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Homozygosity for the 10-repeat dopamine transporter (DAT1) allele is associated with reduced EEG response in males with ASD / Calvin P. SJAARDA in Research in Autism Spectrum Disorders, 60 (April 2019)
[article]
Titre : Homozygosity for the 10-repeat dopamine transporter (DAT1) allele is associated with reduced EEG response in males with ASD Type de document : Texte imprimé et/ou numérique Auteurs : Calvin P. SJAARDA, Auteur ; Mark A. SABBAGH, Auteur ; Shalandra WOOD, Auteur ; Jessica WARD-KING, Auteur ; Amy J. M. MCNAUGHTON, Auteur ; Melissa L. HUDSON, Auteur ; Mingda TAO, Auteur ; Muhammad AYUB, Auteur ; Xudong LIU, Auteur Article en page(s) : p.25-35 Langues : Anglais (eng) Mots-clés : ASD Autism Electroencephalogram DAT1 Dopamine Face processing Index. décimale : PER Périodiques Résumé : Background Individuals with autism spectrum disorder (ASD) have reduced interest in human faces and atypical event-related brain potentials (ERPs) in response to face stimuli, suggesting that face processing may be a functional marker of ASD susceptibility. Method This report explored the visual processing of individuals with ASD (n?=?50) compared with their first-degree relatives (n?=?117) using electroencephalogram (EEG), and associated EEG response with specific polymorphisms in the COMT, OXTR, SLC6A4 and DAT1 genes. Results Polymorphisms in the COMT and OXTR genes were not associated with any specific EEG response; on the other hand, the 5-HTTLPR polymorphism located upstream of SLC6A4 was associated with increased latency of the P1 component of the EEG response, and DAT1 genotype correlated with reduced amplitude of the N170 component in male participants with ASD. Conclusion These results suggest an interaction between DAT1 genotype and male participants with ASD characterized by reduced cognitive performance when processing faces as measured by EEG. Identifying ASD functional markers and grouping individuals with shared genetic biomarkers or endophenotypes may facilitate greater understanding of the heterogeneity underlying ASD leading to improved diagnosis and treatment of ASD. En ligne : https://doi.org/10.1016/j.rasd.2018.12.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=387
in Research in Autism Spectrum Disorders > 60 (April 2019) . - p.25-35[article] Homozygosity for the 10-repeat dopamine transporter (DAT1) allele is associated with reduced EEG response in males with ASD [Texte imprimé et/ou numérique] / Calvin P. SJAARDA, Auteur ; Mark A. SABBAGH, Auteur ; Shalandra WOOD, Auteur ; Jessica WARD-KING, Auteur ; Amy J. M. MCNAUGHTON, Auteur ; Melissa L. HUDSON, Auteur ; Mingda TAO, Auteur ; Muhammad AYUB, Auteur ; Xudong LIU, Auteur . - p.25-35.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 60 (April 2019) . - p.25-35
Mots-clés : ASD Autism Electroencephalogram DAT1 Dopamine Face processing Index. décimale : PER Périodiques Résumé : Background Individuals with autism spectrum disorder (ASD) have reduced interest in human faces and atypical event-related brain potentials (ERPs) in response to face stimuli, suggesting that face processing may be a functional marker of ASD susceptibility. Method This report explored the visual processing of individuals with ASD (n?=?50) compared with their first-degree relatives (n?=?117) using electroencephalogram (EEG), and associated EEG response with specific polymorphisms in the COMT, OXTR, SLC6A4 and DAT1 genes. Results Polymorphisms in the COMT and OXTR genes were not associated with any specific EEG response; on the other hand, the 5-HTTLPR polymorphism located upstream of SLC6A4 was associated with increased latency of the P1 component of the EEG response, and DAT1 genotype correlated with reduced amplitude of the N170 component in male participants with ASD. Conclusion These results suggest an interaction between DAT1 genotype and male participants with ASD characterized by reduced cognitive performance when processing faces as measured by EEG. Identifying ASD functional markers and grouping individuals with shared genetic biomarkers or endophenotypes may facilitate greater understanding of the heterogeneity underlying ASD leading to improved diagnosis and treatment of ASD. En ligne : https://doi.org/10.1016/j.rasd.2018.12.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=387 Interaction of dopamine transporter (DAT1) genotype and maltreatment for ADHD: a latent class analysis / James J. LI in Journal of Child Psychology and Psychiatry, 53-9 (September 2012)
[article]
Titre : Interaction of dopamine transporter (DAT1) genotype and maltreatment for ADHD: a latent class analysis Type de document : Texte imprimé et/ou numérique Auteurs : James J. LI, Auteur ; Steve S. LEE, Auteur Année de publication : 2012 Article en page(s) : p.997-1005 Langues : Anglais (eng) Mots-clés : ADHD latent class analysis gene-environment interaction DAT1 maltreatment Index. décimale : PER Périodiques Résumé : Background: Although the association of the dopamine transporter (DAT1) gene and attention-deficit/hyperactivity disorder (ADHD) has been widely studied, far less is known about its potential interaction with environmental risk factors. Given that maltreatment is a replicated risk factor for ADHD, we explored the interaction between DAT1 and maltreatment with ADHD symptoms defined dimensionally and using latent class analysis (LCA). Method: We tested the association of the 40 base-pair variable number of tandem repeats polymorphism in DAT1, maltreatment, and their interaction in 2,488 boys and girls from the National Longitudinal Study of Adolescent Health. Results: In boys, ADHD symptoms were optimally defined by four classes (Combined, Hyperactive/Impulsive, Inattentive, and Normal), whereas in girls, ADHD symptoms were defined by three classes (Combined, Combined-Mild, Normal). A significant DAT1 × maltreatment interaction revealed that maltreated girls homozygous for the 10-repeat allele had more symptoms of ADHD, and were also 2.5 times more likely to be classified in the Combined ADHD group than in the Normal Group. Conclusions: The underlying structure of ADHD symptoms differed between boys and girls and DAT1 interacted with maltreatment to predict ADHD symptoms and ADHD status derived from LCA. Interactive exchanges between maltreatment and DAT1 for ADHD symptoms, and their implications for intervention, are discussed. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02563.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179
in Journal of Child Psychology and Psychiatry > 53-9 (September 2012) . - p.997-1005[article] Interaction of dopamine transporter (DAT1) genotype and maltreatment for ADHD: a latent class analysis [Texte imprimé et/ou numérique] / James J. LI, Auteur ; Steve S. LEE, Auteur . - 2012 . - p.997-1005.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 53-9 (September 2012) . - p.997-1005
Mots-clés : ADHD latent class analysis gene-environment interaction DAT1 maltreatment Index. décimale : PER Périodiques Résumé : Background: Although the association of the dopamine transporter (DAT1) gene and attention-deficit/hyperactivity disorder (ADHD) has been widely studied, far less is known about its potential interaction with environmental risk factors. Given that maltreatment is a replicated risk factor for ADHD, we explored the interaction between DAT1 and maltreatment with ADHD symptoms defined dimensionally and using latent class analysis (LCA). Method: We tested the association of the 40 base-pair variable number of tandem repeats polymorphism in DAT1, maltreatment, and their interaction in 2,488 boys and girls from the National Longitudinal Study of Adolescent Health. Results: In boys, ADHD symptoms were optimally defined by four classes (Combined, Hyperactive/Impulsive, Inattentive, and Normal), whereas in girls, ADHD symptoms were defined by three classes (Combined, Combined-Mild, Normal). A significant DAT1 × maltreatment interaction revealed that maltreated girls homozygous for the 10-repeat allele had more symptoms of ADHD, and were also 2.5 times more likely to be classified in the Combined ADHD group than in the Normal Group. Conclusions: The underlying structure of ADHD symptoms differed between boys and girls and DAT1 interacted with maltreatment to predict ADHD symptoms and ADHD status derived from LCA. Interactive exchanges between maltreatment and DAT1 for ADHD symptoms, and their implications for intervention, are discussed. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02563.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179 Gene–environment interaction in externalizing problems among adolescents: evidence from the Pelotas 1993 Birth Cohort Study / Christian KIELING in Journal of Child Psychology and Psychiatry, 54-3 (March 2013)
[article]
Titre : Gene–environment interaction in externalizing problems among adolescents: evidence from the Pelotas 1993 Birth Cohort Study Type de document : Texte imprimé et/ou numérique Auteurs : Christian KIELING, Auteur ; Mara H. HUTZ, Auteur ; Júlia P. GENRO, Auteur ; Guilherme V. POLANCZYK, Auteur ; Luciana ANSELMI, Auteur ; Suzi CAMEY, Auteur ; Pedro C. HALLAL, Auteur ; Fernando C. BARROS, Auteur ; Cesar G. VICTORA, Auteur ; Ana Maria B. MENEZES, Auteur ; Luis Augusto ROHDE, Auteur Article en page(s) : p.298-304 Mots-clés : Gene–environment interaction DAT1 maternal smoking MAOA childhood maltreatment externalizing Index. décimale : PER Périodiques Résumé : Background: The study of gene–environment interactions (G × E) is one of the most promising strategies to uncover the origins of mental disorders. Replication of initial findings, however, is essential because there is a strong possibility of publication bias in the literature. In addition, there is a scarcity of research on the topic originated from low- and middle-income countries (LMIC). The aim of this study was to replicate G × E hypotheses for externalizing problems among adolescents in a middle-income country. Methods: As part of the Pelotas 1993 Birth Cohort Study, 5,249 children were enrolled at birth and followed up to the age of 15 years, with an 85.7% retention rate. We sought an interaction between the homozygosity of the 10-repeat allele at the dopamine transporter (DAT1) gene and prenatal maternal smoking in the development of hyperactivity problems during adolescence assessed by the Strengths and Difficulties Questionnaire. We also tested for an interaction between the uVNTR polymorphism at the monoamine oxidase A (MAOA) and the experience of childhood maltreatment in the occurrence of conduct problems among adolescent boys. Results: Although there was a clear association between prenatal maternal smoking and hyperactivity scores in adolescence (p 0.001), no main genetic or interaction effects for the DAT1 gene were detected. Similarly, childhood maltreatment showed to be associated with conduct problems among boys (p 0.001), with no observable main genetic or interaction effects for the MAOA gene. Conclusions: In the largest mental health G × E study performed in a LMIC to date, we did not replicate previous positive findings from the literature. Despite the presence of main environmental effects, there was no evidence of effect modification by genotype status. Additional replication efforts to measure G × E are needed to better understand the origins of mental health and illness, especially in LMIC. En ligne : http://dx.doi.org/10.1111/jcpp.12022 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=191
in Journal of Child Psychology and Psychiatry > 54-3 (March 2013) . - p.298-304[article] Gene–environment interaction in externalizing problems among adolescents: evidence from the Pelotas 1993 Birth Cohort Study [Texte imprimé et/ou numérique] / Christian KIELING, Auteur ; Mara H. HUTZ, Auteur ; Júlia P. GENRO, Auteur ; Guilherme V. POLANCZYK, Auteur ; Luciana ANSELMI, Auteur ; Suzi CAMEY, Auteur ; Pedro C. HALLAL, Auteur ; Fernando C. BARROS, Auteur ; Cesar G. VICTORA, Auteur ; Ana Maria B. MENEZES, Auteur ; Luis Augusto ROHDE, Auteur . - p.298-304.
in Journal of Child Psychology and Psychiatry > 54-3 (March 2013) . - p.298-304
Mots-clés : Gene–environment interaction DAT1 maternal smoking MAOA childhood maltreatment externalizing Index. décimale : PER Périodiques Résumé : Background: The study of gene–environment interactions (G × E) is one of the most promising strategies to uncover the origins of mental disorders. Replication of initial findings, however, is essential because there is a strong possibility of publication bias in the literature. In addition, there is a scarcity of research on the topic originated from low- and middle-income countries (LMIC). The aim of this study was to replicate G × E hypotheses for externalizing problems among adolescents in a middle-income country. Methods: As part of the Pelotas 1993 Birth Cohort Study, 5,249 children were enrolled at birth and followed up to the age of 15 years, with an 85.7% retention rate. We sought an interaction between the homozygosity of the 10-repeat allele at the dopamine transporter (DAT1) gene and prenatal maternal smoking in the development of hyperactivity problems during adolescence assessed by the Strengths and Difficulties Questionnaire. We also tested for an interaction between the uVNTR polymorphism at the monoamine oxidase A (MAOA) and the experience of childhood maltreatment in the occurrence of conduct problems among adolescent boys. Results: Although there was a clear association between prenatal maternal smoking and hyperactivity scores in adolescence (p 0.001), no main genetic or interaction effects for the DAT1 gene were detected. Similarly, childhood maltreatment showed to be associated with conduct problems among boys (p 0.001), with no observable main genetic or interaction effects for the MAOA gene. Conclusions: In the largest mental health G × E study performed in a LMIC to date, we did not replicate previous positive findings from the literature. Despite the presence of main environmental effects, there was no evidence of effect modification by genotype status. Additional replication efforts to measure G × E are needed to better understand the origins of mental health and illness, especially in LMIC. En ligne : http://dx.doi.org/10.1111/jcpp.12022 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=191