Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Résultat de la recherche
1 recherche sur le mot-clé 'Chromosome 22q11.2 deletion syndrome'
Affiner la recherche Générer le flux rss de la recherche
Partager le résultat de cette recherche Faire une suggestion
Atypical development of the executive attention network in children with chromosome 22q11.2 deletion syndrome / J. STODDARD in Journal of Neurodevelopmental Disorders, 3-1 (March 2011)
[article]
Titre : Atypical development of the executive attention network in children with chromosome 22q11.2 deletion syndrome Type de document : Texte imprimé et/ou numérique Auteurs : J. STODDARD, Auteur ; L. BECKETT, Auteur ; T. J. SIMON, Auteur Article en page(s) : p.76-85 Langues : Anglais (eng) Mots-clés : Attention networks task Chromosome 22q11.2 deletion syndrome Cognitive control Index. décimale : PER Périodiques Résumé : Impairment in the executive control of attention has been found in youth with chromosome 22q11.2 deletion syndrome (22q11.2DS). However, how this impairment is modified by other factors, particularly age, is unknown. Forty-six typically developing and 53 children with 22q11.2DS were tested with the attention networks task (ANT) in this cross-sectional study. We used logarithmic transform and linear modeling to assess age effects on the executive index of the ANT. Mixed modeling accounted for between subject variability, age, handedness, catecholamine-O-transferase (COMT; codon 158) genotype, and gender on performance for all experimental conditions (cue x flanker) and their two-level interactions. Children with 22q11.2DS showed a relative, age-dependent executive index impairment but not orienting or alerting network index impairments. In factorial analysis, age was a major predictor of overall performance. There was a significant effect of the 22q11.2DS on overall performance. Of note, children with 22q11.2DS are specifically vulnerable to incongruent flanker interference, especially at younger ages. We did not find an overall effect of COMT genotype or handedness. Children with 22q11.2DS demonstrated age-related impairment in the executive control of attention. Future investigation will likely reveal that there are different developmental trajectories of executive attentional function likely related to the development of schizophrenia in 22q11.2DS. En ligne : http://dx.doi.org/10.1007/s11689-010-9070-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=343
in Journal of Neurodevelopmental Disorders > 3-1 (March 2011) . - p.76-85[article] Atypical development of the executive attention network in children with chromosome 22q11.2 deletion syndrome [Texte imprimé et/ou numérique] / J. STODDARD, Auteur ; L. BECKETT, Auteur ; T. J. SIMON, Auteur . - p.76-85.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 3-1 (March 2011) . - p.76-85
Mots-clés : Attention networks task Chromosome 22q11.2 deletion syndrome Cognitive control Index. décimale : PER Périodiques Résumé : Impairment in the executive control of attention has been found in youth with chromosome 22q11.2 deletion syndrome (22q11.2DS). However, how this impairment is modified by other factors, particularly age, is unknown. Forty-six typically developing and 53 children with 22q11.2DS were tested with the attention networks task (ANT) in this cross-sectional study. We used logarithmic transform and linear modeling to assess age effects on the executive index of the ANT. Mixed modeling accounted for between subject variability, age, handedness, catecholamine-O-transferase (COMT; codon 158) genotype, and gender on performance for all experimental conditions (cue x flanker) and their two-level interactions. Children with 22q11.2DS showed a relative, age-dependent executive index impairment but not orienting or alerting network index impairments. In factorial analysis, age was a major predictor of overall performance. There was a significant effect of the 22q11.2DS on overall performance. Of note, children with 22q11.2DS are specifically vulnerable to incongruent flanker interference, especially at younger ages. We did not find an overall effect of COMT genotype or handedness. Children with 22q11.2DS demonstrated age-related impairment in the executive control of attention. Future investigation will likely reveal that there are different developmental trajectories of executive attentional function likely related to the development of schizophrenia in 22q11.2DS. En ligne : http://dx.doi.org/10.1007/s11689-010-9070-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=343