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Lateralization of Brain Networks and Clinical Severity in Toddlers with Autism Spectrum Disorder: A HARDI Diffusion MRI Study / Eugenia CONTI in Autism Research, 9-3 (March 2016)
[article]
Titre : Lateralization of Brain Networks and Clinical Severity in Toddlers with Autism Spectrum Disorder: A HARDI Diffusion MRI Study Type de document : Texte imprimé et/ou numérique Auteurs : Eugenia CONTI, Auteur ; Sara CALDERONI, Auteur ; Anna GAGLIANESE, Auteur ; Kerstin PANNEK, Auteur ; Sara MAZZOTTI, Auteur ; Stephen ROSE, Auteur ; Danilo SCELFO, Auteur ; Michela TOSETTI, Auteur ; Filippo MURATORI, Auteur ; Giovanni CIONI, Auteur ; Andrea GUZZETTA, Auteur Article en page(s) : p.382-392 Langues : Anglais (eng) Mots-clés : autism autism spectrum disorder diffusion imaging high-angular-resolution diffusion imaging whole brain tractography toddlers brain lateralization cerebral lateralization Index. décimale : PER Périodiques Résumé : Recent diffusion tensor imaging studies in adolescents and children with Autism Spectrum Disorder (ASD) have reported a loss or an inversion of the typical left–right lateralization in fronto-temporal regions crucial for sociocommunicative skills. No studies explored atypical lateralization in toddlers and its correlation with clinical severity of ASD. We recruited a cohort of 20 subjects aged 36 months or younger receiving a first clinical diagnosis of ASD (15 males; age range 20–36 months). Patients underwent diffusion MRI (High-Angular-Resolution Diffusion Imaging protocol). Data from cortical parcellation were combined with tractography to obtain a connection matrix and diffusion indexes (DI) including mean fractional anisotropy (DFA), number of tracts (DNUM), and total tract length (DTTL). A laterality index was generated for each measure, and then correlated with the Autism Diagnostic Observation Schedule-Generic (ADOS-G) total score. Laterality indexes of DFA were significantly correlated with ADOS-G total scores only in two intrafrontal connected areas (correlation was positive in one case and negative in the other). Laterality indexes of DTTL and DNUM showed significant negative correlations (P?0.05) in six connected areas, mainly fronto-temporal. This study provides first evidence of a significant correlation between brain lateralization of diffusion indexes and clinical severity in toddlers with a first diagnosis of ASD. Significant correlations mainly involved regions within the fronto-temporal circuits, known to be crucial for sociocommunicative skills. It is of interest that all correlations but one were negative, suggesting an inversion of the typical left–right asymmetry in subjects with most severe clinical impairment. Autism Res 2016, 9: 382–392. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1533 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285
in Autism Research > 9-3 (March 2016) . - p.382-392[article] Lateralization of Brain Networks and Clinical Severity in Toddlers with Autism Spectrum Disorder: A HARDI Diffusion MRI Study [Texte imprimé et/ou numérique] / Eugenia CONTI, Auteur ; Sara CALDERONI, Auteur ; Anna GAGLIANESE, Auteur ; Kerstin PANNEK, Auteur ; Sara MAZZOTTI, Auteur ; Stephen ROSE, Auteur ; Danilo SCELFO, Auteur ; Michela TOSETTI, Auteur ; Filippo MURATORI, Auteur ; Giovanni CIONI, Auteur ; Andrea GUZZETTA, Auteur . - p.382-392.
Langues : Anglais (eng)
in Autism Research > 9-3 (March 2016) . - p.382-392
Mots-clés : autism autism spectrum disorder diffusion imaging high-angular-resolution diffusion imaging whole brain tractography toddlers brain lateralization cerebral lateralization Index. décimale : PER Périodiques Résumé : Recent diffusion tensor imaging studies in adolescents and children with Autism Spectrum Disorder (ASD) have reported a loss or an inversion of the typical left–right lateralization in fronto-temporal regions crucial for sociocommunicative skills. No studies explored atypical lateralization in toddlers and its correlation with clinical severity of ASD. We recruited a cohort of 20 subjects aged 36 months or younger receiving a first clinical diagnosis of ASD (15 males; age range 20–36 months). Patients underwent diffusion MRI (High-Angular-Resolution Diffusion Imaging protocol). Data from cortical parcellation were combined with tractography to obtain a connection matrix and diffusion indexes (DI) including mean fractional anisotropy (DFA), number of tracts (DNUM), and total tract length (DTTL). A laterality index was generated for each measure, and then correlated with the Autism Diagnostic Observation Schedule-Generic (ADOS-G) total score. Laterality indexes of DFA were significantly correlated with ADOS-G total scores only in two intrafrontal connected areas (correlation was positive in one case and negative in the other). Laterality indexes of DTTL and DNUM showed significant negative correlations (P?0.05) in six connected areas, mainly fronto-temporal. This study provides first evidence of a significant correlation between brain lateralization of diffusion indexes and clinical severity in toddlers with a first diagnosis of ASD. Significant correlations mainly involved regions within the fronto-temporal circuits, known to be crucial for sociocommunicative skills. It is of interest that all correlations but one were negative, suggesting an inversion of the typical left–right asymmetry in subjects with most severe clinical impairment. Autism Res 2016, 9: 382–392. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1533 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285 Widespread Disrupted White Matter Microstructure in Autism Spectrum Disorders / J. FITZGERALD in Journal of Autism and Developmental Disorders, 49-7 (July 2019)
[article]
Titre : Widespread Disrupted White Matter Microstructure in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : J. FITZGERALD, Auteur ; L. GALLAGHER, Auteur ; J. MCGRATH, Auteur Article en page(s) : p.2664-2674 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Dti Diffusion imaging Fractional anisotropy Structural connectivity Tbss Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorders (ASDs) are characterised by impaired social communication and restricted repetitive behaviours. Researchers posit that these core features may be underpinned by disrupted structural connectivity. A tract based spatial statistical analysis of diffusion MRI data was performed to investigate white matter organisation (an indication of structural connectivity) in a well-defined cohort of 45 ASD and 45 age and IQ matched control participants. Aberrant structural connectivity characterised by reduced fractional anisotropy was observed in several fiber pathways in ASD relative to controls. Disrupted white matter organisation was associated with social deficits and restricted repetitive behaviours in ASD. Abnormal structural connectivity is apparent in ASD and may be linked to the core behavioural features of the disorder. En ligne : http://dx.doi.org/10.1007/s10803-016-2803-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401
in Journal of Autism and Developmental Disorders > 49-7 (July 2019) . - p.2664-2674[article] Widespread Disrupted White Matter Microstructure in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / J. FITZGERALD, Auteur ; L. GALLAGHER, Auteur ; J. MCGRATH, Auteur . - p.2664-2674.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-7 (July 2019) . - p.2664-2674
Mots-clés : Autism spectrum disorders Dti Diffusion imaging Fractional anisotropy Structural connectivity Tbss Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorders (ASDs) are characterised by impaired social communication and restricted repetitive behaviours. Researchers posit that these core features may be underpinned by disrupted structural connectivity. A tract based spatial statistical analysis of diffusion MRI data was performed to investigate white matter organisation (an indication of structural connectivity) in a well-defined cohort of 45 ASD and 45 age and IQ matched control participants. Aberrant structural connectivity characterised by reduced fractional anisotropy was observed in several fiber pathways in ASD relative to controls. Disrupted white matter organisation was associated with social deficits and restricted repetitive behaviours in ASD. Abnormal structural connectivity is apparent in ASD and may be linked to the core behavioural features of the disorder. En ligne : http://dx.doi.org/10.1007/s10803-016-2803-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401