) and children's internalizing problems at 79years old. Methods Participants include 53 children (31 girls, 22 boys). Personal air monitoring was conducted over 48 continuous hours during the third trimester of pregnancy to measure 8 PAHs. Mothers reported children's shyness (Emotionality Activity Sociability Temperament Survey) at age 5 and internalizing problems (Child Behavior Checklist) at ages 79. ACC activity was measured by fMRI during the Simon Spatial Incompatibility task at ages 79. Results Shyness mediated the association between prenatal PAH exposure and internalizing problems. Higher prenatal PAH exposure predicted increased shyness, which in turn predicted greater internalizing problems. Moreover, left ACC activity during the Simon task moderated the association between prenatal PAH exposure and internalizing problems. Prenatal PAH exposure predicted increased risk for internalizing problems only when children showed heightened left ACC activity during the resolution of cognitive conflict. Conclusions Our study innovatively synthesizes the fields of developmental psychology and environmental health science to offer new insights into the risk factors for anxiety disorders. Facilitating the development of healthy reactive and regulatory processes may improve the developmental outcomes for children highly exposed to air pollution. En ligne : https://doi.org/10.1111/jcpp.13768 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 The joint effect of air pollution exposure and copy number variation on risk for autism / Dokyoon KIM in Autism Research, 10-9 (September 2017)
[article]
Titre : The joint effect of air pollution exposure and copy number variation on risk for autism Type de document : Texte imprimé et/ou numérique Auteurs : Dokyoon KIM, Auteur ; Heather E. VOLK, Auteur ; Santhosh GIRIRAJAN, Auteur ; Sarah PENDERGRASS, Auteur ; Molly A. HALL, Auteur ; Shefali S. VERMA, Auteur ; Rebecca J. SCHMIDT, Auteur ; Robin L. HANSEN, Auteur ; Debashis GHOSH, Auteur ; Yunin LUDENA-RODRIGUEZ, Auteur ; Kyoungmi KIM, Auteur ; Marylyn D. RITCHIE, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Scott B. SELLECK, Auteur Article en page(s) : p.1470-1480 Langues : Anglais (eng) Mots-clés : autism copy number variation air pollution gene-environment interaction Index. décimale : PER Périodiques Résumé : Autism spectrum disorder is a complex trait with a high degree of heritability as well as documented susceptibility from environmental factors. In this study the contributions of copy number variation, exposure to air pollutants, and the interaction between the two on autism risk, were evaluated in the population-based case-control Childhood Autism Risks from Genetics and Environment (CHARGE) Study. For the current investigation, we included only those CHARGE children (a) who met criteria for autism or typical development and (b) for whom our team had conducted both genetic evaluation of copy number burden and determination of environmental air pollution exposures based on mapping addresses from the pregnancy and early childhood. This sample consisted of 158 cases of children with autism and 147 controls with typical development. Multiple logistic regression models were fit with and without environmental variable-copy number burden interactions. We found no correlation between average air pollution exposure from conception to age 2 years and the child's CNV burden. We found a significant interaction in which a 1SD increase in duplication burden combined with a 1SD increase in ozone exposure was associated with an elevated autism risk (OR 3.4, P?0.005) much greater than the increased risks associated with either genomic duplication (OR 1.85, 95% CI 1.25–2.73) or ozone (OR 1.20, 95% CI 0.93–1.54) alone. Similar results were obtained when CNV and ozone were dichotomized to compare those in the top quartile relative to those having a smaller CNV burden and lower exposure to ozone, and when exposures were assessed separately for pregnancy, the first year of life, and the second year of life. No interactions were observed for other air pollutants, even those that demonstrated main effects; ozone tends to be negatively correlated with the other pollutants examined. While earlier work has demonstrated interactions between the presence of a pathogenic CNV and an environmental exposure [Webb et al., 2016], these findings appear to be the first indication that global copy number variation may increase susceptibility to certain environmental factors, and underscore the need to consider both genomics and environmental exposures as well as the mechanisms by which each may amplify the risks for autism associated with the other. En ligne : http://dx.doi.org/10.1002/aur.1799 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=320
in Autism Research > 10-9 (September 2017) . - p.1470-1480[article] The joint effect of air pollution exposure and copy number variation on risk for autism [Texte imprimé et/ou numérique] / Dokyoon KIM, Auteur ; Heather E. VOLK, Auteur ; Santhosh GIRIRAJAN, Auteur ; Sarah PENDERGRASS, Auteur ; Molly A. HALL, Auteur ; Shefali S. VERMA, Auteur ; Rebecca J. SCHMIDT, Auteur ; Robin L. HANSEN, Auteur ; Debashis GHOSH, Auteur ; Yunin LUDENA-RODRIGUEZ, Auteur ; Kyoungmi KIM, Auteur ; Marylyn D. RITCHIE, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Scott B. SELLECK, Auteur . - p.1470-1480.
Langues : Anglais (eng)
in Autism Research > 10-9 (September 2017) . - p.1470-1480
Mots-clés : autism copy number variation air pollution gene-environment interaction Index. décimale : PER Périodiques Résumé : Autism spectrum disorder is a complex trait with a high degree of heritability as well as documented susceptibility from environmental factors. In this study the contributions of copy number variation, exposure to air pollutants, and the interaction between the two on autism risk, were evaluated in the population-based case-control Childhood Autism Risks from Genetics and Environment (CHARGE) Study. For the current investigation, we included only those CHARGE children (a) who met criteria for autism or typical development and (b) for whom our team had conducted both genetic evaluation of copy number burden and determination of environmental air pollution exposures based on mapping addresses from the pregnancy and early childhood. This sample consisted of 158 cases of children with autism and 147 controls with typical development. Multiple logistic regression models were fit with and without environmental variable-copy number burden interactions. We found no correlation between average air pollution exposure from conception to age 2 years and the child's CNV burden. We found a significant interaction in which a 1SD increase in duplication burden combined with a 1SD increase in ozone exposure was associated with an elevated autism risk (OR 3.4, P?0.005) much greater than the increased risks associated with either genomic duplication (OR 1.85, 95% CI 1.25–2.73) or ozone (OR 1.20, 95% CI 0.93–1.54) alone. Similar results were obtained when CNV and ozone were dichotomized to compare those in the top quartile relative to those having a smaller CNV burden and lower exposure to ozone, and when exposures were assessed separately for pregnancy, the first year of life, and the second year of life. No interactions were observed for other air pollutants, even those that demonstrated main effects; ozone tends to be negatively correlated with the other pollutants examined. While earlier work has demonstrated interactions between the presence of a pathogenic CNV and an environmental exposure [Webb et al., 2016], these findings appear to be the first indication that global copy number variation may increase susceptibility to certain environmental factors, and underscore the need to consider both genomics and environmental exposures as well as the mechanisms by which each may amplify the risks for autism associated with the other. En ligne : http://dx.doi.org/10.1002/aur.1799 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=320 Joint effects of prenatal air pollutant exposure and maternal folic acid supplementation on risk of autism spectrum disorder / J. GOODRICH AMANDA in Autism Research, 11-1 (January 2018)
[article]
Titre : Joint effects of prenatal air pollutant exposure and maternal folic acid supplementation on risk of autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : J. GOODRICH AMANDA, Auteur ; Heather E. VOLK, Auteur ; Daniel J. TANCREDI, Auteur ; Rob MCCONNELL, Auteur ; W. LURMANN FRED, Auteur ; L. HANSEN ROBIN, Auteur ; Rebecca J. SCHMIDT, Auteur Article en page(s) : p.69-80 Langues : Anglais (eng) Mots-clés : autism ASD folic acid air pollution prenatal exposure environmental exposure Index. décimale : PER Périodiques Résumé : Independent studies report that periconceptional folic acid (FA) may decrease the risk of autism spectrum disorder (ASD) while exposure to air pollution may increase ASD risk. We examined the joint effects of gestational FA and air pollution exposures in association with ASD. We studied 346 ASD cases and 260 typically developing controls from the CHARGE case?control study. Self?reported FA intake for each month of pregnancy was quantified. Estimates of exposure to near roadway air pollution (NRP) and criteria air pollutant measures were assigned based on maternal residential history. Among mothers with high FA intake (>800 ?g) in the first pregnancy month, exposure to increasing levels of all air pollutants, except ozone, during the first trimester was associated with decreased ASD risk, while increased ASD risk was observed for the same pollutant among mothers with low FA intake (?800 ?g). This difference was statistically significant for NO2 (e.g., NO2 and low FA intake: OR=1.53 (0.91, 2.56) vs NO2 and high FA intake: OR=0.74 (0.46, 1.19), P?interaction=0.04). Mothers exposed to higher levels (? median) of any air pollutant during the first trimester of pregnancy and who reported low FA intake were at a higher ASD risk compared to mothers exposed to lower levels of that air pollutant and who reported high first month FA intake. Joint effects showed significant (alpha?0.10) departures from expected interaction for NRP and NO2. Our results suggest that periconceptional FA intake may reduce ASD risk in those with high prenatal air pollution exposure. Further study is needed to replicate these findings in larger sample sizes and to understand mechanisms of this potential relationship.. Autism Res 2018, 11: 69?80. ? 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary We examined interactions between periconceptional folic acid (FA) and air pollution exposure on risk of ASD. Mothers exposed to higher levels of air pollution during the first trimester of pregnancy and who reported low supplemental FA intake during the first pregnancy month were at a higher ASD risk compared to mothers exposed to lower levels of air pollution and who reported high first month FA intake. Our results suggest that periconceptional FA intake may reduce ASD risk in those with high prenatal air pollution exposure. En ligne : https://doi.org/10.1002/aur.1885 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=333
in Autism Research > 11-1 (January 2018) . - p.69-80[article] Joint effects of prenatal air pollutant exposure and maternal folic acid supplementation on risk of autism spectrum disorder [Texte imprimé et/ou numérique] / J. GOODRICH AMANDA, Auteur ; Heather E. VOLK, Auteur ; Daniel J. TANCREDI, Auteur ; Rob MCCONNELL, Auteur ; W. LURMANN FRED, Auteur ; L. HANSEN ROBIN, Auteur ; Rebecca J. SCHMIDT, Auteur . - p.69-80.
Langues : Anglais (eng)
in Autism Research > 11-1 (January 2018) . - p.69-80
Mots-clés : autism ASD folic acid air pollution prenatal exposure environmental exposure Index. décimale : PER Périodiques Résumé : Independent studies report that periconceptional folic acid (FA) may decrease the risk of autism spectrum disorder (ASD) while exposure to air pollution may increase ASD risk. We examined the joint effects of gestational FA and air pollution exposures in association with ASD. We studied 346 ASD cases and 260 typically developing controls from the CHARGE case?control study. Self?reported FA intake for each month of pregnancy was quantified. Estimates of exposure to near roadway air pollution (NRP) and criteria air pollutant measures were assigned based on maternal residential history. Among mothers with high FA intake (>800 ?g) in the first pregnancy month, exposure to increasing levels of all air pollutants, except ozone, during the first trimester was associated with decreased ASD risk, while increased ASD risk was observed for the same pollutant among mothers with low FA intake (?800 ?g). This difference was statistically significant for NO2 (e.g., NO2 and low FA intake: OR=1.53 (0.91, 2.56) vs NO2 and high FA intake: OR=0.74 (0.46, 1.19), P?interaction=0.04). Mothers exposed to higher levels (? median) of any air pollutant during the first trimester of pregnancy and who reported low FA intake were at a higher ASD risk compared to mothers exposed to lower levels of that air pollutant and who reported high first month FA intake. Joint effects showed significant (alpha?0.10) departures from expected interaction for NRP and NO2. Our results suggest that periconceptional FA intake may reduce ASD risk in those with high prenatal air pollution exposure. Further study is needed to replicate these findings in larger sample sizes and to understand mechanisms of this potential relationship.. Autism Res 2018, 11: 69?80. ? 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary We examined interactions between periconceptional folic acid (FA) and air pollution exposure on risk of ASD. Mothers exposed to higher levels of air pollution during the first trimester of pregnancy and who reported low supplemental FA intake during the first pregnancy month were at a higher ASD risk compared to mothers exposed to lower levels of air pollution and who reported high first month FA intake. Our results suggest that periconceptional FA intake may reduce ASD risk in those with high prenatal air pollution exposure. En ligne : https://doi.org/10.1002/aur.1885 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=333 Commentary: ‘Unhealthy diet,’ nutrient status, and ADHD symptoms: a confounding role for environmental nitrous oxide exposure – reflections on Rijlaarsdam et al. (2016) / Keith FLUEGGE in Journal of Child Psychology and Psychiatry, 58-1 (January 2017)
PermalinkAbnormal sensory experiences, synaesthesia, and neurodevelopmental disorders / Keith FLUEGGE in Journal of Autism and Developmental Disorders, 47-9 (September 2017)
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