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Altered patterns of brain dynamics linked with body mass index in youth with autism / Lauren KUPIS in Autism Research, 14-5 (May 2021)
[article]
Titre : Altered patterns of brain dynamics linked with body mass index in youth with autism Type de document : Texte imprimé et/ou numérique Auteurs : Lauren KUPIS, Auteur ; Zachary T. GOODMAN, Auteur ; Leigha KIRCHER, Auteur ; Celia ROMERO, Auteur ; Bryce DIRKS, Auteur ; Catie CHANG, Auteur ; Jason S. NOMI, Auteur ; Lucina Q. UDDIN, Auteur Article en page(s) : p.873-886 Langues : Anglais (eng) Mots-clés : autism cognitive flexibility dynamics obesity resting-state functional MRI Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorder (ASD) have higher rates of overweight and obesity (OWOB) compared with typically developing (TD) children. Brain functional connectivity differences have been shown in both ASD and OWOB. However, only one study to date has examined ASD and OWOB concurrently, so little is known regarding the neural mechanisms associated with the higher prevalence of OWOB and its behavioral impacts in ASD. We investigated co-activation patterns (CAPs) of brain regions identified by independent component analysis in 129 children and adolescents between 6 and 18?years of age (n =?68 ASD). We examined the interaction between body mass index (BMI) and diagnosis in predicting dynamic brain metrics (dwell time, DT; frequency of occurrence, and transitions between states) as well as dimensional brain-behavior relationships. The relationship between BMI and brain dynamics was moderated by diagnosis (ASD, TD), particularly among the frequency of CAP 4, characterized by co-activation of lateral frontoparietal, temporal, and frontal networks. This pattern was negatively associated with parent-reported inhibition skills. Children with ASD had shorter CAP 1, characterized by co-activation of the subcortical, temporal, sensorimotor, and frontal networks, and CAP 4 DTs compared with TD children. CAP 1 DT was negatively associated with cognitive flexibility, inhibition, social functioning, and BMI. Cognitive flexibility moderated the relationship between BMI and brain dynamics in the visual network. Our findings provide novel evidence of neural mechanisms associated with OWOB in children with ASD. Further, poorer cognitive flexibility may result in increased vulnerability for children with ASD and co-occurring OWOB. LAY SUMMARY: Obesity is a societal epidemic and is common in autism, however, little is known about the neural mechanisms associated with the higher rates of obesity in autism. Here, we find unique patterns of brain dynamics associated with obesity in autism that were not observed in typically developing children. Further, the relationship between body mass index and brain dynamics depended on cognitive flexibility. These findings suggest that individuals with autism may be more vulnerable to the effects of obesity on brain function. Autism Res 2021, 14: 873-886. © 2021 International Society for Autism Research, Wiley Periodicals LLC. En ligne : http://dx.doi.org/10.1002/aur.2488 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=444
in Autism Research > 14-5 (May 2021) . - p.873-886[article] Altered patterns of brain dynamics linked with body mass index in youth with autism [Texte imprimé et/ou numérique] / Lauren KUPIS, Auteur ; Zachary T. GOODMAN, Auteur ; Leigha KIRCHER, Auteur ; Celia ROMERO, Auteur ; Bryce DIRKS, Auteur ; Catie CHANG, Auteur ; Jason S. NOMI, Auteur ; Lucina Q. UDDIN, Auteur . - p.873-886.
Langues : Anglais (eng)
in Autism Research > 14-5 (May 2021) . - p.873-886
Mots-clés : autism cognitive flexibility dynamics obesity resting-state functional MRI Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorder (ASD) have higher rates of overweight and obesity (OWOB) compared with typically developing (TD) children. Brain functional connectivity differences have been shown in both ASD and OWOB. However, only one study to date has examined ASD and OWOB concurrently, so little is known regarding the neural mechanisms associated with the higher prevalence of OWOB and its behavioral impacts in ASD. We investigated co-activation patterns (CAPs) of brain regions identified by independent component analysis in 129 children and adolescents between 6 and 18?years of age (n =?68 ASD). We examined the interaction between body mass index (BMI) and diagnosis in predicting dynamic brain metrics (dwell time, DT; frequency of occurrence, and transitions between states) as well as dimensional brain-behavior relationships. The relationship between BMI and brain dynamics was moderated by diagnosis (ASD, TD), particularly among the frequency of CAP 4, characterized by co-activation of lateral frontoparietal, temporal, and frontal networks. This pattern was negatively associated with parent-reported inhibition skills. Children with ASD had shorter CAP 1, characterized by co-activation of the subcortical, temporal, sensorimotor, and frontal networks, and CAP 4 DTs compared with TD children. CAP 1 DT was negatively associated with cognitive flexibility, inhibition, social functioning, and BMI. Cognitive flexibility moderated the relationship between BMI and brain dynamics in the visual network. Our findings provide novel evidence of neural mechanisms associated with OWOB in children with ASD. Further, poorer cognitive flexibility may result in increased vulnerability for children with ASD and co-occurring OWOB. LAY SUMMARY: Obesity is a societal epidemic and is common in autism, however, little is known about the neural mechanisms associated with the higher rates of obesity in autism. Here, we find unique patterns of brain dynamics associated with obesity in autism that were not observed in typically developing children. Further, the relationship between body mass index and brain dynamics depended on cognitive flexibility. These findings suggest that individuals with autism may be more vulnerable to the effects of obesity on brain function. Autism Res 2021, 14: 873-886. © 2021 International Society for Autism Research, Wiley Periodicals LLC. En ligne : http://dx.doi.org/10.1002/aur.2488 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=444 Evaluating the importance of social motor synchronization and motor skill for understanding autism / Paula FITZPATRICK in Autism Research, 10-10 (October 2017)
[article]
Titre : Evaluating the importance of social motor synchronization and motor skill for understanding autism Type de document : Texte imprimé et/ou numérique Auteurs : Paula FITZPATRICK, Auteur ; Veronica ROMERO, Auteur ; Joseph L. AMARAL, Auteur ; Amie DUNCAN, Auteur ; Holly D. BARNARD, Auteur ; Michael J. RICHARDSON, Auteur ; R.C. SCHMIDT, Auteur Article en page(s) : p.1687-1699 Langues : Anglais (eng) Mots-clés : autism social synchronization dynamics social interaction motor skill Index. décimale : PER Périodiques Résumé : Impairments in social interaction and communicating with others are core features of autism spectrum disorder (ASD), but the specific processes underlying such social competence impairments are not well understood. An important key for increasing our understanding of ASD-specific social deficits may lie with the social motor synchronization that takes place when we implicitly coordinate our bodies with others. Here, we tested whether dynamical measures of synchronization differentiate children with ASD from controls and further explored the relationships between synchronization ability and motor control problems. We found (a) that children with ASD exhibited different and less stable patterns of social synchronization ability than controls; (b) children with ASD performed motor movements that were slower and more variable in both spacing and timing; and (c) some social synchronization that involved motor timing was related to motor ability but less rhythmic synchronization was not. These findings raise the possibility that objective dynamical measures of synchronization ability and motor skill could provide new insights into understanding the social deficits in ASD that could ultimately aid clinical diagnosis and prognosis. Autism Res 2017, 10: 1687–1699. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1808 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322
in Autism Research > 10-10 (October 2017) . - p.1687-1699[article] Evaluating the importance of social motor synchronization and motor skill for understanding autism [Texte imprimé et/ou numérique] / Paula FITZPATRICK, Auteur ; Veronica ROMERO, Auteur ; Joseph L. AMARAL, Auteur ; Amie DUNCAN, Auteur ; Holly D. BARNARD, Auteur ; Michael J. RICHARDSON, Auteur ; R.C. SCHMIDT, Auteur . - p.1687-1699.
Langues : Anglais (eng)
in Autism Research > 10-10 (October 2017) . - p.1687-1699
Mots-clés : autism social synchronization dynamics social interaction motor skill Index. décimale : PER Périodiques Résumé : Impairments in social interaction and communicating with others are core features of autism spectrum disorder (ASD), but the specific processes underlying such social competence impairments are not well understood. An important key for increasing our understanding of ASD-specific social deficits may lie with the social motor synchronization that takes place when we implicitly coordinate our bodies with others. Here, we tested whether dynamical measures of synchronization differentiate children with ASD from controls and further explored the relationships between synchronization ability and motor control problems. We found (a) that children with ASD exhibited different and less stable patterns of social synchronization ability than controls; (b) children with ASD performed motor movements that were slower and more variable in both spacing and timing; and (c) some social synchronization that involved motor timing was related to motor ability but less rhythmic synchronization was not. These findings raise the possibility that objective dynamical measures of synchronization ability and motor skill could provide new insights into understanding the social deficits in ASD that could ultimately aid clinical diagnosis and prognosis. Autism Res 2017, 10: 1687–1699. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1808 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322 Social Motor Synchronization: Insights for Understanding Social Behavior in Autism / Paula FITZPATRICK in Journal of Autism and Developmental Disorders, 47-7 (July 2017)
[article]
Titre : Social Motor Synchronization: Insights for Understanding Social Behavior in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Paula FITZPATRICK, Auteur ; Veronica ROMERO, Auteur ; Joseph L. AMARAL, Auteur ; Amie DUNCAN, Auteur ; Holly D. BARNARD, Auteur ; Michael J. RICHARDSON, Auteur ; R.C. SCHMIDT, Auteur Article en page(s) : p.2092-2107 Langues : Anglais (eng) Mots-clés : Autism Social synchronization Dynamics Social interaction Index. décimale : PER Périodiques Résumé : Impairments in social interaction and communication are critical features of ASD but the underlying processes are poorly understood. An under-explored area is the social motor synchronization that happens when we coordinate our bodies with others. Here, we explored the relationships between dynamical measures of social motor synchronization and assessments of ASD traits. We found (a) spontaneous social motor synchronization was associated with responding to joint attention, cooperation, and theory of mind while intentional social motor synchronization was associated with initiating joint attention and theory of mind; and (b) social motor synchronization was associated with ASD severity but not fully explained by motor problems. Findings suggest that objective measures of social motor synchronization may provide insights into understanding ASD traits. En ligne : https://doi.org/10.1007/s10803-017-3124-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=314
in Journal of Autism and Developmental Disorders > 47-7 (July 2017) . - p.2092-2107[article] Social Motor Synchronization: Insights for Understanding Social Behavior in Autism [Texte imprimé et/ou numérique] / Paula FITZPATRICK, Auteur ; Veronica ROMERO, Auteur ; Joseph L. AMARAL, Auteur ; Amie DUNCAN, Auteur ; Holly D. BARNARD, Auteur ; Michael J. RICHARDSON, Auteur ; R.C. SCHMIDT, Auteur . - p.2092-2107.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 47-7 (July 2017) . - p.2092-2107
Mots-clés : Autism Social synchronization Dynamics Social interaction Index. décimale : PER Périodiques Résumé : Impairments in social interaction and communication are critical features of ASD but the underlying processes are poorly understood. An under-explored area is the social motor synchronization that happens when we coordinate our bodies with others. Here, we explored the relationships between dynamical measures of social motor synchronization and assessments of ASD traits. We found (a) spontaneous social motor synchronization was associated with responding to joint attention, cooperation, and theory of mind while intentional social motor synchronization was associated with initiating joint attention and theory of mind; and (b) social motor synchronization was associated with ASD severity but not fully explained by motor problems. Findings suggest that objective measures of social motor synchronization may provide insights into understanding ASD traits. En ligne : https://doi.org/10.1007/s10803-017-3124-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=314