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A Bayesian multilevel analysis of the longitudinal associations between relationship quality and suicidal ideation and attempts among youth with bipolar disorder / C. J. R. SEWALL in Journal of Child Psychology and Psychiatry, 62-7 (July 2021)
[article]
Titre : A Bayesian multilevel analysis of the longitudinal associations between relationship quality and suicidal ideation and attempts among youth with bipolar disorder Type de document : Texte imprimé et/ou numérique Auteurs : C. J. R. SEWALL, Auteur ; J. M. GIRARD, Auteur ; J. MERRANKO, Auteur ; D. HAFEMAN, Auteur ; B. I. GOLDSTEIN, Auteur ; M. STROBER, Auteur ; H. HOWER, Auteur ; L. M. WEINSTOCK, Auteur ; S. YEN, Auteur ; N. D. RYAN, Auteur ; M. B. KELLER, Auteur ; F. LIAO, Auteur ; Rasim S. DILER, Auteur ; M. KAY GILL, Auteur ; David A. AXELSON, Auteur ; Boris BIRMAHER, Auteur ; Tina R. GOLDSTEIN, Auteur Article en page(s) : p.905-915 Langues : Anglais (eng) Mots-clés : Adolescent Bayes Theorem Bipolar Disorder/epidemiology Humans Multilevel Analysis Risk Factors Suicidal Ideation Suicide, Attempted Bayesian analysis Suicide adolescence bipolar disorder parent-child relationships peer relationships Index. décimale : PER Périodiques Résumé : BACKGROUND: Youth with bipolar disorder (BD) are at high risk for suicidal thoughts and behaviors and frequently experience interpersonal impairment, which is a risk factor for suicide. Yet, no study to date has examined the longitudinal associations between relationship quality in family/peer domains and suicidal thoughts and behaviors among youth with BD. Thus, we investigated how between-person differences - reflecting the average relationship quality across time - and within-person changes, reflecting recent fluctuations in relationship quality, act as distal and/or proximal risk factors for suicidal ideation (SI) and suicide attempts. METHODS: We used longitudinal data from the Course and Outcome of Bipolar Youth Study (N = 413). Relationship quality variables were decomposed into stable (i.e., average) and varying (i.e., recent) components and entered, along with major clinical covariates, into separate Bayesian multilevel models predicting SI and suicide attempt. We also examined how the relationship quality effects interacted with age and sex. RESULTS: Poorer average relationship quality with parents (? = -.33, 95% Bayesian highest density interval (HDI) [-0.54, -0.11]) or friends (? = -.33, 95% HDI [-0.55, -0.11]) was longitudinally associated with increased risk of SI but not suicide attempt. Worsening recent relationship quality with parents (? = -.10, 95% HDI [-0.19, -0.03]) and, to a lesser extent, friends (? = -.06, 95% HDI [-0.15, 0.03]) was longitudinally associated with increased risk of SI, but only worsening recent relationship quality with parents was also associated with increased risk of suicide attempt (? = -.15, 95% HDI [-0.31, 0.01]). The effects of certain relationship quality variables were moderated by gender but not age. CONCLUSIONS: Among youth with BD, having poorer average relationship quality with peers and/or parents represents a distal risk factor for SI but not suicide attempts. Additionally, worsening recent relationship quality with parents may be a time-sensitive indicator of increased risk for SI or suicide attempt. En ligne : http://dx.doi.org/10.1111/jcpp.13343 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456
in Journal of Child Psychology and Psychiatry > 62-7 (July 2021) . - p.905-915[article] A Bayesian multilevel analysis of the longitudinal associations between relationship quality and suicidal ideation and attempts among youth with bipolar disorder [Texte imprimé et/ou numérique] / C. J. R. SEWALL, Auteur ; J. M. GIRARD, Auteur ; J. MERRANKO, Auteur ; D. HAFEMAN, Auteur ; B. I. GOLDSTEIN, Auteur ; M. STROBER, Auteur ; H. HOWER, Auteur ; L. M. WEINSTOCK, Auteur ; S. YEN, Auteur ; N. D. RYAN, Auteur ; M. B. KELLER, Auteur ; F. LIAO, Auteur ; Rasim S. DILER, Auteur ; M. KAY GILL, Auteur ; David A. AXELSON, Auteur ; Boris BIRMAHER, Auteur ; Tina R. GOLDSTEIN, Auteur . - p.905-915.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 62-7 (July 2021) . - p.905-915
Mots-clés : Adolescent Bayes Theorem Bipolar Disorder/epidemiology Humans Multilevel Analysis Risk Factors Suicidal Ideation Suicide, Attempted Bayesian analysis Suicide adolescence bipolar disorder parent-child relationships peer relationships Index. décimale : PER Périodiques Résumé : BACKGROUND: Youth with bipolar disorder (BD) are at high risk for suicidal thoughts and behaviors and frequently experience interpersonal impairment, which is a risk factor for suicide. Yet, no study to date has examined the longitudinal associations between relationship quality in family/peer domains and suicidal thoughts and behaviors among youth with BD. Thus, we investigated how between-person differences - reflecting the average relationship quality across time - and within-person changes, reflecting recent fluctuations in relationship quality, act as distal and/or proximal risk factors for suicidal ideation (SI) and suicide attempts. METHODS: We used longitudinal data from the Course and Outcome of Bipolar Youth Study (N = 413). Relationship quality variables were decomposed into stable (i.e., average) and varying (i.e., recent) components and entered, along with major clinical covariates, into separate Bayesian multilevel models predicting SI and suicide attempt. We also examined how the relationship quality effects interacted with age and sex. RESULTS: Poorer average relationship quality with parents (? = -.33, 95% Bayesian highest density interval (HDI) [-0.54, -0.11]) or friends (? = -.33, 95% HDI [-0.55, -0.11]) was longitudinally associated with increased risk of SI but not suicide attempt. Worsening recent relationship quality with parents (? = -.10, 95% HDI [-0.19, -0.03]) and, to a lesser extent, friends (? = -.06, 95% HDI [-0.15, 0.03]) was longitudinally associated with increased risk of SI, but only worsening recent relationship quality with parents was also associated with increased risk of suicide attempt (? = -.15, 95% HDI [-0.31, 0.01]). The effects of certain relationship quality variables were moderated by gender but not age. CONCLUSIONS: Among youth with BD, having poorer average relationship quality with peers and/or parents represents a distal risk factor for SI but not suicide attempts. Additionally, worsening recent relationship quality with parents may be a time-sensitive indicator of increased risk for SI or suicide attempt. En ligne : http://dx.doi.org/10.1111/jcpp.13343 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 Mental disorders in preadolescent children at familial high-risk of schizophrenia or bipolar disorder - a four-year follow-up study: The Danish High Risk and Resilience Study, VIA 11: The Danish High Risk and Resilience Study, VIA 11 / Maja GREGERSEN in Journal of Child Psychology and Psychiatry, 63-9 (September 2022)
[article]
Titre : Mental disorders in preadolescent children at familial high-risk of schizophrenia or bipolar disorder - a four-year follow-up study: The Danish High Risk and Resilience Study, VIA 11: The Danish High Risk and Resilience Study, VIA 11 Type de document : Texte imprimé et/ou numérique Auteurs : Maja GREGERSEN, Auteur ; Anne SØNDERGAARD, Auteur ; Julie Marie BRANDT, Auteur ; Ditte ELLERSGAARD, Auteur ; Sinnika Birkehoj ROHD, Auteur ; Carsten HJORTHØJ, Auteur ; Jessica OHLAND, Auteur ; Mette Falkenberg KRANTZ, Auteur ; Martin WILMS, Auteur ; Anna Krogh ANDREASSEN, Auteur ; Christina Bruun KNUDSEN, Auteur ; Lotte VEDDUM, Auteur ; Aja GREVE, Auteur ; Vibeke BLIKSTED, Auteur ; Ole MORS, Auteur ; Lars CLEMMENSEN, Auteur ; Jens Richardt MØLLEGAARD JEPSEN, Auteur ; Merete NORDENTOFT, Auteur ; Nicoline HEMAGER, Auteur ; Anne Amalie Elgaard THORUP, Auteur Article en page(s) : p.1046-1056 Langues : Anglais (eng) Mots-clés : Bipolar Disorder/epidemiology Child Child, Preschool Denmark/epidemiology Follow-Up Studies Humans Longitudinal Studies Schizophrenia/epidemiology Child and adolescent psychiatry bipolar disorder familial high-risk psychopathology schizophrenia Index. décimale : PER Périodiques Résumé : BACKGROUND: Children at familial high-risk of schizophrenia and bipolar disorder have an elevated prevalence of mental disorders but studies of children within a narrow age range are lacking and there are few conjoint studies of these two groups. Knowledge on their mental health is important for prevention and early intervention. METHODS: The authors examined mental disorders and global functioning in children at familial high-risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP) compared with population-based controls. In a longitudinal cohort study, 450 children (FHR-SZ, n=171; FHR-BP, n=104; controls, n=175), were assessed for Axis I disorders at baseline and four-year follow-up (mean age 11.9, SD 0.2) with the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children and for global functioning with Children's Global Assessment Scale. RESULTS: Cumulative incidence of Any Axis I disorder was elevated by age 11 in children at FHR-SZ (54.4%, OR 3.0, 95% CI 1.9-4.7, p<.001) and children at FHR-BP (52.9%, OR 2.8, 95% CI 1.7-4.7, p<.001) compared with controls (28.6%). Children at FHR-SZ and FHR-BP had higher rates of affective disorders (OR 4.4, 95% CI 1.4-13.5, p=.009; OR 5.1, 95% CI 1.6-16.4, p=.007), anxiety disorders (OR 2.1, 95% CI 1.1-4.0, p=.02; OR 3.0, 95% CI 1.5-6.1, p=.002), and stress and adjustment disorders (OR 3.3, 95% CI 1.4-7.5, p=.006; OR 5.3, 95% CI 2.2-12.4, p<.001). Disruptive behavior disorders (OR 2.8, 95% CI 1.0-7.3, p=.04) and ADHD (OR 2.9, 95% CI 1.6-5.3, p<.001) were elevated in children at FHR-SZ. Both FHR groups had lower global functioning than controls. Cumulative incidence of disorders increased equally across the three groups from early childhood to preadolescence and level of functioning did not change differentially. CONCLUSIONS: Children at FHR-SZ and FHR-BP have an elevated prevalence of mental disorders and poorer functioning than controls. Vulnerability in children at FHR manifests early and remains stable throughout childhood. Early attention toward their mental health and identification of those in need of intervention is warranted. En ligne : http://dx.doi.org/10.1111/jcpp.13548 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486
in Journal of Child Psychology and Psychiatry > 63-9 (September 2022) . - p.1046-1056[article] Mental disorders in preadolescent children at familial high-risk of schizophrenia or bipolar disorder - a four-year follow-up study: The Danish High Risk and Resilience Study, VIA 11: The Danish High Risk and Resilience Study, VIA 11 [Texte imprimé et/ou numérique] / Maja GREGERSEN, Auteur ; Anne SØNDERGAARD, Auteur ; Julie Marie BRANDT, Auteur ; Ditte ELLERSGAARD, Auteur ; Sinnika Birkehoj ROHD, Auteur ; Carsten HJORTHØJ, Auteur ; Jessica OHLAND, Auteur ; Mette Falkenberg KRANTZ, Auteur ; Martin WILMS, Auteur ; Anna Krogh ANDREASSEN, Auteur ; Christina Bruun KNUDSEN, Auteur ; Lotte VEDDUM, Auteur ; Aja GREVE, Auteur ; Vibeke BLIKSTED, Auteur ; Ole MORS, Auteur ; Lars CLEMMENSEN, Auteur ; Jens Richardt MØLLEGAARD JEPSEN, Auteur ; Merete NORDENTOFT, Auteur ; Nicoline HEMAGER, Auteur ; Anne Amalie Elgaard THORUP, Auteur . - p.1046-1056.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-9 (September 2022) . - p.1046-1056
Mots-clés : Bipolar Disorder/epidemiology Child Child, Preschool Denmark/epidemiology Follow-Up Studies Humans Longitudinal Studies Schizophrenia/epidemiology Child and adolescent psychiatry bipolar disorder familial high-risk psychopathology schizophrenia Index. décimale : PER Périodiques Résumé : BACKGROUND: Children at familial high-risk of schizophrenia and bipolar disorder have an elevated prevalence of mental disorders but studies of children within a narrow age range are lacking and there are few conjoint studies of these two groups. Knowledge on their mental health is important for prevention and early intervention. METHODS: The authors examined mental disorders and global functioning in children at familial high-risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP) compared with population-based controls. In a longitudinal cohort study, 450 children (FHR-SZ, n=171; FHR-BP, n=104; controls, n=175), were assessed for Axis I disorders at baseline and four-year follow-up (mean age 11.9, SD 0.2) with the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children and for global functioning with Children's Global Assessment Scale. RESULTS: Cumulative incidence of Any Axis I disorder was elevated by age 11 in children at FHR-SZ (54.4%, OR 3.0, 95% CI 1.9-4.7, p<.001) and children at FHR-BP (52.9%, OR 2.8, 95% CI 1.7-4.7, p<.001) compared with controls (28.6%). Children at FHR-SZ and FHR-BP had higher rates of affective disorders (OR 4.4, 95% CI 1.4-13.5, p=.009; OR 5.1, 95% CI 1.6-16.4, p=.007), anxiety disorders (OR 2.1, 95% CI 1.1-4.0, p=.02; OR 3.0, 95% CI 1.5-6.1, p=.002), and stress and adjustment disorders (OR 3.3, 95% CI 1.4-7.5, p=.006; OR 5.3, 95% CI 2.2-12.4, p<.001). Disruptive behavior disorders (OR 2.8, 95% CI 1.0-7.3, p=.04) and ADHD (OR 2.9, 95% CI 1.6-5.3, p<.001) were elevated in children at FHR-SZ. Both FHR groups had lower global functioning than controls. Cumulative incidence of disorders increased equally across the three groups from early childhood to preadolescence and level of functioning did not change differentially. CONCLUSIONS: Children at FHR-SZ and FHR-BP have an elevated prevalence of mental disorders and poorer functioning than controls. Vulnerability in children at FHR manifests early and remains stable throughout childhood. Early attention toward their mental health and identification of those in need of intervention is warranted. En ligne : http://dx.doi.org/10.1111/jcpp.13548 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486