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Altered Metabolic Characteristics in Plasma of Young Boys with Autism Spectrum Disorder / Lei WANG in Journal of Autism and Developmental Disorders, 52-11 (November 2022)
[article]
Titre : Altered Metabolic Characteristics in Plasma of Young Boys with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Lei WANG, Auteur ; Ruixuan ZHENG, Auteur ; Ying XU, Auteur ; Ziyun ZHOU, Auteur ; Ping GUAN, Auteur ; Yanling WU, Auteur ; Jian ZHOU, Auteur ; Zaohuo CHENG, Auteur ; Lili ZHANG, Auteur Article en page(s) : p.4897-4907 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis Biomarkers Child Choline Chromatography, Liquid Humans Male Ornithine Tandem Mass Spectrometry Autism Spectrum Disorder (ASD) Liquid chromatography-tandem mass spectrometry (LC-MS/MS) Metabolic profile Plasma Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is a serious neurodevelopmental disorder with no clinical biomarker. This study used untargeted metabolomic analysis to identify metabolic characteristics in plasma that can distinguish ASD children. 29 boys with ASD (3.02 Â+ 0.67Â years) and 30 typically developing (TD) boys (3.13 Â+ 0.46Â years) were recruited. Developmental and behavioral assessments were conducted in ASD group. Samples of plasma were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The association between metabolite concentration and scale score was assessed by Spearman rank correlation. Altered metabolic characteristics were found in boys with ASD. In Receiver Operating Characteristic (ROC) analysis, ornithine had the highest AUC (Area under ROC) value. Furthermore, the concentration of choline and ornithine was negatively correlated with ABC-language score in ASD group. En ligne : http://dx.doi.org/10.1007/s10803-021-05364-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489
in Journal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.4897-4907[article] Altered Metabolic Characteristics in Plasma of Young Boys with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Lei WANG, Auteur ; Ruixuan ZHENG, Auteur ; Ying XU, Auteur ; Ziyun ZHOU, Auteur ; Ping GUAN, Auteur ; Yanling WU, Auteur ; Jian ZHOU, Auteur ; Zaohuo CHENG, Auteur ; Lili ZHANG, Auteur . - p.4897-4907.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.4897-4907
Mots-clés : Autism Spectrum Disorder/diagnosis Biomarkers Child Choline Chromatography, Liquid Humans Male Ornithine Tandem Mass Spectrometry Autism Spectrum Disorder (ASD) Liquid chromatography-tandem mass spectrometry (LC-MS/MS) Metabolic profile Plasma Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is a serious neurodevelopmental disorder with no clinical biomarker. This study used untargeted metabolomic analysis to identify metabolic characteristics in plasma that can distinguish ASD children. 29 boys with ASD (3.02 Â+ 0.67Â years) and 30 typically developing (TD) boys (3.13 Â+ 0.46Â years) were recruited. Developmental and behavioral assessments were conducted in ASD group. Samples of plasma were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The association between metabolite concentration and scale score was assessed by Spearman rank correlation. Altered metabolic characteristics were found in boys with ASD. In Receiver Operating Characteristic (ROC) analysis, ornithine had the highest AUC (Area under ROC) value. Furthermore, the concentration of choline and ornithine was negatively correlated with ABC-language score in ASD group. En ligne : http://dx.doi.org/10.1007/s10803-021-05364-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489 Commentary: ‘Unhealthy diet,’ nutrient status, and ADHD symptoms: a confounding role for environmental nitrous oxide exposure – reflections on Rijlaarsdam et al. (2016) / Keith FLUEGGE in Journal of Child Psychology and Psychiatry, 58-1 (January 2017)
[article]
Titre : Commentary: ‘Unhealthy diet,’ nutrient status, and ADHD symptoms: a confounding role for environmental nitrous oxide exposure – reflections on Rijlaarsdam et al. (2016) Type de document : Texte imprimé et/ou numérique Auteurs : Keith FLUEGGE, Auteur Article en page(s) : p.28-29 Langues : Anglais (eng) Mots-clés : Choline nitrous oxide air pollution dynorphin kappa opioid receptor Index. décimale : PER Périodiques Résumé : Rijlaarsdam et al. (2016) recently published their findings utilizing a longitudinal design showing that prenatal ‘unhealthy diet’ was positively associated with IGF2 DNA methylation at birth across both youth cohorts. However, only in the EOP youth was prenatal ‘unhealthy diet’ positively associated with ADHD symptoms presumably through IGF2 DNA hypermethylation. Rijlaarsdam et al.'s () choice to assess high fat and sugar diet with the Food Frequency Questionnaire (FFQ) may offer some indication as to prenatal nutrient status, as the foods identified by the FFQ in their study are relatively low in free choline. It has been shown that gestational choline deficiency in rats leads to hypermethylation of IGF2. Consistent with the literature describing an association between air pollution and cognitive neurodevelopmental impairment, the author of this commentary has previously proposed through empirical investigation that chronic environmental exposure to the trace levels of the pervasive air pollutant, nitrous oxide (N2O), may facilitate core features of neurodevelopmental disorders, like ADHD. Impaired acetylcholine synthesis in rats exposed to N2O has been shown, with a 53% reduction in [1-2H2,2-2H2] choline. Low-dose N2O exposure is also thought to stimulate central release of opioid peptides, like dynorphin, which play a role in significantly increasing food intake behavior and/or modulating sucrose intake. Taken altogether, these studies present a strong confounder to the interpretation made by Rijlaarsdam et al. () that prenatal ‘unhealthy diet’ may play a role in the onset of ADHD symptoms in youth with EOP conduct problems through induction of IGF2 DNA hypermethylation. While the ‘unhealthy diet’ may represent possible maternal nutrient deficiencies during gestation, it is also possible that exposure to air pollutants, particularly N2O, may not only directly reduce fetal cholinergic status thereby enhancing IGF2 DNA hypermethylation but may also significantly modulate maternal food intake behaviors (i.e. sucrose). En ligne : http://dx.doi.org/10.1111/jcpp.12649 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298
in Journal of Child Psychology and Psychiatry > 58-1 (January 2017) . - p.28-29[article] Commentary: ‘Unhealthy diet,’ nutrient status, and ADHD symptoms: a confounding role for environmental nitrous oxide exposure – reflections on Rijlaarsdam et al. (2016) [Texte imprimé et/ou numérique] / Keith FLUEGGE, Auteur . - p.28-29.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 58-1 (January 2017) . - p.28-29
Mots-clés : Choline nitrous oxide air pollution dynorphin kappa opioid receptor Index. décimale : PER Périodiques Résumé : Rijlaarsdam et al. (2016) recently published their findings utilizing a longitudinal design showing that prenatal ‘unhealthy diet’ was positively associated with IGF2 DNA methylation at birth across both youth cohorts. However, only in the EOP youth was prenatal ‘unhealthy diet’ positively associated with ADHD symptoms presumably through IGF2 DNA hypermethylation. Rijlaarsdam et al.'s () choice to assess high fat and sugar diet with the Food Frequency Questionnaire (FFQ) may offer some indication as to prenatal nutrient status, as the foods identified by the FFQ in their study are relatively low in free choline. It has been shown that gestational choline deficiency in rats leads to hypermethylation of IGF2. Consistent with the literature describing an association between air pollution and cognitive neurodevelopmental impairment, the author of this commentary has previously proposed through empirical investigation that chronic environmental exposure to the trace levels of the pervasive air pollutant, nitrous oxide (N2O), may facilitate core features of neurodevelopmental disorders, like ADHD. Impaired acetylcholine synthesis in rats exposed to N2O has been shown, with a 53% reduction in [1-2H2,2-2H2] choline. Low-dose N2O exposure is also thought to stimulate central release of opioid peptides, like dynorphin, which play a role in significantly increasing food intake behavior and/or modulating sucrose intake. Taken altogether, these studies present a strong confounder to the interpretation made by Rijlaarsdam et al. () that prenatal ‘unhealthy diet’ may play a role in the onset of ADHD symptoms in youth with EOP conduct problems through induction of IGF2 DNA hypermethylation. While the ‘unhealthy diet’ may represent possible maternal nutrient deficiencies during gestation, it is also possible that exposure to air pollutants, particularly N2O, may not only directly reduce fetal cholinergic status thereby enhancing IGF2 DNA hypermethylation but may also significantly modulate maternal food intake behaviors (i.e. sucrose). En ligne : http://dx.doi.org/10.1111/jcpp.12649 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298