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Interrogating the validity of cumulative indices of environmental and genetic risk for negative developmental outcomes / Keith F. WIDAMAN in Development and Psychopathology, 35-3 (August 2023)
[article]
Titre : Interrogating the validity of cumulative indices of environmental and genetic risk for negative developmental outcomes Type de document : Texte imprimé et/ou numérique Auteurs : Keith F. WIDAMAN, Auteur Article en page(s) : p.1171-1187 Langues : Anglais (eng) Mots-clés : environmental risk G*E interaction genetic risk regression analysis risk indices Index. décimale : PER Périodiques Résumé : Indices of cumulative risk (CR) have long been used in developmental research to encode the number of risk factors a child or adolescent experiences that may impede optimal developmental outcomes. Initial contributions concentrated on indices of cumulative environmental risk; more recently, indices of cumulative genetic risk have been employed. In this article, regression analytic methods are proposed for interrogating strongly the validity of risk indices by testing optimality of compositing weights, enabling more informative modeling of effects of CR indices. Reanalyses of data from two studies are reported. One study involved 10 environmental risk factors predicting Verbal IQ in 215 four-year-old children. The second study included an index of genetic CR in a G*E interaction investigation of 281 target participants assessed at age 15 years and then again at age 31 years for observed hostility during videotaped interactions with close family relations. Principles to guide evaluation of results of statistical modeling are presented, and implications of results for research and theory are discussed. The ultimate goals of this paper are to develop stronger tests of conjectures involving CR indices and to promote methods for improving replicability of results across studies. En ligne : http://dx.doi.org/10.1017/S0954579421001097 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510
in Development and Psychopathology > 35-3 (August 2023) . - p.1171-1187[article] Interrogating the validity of cumulative indices of environmental and genetic risk for negative developmental outcomes [Texte imprimé et/ou numérique] / Keith F. WIDAMAN, Auteur . - p.1171-1187.
Langues : Anglais (eng)
in Development and Psychopathology > 35-3 (August 2023) . - p.1171-1187
Mots-clés : environmental risk G*E interaction genetic risk regression analysis risk indices Index. décimale : PER Périodiques Résumé : Indices of cumulative risk (CR) have long been used in developmental research to encode the number of risk factors a child or adolescent experiences that may impede optimal developmental outcomes. Initial contributions concentrated on indices of cumulative environmental risk; more recently, indices of cumulative genetic risk have been employed. In this article, regression analytic methods are proposed for interrogating strongly the validity of risk indices by testing optimality of compositing weights, enabling more informative modeling of effects of CR indices. Reanalyses of data from two studies are reported. One study involved 10 environmental risk factors predicting Verbal IQ in 215 four-year-old children. The second study included an index of genetic CR in a G*E interaction investigation of 281 target participants assessed at age 15 years and then again at age 31 years for observed hostility during videotaped interactions with close family relations. Principles to guide evaluation of results of statistical modeling are presented, and implications of results for research and theory are discussed. The ultimate goals of this paper are to develop stronger tests of conjectures involving CR indices and to promote methods for improving replicability of results across studies. En ligne : http://dx.doi.org/10.1017/S0954579421001097 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510 Annual Research Review: DNA methylation as a mediator in the association between risk exposure and child and adolescent psychopathology / Edward D. BARKER in Journal of Child Psychology and Psychiatry, 59-4 (April 2018)
[article]
Titre : Annual Research Review: DNA methylation as a mediator in the association between risk exposure and child and adolescent psychopathology Type de document : Texte imprimé et/ou numérique Auteurs : Edward D. BARKER, Auteur ; E. WALTON, Auteur ; Charlotte A. M. CECIL, Auteur Article en page(s) : p.303-322 Langues : Anglais (eng) Mots-clés : DNA methylation adolescence childhood developmental psychopathology environmental risk epigenetics externalising problems internalising problems Index. décimale : PER Périodiques Résumé : BACKGROUND: DNA methylation (DNAm) is a potential mechanism for propagating the effects of environmental exposures on child and adolescent mental health. In recent years, this field has experienced steady growth. METHODS: We provide a strategic review of the current child and adolescent literature to evaluate evidence for a mediating role of DNAm in the link between environmental risks and psychopathological outcomes, with a focus on internalising and externalising difficulties. RESULTS: Based on the studies presented, we conclude that there is preliminary evidence to support that (a) environmental factors, such as diet, neurotoxic exposures and stress, influence offspring DNAm, and that (b) variability in DNAm, in turn, is associated with child and adolescent psychopathology. Overall, very few studies have examined DNAm in relation to both exposures and outcomes, and almost all analyses have been correlational in nature. CONCLUSIONS: DNAm holds potential as a biomarker indexing both environmental risk exposure and vulnerability for child psychopathology. However, the extent to which it may represent a causal mediator is not clear. In future, collection of prospective risk exposure, DNAm and outcomes - as well as functional characterisation of epigenetic findings - will assist in determining the role of DNAm in the link between risk exposure and psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.12782 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=353
in Journal of Child Psychology and Psychiatry > 59-4 (April 2018) . - p.303-322[article] Annual Research Review: DNA methylation as a mediator in the association between risk exposure and child and adolescent psychopathology [Texte imprimé et/ou numérique] / Edward D. BARKER, Auteur ; E. WALTON, Auteur ; Charlotte A. M. CECIL, Auteur . - p.303-322.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-4 (April 2018) . - p.303-322
Mots-clés : DNA methylation adolescence childhood developmental psychopathology environmental risk epigenetics externalising problems internalising problems Index. décimale : PER Périodiques Résumé : BACKGROUND: DNA methylation (DNAm) is a potential mechanism for propagating the effects of environmental exposures on child and adolescent mental health. In recent years, this field has experienced steady growth. METHODS: We provide a strategic review of the current child and adolescent literature to evaluate evidence for a mediating role of DNAm in the link between environmental risks and psychopathological outcomes, with a focus on internalising and externalising difficulties. RESULTS: Based on the studies presented, we conclude that there is preliminary evidence to support that (a) environmental factors, such as diet, neurotoxic exposures and stress, influence offspring DNAm, and that (b) variability in DNAm, in turn, is associated with child and adolescent psychopathology. Overall, very few studies have examined DNAm in relation to both exposures and outcomes, and almost all analyses have been correlational in nature. CONCLUSIONS: DNAm holds potential as a biomarker indexing both environmental risk exposure and vulnerability for child psychopathology. However, the extent to which it may represent a causal mediator is not clear. In future, collection of prospective risk exposure, DNAm and outcomes - as well as functional characterisation of epigenetic findings - will assist in determining the role of DNAm in the link between risk exposure and psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.12782 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=353 Maternal Smoking and Autism Spectrum Disorder: A Meta-analysis / Brittany N. ROSEN in Journal of Autism and Developmental Disorders, 45-6 (June 2015)
[article]
Titre : Maternal Smoking and Autism Spectrum Disorder: A Meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : Brittany N. ROSEN, Auteur ; Brian K. LEE, Auteur ; Nora L. LEE, Auteur ; Yunwen YANG, Auteur ; Igor BURSTYN, Auteur Article en page(s) : p.1689-1698 Langues : Anglais (eng) Mots-clés : Autism Tobacco smoke Epidemiology Systematic review In-utero exposure Environmental risk Exposure misclassification Index. décimale : PER Périodiques Résumé : We conducted a meta-analysis of 15 studies on maternal prenatal smoking and ASD risk in offspring. Using a random-effects model, we found no evidence of an association (summary OR 1.02, 95 % CI 0.93–1.12). Stratifying by study design, birth year, type of healthcare system, and adjustment for socioeconomic status or psychiatric history did not alter the findings. There was evidence that ascertaining exposure at the time of birth produced a lower summary OR than when this information was gathered after birth. There was no evidence of publication bias. Non-differential exposure misclassification was shown to have the potential for negligible influence on the results. We found no evidence to support a measurable association between maternal prenatal smoking and ASD in offspring. En ligne : http://dx.doi.org/10.1007/s10803-014-2327-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259
in Journal of Autism and Developmental Disorders > 45-6 (June 2015) . - p.1689-1698[article] Maternal Smoking and Autism Spectrum Disorder: A Meta-analysis [Texte imprimé et/ou numérique] / Brittany N. ROSEN, Auteur ; Brian K. LEE, Auteur ; Nora L. LEE, Auteur ; Yunwen YANG, Auteur ; Igor BURSTYN, Auteur . - p.1689-1698.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-6 (June 2015) . - p.1689-1698
Mots-clés : Autism Tobacco smoke Epidemiology Systematic review In-utero exposure Environmental risk Exposure misclassification Index. décimale : PER Périodiques Résumé : We conducted a meta-analysis of 15 studies on maternal prenatal smoking and ASD risk in offspring. Using a random-effects model, we found no evidence of an association (summary OR 1.02, 95 % CI 0.93–1.12). Stratifying by study design, birth year, type of healthcare system, and adjustment for socioeconomic status or psychiatric history did not alter the findings. There was evidence that ascertaining exposure at the time of birth produced a lower summary OR than when this information was gathered after birth. There was no evidence of publication bias. Non-differential exposure misclassification was shown to have the potential for negligible influence on the results. We found no evidence to support a measurable association between maternal prenatal smoking and ASD in offspring. En ligne : http://dx.doi.org/10.1007/s10803-014-2327-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259