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Co-occurring Down Syndrome and Autism Spectrum Disorder: Cognitive, Adaptive, and Behavioral Characteristics / K. R. BRADBURY in Journal of Autism and Developmental Disorders, 52-3 (March 2022)
[article]
Titre : Co-occurring Down Syndrome and Autism Spectrum Disorder: Cognitive, Adaptive, and Behavioral Characteristics Type de document : Texte imprimé et/ou numérique Auteurs : K. R. BRADBURY, Auteur ; Emily I. ANDERBERG, Auteur ; L. HUANG-STORMS, Auteur ; I. VASILE, Auteur ; R. K. GREENE, Auteur ; S. W. DUVALL, Auteur Article en page(s) : p.1235-1246 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/complications/epidemiology/psychology Child Cognition Cognitive Dysfunction Down Syndrome/complications/epidemiology/psychology Humans Adaptive functioning Autism spectrum disorder Cognitive functioning Down syndrome Dual diagnosis Emotional and behavioral functioning Index. décimale : PER Périodiques Résumé : The current study explores functioning in individuals with co-occurring Autism Spectrum Disorder and Down Syndrome (ASD+DS; n?=?23), individuals with ASD and cognitive impairment (ASD+ID; n?=?99) and individuals with idiopathic ID (n?=?38). ANCOVA results revealed that individuals with ASD+DS showed strengths in behavioral functioning compared to individuals with ID and more similar behavioral functioning to those with ASD+ID (?(2)?=?0.12), with the exception of disruptive behaviors. Cognitive functioning (?(c)?=?0.41) and ASD symptomatology (?(2)?=?0.11) were more comparable for children with ASD+DS and ASD?+?ID than for individuals with ID. Individuals with ASD+DS had the lowest overall adaptive skills (?(2)?=?0.11). Findings highlight similarities between ASD+DS and ASD+ID groups, emphasizing the importance of ASD identification within the DS population to provide access to specific interventions. En ligne : http://dx.doi.org/10.1007/s10803-021-05016-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455
in Journal of Autism and Developmental Disorders > 52-3 (March 2022) . - p.1235-1246[article] Co-occurring Down Syndrome and Autism Spectrum Disorder: Cognitive, Adaptive, and Behavioral Characteristics [Texte imprimé et/ou numérique] / K. R. BRADBURY, Auteur ; Emily I. ANDERBERG, Auteur ; L. HUANG-STORMS, Auteur ; I. VASILE, Auteur ; R. K. GREENE, Auteur ; S. W. DUVALL, Auteur . - p.1235-1246.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-3 (March 2022) . - p.1235-1246
Mots-clés : Autism Spectrum Disorder/complications/epidemiology/psychology Child Cognition Cognitive Dysfunction Down Syndrome/complications/epidemiology/psychology Humans Adaptive functioning Autism spectrum disorder Cognitive functioning Down syndrome Dual diagnosis Emotional and behavioral functioning Index. décimale : PER Périodiques Résumé : The current study explores functioning in individuals with co-occurring Autism Spectrum Disorder and Down Syndrome (ASD+DS; n?=?23), individuals with ASD and cognitive impairment (ASD+ID; n?=?99) and individuals with idiopathic ID (n?=?38). ANCOVA results revealed that individuals with ASD+DS showed strengths in behavioral functioning compared to individuals with ID and more similar behavioral functioning to those with ASD+ID (?(2)?=?0.12), with the exception of disruptive behaviors. Cognitive functioning (?(c)?=?0.41) and ASD symptomatology (?(2)?=?0.11) were more comparable for children with ASD+DS and ASD?+?ID than for individuals with ID. Individuals with ASD+DS had the lowest overall adaptive skills (?(2)?=?0.11). Findings highlight similarities between ASD+DS and ASD+ID groups, emphasizing the importance of ASD identification within the DS population to provide access to specific interventions. En ligne : http://dx.doi.org/10.1007/s10803-021-05016-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 Complex Interplay Between Cognitive Ability and Social Motivation in Predicting Social Skill: A Unique Role for Social Motivation in Children With Autism / Elena ITSKOVICH in Autism Research, 14-1 (January 2021)
[article]
Titre : Complex Interplay Between Cognitive Ability and Social Motivation in Predicting Social Skill: A Unique Role for Social Motivation in Children With Autism Type de document : Texte imprimé et/ou numérique Auteurs : Elena ITSKOVICH, Auteur ; Olena ZYGA, Auteur ; Robin A. LIBOVE, Auteur ; Jennifer M. PHILLIPS, Auteur ; Joseph P. GARNER, Auteur ; Karen J. PARKER, Auteur Article en page(s) : p.86-92 Langues : Anglais (eng) Mots-clés : autism spectrum disorder children cognitive dysfunction intelligence tests motivation social skill socialization Index. décimale : PER Périodiques Résumé : Impairment in social interaction is a core feature of autism spectrum disorder (ASD), but the factors which contribute to this social skill deficiency are poorly understood. Previous research has shown that cognitive ability can impact social skill development in ASD. Yet, children with ASD whose cognitive abilities are in the normal range nevertheless demonstrate deficits in social skill. More recently, the social motivation theory of ASD has emerged as a framework by which to understand how failure to seek social experiences may lead to social skill deficits. This study was designed to better understand the relationships between cognitive ability, social motivation, and social skill in a well-characterized cohort of children with ASD (n = 79), their unaffected siblings (n = 50), and unrelated neurotypical controls (n = 60). The following instruments were used: The Stanford-Binet intelligence quotient (IQ), the Social Responsiveness Scale's Social Motivation Subscale, and the Vineland Adaptive Behavior Scales' Socialization Standard Score. We found that lower cognitive ability contributed to diminished social skill, but did so universally in all children. In contrast, social motivation strongly predicted social skill only in children with ASD, such that those with the lowest social motivation exhibited the greatest social skill impairment. Notably, this relationship was observed across a large range of intellectual ability but was most pronounced in those with IQs???80. These findings establish a unique link between social motivation and social skill in ASD and support the hypothesis that low social motivation may impair social skill acquisition in this disorder, particularly in children without intellectual disability. LAY SUMMARY: The relationships between cognitive ability, social motivation, and social skill are poorly understood. Here we report that cognitive ability predicts social skill in all children, whereas social motivation predicts social skill only in children with autism. These results establish a unique link between social motivation and social skill in autism, and suggest that low social motivation may impair social skill acquisition in this disorder, particularly in those without intellectual disability. En ligne : http://dx.doi.org/10.1002/aur.2409 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=441
in Autism Research > 14-1 (January 2021) . - p.86-92[article] Complex Interplay Between Cognitive Ability and Social Motivation in Predicting Social Skill: A Unique Role for Social Motivation in Children With Autism [Texte imprimé et/ou numérique] / Elena ITSKOVICH, Auteur ; Olena ZYGA, Auteur ; Robin A. LIBOVE, Auteur ; Jennifer M. PHILLIPS, Auteur ; Joseph P. GARNER, Auteur ; Karen J. PARKER, Auteur . - p.86-92.
Langues : Anglais (eng)
in Autism Research > 14-1 (January 2021) . - p.86-92
Mots-clés : autism spectrum disorder children cognitive dysfunction intelligence tests motivation social skill socialization Index. décimale : PER Périodiques Résumé : Impairment in social interaction is a core feature of autism spectrum disorder (ASD), but the factors which contribute to this social skill deficiency are poorly understood. Previous research has shown that cognitive ability can impact social skill development in ASD. Yet, children with ASD whose cognitive abilities are in the normal range nevertheless demonstrate deficits in social skill. More recently, the social motivation theory of ASD has emerged as a framework by which to understand how failure to seek social experiences may lead to social skill deficits. This study was designed to better understand the relationships between cognitive ability, social motivation, and social skill in a well-characterized cohort of children with ASD (n = 79), their unaffected siblings (n = 50), and unrelated neurotypical controls (n = 60). The following instruments were used: The Stanford-Binet intelligence quotient (IQ), the Social Responsiveness Scale's Social Motivation Subscale, and the Vineland Adaptive Behavior Scales' Socialization Standard Score. We found that lower cognitive ability contributed to diminished social skill, but did so universally in all children. In contrast, social motivation strongly predicted social skill only in children with ASD, such that those with the lowest social motivation exhibited the greatest social skill impairment. Notably, this relationship was observed across a large range of intellectual ability but was most pronounced in those with IQs???80. These findings establish a unique link between social motivation and social skill in ASD and support the hypothesis that low social motivation may impair social skill acquisition in this disorder, particularly in children without intellectual disability. LAY SUMMARY: The relationships between cognitive ability, social motivation, and social skill are poorly understood. Here we report that cognitive ability predicts social skill in all children, whereas social motivation predicts social skill only in children with autism. These results establish a unique link between social motivation and social skill in autism, and suggest that low social motivation may impair social skill acquisition in this disorder, particularly in those without intellectual disability. En ligne : http://dx.doi.org/10.1002/aur.2409 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=441 A multidisciplinary approach unravels early and persistent effects of X-ray exposure at the onset of prenatal neurogenesis / T. VERREET in Journal of Neurodevelopmental Disorders, 7-1 (December 2015)
[article]
Titre : A multidisciplinary approach unravels early and persistent effects of X-ray exposure at the onset of prenatal neurogenesis Type de document : Texte imprimé et/ou numérique Auteurs : T. VERREET, Auteur ; R. QUINTENS, Auteur ; D. VAN DAM, Auteur ; M. VERSLEGERS, Auteur ; M. TANORI, Auteur ; A. CASCIATI, Auteur ; M. NEEFS, Auteur ; L. LEYSEN, Auteur ; A. MICHAUX, Auteur ; A. JANSSEN, Auteur ; E. D'AGOSTINO, Auteur ; G. VANDE VELDE, Auteur ; S. BAATOUT, Auteur ; L. MOONS, Auteur ; S. PAZZAGLIA, Auteur ; A. SARAN, Auteur ; U. HIMMELREICH, Auteur ; P. P. DE DEYN, Auteur ; M. A. BENOTMANE, Auteur Article en page(s) : p.3 Langues : Anglais (eng) Mots-clés : Apoptosis Brain development Cognitive dysfunction Mri Radiation Index. décimale : PER Périodiques Résumé : BACKGROUND: In humans, in utero exposure to ionising radiation results in an increased prevalence of neurological aberrations, such as small head size, mental retardation and decreased IQ levels. Yet, the association between early damaging events and long-term neuronal anomalies remains largely elusive. METHODS: Mice were exposed to different X-ray doses, ranging between 0.0 and 1.0 Gy, at embryonic days (E) 10, 11 or 12 and subjected to behavioural tests at 12 weeks of age. Underlying mechanisms of irradiation at E11 were further unravelled using magnetic resonance imaging (MRI) and spectroscopy, diffusion tensor imaging, gene expression profiling, histology and immunohistochemistry. RESULTS: Irradiation at the onset of neurogenesis elicited behavioural changes in young adult mice, dependent on the timing of exposure. As locomotor behaviour and hippocampal-dependent spatial learning and memory were most particularly affected after irradiation at E11 with 1.0 Gy, this condition was used for further mechanistic analyses, focusing on the cerebral cortex and hippocampus. A classical p53-mediated apoptotic response was found shortly after exposure. Strikingly, in the neocortex, the majority of apoptotic and microglial cells were residing in the outer layer at 24 h after irradiation, suggesting cell death occurrence in differentiating neurons rather than proliferating cells. Furthermore, total brain volume, cortical thickness and ventricle size were decreased in the irradiated embryos. At 40 weeks of age, MRI showed that the ventricles were enlarged whereas N-acetyl aspartate concentrations and functional anisotropy were reduced in the cortex of the irradiated animals, indicating a decrease in neuronal cell number and persistent neuroinflammation. Finally, in the hippocampus, we revealed a reduction in general neurogenic proliferation and in the amount of Sox2-positive precursors after radiation exposure, although only at a juvenile age. CONCLUSIONS: Our findings provide evidence for a radiation-induced disruption of mouse brain development, resulting in behavioural differences. We propose that alterations in cortical morphology and juvenile hippocampal neurogenesis might both contribute to the observed aberrant behaviour. Furthermore, our results challenge the generally assumed view of a higher radiosensitivity in dividing cells. Overall, this study offers new insights into irradiation-dependent effects in the embryonic brain, of relevance for the neurodevelopmental and radiobiological field. En ligne : http://dx.doi.org/10.1186/1866-1955-7-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347
in Journal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.3[article] A multidisciplinary approach unravels early and persistent effects of X-ray exposure at the onset of prenatal neurogenesis [Texte imprimé et/ou numérique] / T. VERREET, Auteur ; R. QUINTENS, Auteur ; D. VAN DAM, Auteur ; M. VERSLEGERS, Auteur ; M. TANORI, Auteur ; A. CASCIATI, Auteur ; M. NEEFS, Auteur ; L. LEYSEN, Auteur ; A. MICHAUX, Auteur ; A. JANSSEN, Auteur ; E. D'AGOSTINO, Auteur ; G. VANDE VELDE, Auteur ; S. BAATOUT, Auteur ; L. MOONS, Auteur ; S. PAZZAGLIA, Auteur ; A. SARAN, Auteur ; U. HIMMELREICH, Auteur ; P. P. DE DEYN, Auteur ; M. A. BENOTMANE, Auteur . - p.3.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.3
Mots-clés : Apoptosis Brain development Cognitive dysfunction Mri Radiation Index. décimale : PER Périodiques Résumé : BACKGROUND: In humans, in utero exposure to ionising radiation results in an increased prevalence of neurological aberrations, such as small head size, mental retardation and decreased IQ levels. Yet, the association between early damaging events and long-term neuronal anomalies remains largely elusive. METHODS: Mice were exposed to different X-ray doses, ranging between 0.0 and 1.0 Gy, at embryonic days (E) 10, 11 or 12 and subjected to behavioural tests at 12 weeks of age. Underlying mechanisms of irradiation at E11 were further unravelled using magnetic resonance imaging (MRI) and spectroscopy, diffusion tensor imaging, gene expression profiling, histology and immunohistochemistry. RESULTS: Irradiation at the onset of neurogenesis elicited behavioural changes in young adult mice, dependent on the timing of exposure. As locomotor behaviour and hippocampal-dependent spatial learning and memory were most particularly affected after irradiation at E11 with 1.0 Gy, this condition was used for further mechanistic analyses, focusing on the cerebral cortex and hippocampus. A classical p53-mediated apoptotic response was found shortly after exposure. Strikingly, in the neocortex, the majority of apoptotic and microglial cells were residing in the outer layer at 24 h after irradiation, suggesting cell death occurrence in differentiating neurons rather than proliferating cells. Furthermore, total brain volume, cortical thickness and ventricle size were decreased in the irradiated embryos. At 40 weeks of age, MRI showed that the ventricles were enlarged whereas N-acetyl aspartate concentrations and functional anisotropy were reduced in the cortex of the irradiated animals, indicating a decrease in neuronal cell number and persistent neuroinflammation. Finally, in the hippocampus, we revealed a reduction in general neurogenic proliferation and in the amount of Sox2-positive precursors after radiation exposure, although only at a juvenile age. CONCLUSIONS: Our findings provide evidence for a radiation-induced disruption of mouse brain development, resulting in behavioural differences. We propose that alterations in cortical morphology and juvenile hippocampal neurogenesis might both contribute to the observed aberrant behaviour. Furthermore, our results challenge the generally assumed view of a higher radiosensitivity in dividing cells. Overall, this study offers new insights into irradiation-dependent effects in the embryonic brain, of relevance for the neurodevelopmental and radiobiological field. En ligne : http://dx.doi.org/10.1186/1866-1955-7-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347